{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:17:45Z","timestamp":1764937065862,"version":"3.37.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Esophagus"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s10388-019-00662-3","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T16:03:37Z","timestamp":1553875417000},"page":"309-315","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Obesity and hiatal hernia may be non-allergic risk factors for esophageal eosinophilia in Japanese adults"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-1249","authenticated-orcid":false,"given":"Fumio","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamami","family":"Morisaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Otani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Hosomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Nagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Kamata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Taira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akemi","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Yamagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Tanigawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Kawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"662_CR1","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/ajg.2013.71","volume":"108","author":"ES Dellon","year":"2013","unstructured":"Dellon ES, Gonsalves N, Hirano I, et al. ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). Am J Gastroenterol. 2013;108:679\u201392.","journal-title":"Am J Gastroenterol"},{"key":"662_CR2","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1056\/NEJMra1502863","volume":"373","author":"GT Furuta","year":"2015","unstructured":"Furuta GT, Katzka DA. Eosinophilic esophagitis. N Engl J Med. 2015;373:1640\u20138.","journal-title":"N Engl J Med"},{"key":"662_CR3","doi-asserted-by":"publisher","first-page":"2928","DOI":"10.1007\/s10620-016-4204-4","volume":"61","author":"E Mansoor","year":"2016","unstructured":"Mansoor E, Cooper GS. The 2010\u20132015 prevalence of eosinophilic esophagitis in the USA: a population-based study. Dig Dis Sci. 2016;61:2928\u201334.","journal-title":"Dig Dis Sci"},{"issue":"1349\u201350","key":"662_CR4","first-page":"e5","volume":"128","author":"P Hruz","year":"2011","unstructured":"Hruz P, Straumann A, Bussmann C, et al. Escalating incidence of eosinophilic esophagitis: a 20-year prospective, population-based study in Olten County, Switzerland. J Allergy Clin Immunol. 2011;128(1349\u201350):e5.","journal-title":"J Allergy Clin Immunol."},{"key":"662_CR5","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1136\/gut.2006.107714","volume":"56","author":"J Ronkainen","year":"2007","unstructured":"Ronkainen J, Talley NJ, Aro P, et al. Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the population-based Kalixanda study. Gut. 2007;56:615\u201320.","journal-title":"Gut"},{"issue":"589\u201396","key":"662_CR6","first-page":"e1","volume":"12","author":"ES Dellon","year":"2014","unstructured":"Dellon ES, Jensen ET, Martin CF, et al. Prevalence of eosinophilic esophagitis in the United States. Clin Gastroenterol Hepatol. 2014;12(589\u201396):e1.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"662_CR7","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.2169\/internalmedicine.51.8670","volume":"51","author":"Y Fujiwara","year":"2012","unstructured":"Fujiwara Y, Sugawa T, Tanaka F, et al. A multicenter study on the prevalence of eosinophilic esophagitis and PPI-responsive esophageal eosinophilic infiltration. Intern Med. 2012;51:3235\u20139.","journal-title":"Intern Med"},{"key":"662_CR8","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1007\/s00535-011-0435-5","volume":"46","author":"H Fujishiro","year":"2011","unstructured":"Fujishiro H, Amano Y, Kushiyama Y, et al. Eosinophilic esophagitis investigated by upper gastrointestinal endoscopy in Japanese patients. J Gastroenterol. 2011;46:1142\u20134.","journal-title":"J Gastroenterol"},{"key":"662_CR9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1097\/MPG.0b013e318290d15a","volume":"57","author":"ET Jensen","year":"2013","unstructured":"Jensen ET, Kappelman MD, Kim HP, et al. Early life exposures as risk factors for pediatric eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2013;57:67\u201371.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"662_CR10","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.jaci.2011.07.027","volume":"128","author":"FA Nimwegen van","year":"2011","unstructured":"van Nimwegen FA, Penders J, Stobberingh EE, et al. Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. J Allergy Clin Immunol. 2011;128:948\u201355.e1\u20133.","journal-title":"J Allergy Clin Immunol."},{"key":"662_CR11","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1111\/j.1572-0241.2003.07390.x","volume":"98","author":"JE Markowitz","year":"2003","unstructured":"Markowitz JE, Spergel JM, Ruchelli E, et al. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol. 2003;98:777\u201382.","journal-title":"Am J Gastroenterol"},{"key":"662_CR12","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1007\/s10620-014-3512-9","volume":"60","author":"X Ma","year":"2015","unstructured":"Ma X, Xu Q, Zheng Y, et al. Prevalence of esophageal eosinophilia and eosinophilic esophagitis in adults: a population-based endoscopic study in Shanghai, China. Dig Dis Sci. 2015;60:1716\u201323.","journal-title":"Dig Dis Sci."},{"key":"662_CR13","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nrgastro.2015.75","volume":"12","author":"L Kia","year":"2015","unstructured":"Kia L, Hirano I. Distinguishing GERD from eosinophilic oesophagitis: concepts and controversies. Nat Rev Gastroenterol Hepatol. 2015;12:379\u201386.","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"662_CR14","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1159\/000357080","volume":"32","author":"DA Katzka","year":"2014","unstructured":"Katzka DA. The complex relationship between eosinophilic esophagitis and gastroesophageal reflux disease. Dig Dis. 2014;32:93\u20137.","journal-title":"Dig Dis"},{"key":"662_CR15","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1111\/j.1572-0241.2006.00562.x","volume":"101","author":"P Ngo","year":"2006","unstructured":"Ngo P, Furuta GT, Antonioli DA, et al. Eosinophils in the esophagus\u2014peptic or allergic eosinophilic esophagitis? Case series of three patients with esophageal eosinophilia. Am J Gastroenterol. 2006;101:1666\u201370.","journal-title":"Am J Gastroenterol"},{"key":"662_CR16","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1053\/gast.1996.v111.pm8898633","volume":"111","author":"NA Tobey","year":"1996","unstructured":"Tobey NA, Carson JL, Alkiek RA, et al. Dilated intercellular spaces: a morphological feature of acid reflux\u2014damaged human esophageal epithelium. Gastroenterology. 1996;111:1200\u20135.","journal-title":"Gastroenterology"},{"key":"662_CR17","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.gtc.2014.02.004","volume":"43","author":"E Cheng","year":"2014","unstructured":"Cheng E, Souza RF, Spechler SJ. Eosinophilic esophagitis: interactions with gastroesophageal reflux disease. Gastroenterol Clin N Am. 2014;43:243\u201356.","journal-title":"Gastroenterol Clin N Am"},{"key":"662_CR18","first-page":"1","volume":"94","author":"M Kanazawa","year":"2005","unstructured":"Kanazawa M, Yoshiike N, Osaka T, et al. Criteria and classification of obesity in Japan and Asia-Oceania. World Rev Nutr Diet. 2005;94:1\u201312.","journal-title":"World Rev Nutr Diet"},{"key":"662_CR19","doi-asserted-by":"publisher","first-page":"e73430","DOI":"10.1371\/journal.pone.0073430","volume":"8","author":"Y Saisho","year":"2013","unstructured":"Saisho Y, Hirose H, Roberts R, et al. C-reactive protein, high-molecular-weight adiponectin and development of metabolic syndrome in the Japanese general population: a longitudinal cohort study. PLoS One. 2013;8:e73430.","journal-title":"PLoS One"},{"key":"662_CR20","doi-asserted-by":"publisher","first-page":"e0192951","DOI":"10.1371\/journal.pone.0192951","volume":"13","author":"A Masuda","year":"2018","unstructured":"Masuda A, Fujita T, Murakami M, et al. Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett\u2019s esophagus. PLoS One. 2018;13:e0192951.","journal-title":"PLoS One"},{"key":"662_CR21","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s10388-018-0648-2","volume":"16","author":"S Takashima","year":"2018","unstructured":"Takashima S, Tanaka F, Otani K, et al. Barrett\u2019s esophagus is negatively associated with eosinophilic esophagitis in Japanese subjects. Esophagus. 2018;16:78. \n                    https:\/\/doi.org\/10.1007\/s10388-018-0648-2\n                    \n                  \n                           (Epub ahead of print).","journal-title":"Esophagus"},{"key":"662_CR22","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transplant. 