{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T03:08:48Z","timestamp":1771211328123,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19lk0201088h0001"],"award-info":[{"award-number":["19lk0201088h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21lk0201144h0001"],"award-info":[{"award-number":["21lk0201144h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K08334"],"award-info":[{"award-number":["20K08334"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Esophagus"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10388-021-00887-1","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T13:55:20Z","timestamp":1633874120000},"page":"332-342","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7070-6610","authenticated-orcid":false,"given":"Eikichi","family":"Ihara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruei","family":"Ogino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Muta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Hata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopeng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Minoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Esaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatoshi","family":"Chinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,9]]},"reference":[{"key":"887_CR1","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/nmo.12477","volume":"27","author":"PJ Kahrilas","year":"2015","unstructured":"Kahrilas PJ, Bredenoord AJ, Fox M, et al. The Chicago classification of esophageal motility disorders, v3.0. Neurogastroenterol Motil. 2015;27:160\u201374.","journal-title":"Neurogastroenterol Motil"},{"key":"887_CR2","doi-asserted-by":"crossref","first-page":"e14058","DOI":"10.1111\/nmo.14058","volume":"33","author":"R Yadlapati","year":"2021","unstructured":"Yadlapati R, Kahrilas PJ, Fox MR, et al. Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0((c)). Neurogastroenterol Motil. 2021;33:e14058.","journal-title":"Neurogastroenterol Motil"},{"key":"887_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000452354","volume":"95","author":"E Ihara","year":"2017","unstructured":"Ihara E, Muta K, Fukaura K, et al. Diagnosis and treatment strategy of achalasia subtypes and esophagogastric junction outflow obstruction based on high-resolution manometry. Digestion. 2017;95:29\u201335.","journal-title":"Digestion"},{"key":"887_CR4","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/0016-5085(95)90072-1","volume":"108","author":"A Trifan","year":"1995","unstructured":"Trifan A, Shaker R, Ren J, et al. Inhibition of resting lower esophageal sphincter pressure by pharyngeal water stimulation in humans. Gastroenterology. 1995;108:441\u20136.","journal-title":"Gastroenterology"},{"key":"887_CR5","doi-asserted-by":"publisher","first-page":"7898","DOI":"10.1038\/s41598-021-87052-x","volume":"11","author":"K Muta","year":"2021","unstructured":"Muta K, Ihara E, Hamada S, et al. Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows. Sci Rep. 2021;11:7898.","journal-title":"Sci Rep"},{"key":"887_CR6","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1517\/13543784.2011.562890","volume":"20","author":"J Tack","year":"2011","unstructured":"Tack J, Janssen P. Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia. Expert Opin Investig Drugs. 2011;20:701\u201312.","journal-title":"Expert Opin Investig Drugs"},{"key":"887_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1159\/000447010","volume":"94","author":"K Muta","year":"2016","unstructured":"Muta K, Ihara E, Fukaura K, et al. Effects of acotiamide on the esophageal motility function in patients with esophageal motility disorders: a pilot study. Digestion. 2016;94:9\u201316.","journal-title":"Digestion"},{"issue":"540\u2013545","key":"887_CR8","first-page":"e250","volume":"24","author":"H Kusunoki","year":"2012","unstructured":"Kusunoki H, Haruma K, Manabe N, et al. Therapeutic efficacy of acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying: randomized controlled study evaluation by real-time ultrasonography. Neurogastroenterol Motil. 2012;24(540\u2013545):e250-541.","journal-title":"Neurogastroenterol Motil"},{"key":"887_CR9","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1159\/000487708","volume":"98","author":"K Fukaura","year":"2018","unstructured":"Fukaura K, Ihara E, Ogino H, et al. Mucosally expressed cytokines are associated with the esophageal motility function. Digestion. 2018;98:95\u2013103.","journal-title":"Digestion"},{"key":"887_CR10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000503340","volume":"102","author":"S Hamada","year":"2021","unstructured":"Hamada S, Ihara E, Ikeda H, et al. Clinical characterization of vonoprazan-refractory gastroesophageal reflux disease. Digestion. 2021;102:197\u2013204.","journal-title":"Digestion"},{"key":"887_CR11","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1007\/s00535-004-1417-7","volume":"39","author":"M Kusano","year":"2004","unstructured":"Kusano M, Shimoyama Y, Sugimoto S, et al. Development and evaluation of FSSG: frequency scale for the symptoms of GERD. J Gastroenterol. 