{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:59:55Z","timestamp":1790402395291,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100017346","name":"Boehringer Ingelheim Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017346","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Jpn J Ophthalmol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the natural course of geographic atrophy (GA) in Japanese patients, with a focus on factors associated with the change of GA size over time and visual acuity decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Retrospective, single-center observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed 40 eyes of 40 patients with GA and longitudinal fundus autofluorescence (FAF) imaging. Annual progression rates were calculated as square root\u2013transformed (mm\/year). Assessed factors included age, sex, smoking history, diabetes, hypertension, baseline best-corrected visual acuity (BCVA), baseline lesion size, foveal center involvement, choroidal thickness, FAF subtypes, and presence of subretinal drusenoid deposits (SDD). Visual outcomes were assessed as change in BCVA (\u0394BCVA, logarithm of the minimum angle of resolution (logMAR)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age was 75.5 years; 50% of eyes had SDD. The median annual GA progression rate was 0.16 mm\/year in square root units. Baseline GA area and the presence of SDD were independent predictors of GA progression (\u03b2 = \u22120.0837, p = 0.015; \u03b2 = +0.3064, p = 0.009, respectively). In multivariable analysis, baseline GA area also remained a significant predictor of visual deterioration (\u03b2 = +0.1369, p = 0.002). When stratified by FAF patterns, there was significant worsening of BCVA in the Diffuse (p = 0.0027) and Banded (p = 0.0117) subtypes, whereas the None and Other subtypes did not show significant changes in BCVA over one year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SDD was identified as a significant risk factor for GA progression in Japanese patients. These findings improve understanding of natural history of GA in Japanese population and may inform risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10384-026-01388-3","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:42:58Z","timestamp":1782715378000},"page":"1154-1164","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Geographic atrophy progression and subretinal drusenoid deposits in a real-world Japanese cohort"],"prefix":"10.1007","volume":"70","author":[{"given":"Takuya","family":"Takayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-4730","authenticated-orcid":false,"given":"Hidenori","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Tsuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieh","family":"Esmaeelpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Inoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Tampo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyouta","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Fukuju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikatsu","family":"Kaburaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Yanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"1388_CR1","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.ophtha.2010.08.018","volume":"118","author":"Z Yehoshua","year":"2011","unstructured":"Yehoshua Z, Rosenfeld PJ, Gregori G, Feuer WJ, Falc\u00e3o M, Lujan BJ, et al. 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Takayama, Grants or contracts (Alcon); H. Takahashi, Grants or contracts (Kyowa Kirin, Novartis, Bayer, Linical), Consulting fees (Boehringer Ingelheim), Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events (Kyowa Kirin, Santen, Bayer, Senju, Boehringer Ingelheim, Chugai, HOYA, Novartis, Nikon), Support for attending meetings and\/or travel (Kyowa Kirin, Santen, Bayer, Senju, Boehringer Ingelheim, Chugai, HOYA, Novartis, Nikon), Patents planned, issued or pending (DeepEyeVision), Stock or stock options (DeepEyeVision); T. Tsuge, Employee (DeepEyeVision); M. Chiba, Employee (DeepEyeVision); M. Esmaeelpour, Employee (Boehringer Ingelheim); S. Inoda, Grants or contracts (HOYA, Chugai, Santen), Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events (Kowa, Santen, Novartis, Bayer, Chugai, Astellas, Senju); H. Tampo, None ; Y. Hashimoto, None; K. Kimura, Employee (Boehringer Ingelheim); Y. Fukuju, Patents planned, issued or pending (DeepEyeVision), Stock or stock options (DeepEyeVision); T. Kaburaki, Grants or contracts (Eisai, Santen, AbbVie, Senju, Daiichi-Sankyo, Kowa, HOYA, Alcon), Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events (Santen, AbbVie, Novartis, Tanabe-Mitsubishi, Eisai, Kowa, Wakamoto, Senju, Otsuka, Ono, Daiichi-Sankyo, Chugai), Support for attending meetings and\/or travel (Santen, AbbVie, Novartis, Tanabe-Mitsubishi, Eisai, Kowa, Wakamoto, Senju, Otsuka, Ono, Daiichi-Sankyo, Chugai); Y. Yanagi, None.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}