2013;48:452\u20138.","journal-title":"Bone Marrow Transplant"},{"key":"662_CR23","first-page":"OC01","volume":"11","author":"B Vaishnav","year":"2017","unstructured":"Vaishnav B, Bamanikar A, Maske P, et al. Gastroesophageal reflux disease and its association with body mass index: clinical and endoscopic study. J Clin Diagn Res. 2017;11:OC01\u20134.","journal-title":"J Clin Diagn Res."},{"key":"662_CR24","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1007\/s00535-009-0047-5","volume":"44","author":"Y Fujiwara","year":"2009","unstructured":"Fujiwara Y, Arakawa T. Epidemiology and clinical characteristics of GERD in the Japanese population. J Gastroenterol. 2009;44:518\u201334.","journal-title":"J Gastroenterol"},{"key":"662_CR25","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1097\/MCG.0b013e318205e164","volume":"45","author":"S Gaddam","year":"2011","unstructured":"Gaddam S, Maddur H, Wani S, et al. Risk factors for nocturnal reflux in a large GERD cohort. J Clin Gastroenterol. 2011;45:764\u20138.","journal-title":"J Clin Gastroenterol"},{"key":"662_CR26","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1053\/j.gastro.2018.07.009","volume":"155","author":"ES Dellon","year":"2018","unstructured":"Dellon ES, Liacouras CA, Molina-Infante J, et al. Updated international consensus diagnostic criteria for eosinophilic esophagitis: proceedings of the AGREE conference. Gastroenterology. 2018;155:1022\u201333.e10.","journal-title":"Gastroenterology."},{"key":"662_CR27","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.gtc.2015.03.001","volume":"44","author":"AK Chandar","year":"2015","unstructured":"Chandar AK, Iyer PG. Role of obesity in the pathogenesis and progression of Barrett\u2019s esophagus. Gastroenterol Clin N Am. 2015;44:249\u201364.","journal-title":"Gastroenterol Clin N Am"},{"key":"662_CR28","doi-asserted-by":"publisher","first-page":"G1052","DOI":"10.1152\/ajpgi.00279.2001","volume":"282","author":"JE Pandolfino","year":"2002","unstructured":"Pandolfino JE, Shi G, Curry J, et al. Esophagogastric junction distensibility: a factor contributing to sphincter incompetence. Am J Physiol Gastrointest Liver Physiol. 2002;282:G1052\u20138.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"662_CR29","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00535-016-1213-1","volume":"52","author":"D Jiao","year":"2017","unstructured":"Jiao D, Ishimura N, Maruyama R, et al. Similarities and differences among eosinophilic esophagitis, proton-pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: comparisons of clinical, endoscopic, and histopathological findings in Japanese patients. J Gastroenterol. 2017;52:203\u201310.","journal-title":"J Gastroenterol"},{"key":"662_CR30","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1053\/j.gastro.2008.02.016","volume":"134","author":"RC Kapel","year":"2008","unstructured":"Kapel RC, Miller JK, Torres C, et al. Eosinophilic esophagitis: a prevalent disease in the United States that affects all age groups. Gastroenterology. 2008;134:1316\u201321.","journal-title":"Gastroenterology"}],"container-title":["Esophagus"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10388-019-00662-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10388-019-00662-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10388-019-00662-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T00:20:30Z","timestamp":1585354830000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10388-019-00662-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,29]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["662"],"URL":"https:\/\/doi.org\/10.1007\/s10388-019-00662-3","relation":{},"ISSN":["1612-9059","1612-9067"],"issn-type":[{"type":"print","value":"1612-9059"},{"type":"electronic","value":"1612-9067"}],"subject":[],"published":{"date-parts":[[2019,3,29]]},"assertion":[{"value":"5 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The study protocol was in accordance with the Declaration of Helsinki and was approved by the institutional review board of the Osaka City University Graduate School of Medicine (September 2016, Protocol number 3564). The need for informed consent has been waived by the institutional review board of the Osaka City University Graduate School of Medicine. We have disclosed the information about this study on our home page on the Internet and the patients had the opportunity to opt out.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement"}},{"value":"The authors declare no conflict of interests for this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}