{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:56:46Z","timestamp":1785412606476,"version":"3.56.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"GERD Society"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Esophagus"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s10388-022-00960-3","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T04:02:33Z","timestamp":1665979353000},"page":"309-316","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Causal effect of anxiety and depression status on the symptoms of gastroesophageal reflux disease and functional dyspepsia during proton pump inhibitor therapy"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4472-1008","authenticated-orcid":false,"given":"Koji","family":"Nakada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Oshio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Matsuhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Iwakiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Joh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Haruma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"960_CR1","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.2169\/internalmedicine.50.4731","volume":"50","author":"N Manabe","year":"2011","unstructured":"Manabe N, Haruma K, Kamada T, et al. Changes of upper gastrointestinal symptoms and endoscopic findings in Japan over 25 years. Intern Med. 2011;50:1357\u201363.","journal-title":"Intern Med"},{"key":"960_CR2","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1080\/00365520701204204","volume":"42","author":"DR De Vries","year":"2007","unstructured":"De Vries DR, Van Herwaarden MA, Baron A, et al. Concomitant functional dyspepsia and irritable bowel syndrome decrease health-related quality of life in gastroesophageal reflux disease. Scand J Gastroenterol. 2007;42:951\u20136.","journal-title":"Scand J Gastroenterol"},{"key":"960_CR3","doi-asserted-by":"publisher","first-page":"447","DOI":"10.5056\/jnm14080","volume":"20","author":"Y Fujiwara","year":"2014","unstructured":"Fujiwara Y, Arakawa T. Overlap in patients with dyspepsia\/functional dyspepsia. J Neurogastroenterol Motil. 2014;20:447\u201357.","journal-title":"J Neurogastroenterol Motil"},{"key":"960_CR4","doi-asserted-by":"publisher","first-page":"5216","DOI":"10.3748\/wjg.v23.i28.5216","volume":"23","author":"K Nakada","year":"2017","unstructured":"Nakada K, Matsuhashi N, Iwakiri K, et al. Development and validation of a simple and multifaceted instrument, GERD-TEST, for the clinical evaluation of gastroesophageal reflux and dyspeptic symptoms. World J Gastroenterol. 2017;23:5216\u201328.","journal-title":"World J Gastroenterol"},{"key":"960_CR5","doi-asserted-by":"publisher","first-page":"593","DOI":"10.5056\/jnm18069","volume":"24","author":"JM Choi","year":"2018","unstructured":"Choi JM, Yang JI, Kang SJ, et al. Association between anxiety and depression and gastroesophageal reflux disease: results from a large cross-sectional study. J Neurogastroenterol Motil. 2018;24:593\u2013602.","journal-title":"J Neurogastroenterol Motil"},{"key":"960_CR6","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1080\/00365521.2016.1224383","volume":"52","author":"M Okuyama","year":"2017","unstructured":"Okuyama M, Takaishi O, Nakahara K, et al. Associations among gastroesophageal reflux disease, psychological stress, and sleep disturbances in Japanese adults. Scand J Gastroenterol. 2017;52:44\u20139.","journal-title":"Scand J Gastroenterol"},{"key":"960_CR7","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.3748\/wjg.v21.i14.4302","volume":"21","author":"XJ Yang","year":"2015","unstructured":"Yang XJ, Jiang HM, Hou XH, et al. Anxiety and depression in patients with gastroesophageal reflux disease and their effect on quality of life. World J Gastroenterol. 2015;21:4302\u20139.","journal-title":"World J Gastroenterol"},{"key":"960_CR8","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/j.1365-2036.2008.03619.x","volume":"27","author":"S Haag","year":"2008","unstructured":"Haag S, Senf W, H\u00e4user W, et al. Impairment of health-related quality of life in functional dyspepsia and chronic liver disease: the influence of depression and anxiety. Aliment Pharmacol Ther. 2008;27:561\u201371.","journal-title":"Aliment Pharmacol Ther"},{"key":"960_CR9","doi-asserted-by":"publisher","first-page":"259","DOI":"10.5009\/gnl.2009.3.4.259","volume":"3","author":"JH Oh","year":"2009","unstructured":"Oh JH, Kim TS, Choi MG, et al. Relationship between psychological factors and quality of life in subtypes of gastroesophageal reflux disease. Gut Liver. 