{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:34:01Z","timestamp":1790703241936,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100011103","name":"Sixth Framework Programme","doi-asserted-by":"publisher","award":["LSHC-CT-2006-037409"],"award-info":[{"award-number":["LSHC-CT-2006-037409"]}],"id":[{"id":"10.13039\/100011103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Esophagus"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s10388-020-00769-y","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T14:02:47Z","timestamp":1597932167000},"page":"346-352","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Esophagus stretch tests: Biomechanics for tissue engineering and possible implications on the outcome of esophageal atresia repairs performed under excessive tension"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7635-7490","authenticated-orcid":false,"given":"Amulya K.","family":"Saxena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ede","family":"Biro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard A.","family":"Holzapfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"key":"769_CR1","first-page":"910","volume":"59","author":"DC Clark","year":"1999","unstructured":"Clark DC. Esophageal atresia and tracheoesophageal fistula. Am Fam Phycisian. 1999;59:910\u20136.","journal-title":"Am Fam Phycisian"},{"key":"769_CR2","first-page":"672","volume":"76","author":"C Haight","year":"1943","unstructured":"Haight C, Towsley H. Congenital atresia of the esophagus with tracheoesophageal fistula: extrapleural ligation of fistula and end-to-end anastomosis of esophageal segments. Surg Gynecol Obstet. 1943;76:672\u201388.","journal-title":"Surg Gynecol Obstet"},{"key":"769_CR3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1750-1172-2-24","volume":"2","author":"L Spitz","year":"2007","unstructured":"Spitz L. Oesophageal atresia. Orphanet J Rare Dis. 2007;2:24.","journal-title":"Orphanet J Rare Dis"},{"key":"769_CR4","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/BF01297188","volume":"32","author":"JA Biller","year":"1987","unstructured":"Biller JA, Allen JL, Schuster SR, Treves ST, Winter HS. Long-term evaluation of esophageal and pulmonary function in patients with repaired esophageal atresia and tracheoesophageal fistula. Dig Dis Sci. 1987;32:985\u201390.","journal-title":"Dig Dis Sci"},{"key":"769_CR5","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1007\/s003830000348","volume":"16","author":"HK Dutta","year":"2000","unstructured":"Dutta HK, Rajani M, Bhatnagar V. Cineradiographic evaluation of postoperative patients with esophageal atresia and tracheoesophageal fistula. Pediatr Surg Int. 2000;16:322\u20135.","journal-title":"Pediatr Surg Int"},{"key":"769_CR6","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1097\/MPG.0b013e3182868773","volume":"56","author":"C Lemoine","year":"2013","unstructured":"Lemoine C, Aspirot A, Le Henaff G, Piloquet H, L\u00e9vesque D, Faure C. Characterization of esophageal motility following esophageal atresia repair using high-resolution esophageal manometry. J Pediatr Gastroenterol Nutr. 2013;56:609\u201314.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"769_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1055\/s-0033-1347912","volume":"23","author":"RJ Rintala","year":"2013","unstructured":"Rintala RJ, Pakarinen MP. Long-term outcome of esophageal anastomosis. Eur J Pediatr Surg. 2013;23:219\u201325.","journal-title":"Eur J Pediatr Surg"},{"key":"769_CR8","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/S1055-8586(98)70028-9","volume":"7","author":"L Spitz","year":"1998","unstructured":"Spitz L, Ruangtrakool R. Esophageal substitution. Semin Pediatr Surg. 1998;7:130\u20133.","journal-title":"Semin Pediatr Surg"},{"key":"769_CR9","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/0022-3468(93)90499-B","volume":"28","author":"EL Cusick","year":"1993","unstructured":"Cusick EL, Batchelor AA, Spicer RD. Development of a technique for jejunal interposition in long-gap esophageal atresia. J Pediatr Surg. 1993;28:990\u20134.","journal-title":"J Pediatr Surg"},{"key":"769_CR10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S0022-3468(96)90316-4","volume":"31","author":"JG Raffensperger","year":"1996","unstructured":"Raffensperger JG, Kuck SR, Reynolds