2004;39:888\u201391.","journal-title":"J Gastroenterol"},{"key":"887_CR12","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1016\/S0016-5085(97)70011-8","volume":"113","author":"AJ Porter","year":"1997","unstructured":"Porter AJ, Wattchow DA, Brookes SJ, et al. The neurochemical coding and projections of circular muscle motor neurons in the human colon. Gastroenterology. 1997;113:1916\u201323.","journal-title":"Gastroenterology"},{"key":"887_CR13","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00418-014-1306-y","volume":"143","author":"R Chiocchetti","year":"2015","unstructured":"Chiocchetti R, Giancola F, Mazzoni M, et al. Excitatory and inhibitory enteric innervation of horse lower esophageal sphincter. Histochem Cell Biol. 2015;143:625\u201335.","journal-title":"Histochem Cell Biol"},{"key":"887_CR14","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/j.1365-2982.2009.01449.x","volume":"22","author":"K Matsueda","year":"2010","unstructured":"Matsueda K, Hongo M, Tack J, et al. Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia\u2014100 mg t.i.d. is an optimal dosage. Neurogastroenterol Motil. 2010;22:618-e173.","journal-title":"Neurogastroenterol Motil"},{"key":"887_CR15","doi-asserted-by":"crossref","first-page":"e14053","DOI":"10.1111\/nmo.14053","volume":"33","author":"R Yadlapati","year":"2021","unstructured":"Yadlapati R, Pandolfino JE, Fox MR, et al. What is new in Chicago classification version 40? Neurogastroenterol Motil. 2021;33:e14053.","journal-title":"Neurogastroenterol Motil"},{"key":"887_CR16","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.gie.2020.04.076","volume":"92","author":"JA Sloan","year":"2020","unstructured":"Sloan JA, Triggs JR, Pandolfino JE, et al. Treatment experience with a novel 30-mm hydrostatic balloon in esophageal dysmotility: a multicenter retrospective analysis. Gastrointest Endosc. 2020;92:1251\u20137.","journal-title":"Gastrointest Endosc"},{"key":"887_CR17","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3748\/wjg.v25.i4.411","volume":"25","author":"S Samo","year":"2019","unstructured":"Samo S, Qayed E. Esophagogastric junction outflow obstruction: Where are we now in diagnosis and management? World J Gastroenterol. 2019;25:411\u20137.","journal-title":"World J Gastroenterol"},{"key":"887_CR18","doi-asserted-by":"publisher","first-page":"E1137","DOI":"10.1055\/a-1198-4643","volume":"8","author":"Y Ichkhanian","year":"2020","unstructured":"Ichkhanian Y, Sanaei O, Canakis A, et al. Esophageal peroral endoscopic myotomy (POEM) for treatment of esophagogastric junction outflow obstruction: results from the first prospective trial. Endosc Int Open. 2020;8:E1137\u201343.","journal-title":"Endosc Int Open"},{"key":"887_CR19","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1111\/den.13239","volume":"30","author":"H Inoue","year":"2018","unstructured":"Inoue H, Shiwaku H, Iwakiri K, et al. Clinical practice guidelines for peroral endoscopic myotomy. Dig Endosc. 2018;30:563\u201379.","journal-title":"Dig Endosc"},{"key":"887_CR20","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1053\/j.gastro.2017.10.001","volume":"153","author":"PJ Kahrilas","year":"2017","unstructured":"Kahrilas PJ, Katzka D, Richter JE. Clinical practice update: the use of per-oral endoscopic myotomy in achalasia: expert review and best practice advice from the AGA institute. Gastroenterology. 2017;153:1205\u201311.","journal-title":"Gastroenterology"},{"key":"887_CR21","doi-asserted-by":"publisher","first-page":"E1031","DOI":"10.1055\/a-0625-6288","volume":"6","author":"MA Khashab","year":"2018","unstructured":"Khashab MA, Familiari P, Draganov PV, et al. Peroral endoscopic myotomy is effective and safe in non-achalasia esophageal motility disorders: an international multicenter study. Endosc Int Open. 2018;6:E1031\u20136.","journal-title":"Endosc Int Open"}],"container-title":["Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10388-021-00887-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10388-021-00887-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10388-021-00887-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T19:21:40Z","timestamp":1699644100000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10388-021-00887-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,9]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["887"],"URL":"https:\/\/doi.org\/10.1007\/s10388-021-00887-1","relation":{},"ISSN":["1612-9059","1612-9067"],"issn-type":[{"value":"1612-9059","type":"print"},{"value":"1612-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,9]]},"assertion":[{"value":"11 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"E.I. belongs to an endowed course supported by the companies including Ono pharmaceutical Co., Ltd., Miyarisan Pharmaceutical Co. Ltd., Sanwa Kagaku Kenkyusho Co., Ltd., Otsuka Pharmaceutical Factory, Inc., Fujifilm Medical Co., Ltd., Terumo corporation, FANCL corporation, Ohga pharmacy, and Abbott Japan, LLC. E.I. receives lecture honorarium from Takeda Pharmaceutical Company. Y.O. conducts collaborative research with Fujifilm Medical Co., Ltd. and FANCL corporation. H.O., K.M., S.H., M.W., Y.H., H.I., X.B.,Y.M., M.E., Y.T., and T.C. declare no conflict of interest in association with this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}