{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:30:23Z","timestamp":1785767423593,"version":"3.56.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2020CR2029B"],"award-info":[{"award-number":["SHDC2020CR2029B"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Esophagus"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To evaluate the long-term efficacy of transoral incisionless fundoplication (TIF) with Medigus Ultrasonic Surgical Endostapler (MUSE) for gastroesophageal reflux disease (GERD).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 16 patients with proton pump inhibitor-dependent gastroesophageal reflux disease had undergone TIF by MUSE in Shanghai General Hospital \uff08Shanghai, China\uff09from March 2017 to December 2018. Patients were followed up at 6\u00a0months, and the GERD-health-related quality of life (GERD-HRQL) questionnaire score, the GERD questionnaire (GERD-Q) score, high-resolution esophageal manometry (HREM) and 24\u00a0h esophageal pH parameters, the Hill grade of the gastroesophageal flap valve (GEFV) and daily Proton pump inhibitor (PPI) consumption before and after procedure were compared. Patients also were followed up at 3\u00a0years and 5\u00a0years using a structured questionnaire via phone which evaluated symptoms of reflux, dose of PPI medication and side effects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Follow-up data were collected from 13 patients, ranging from 38 to 63\u00a0months, 53\u00a0months on average. 10\/13 patients reported symptomatic improvement and daily PPI consumption was stopped or halved in 11\/13. After procedure, the mean scores of GERD-HRQL and GERD-Q were significantly increased. The mean DeMeester score, the mean acid exposure time percentage and the mean number of acid reflux episodes were significantly lower. The mean rest pressure at lower esophageal sphincter (LES) had no significant difference.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>TIF by MUSE has significant efficacy in the treatment of PPI-dependent GERD, which can improve symptoms and life quality of patients, and reduce the acid exposure time for long-term. Chictr.org.cn.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial Registration<\/jats:title>\n                <jats:p>ChiCTR2000034350.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10388-023-00992-3","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T11:30:32Z","timestamp":1678102232000},"page":"581-586","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The long-term efficacy of transoral incisionless fundoplication with Medigus Ultrasonic Surgical Endostapler (MUSE) for gastroesophageal reflux disease"],"prefix":"10.1007","volume":"20","clinical-trial-number":[{"clinical-trial-number":"chictr2000034350","registry":"10.18810\/chictr"}],"author":[{"given":"Shien","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingya","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanzhao","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingpiao","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"992_CR1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x","author":"N Vakil","year":"2006","unstructured":"Vakil N, van Zanten SV, Kahrilas P, et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006. https:\/\/doi.org\/10.1111\/j.1572-0241.2006.00630.x.","journal-title":"Am J Gastroenterol"},{"key":"992_CR2","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3760\/cma.j.cn311367-20200918-00558","volume":"40","author":"Association CS of GM","year":"2020","unstructured":"Association CS of GM. Chinese expert consensus of gastroesophageal reflux disease in. Chin J Dig. 2020;40:649\u201363. https:\/\/doi.org\/10.3760\/cma.j.cn311367-20200918-00558.","journal-title":"Chin J Dig"},{"key":"992_CR3","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X38240","author":"VN Joish","year":"2005","unstructured":"Joish VN, Donaldson G, Stockdale W, et al. The economic impact of GERD and PUD: examination of direct and indirect costs using a large integrated employer claims database. Curr Med Res Opin. 2005. https:\/\/doi.org\/10.1185\/030079905X38240.","journal-title":"Curr Med Res Opin"},{"key":"992_CR4","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13737","author":"LH Eusebi","year":"2017","unstructured":"Eusebi LH, Rabitti S, Artesiani ML, et al. Proton pump inhibitors: risks of long-term use. J Gastroenterol Hepatol. 2017. https:\/\/doi.org\/10.1111\/jgh.13737.","journal-title":"J Gastroenterol Hepatol"},{"key":"992_CR5","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/ajg.2012.444","volume":"108","author":"PO Katz","year":"2013","unstructured":"Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Off J Am Coll Gastroenterol ACG. 2013;108:308\u201328. https:\/\/doi.org\/10.1038\/ajg.2012.444.","journal-title":"Off J Am Coll Gastroenterol ACG"},{"key":"992_CR6","doi-asserted-by":"publisher","DOI":"10.1055\/a-1124-3187","author":"PA Testoni","year":"2020","unstructured":"Testoni PA, Testoni S, Mazzoleni G, et al. Transoral incisionless fundoplication with an ultrasonic surgical endostapler for the treatment of gastroesophageal reflux disease: 12-month outcomes. Endoscopy. 2020. https:\/\/doi.org\/10.1055\/a-1124-3187.","journal-title":"Endoscopy"},{"key":"992_CR7","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14511","author":"BS Kushner","year":"2020","unstructured":"Kushner BS, Awad MM, Mikami DJ, et al. Endoscopic treatments for GERD. Ann N Y Acad Sci. 2020. https:\/\/doi.org\/10.1111\/nyas.14511.","journal-title":"Ann N Y Acad Sci"},{"key":"992_CR8","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/j.1442-2050.2007.00658.x","volume":"20","author":"V Velanovich","year":"2007","unstructured":"Velanovich V. The development of the GERD-HRQL symptom severity instrument. Dis Esophagus Off J Int Soc Dis Esophagus. 