{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:00:53Z","timestamp":1790402453414,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Jpn J Ophthalmol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>S-1 is a first-line oral anti-cancer drug widely used in Japan. This study evaluated surgical outcomes for S-1\u2013associated tear drainage system disorders (S-1\/TDSD) and explored strategies to improve outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Multicenter, retrospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-one patients (89 sides; 31 men and 20 women; mean age \u00b1 SD, 68.7 \u00b1 10.7 years; range 49\u250085 years) with S-1\/TDSD were included. Surgical procedures performed were: three-snip procedure; exploratory horizontal part canaliculotomy; probing with tube placement; and conjunctivodacryocystorhinostomy with Jones tube insertion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cases were classified as: punctal occlusion (Group a, 34 sides), both stenosed canaliculi (Group b, 2 sides), patent canaliculus and mono-canalicular obstruction (CO) (Group c, 9 sides), one soft or tightCO and contralateral softCO (Group d, 13 sides), tightCOs in both canaliculi (Group e, 27 sides), and common CO (Group f, 4 sides). The three-snip procedure for Group a was successful in 32 of 34 sides (94.1%). Probing with intubation for Group b was successful in all cases (2\/2). Conjunctivodacryocystorhinostomy for Group e was successful in 15 of 20 sides (75.0%) and dacryoendoscopic canaliculo-incision for Group e was successful in 4 of 4 sides (100%). However, exploratory horizontal part canaliculotomy and probing for Groups c and d were successful in 14%\u250042% of cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The three-snip procedure for punctal occlusions showed favorable outcomes but procedures preserving the canaliculus, especially in patients with horizontal CO, did not yield good results, even for an affected single canaliculus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10384-026-01377-6","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:43:00Z","timestamp":1781160180000},"page":"1099-1105","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical procedures and outcomes in patients with tear drainage system disorders associated with the anticancer agent S-1"],"prefix":"10.1007","volume":"70","author":[{"given":"Tsugihisa","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Sounou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Higashide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"1377_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10120-022-01331-8","volume":"26","author":"Japanese gastric cancer association","year":"2023","unstructured":"Japanese gastric cancer association. Japanese gastric cancer treatment guidelines 2021 (6th edition). Gastric Cancer. 2023;26:1\u201325.","journal-title":"Gastric Cancer"},{"key":"1377_CR2","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ajo.2005.01.052","volume":"140","author":"B Esmaeli","year":"2005","unstructured":"Esmaeli B, Golio D, Lubecki L, Ajani J. Canalicular and nasolacrimal duct blockage: an ocular side effect associated with the antineoplastic drug S-1. Am J Ophthalmol. 2005;140:325\u20137.","journal-title":"Am J Ophthalmol"},{"key":"1377_CR3","first-page":"259","volume":"38","author":"H Kitamura","year":"2011","unstructured":"Kitamura H, Miyanaga T, Shin H, Fujita M, Miyazaki M, Yagi D, et al. Investigation of epiphora following S-1 therapy. Gan To Kagaku Ryoho. 2011;38:259\u201362 ((in Japanese)).","journal-title":"Gan To Kagaku Ryoho"},{"key":"1377_CR4","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1007\/s10384-012-0127-6","volume":"56","author":"T Sasaki","year":"2012","unstructured":"Sasaki T, Miyashita H, Miyanaga T, Yamamoto K, Sugiyama K. Dacryoendoscopic observation and incidence of canalicular obstruction\/stenosis associated with S-1, an oral anticancer drug. Jpn J Ophthalmol. 2012;56:214\u20138.","journal-title":"Jpn J Ophthalmol"},{"key":"1377_CR5","doi-asserted-by":"publisher","first-page":"30","DOI":"10.4143\/crt.2016.569","volume":"50","author":"N Kim","year":"2018","unstructured":"Kim N, Kim JW, Baek JH, Kim J-S, Choung H-K, Kim T-Y, et al. S-1-induced lacrimal drainage obstruction and its association with ingredients\/metabolites of S-1 in tears and plasma: a prospective multi-institutional study. 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Sasaki, Patents issued, with no payments received (Fiber tech); T. Sounou, None; T. Higashide, None.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}