{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:12:44Z","timestamp":1790197964540,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Esophagus"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10388-021-00881-7","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T15:58:27Z","timestamp":1633881507000},"page":"324-331","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and safety of peroral endoscopic myotomy in 100 older patients"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4853-141X","authenticated-orcid":false,"given":"Hiroki","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironari","family":"Shiwaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Ohmiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Shiwaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,9]]},"reference":[{"key":"881_CR1","doi-asserted-by":"crossref","unstructured":"S. JE. Descriptive rules for achalasia of the Esophagus, 2012: 4th Edition. Esophagus 2017;14:275\u2013289.","DOI":"10.1007\/s10388-017-0589-1"},{"key":"881_CR2","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1038\/ajg.2013.196","volume":"108","author":"MF Vaezi","year":"2013","unstructured":"Vaezi MF, Pandolfino JE, Vela MF. ACG clinical guideline: diagnosis and management of achalasia. Am J Gastroenterol. 2013;108:1238\u201349.","journal-title":"Am J Gastroenterol"},{"key":"881_CR3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1055\/s-0029-1244080","volume":"42","author":"H Inoue","year":"2010","unstructured":"Inoue H, Minami H, Kobayashi Y, et al. Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy. 2010;42:265\u201371.","journal-title":"Endoscopy"},{"key":"881_CR4","first-page":"141","volume":"27","author":"E Heller","year":"1914","unstructured":"Heller E. Extramukose Kardioplastik beim chronischen Kardiospasmus mit Dilatation des Oesophagus. Mitteilungen aus den Grenzgebieten der Medizin und Chirurgie. 1914;27:141.","journal-title":"Mitteilungen aus den Grenzgebieten der Medizin und Chirurgie"},{"key":"881_CR5","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1136\/gut.27.8.986","volume":"27","author":"J Cox","year":"1986","unstructured":"Cox J, Buckton GK, Bennett JR. Balloon dilatation in achalasia: a new dilator. Gut. 1986;27:986\u20139.","journal-title":"Gut"},{"key":"881_CR6","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1055\/s-0042-114426","volume":"48","author":"E Akintoye","year":"2016","unstructured":"Akintoye E, Kumar N, Obaitan I, et al. Peroral endoscopic myotomy: a meta-analysis. Endoscopy. 2016;48:1059\u201368.","journal-title":"Endoscopy"},{"key":"881_CR7","doi-asserted-by":"publisher","first-page":"4817","DOI":"10.1007\/s00464-016-4813-1","volume":"30","author":"H Shiwaku","year":"2016","unstructured":"Shiwaku H, Inoue H, Yamashita K, et al. Peroral endoscopic myotomy for esophageal achalasia: outcomes of the first over 100 patients with short-term follow-up. Surg Endosc. 2016;30:4817\u201326.","journal-title":"Surg Endosc"},{"key":"881_CR8","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.gie.2019.11.020","volume":"91","author":"H Shiwaku","year":"2020","unstructured":"Shiwaku H, Inoue H, Sato H, et al. Peroral endoscopic myotomy for achalasia: a prospective multicenter study in Japan. Gastrointest Endosc. 2020;91:1037-1044.e2.","journal-title":"Gastrointest Endosc"},{"key":"881_CR9","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1056\/NEJMoa1905380","volume":"381","author":"YB Werner","year":"2019","unstructured":"Werner YB, Hakanson B, Martinek J, et al. Endoscopic or surgical myotomy in patients with idiopathic achalasia. N Engl J Med. 2019;381:2219\u201329.","journal-title":"N Engl J Med"},{"key":"881_CR10","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1001\/jama.2019.8859","volume":"322","author":"FA Ponds","year":"2019","unstructured":"Ponds FA, Fockens P, Lei A, et al. Effect of peroral endoscopic myotomy vs pneumatic dilation on symptom severity and treatment outcomes among treatment-naive patients with achalasia: a randomized clinical trial. JAMA. 2019;322:134\u201344.","journal-title":"JAMA"},{"key":"881_CR11","doi-asserted-by":"publisher","first-page":"9175","DOI":"10.3748\/wjg.v21.i30.9175","volume":"21","author":"CJ Li","year":"2015","unstructured":"Li CJ, Tan YY, Wang XH, et al. Peroral endoscopic myotomy for achalasia in patients aged \u2265 65 years. World J Gastroenterol. 