2007;20:130\u20134. https:\/\/doi.org\/10.1111\/j.1442-2050.2007.00658.x.","journal-title":"Dis Esophagus Off J Int Soc Dis Esophagus"},{"key":"992_CR9","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1111\/j.1365-2036.2009.04142.x","volume":"30","author":"R Jones","year":"2009","unstructured":"Jones R, Junghard O, Dent J, et al. Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care. Aliment Pharmacol Ther. 2009;30:1030\u20138. https:\/\/doi.org\/10.1111\/j.1365-2036.2009.04142.x.","journal-title":"Aliment Pharmacol Ther"},{"key":"992_CR10","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00464-007-9618-9","volume":"22","author":"GB Cadi\u00e8re","year":"2008","unstructured":"Cadi\u00e8re GB, Rajan A, Germay O, et al. Endoluminal fundoplication by a transoral device for the treatment of GERD: a feasibility study. Surg Endosc. 2008;22:333\u201342. https:\/\/doi.org\/10.1007\/s00464-007-9618-9.","journal-title":"Surg Endosc"},{"key":"992_CR11","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.dld.2012.03.019","volume":"44","author":"PA Testoni","year":"2012","unstructured":"Testoni PA, Vailati C. Transoral incisionless fundoplication with EsophyX\u00ae for treatment of gastro-oesphageal reflux disease. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver. 2012;44:631\u20135. https:\/\/doi.org\/10.1016\/j.dld.2012.03.019.","journal-title":"Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver"},{"key":"992_CR12","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1136\/gutjnl-2020-321811","volume":"71","author":"R Kalapala","year":"2022","unstructured":"Kalapala R, Karyampudi A, Nabi Z, et al. Endoscopic full-thickness plication for the treatment of PPI-dependent GERD: results from a randomised, sham controlled trial. Gut. 2022;71:686\u201394. https:\/\/doi.org\/10.1136\/gutjnl-2020-321811.","journal-title":"Gut"},{"key":"992_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.08.001","author":"N Thosani","year":"2017","unstructured":"Thosani N, Goodman A, Manfredi M, et al. Endoscopic anti-reflux devices (with videos). Gastrointest Endosc. 2017. https:\/\/doi.org\/10.1016\/j.gie.2017.08.001.","journal-title":"Gastrointest Endosc"},{"key":"992_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-016-0521-1","author":"G Triadafilopoulos","year":"2016","unstructured":"Triadafilopoulos G. Endoscopic options for gastroesophageal reflux: where are we now and what does the future hold? Curr Gastroenterol Rep. 2016. https:\/\/doi.org\/10.1007\/s11894-016-0521-1.","journal-title":"Curr Gastroenterol Rep"},{"key":"992_CR15","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-015-4622-y","author":"HJ Kim","year":"2016","unstructured":"Kim HJ, Kwon CI, Kessler WR, et al. Long-term follow-up results of endoscopic treatment of gastroesophageal reflux disease with the MUSETM endoscopic stapling device. Surg Endosc. 2016. https:\/\/doi.org\/10.1007\/s00464-015-4622-y.","journal-title":"Surg Endosc"},{"key":"992_CR16","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1007\/s00464-014-3731-3","volume":"29","author":"J Zacherl","year":"2015","unstructured":"Zacherl J, Roy-Shapira A, Bonavina L, et al. Endoscopic anterior fundoplication with the Medigus Ultrasonic Surgical Endostapler (MUSE\u2122) for gastroesophageal reflux disease: 6-month results from a multi-center prospective trial. Surg Endosc. 2015;29:220\u20139. https:\/\/doi.org\/10.1007\/s00464-014-3731-3.","journal-title":"Surg Endosc"},{"key":"992_CR17","doi-asserted-by":"publisher","first-page":"5023","DOI":"10.1007\/s00464-021-08860-w","volume":"36","author":"SGG Testoni","year":"2022","unstructured":"Testoni SGG, Cilona MB, Mazzoleni G, et al. Transoral incisionless fundoplication with Medigus ultrasonic surgical endostapler (MUSE) for the treatment of gastro-esophageal reflux disease: outcomes up to 3 years. Surg Endosc. 2022;36:5023\u201331. https:\/\/doi.org\/10.1007\/s00464-021-08860-w.","journal-title":"Surg Endosc"},{"key":"992_CR18","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1007\/s00464-014-3461-6","volume":"28","author":"M Noar","year":"2014","unstructured":"Noar M, Squires P, Noar E, et al. Long-term maintenance effect of radiofrequency energy delivery for refractory GERD: a decade later. Surg Endosc. 2014;28:2323\u201333. https:\/\/doi.org\/10.1007\/s00464-014-3461-6.","journal-title":"Surg Endosc"}],"container-title":["Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10388-023-00992-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10388-023-00992-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10388-023-00992-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T13:11:34Z","timestamp":1685625094000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10388-023-00992-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,6]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["992"],"URL":"https:\/\/doi.org\/10.1007\/s10388-023-00992-3","relation":{},"ISSN":["1612-9059","1612-9067"],"issn-type":[{"value":"1612-9059","type":"print"},{"value":"1612-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,6]]},"assertion":[{"value":"6 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study in this article have been approved by the ethics committee of Shanghai General Hospital (N.2016-09) and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}