M, et al. Intestinal bypass of the esophagus. J Pediatr Surg. 1996;31:38\u201346.","journal-title":"J Pediatr Surg"},{"key":"769_CR11","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.jpedsurg.2006.07.004","volume":"41","author":"L Spitz","year":"2006","unstructured":"Spitz L. Esophageal atresia- lessons I have learned in a 40-year experience. J Pediatr Surg. 2006;41:1635\u201340.","journal-title":"J Pediatr Surg"},{"key":"769_CR12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1308\/003588408X242222","volume":"90","author":"GS Arul","year":"2008","unstructured":"Arul GS, Parikh D. Oesophageal replacement in children. Ann R Coll Surg Engl. 2008;90:7\u201312.","journal-title":"Ann R Coll Surg Engl"},{"key":"769_CR13","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1007\/s10620-009-0767-7","volume":"54","author":"O Atug","year":"2009","unstructured":"Atug O, Dobrucali A, Orlando RC. Critical pH level of lye (NaOH) for esophageal injury. Dig Dis Sci. 2009;54:980\u20137.","journal-title":"Dig Dis Sci"},{"key":"769_CR14","doi-asserted-by":"publisher","first-page":"911","DOI":"10.3109\/15563650903438566","volume":"47","author":"AC Bronstein","year":"2009","unstructured":"Bronstein AC, Spyker DA, Cantilena LR Jr, et al. 2008 Annual report of the American association of poison control centers\u2019 national poison data system (NPDS): 26th annual report. Clin Toxicol (Phila). 2009;47:911\u20131084.","journal-title":"Clin Toxicol (Phila)"},{"key":"769_CR15","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1089\/ten.tec.2009.0145","volume":"16","author":"AK Saxena","year":"2010","unstructured":"Saxena AK, Ainoedhofer H, H\u00f6llwarth ME. Culture of ovine epithelial cells and in vitro esophagus tissue engineering. Tissue Eng Part C Methods. 2010;16:109\u201314.","journal-title":"Tissue Eng Part C Methods"},{"key":"769_CR16","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s10353-011-0617-7","volume":"43","author":"K Kofler","year":"2011","unstructured":"Kofler K, Ainoedhofer H, Tausendsch\u00f6n J, H\u00f6llwarth ME, Saxena AK. Esophageal smooth muscle cells dedifferentiate with loss of a-smooth muscle actin expression after 8 weeks of explant expansion in vitro culture: Implications on esophagus tissue engineering. Eur Surg. 2011;43:168\u201373.","journal-title":"Eur Surg"},{"key":"769_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00383-009-2512-x","volume":"26","author":"K Kofler","year":"2010","unstructured":"Kofler K, Ainoedhofer H, H\u00f6llwarth ME, Saxena AK. Fluorescence-activated cell sorting of PCK-26 antigen-positive cells enables selection of ovine esophageal epithelial cells with improved viability on scaffolds for esophagus tissue engineering. Pediatr Surg Int. 2010;26:97\u2013104.","journal-title":"Pediatr Surg Int"},{"key":"769_CR18","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.jpedsurg.2012.01.033","volume":"47","author":"V Malvasio","year":"2012","unstructured":"Malvasio V, Ainoedhofer H, Ackbar R, H\u00f6llwarth ME, Saxena AK. Effects of sodium hydroxide exposure on esophageal epithelial cells in an in vitro ovine model: implications for esophagus tissue engineering. J Pediatr Surg. 2012;47:874\u201380.","journal-title":"J Pediatr Surg"},{"key":"769_CR19","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.jpedsurg.2010.02.005","volume":"45","author":"AK Saxena","year":"2010","unstructured":"Saxena AK, Baumgart H, Komann C, Ainoedhofer H, Soltysiak P, Kofler K, H\u00f6llwarth ME. Esophagus tissue engineering: in situ generation of rudimentary tubular vascularized esophageal conduit using the ovine model. J Pediatr Surg. 2010;45:859\u201364.","journal-title":"J Pediatr Surg"},{"key":"769_CR20","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1115\/1.1800557","volume":"126","author":"GA Holzapfel","year":"2004","unstructured":"Holzapfel GA, Sommer G, Regitnig P. Anisotropic mechanical properties of tissue components in human atherosclerotic plaques. J Biomech Eng. 2004;126:657\u201365.","journal-title":"J Biomech Eng"},{"key":"769_CR21","doi-asserted-by":"publisher","first-page":"021007","DOI":"10.1115\/1.2898733","volume":"130","author":"G Sommer","year":"2008","unstructured":"Sommer G, Gasser TC, Regitnig P, Auer M, Holzapfel GA. Dissection properties of the human aortic media: an experimental