2015;21:9175\u201381.","journal-title":"World J Gastroenterol"},{"key":"881_CR12","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.gie.2017.02.007","volume":"87","author":"YI Chen","year":"2018","unstructured":"Chen YI, Inoue H, Ujiki M, et al. An international multicenter study evaluating the clinical efficacy and safety of per-oral endoscopic myotomy in octogenarians. Gastrointest Endosc. 2018;87:956\u201361.","journal-title":"Gastrointest Endosc"},{"key":"881_CR13","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s10388-020-00746-5","volume":"17","author":"MR Sanaka","year":"2020","unstructured":"Sanaka MR, Chadalavada P, Alomari M, et al. Peroral endoscopic myotomy is a safe and effective treatment modality for geriatric patients with achalasia. Esophagus. 2020;17:484\u201391.","journal-title":"Esophagus"},{"key":"881_CR14","doi-asserted-by":"crossref","unstructured":"Abe H, Tanaka S, Kawara F, et al. Comparison of the safety and efficacy of peroral endoscopic myotomy between octogenarians and non-octogenarians. Dig Endosc 2020.","DOI":"10.1111\/den.13686"},{"key":"881_CR15","unstructured":"WorldHealthOrganization. Men Ageing And Health. https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/66941\/WHO_NMH_NPH_01.2.pdf (Accessed 1 Feb 2021)."},{"key":"881_CR16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3143\/geriatrics.43.27","volume":"43","author":"H Orimo","year":"2006","unstructured":"Orimo H. Reviewing the definition of elderly. Nihon Ronen Igakkai Zasshi. 2006;43:27\u201334.","journal-title":"Nihon Ronen Igakkai Zasshi"},{"issue":"281\u201392","key":"881_CR17","first-page":"vi","volume":"11","author":"VF Eckardt","year":"2001","unstructured":"Eckardt VF. Clinical presentations and complications of achalasia. Gastrointest Endosc Clin N Am. 2001;11(281\u201392):vi.","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"881_CR18","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1111\/den.13239","volume":"30","author":"H Inoue","year":"2018","unstructured":"Inoue H, Shiwaku H, Iwakiri K, et al. Clinical practice guidelines for peroral endoscopic myotomy. Dig Endosc. 2018;30:563\u201379.","journal-title":"Dig Endosc"},{"key":"881_CR19","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/nmo.12477","volume":"27","author":"PJ Kahrilas","year":"2015","unstructured":"Kahrilas PJ, Bredenoord AJ, Fox M, et al. The Chicago Classification of esophageal motility disorders, v3.0. Neurogastroenterol Motil. 2015;27:160\u201374.","journal-title":"Neurogastroenterol Motil"},{"key":"881_CR20","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","volume":"250","author":"PA Clavien","year":"2009","unstructured":"Clavien PA, Barkun J, de Oliveira ML, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250:187\u201396.","journal-title":"Ann Surg"},{"key":"881_CR21","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1007\/s00535-004-1417-7","volume":"39","author":"M Kusano","year":"2004","unstructured":"Kusano M, Shimoyama Y, Sugimoto S, et al. Development and evaluation of FSSG: frequency scale for the symptoms of GERD. J Gastroenterol. 2004;39:888\u201391.","journal-title":"J Gastroenterol"},{"issue":"Suppl 1","key":"881_CR22","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1159\/000101080","volume":"75","author":"KD Bardhan","year":"2007","unstructured":"Bardhan KD, Stanghellini V, Armstrong D, et al. Evaluation of GERD symptoms during therapy. Part I. Development of the new GERD questionnaire ReQuest. Digestion. 2007;75(Suppl 1):32\u201340.","journal-title":"Digestion"},{"key":"881_CR23","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1053\/gast.1996.v111.pm8698230","volume":"111","author":"D Armstrong","year":"1996","unstructured":"Armstrong D, Bennett JR, Blum AL, et al. The endoscopic assessment of esophagitis: a progress report on observer agreement. Gastroenterology. 1996;111:85\u201392.","journal-title":"Gastroenterology"},{"key":"881_CR24","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.gie.2013.10.023","volume":"79","author":"F Baldaque-Silva","year":"2014","unstructured":"Baldaque-Silva F, Marques M, Vilas-Boas F, et al. New transillumination auxiliary technique for peroral endoscopic myotomy. Gastrointest Endosc. 2014;79:544\u20135.","journal-title":"Gastrointest Endosc"},{"key":"881_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10388-019-00689-6","volume":"17","author":"H Inoue","year":"2020","unstructured":"Inoue H, Shiwaku H, Kobayashi Y, et al. Statement for gastroesophageal reflux disease after peroral endoscopic myotomy from an international multicenter experience. Esophagus. 