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Abumanhal, None; M. Ito, None; K. Sugiura, None; Y. Takahashi, Consulting fees (Amgen, Santen, Chugai, Ono), Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events (Amgen).","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The institutional review board (IRB) of Aichi Medical University Hospital approved this study, which was conducted in accordance with the tenets of the Declaration of Helsinki and its later amendments (approval number, 2021-001). The IRB granted a waiver of informed consent for this study based on the ethical guidelines for medical and health research involving human subjects established by the Japanese Ministry of Education, Culture, Sports, Science, and Technology; and by the Ministry of Health, Labour, and Welfare. The waiver was granted because the study was not an interventional study. Nevertheless, at the request of the IRB, an outline of the study was published on our university website that was available for public viewing, which also gave the patients an option to refuse to participate in the study, although none did. Personal identifiers were removed from the records prior to data analysis.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article was posted as a preprint on Research Square on February 16, 2026. doi:\n                      \n                      .","order":3,"name":"Ethics","label":"Previous posting","group":{"name":"EthicsHeading","label":"Declarations"}}]}}