{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T05:44:13Z","timestamp":1786167853084,"version":"build-2736575974"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"TAEJOON PHARM Co. Ltd., South Korea."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Jpn J Ophthalmol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10384-026-01335-2","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:25:22Z","timestamp":1772004322000},"page":"915-922","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A prospective, randomized study comparing the effects of preservative-free latanoprost and preserved latanoprost eyedrops on MMP-9 expression and ocular surface disease index in glaucoma patients"],"prefix":"10.1007","volume":"70","author":[{"given":"Edward","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0003-0034","authenticated-orcid":false,"given":"Ji-Hye","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chungkwon","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"1335_CR1","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1080\/03007995.2016.1202818","volume":"32","author":"F Aptel","year":"2016","unstructured":"Aptel F, Choudhry R, Stalmans I. Preservative-free versus preserved latanoprost eye drops in patients with open angle glaucoma or ocular hypertension. Curr Med Res Opin. 2016;32:1457\u201363.","journal-title":"Curr Med Res Opin"},{"key":"1335_CR2","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1097\/IJG.0b013e31815c5f4f","volume":"17","author":"EW Leung","year":"2008","unstructured":"Leung EW, Medeiros FA, Weinreb RN. Prevalence of ocular surface disease in glaucoma patients. J Glaucoma. 2008;17:350\u20135.","journal-title":"J Glaucoma"},{"key":"1335_CR3","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1097\/ICO.0b013e3181c325b2","volume":"29","author":"RD Fechtner","year":"2010","unstructured":"Fechtner RD, Godfrey DG, Budenz D, Stewart JA, Stewart WC, Jasek MC. Prevalence of ocular surface complaints in patients with glaucoma using topical intraocular pressure-lowering medications. Cornea. 2010;29:618\u201321.","journal-title":"Cornea"},{"key":"1335_CR4","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1016\/j.ophtha.2013.03.045","volume":"120","author":"PM Mathews","year":"2013","unstructured":"Mathews PM, Ramulu PY, Friedman DS, Utine CA, Akpek EK. Evaluation of ocular surface disease in patients with glaucoma. Ophthalmology. 2013;120:2241\u20138.","journal-title":"Ophthalmology"},{"key":"1335_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ajo.2011.05.033","volume":"153","author":"SE Skalicky","year":"2012","unstructured":"Skalicky SE, Goldberg I, McCluskey P. Ocular surface disease and quality of life in patients with glaucoma. Am J Ophthalmol. 2012;153:1\u20139.","journal-title":"Am J Ophthalmol"},{"key":"1335_CR6","doi-asserted-by":"publisher","first-page":"625","DOI":"10.2147\/OPTH.S81247","volume":"9","author":"B Cvenkel","year":"2015","unstructured":"Cvenkel B, \u0160tunf \u0160, Srebotnik Kirbi\u0161 I, Strojan Fle\u017ear M. Symptoms and signs of ocular surface disease related to topical medication in patients with glaucoma. Clin Ophthalmol. 2015;9:625\u201331.","journal-title":"Clin Ophthalmol"},{"key":"1335_CR7","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1240537","volume":"2019","author":"A Zaleska-\u017bmijewska","year":"2019","unstructured":"Zaleska-\u017bmijewska A, Strzemecka E, Wawrzyniak ZM, Szaflik JP. Extracellular MMP-9-based assessment of ocular surface inflammation in patients with primary open-angle glaucoma. J Ophthalmol. 2019;2019:1240537. https:\/\/doi.org\/10.1155\/2019\/1240537.","journal-title":"J Ophthalmol"},{"key":"1335_CR8","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1038\/s41433-020-0993-y","volume":"35","author":"DW Kim","year":"2021","unstructured":"Kim DW, Seo JH, Lim SH. Evaluation of ocular surface disease in elderly patients with glaucoma: expression of matrix metalloproteinase-9 in tears. Eye. 2021;35:892\u2013900.","journal-title":"Eye"},{"key":"1335_CR9","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1001\/archophthalmol.2010.40","volume":"128","author":"N Honda","year":"2010","unstructured":"Honda N, Miyai T, Nejima R, Miyata K, Mimura T, Usui T, et al. Effect of latanoprost on the expression of matrix metalloproteinases and tissue inhibitor of metalloproteinase 1 on the ocular surface. Arch Ophthalmol. 2010;128:466\u201371.","journal-title":"Arch Ophthalmol"},{"key":"1335_CR10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175\u201391.","journal-title":"Behav Res Methods"},{"key":"1335_CR11","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1167\/iovs.08-2476","volume":"50","author":"S Chotikavanich","year":"2009","unstructured":"Chotikavanich S, de Paiva CS, de Li Q, Chen JJ, Bian F, Farley WJ, et al. Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Investig Ophthalmol Vis Sci. 2009;50:3203\u20139.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1335_CR12","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1016\/j.ophtha.2016.07.028","volume":"123","author":"EM Messmer","year":"2016","unstructured":"Messmer EM, von Lindenfels V, Garbe A, Kampik A. Matrix metalloproteinase 9 testing in dry eye disease using a commercially available point-of-care immunoassay. Ophthalmology. 