{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:45:35Z","timestamp":1782708335330,"version":"3.54.5"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Jpn J Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the association between the anatomical location of conjunctivochalasis (CCh) and subjective chief complaints in patients who underwent surgical treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Retrospective multicenter study<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 39 eyes of 27 patients undergoing surgery for symptomatic CCh. CCh location was classified as total, nasal, nasal-plus-temporal, or temporal; chief complaints were registered as discomfort\/foreign body sensation (FBS), epiphora, or cosmetic complaint. Associations were evaluated by Chi-square test (Cram\u00e9r\u2019s V) and pairwise Fisher\u2019s exact tests; age differences by Kruskal\u2013Wallis test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant association was found between CCh location and chief complaint (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      = 35.48,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.000003; Cram\u00e9r\u2019s V = 0.674). Total CCh was predominantly associated with discomfort\/FBS (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0038). Nasal CCh showed a predominant pattern of epiphora. Nasal-plus-temporal CCh showed a mixed pattern, epiphora and discomfort\/FBS. Temporal CCh was observed predominantly\u00a0with cosmetic complaints (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). Patients with cosmetic complaints were significantly younger than those in other symptom groups (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this surgically selected cohort, subjective symptoms were significantly associated with CCh location. Total CCh was associated with discomfort\/FBS, nasal CCh with epiphora, and temporal CCh with cosmetic complaints. The combination of CCh location and patient age may further clarify the clinical presentation: older patients with total CCh sought surgery for mechanical irritation, while younger patients with temporal CCh sought surgery for cosmetic reasons. Recognizing this location- and age-based pattern may help clinicians anticipate the chief complaint and support individualized surgical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10384-026-01394-5","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:19:11Z","timestamp":1782706751000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between the anatomical location of conjunctivochalasis and subjective symptoms: a multicenter retrospective study"],"prefix":"10.1007","author":[{"given":"Seika","family":"Den","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Toda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"1394_CR1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/S0002-9394(42)93297-5","volume":"25","author":"WL Hughes","year":"1942","unstructured":"Hughes WL. 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Den, None; I. Toda, None; T. Nakano, Grants or contracts (Kyowa Medical, ZEISS, KURIBARA MEDICAL INSTRUMENTS, Alexion, HOYA, Kowa, Senju, Bristol Myers Squibb, Santen, Uni-Hite, IOL medical, Lumenis, ANA, GSK, JAL).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}