study. J Biomech Eng. 2008;130:021007.","journal-title":"J Biomech Eng"},{"key":"769_CR22","first-page":"275","volume":"16","author":"L Mullins","year":"1947","unstructured":"Mullins L. Effect of stretching on the properties of rubber. J Rubber Res. 1947;16:275\u201389.","journal-title":"J Rubber Res"},{"key":"769_CR23","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/ten.teb.2009.0700","volume":"16","author":"AK Saxena","year":"2010","unstructured":"Saxena AK. Congenital anomalies of soft tissues: birth defects depending on tissue engineering solutions and present advances in regenerative medicine. Tissue Eng Part B Rev. 2010;16:455\u201366.","journal-title":"Tissue Eng Part B Rev"},{"key":"769_CR24","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00383-010-2591-8","volume":"26","author":"AK Saxena","year":"2010","unstructured":"Saxena AK. Tissue engineering and regenerative medicine research perspectives for pediatric surgery. Pediatr Surg Int. 2010;26:557\u201373.","journal-title":"Pediatr Surg Int"},{"key":"769_CR25","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/dote.12058","volume":"26","author":"A Aspirot","year":"2013","unstructured":"Aspirot A, Faure C. Esophageal dysmotility: characterization and pathophysiology. Dis Esophagus. 2013;26:405\u201359.","journal-title":"Dis Esophagus"},{"key":"769_CR26","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/0022-3468(93)90029-K","volume":"28","author":"T Shono","year":"1993","unstructured":"Shono T, Suita S, Arima T, et al. Motility function of the esophagus before primary anastomosis in esophageal atresia. J Pediatr Surg. 1993;28:673\u20136.","journal-title":"J Pediatr Surg"},{"key":"769_CR27","first-page":"1","volume":"20","author":"P Soltysiak","year":"2010","unstructured":"Soltysiak P, H\u00f6llwarth ME, Saxena AK. Comparisson of suture techniques in the formation of collagen scaffold tubes for composite tubular organ tissue engineering. Biomed Mater Eng. 2010;20:1\u201311.","journal-title":"Biomed Mater Eng"},{"key":"769_CR28","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s10388-013-0378-4","volume":"10","author":"T Macheiner","year":"2013","unstructured":"Macheiner T, Ackbar R, Saxena AK. Isolation, identification and culture of myenteric plexus cells from ovine esophagus. Esophagus. 2013;10:144\u20138.","journal-title":"Esophagus"},{"key":"769_CR29","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jss.2010.11.899","volume":"174","author":"R Ackbar","year":"2012","unstructured":"Ackbar R, Malvasio V, Holzer P, Saxena AK. In vitro effect of bethanechol and suberyldicholine on regions of guinea pig esophagus. J Surg Res. 2012;174:56\u201361.","journal-title":"J Surg Res"},{"key":"769_CR30","doi-asserted-by":"publisher","first-page":"9379","DOI":"10.1016\/j.actbio.2013.07.041","volume":"9","author":"G Sommer","year":"2013","unstructured":"Sommer G, Schriefl A, Zeindlinger G, Katzensteiner A, Ain\u00f6dhofer H, Saxena AK, Holzapfel GA. Multiaxial mechanical response and constitutive modeling of esophageal tissues: impact on esophageal tissue engineering. Acta Biomater. 2013;9:9379\u201391.","journal-title":"Acta Biomater"}],"container-title":["Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10388-020-00769-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10388-020-00769-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10388-020-00769-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T23:36:04Z","timestamp":1629416164000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10388-020-00769-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,20]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["769"],"URL":"https:\/\/doi.org\/10.1007\/s10388-020-00769-y","relation":{},"ISSN":["1612-9059","1612-9067"],"issn-type":[{"value":"1612-9059","type":"print"},{"value":"1612-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,20]]},"assertion":[{"value":"22 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All experiments were performed according to the local and national research guidelines approved for the EuroSTEC project.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement"}},{"value":"All authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this type of study, no formal consent is required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}