2016;123:2300\u20138.","journal-title":"Ophthalmology"},{"key":"1335_CR13","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1136\/bjophthalmol-2015-307607","volume":"100","author":"TC Chan","year":"2016","unstructured":"Chan TC, Ye C, Chan KP, Chu KO, Jhanji V. Evaluation of point-of-care test for elevated tear matrix metalloproteinase 9 in post-LASIK dry eyes. Br J Ophthalmol. 2016;100:1188\u201391.","journal-title":"Br J Ophthalmol"},{"key":"1335_CR14","first-page":"1703","volume":"41","author":"L Sobrin","year":"2000","unstructured":"Sobrin L, Liu Z, Monroy DC, Solomon A, Selzer MG, Lokeshwar BL, et al. Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. Investig Ophthalmol Vis Sci. 2000;41:1703\u20139.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1335_CR15","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1167\/iovs.04-0299","volume":"45","author":"DQ Li","year":"2004","unstructured":"Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Investig Ophthalmol Vis Sci. 2004;45:4302\u201311.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1335_CR16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0002-9440(10)62232-8","volume":"166","author":"SC Pflugfelder","year":"2005","unstructured":"Pflugfelder SC, Farley W, Luo L, Chen LZ, de Paiva CS, Olmos LC, et al. Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005;166:61\u201371.","journal-title":"Am J Pathol"},{"key":"1335_CR17","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.2147\/OPTH.S89700","volume":"9","author":"JD Bartlett","year":"2015","unstructured":"Bartlett JD, Keith MS, Sudharshan L, Snedecor SJ. Associations between signs and symptoms of dry eye disease: a systematic review. Clin Ophthalmol. 2015;9:1719\u201330.","journal-title":"Clin Ophthalmol"},{"key":"1335_CR18","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.ajo.2025.05.033","volume":"279","author":"JS Wolffsohn","year":"2025","unstructured":"Wolffsohn JS, Ben\u00edtez-Del-Castillo JM, Loya-Garcia D, Inomata T, Iyer G, Liang L, et al. TFOS DEWS III: diagnostic methodology. Am J Ophthalmol. 2025;279:387\u2013450.","journal-title":"Am J Ophthalmol"},{"key":"1335_CR19","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/S0161-6420(97)30124-9","volume":"104","author":"LJ Sullivan","year":"1997","unstructured":"Sullivan LJ, McCurrach F, Lee S, Taylor HR, Rolando M, Marechal-Courtois C, et al. Efficacy and safety of 0.3% carbomer gel compared to placebo in patients with moderate-to-severe dry eye syndrome. Ophthalmology. 1997;104:1402\u20138.","journal-title":"Ophthalmology"},{"key":"1335_CR20","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/ICO.0000000000000660","volume":"35","author":"SH Chung","year":"2016","unstructured":"Chung SH, Lim SA, Tchach H. Efficacy and safety of carbomer-based lipid-containing artificial tear formulations in patients with dry eye syndrome. Cornea. 2016;35:181\u20136.","journal-title":"Cornea"},{"key":"1335_CR21","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1159\/000334791","volume":"50","author":"C Baudouin","year":"2012","unstructured":"Baudouin C. Ocular surface and external filtration surgery: mutual relationships. Dev Ophthalmol. 2012;50:64\u201378.","journal-title":"Dev Ophthalmol"},{"key":"1335_CR22","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1097\/IJG.0b013e31825af67d","volume":"22","author":"C Boimer","year":"2013","unstructured":"Boimer C, Birt CM. Preservative exposure and surgical outcomes in glaucoma patients: the PESO study. J Glaucoma. 2013;22:730\u20135.","journal-title":"J Glaucoma"},{"key":"1335_CR23","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1097\/IJG.0000000000001041","volume":"27","author":"P Dubrulle","year":"2018","unstructured":"Dubrulle P, Labb\u00e9 A, Brasnu E, Liang H, Hamard P, Meziani L, et al. Influence of treating ocular surface disease on intraocular pressure in glaucoma patients intolerant to their topical treatments: a report of 10 cases. J Glaucoma. 2018;27:1105\u201311.","journal-title":"J Glaucoma"},{"key":"1335_CR24","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jtos.2015.10.004","volume":"14","author":"NL Lanza","year":"2016","unstructured":"Lanza NL, Valenzuela F, Perez VL, Galor A. The matrix metalloproteinase 9 point-of-care test in dry eye. Ocul Surf. 2016;14:189\u201395.","journal-title":"Ocul Surf"}],"container-title":["Japanese Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10384-026-01335-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10384-026-01335-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10384-026-01335-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T05:22:54Z","timestamp":1786166574000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10384-026-01335-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["1335"],"URL":"https:\/\/doi.org\/10.1007\/s10384-026-01335-2","relation":{},"ISSN":["0021-5155","1613-2246"],"issn-type":[{"value":"0021-5155","type":"print"},{"value":"1613-2246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"17 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"E. Kang, None; J-H. Park, None; C. Yoo, None; Y. Y. Kim, None.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}