2020;17:3\u201310.","journal-title":"Esophagus"},{"key":"881_CR26","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s00535-018-01544-8","volume":"54","author":"H Sato","year":"2019","unstructured":"Sato H, Yokomichi H, Takahashi K, et al. Epidemiological analysis of achalasia in Japan using a large-scale claims database. J Gastroenterol. 2019;54:621\u20137.","journal-title":"J Gastroenterol"},{"key":"881_CR27","unstructured":"UnitedNations. World population ageing 2019. https:\/\/www.un.org\/en\/development\/desa\/population\/publications\/pdf\/ageing\/WorldPopulationAgeing2019-Report.pdf (Accessed 1 Feb 2021)."},{"key":"881_CR28","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1097\/SLA.0000000000002311","volume":"267","author":"F Schlottmann","year":"2018","unstructured":"Schlottmann F, Luckett DJ, Fine J, et al. Laparoscopic heller myotomy versus peroral endoscopic myotomy (POEM) for achalasia: a systematic review and meta-analysis. Ann Surg. 2018;267:451\u201360.","journal-title":"Ann Surg"},{"key":"881_CR29","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.gie.2017.10.022","volume":"87","author":"A Repici","year":"2018","unstructured":"Repici A, Fuccio L, Maselli R, et al. GERD after per-oral endoscopic myotomy as compared with Heller\u2019s myotomy with fundoplication: a systematic review with meta-analysis. Gastrointest Endosc. 2018;87:934-943.e18.","journal-title":"Gastrointest Endosc"},{"key":"881_CR30","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1056\/NEJM199604183341603","volume":"334","author":"EJ Kuipers","year":"1996","unstructured":"Kuipers EJ, Lundell L, Klinkenberg-Knol EC, et al. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. N Engl J Med. 1996;334:1018\u201322.","journal-title":"N Engl J Med"},{"key":"881_CR31","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/apt.13324","volume":"42","author":"L Lundell","year":"2015","unstructured":"Lundell L, Vieth M, Gibson F, et al. Systematic review: the effects of long-term proton pump inhibitor use on serum gastrin levels and gastric histology. Aliment Pharmacol Ther. 2015;42:649\u201363.","journal-title":"Aliment Pharmacol Ther"},{"key":"881_CR32","unstructured":"WorldHealthOrganization. Epidemiology and prevention of cardiovascular diseases in elderly people: report of a WHO study group 1995. https:\/\/apps.who.int\/iris\/handle\/10665\/37412 (Accessed 1 Feb 2021)."},{"key":"881_CR33","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.dld.2012.07.019","volume":"44","author":"S Roman","year":"2012","unstructured":"Roman S, Zerbib F, Queneherv\u00e9 L, et al. The Chicago classification for achalasia in a French multicentric cohort. Dig Liver Dis. 2012;44:976\u201380.","journal-title":"Dig Liver Dis"},{"key":"881_CR34","doi-asserted-by":"publisher","first-page":"485","DOI":"10.5056\/jnm.2013.19.4.485","volume":"19","author":"JY Lee","year":"2013","unstructured":"Lee JY, Kim N, Kim SE, et al. Clinical characteristics and treatment outcomes of 3 subtypes of achalasia according to the Chicago classification in a tertiary institute in Korea. J Neurogastroenterol Motil. 2013;19:485\u201394.","journal-title":"J Neurogastroenterol Motil"}],"container-title":["Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10388-021-00881-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10388-021-00881-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10388-021-00881-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T03:08:40Z","timestamp":1647313720000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10388-021-00881-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,9]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["881"],"URL":"https:\/\/doi.org\/10.1007\/s10388-021-00881-7","relation":{},"ISSN":["1612-9059","1612-9067"],"issn-type":[{"value":"1612-9059","type":"print"},{"value":"1612-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,9]]},"assertion":[{"value":"30 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interests for this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All patients gave informed consent before undergoing POEM, and institutional review board approval was obtained for this study (approval number U19-04-002). The study was conducted according to the principles of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}