2009;3:259\u201365.","journal-title":"Gut Liver"},{"key":"960_CR10","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1471-230X-11-52","volume":"11","author":"RC Heading","year":"2011","unstructured":"Heading RC, M\u00f6nnikes H, Tholen A, et al. Prediction of response to PPI therapy and factors influencing treatment outcome in patients with GORD: a prospective pragmatic trial using pantoprazole. BMC Gastroenterol. 2011;11:52.","journal-title":"BMC Gastroenterol"},{"key":"960_CR11","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.3748\/wjg.v21.i6.1932","volume":"21","author":"SM Jiang","year":"2015","unstructured":"Jiang SM, Jia L, Lei XG, et al. Incidence and psychological-behavioral characteristics of refractory functional dyspepsia: a large, multi-center, prospective investigation from China. World J Gastroenterol. 2015;21:1932\u20137.","journal-title":"World J Gastroenterol"},{"key":"960_CR12","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s00535-015-1073-0","volume":"50","author":"N Matsuhashi","year":"2015","unstructured":"Matsuhashi N, Kudo M, Yoshida N, et al. Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease: a multicenter prospective observational study. J Gastroenterol. 2015;50:1173\u201383.","journal-title":"J Gastroenterol"},{"key":"960_CR13","doi-asserted-by":"publisher","first-page":"3124","DOI":"10.3748\/wjg.v19.i20.3124","volume":"19","author":"XP Niu","year":"2013","unstructured":"Niu XP, Yu BP, Wang YD, et al. Risk factors for proton pump inhibitor refractoriness in Chinese patients with non-erosive reflux disease. World J Gastroenterol. 2013;19:3124\u20139.","journal-title":"World J Gastroenterol"},{"key":"960_CR14","doi-asserted-by":"publisher","first-page":"195","DOI":"10.4103\/2277-9175.190936","volume":"5","author":"P Adibi","year":"2016","unstructured":"Adibi P, Keshteli AH, Daghaghzadeh H, et al. Association of anxiety, depression, and psychological distress in people with and without functional dyspepsia. Adv Biomed Res. 2016;5:195.","journal-title":"Adv Biomed Res"},{"key":"960_CR15","first-page":"259","volume":"30","author":"T Esterita","year":"2021","unstructured":"Esterita T, Dewi S, Suryatenggara FG, et al. Association of functional dyspepsia with depression and anxiety: a systematic review. J Gastrointestin Liver Dis. 2021;30:259\u201366.","journal-title":"J Gastrointestin Liver Dis"},{"key":"960_CR16","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1111\/j.1572-0241.2006.00630.x","volume":"101","author":"N Vakil","year":"2006","unstructured":"Vakil N, van Zanten SV, Kahrilas P, et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900\u201320.","journal-title":"Am J Gastroenterol"},{"key":"960_CR17","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00535-006-1775-4","volume":"41","author":"M Hongo","year":"2006","unstructured":"Hongo M. Minimal changes in reflux esophagitis: red ones and white ones. J Gastroenterol. 2006;41:95\u20139.","journal-title":"J Gastroenterol"},{"key":"960_CR18","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1023\/A:1026179517081","volume":"12","author":"DM Turner-Bowker","year":"2003","unstructured":"Turner-Bowker DM, Bayliss MS, Ware JE Jr, et al. Usefulness of the SF-8 Health Survey for comparing the impact of migraine and other conditions. Qual Life Res. 2003;12:1003\u201312.","journal-title":"Qual Life Res"},{"key":"960_CR19","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","volume":"67","author":"AS Zigmond","year":"1983","unstructured":"Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67:361\u201370.","journal-title":"Acta Psychiatr Scand"},{"key":"960_CR20","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","volume":"112","author":"J Cohen","year":"1992","unstructured":"Cohen J. A power primer. Psychol Bull. 1992;112:155\u20139.","journal-title":"Psychol Bull"},{"key":"960_CR21","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1037\/0033-2909.82.6.887","volume":"82","author":"DA Kenny","year":"1975","unstructured":"Kenny DA. Cross-lagged panel correlation: a test for spuriousness. Psychol Bull. 1975;82:887\u2013903.","journal-title":"Psychol Bull"},{"key":"960_CR22","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1177\/2050640616650061","volume":"5","author":"A D'Alessandro","year":"2017","unstructured":"D\u2019Alessandro A, Zito FP, Pesce M, et al. Specific dyspeptic symptoms are associated with poor response to therapy in patients with gastroesophageal reflux disease. United European Gastroenterol J. 2017;5:54\u20139.","journal-title":"United European Gastroenterol J"},{"key":"960_CR23","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1136\/gutjnl-2011-300798","volume":"61","author":"F Zerbib","year":"2012","unstructured":"Zerbib F, Belhocine K, Simon M, et al. Clinical, but not oesophageal pH-impedance, profiles predict response to proton pump inhibitors in gastro-oesophageal reflux disease. Gut. 2012;61:501\u20136.","journal-title":"Gut"},{"key":"960_CR24","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1007\/s00535-005-1687-8","volume":"40","author":"M Hojo","year":"2005","unstructured":"Hojo M, Miwa H, Yokoyama T, et al. Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review. J Gastroenterol. 2005;40:1036\u201342.","journal-title":"J Gastroenterol"},{"key":"960_CR25","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1111\/j.1365-2036.2007.03277.x","volume":"25","author":"S Haag","year":"2007","unstructured":"Haag S, Senf W, Tagay S, et al. Is there a benefit from intensified medical and psychological interventions in patients with functional dyspepsia not responding to conventional therapy? Aliment Pharmacol Ther. 2007;25:973\u201386.","journal-title":"Aliment Pharmacol Ther"},{"key":"960_CR26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3109\/00365529309098330","volume":"195","author":"TL Abell","year":"1993","unstructured":"Abell TL, Cutts TF, Cooper T. Effect of cisapride therapy for severe dyspepsia on gastrointestinal symptoms and quality of life. Scand J Gastroenterol Suppl. 1993;195:60\u20136 (Discussion 63\u20134).","journal-title":"Scand J Gastroenterol Suppl"},{"key":"960_CR27","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1007\/s00535-016-1260-7","volume":"52","author":"K Nakamura","year":"2017","unstructured":"Nakamura K, Tomita T, Oshima T, et al. A double-blind placebo controlled study of acotiamide hydrochloride for efficacy on gastrointestinal motility of patients with functional dyspepsia. J Gastroenterol. 2017;52:602\u201310.","journal-title":"J Gastroenterol"},{"key":"960_CR28","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1007\/s00535-019-01546-0","volume":"54","author":"K Isshi","year":"2019","unstructured":"Isshi K, Matsuhashi N, Joh T, et al. Proton pump inhibitor monotherapy is effective to attenuate dyspepsia symptoms associated with gastroesophageal reflux disease: a multicenter prospective observational study. J Gastroenterol. 2019;54:492\u2013500.","journal-title":"J Gastroenterol"},{"key":"960_CR29","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1080\/00365520600615781","volume":"41","author":"P Bytzer","year":"2006","unstructured":"Bytzer P, Morocutti A, Kennerly P, et al. Effect of rabeprazole and omeprazole on the onset of gastro-oesophageal reflux disease symptom relief during the first seven days of treatment. Scand J Gastroenterol. 2006;41:1132\u201340.","journal-title":"Scand J Gastroenterol"},{"key":"960_CR30","doi-asserted-by":"publisher","first-page":"990","DOI":"10.3748\/wjg.15.990","volume":"15","author":"RN Zheng","year":"2009","unstructured":"Zheng RN. Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis. World J Gastroenterol. 2009;15:990\u20135.","journal-title":"World J Gastroenterol"}],"container-title":["Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10388-022-00960-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10388-022-00960-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10388-022-00960-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T10:08:57Z","timestamp":1679134137000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10388-022-00960-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["960"],"URL":"https:\/\/doi.org\/10.1007\/s10388-022-00960-3","relation":{},"ISSN":["1612-9059","1612-9067"],"issn-type":[{"value":"1612-9059","type":"print"},{"value":"1612-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,17]]},"assertion":[{"value":"15 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest related to the publication of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki (sixth revision, 2008).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard"}},{"value":"Written informed consent was obtained from all enrolled patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent statement"}},{"value":"This study was approved by the local ethics committees of each participating institution or the central ethics committee of Nishi Clinic, Osaka, Japan.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}}]}}