{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:15:52Z","timestamp":1792782952722,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100017702","name":"Innovation and Entrepreneurship Talent Project of Lanzhou","doi-asserted-by":"publisher","award":["2021-RC-110"],"award-info":[{"award-number":["2021-RC-110"]}],"id":[{"id":"10.13039\/501100017702","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Project of Gansu Provincial Administration of Traditional Chinese Medicine","award":["GZKG-2024-68"],"award-info":[{"award-number":["GZKG-2024-68"]}],"id":[{"id":"https:\/\/ror.org\/03x55t826","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EcoHealth"],"DOI":"10.1007\/s10393-026-01792-8","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T08:30:47Z","timestamp":1776241847000},"page":"410-420","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatial Distribution and Determinants of Kashin\u2013Beck Disease in Gansu Province, China"],"prefix":"10.1007","volume":"23","author":[{"given":"Shaolun","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"issue":"3","key":"1792_CR1","doi-asserted-by":"publisher","first-page":"e0298099","DOI":"10.1371\/journal.pone.0298099","volume":"19","author":"Y An","year":"2024","unstructured":"An Y, Peng L, Geng L (2024) Spatio-temporal evolution and driving factors of new urbanization in central China based on multi-source data. Plos One 19(3):e0298099. https:\/\/doi.org\/10.1371\/journal.pone.0298099","journal-title":"Plos One"},{"key":"1792_CR3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s12011-015-0333-4","volume":"168","author":"Z Chen","year":"2015","unstructured":"Chen Z, Li H, Yang L, Wang W, Li Y, Gong H, Guo M, Nima C, Zhao S, Wang J, Ye B (2015) Hair selenium levels of school children in Kashin-Beck disease endemic areas in Tibet, China. Biological Trace Element Research 168:25\u201332. https:\/\/doi.org\/10.1007\/s12011-015-0333-4","journal-title":"Biological Trace Element Research"},{"key":"1792_CR4","doi-asserted-by":"publisher","unstructured":"Chen, X., Chen, G., Shao, J., GE, P., LI, P., **e, X., & Liao, Y. (2016). Prevalence and prevention of Kaschin-Beck disease in different ecotypic areas in Gansu Province.\u00a0Chinese Journal of Endemiology, pp.672\u2013676. https:\/\/doi.org\/10.3760\/cma.j.issn.2095-4255.2016.09.012","DOI":"10.3760\/cma.j.issn.2095-4255.2016.09.012"},{"key":"1792_CR5","doi-asserted-by":"publisher","unstructured":"Cui, S., Que, W., Jiao, Z., Deng, Q., Zhang, X., Cao, Y., Liu, N., Li, A., Sowanou, A., Li, Z., & Wang, T. (2024). Disease and economic burden of Kashin-Beck disease\u2014China, 2021.\u00a0China CDC Weekly,\u00a06(2), p.40. https:\/\/doi.org\/10.46234\/ccdcw2024.009","DOI":"10.46234\/ccdcw2024.009"},{"issue":"2","key":"1792_CR6","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s10661-023-12241-2","volume":"196","author":"H Dadashpoor","year":"2024","unstructured":"Dadashpoor H, Khaleghinia A, Shabrang A (2024) Explaining the role of land use changes on land surface temperature in an arid and semi-arid metropolitan area with multi-scale spatial regression analysis. Environmental Monitoring and Assessment 196(2):124. https:\/\/doi.org\/10.1007\/s10661-023-12241-2","journal-title":"Environmental Monitoring and Assessment"},{"key":"1792_CR7","doi-asserted-by":"publisher","first-page":"105919","DOI":"10.1016\/j.cmpb.2020.105919","volume":"200","author":"J Dang","year":"2021","unstructured":"Dang J, Li H, Niu K, Xu Z, Lin J, He Z (2021) Kashin-Beck disease diagnosis based on deep learning from hand X-ray images. Computer Methods and Programs in Biomedicine 200:105919. https:\/\/doi.org\/10.1016\/j.cmpb.2020.105919","journal-title":"Computer Methods and Programs in Biomedicine"},{"issue":"21","key":"1792_CR8","doi-asserted-by":"publisher","first-page":"4668","DOI":"10.3390\/nu15214668","volume":"15","author":"M Dobrzy\u0144ska","year":"2023","unstructured":"Dobrzy\u0144ska M, Kaczmarek K, Przys\u0142awski J, Drzyma\u0142a-Czy\u017c S (2023) Selenium in infants and preschool children nutrition: A literature review. Nutrients 15(21):4668. https:\/\/doi.org\/10.3390\/nu15214668","journal-title":"Nutrients"},{"key":"1792_CR9","doi-asserted-by":"publisher","unstructured":"Edwards, S.G., Kharbikar, L.L., Dickin, E.T., MacDonald, S., & Scudamore, K.A. (2018). Impact of pre-harvest rainfall on the distribution of fusarium mycotoxins in wheat mill fractions.\u00a0Food Control,\u00a089, pp.150\u2013156. https:\/\/doi.org\/10.1016\/j.foodcont.2018.02.009","DOI":"10.1016\/j.foodcont.2018.02.009"},{"key":"1792_CR10","doi-asserted-by":"publisher","DOI":"10.5152\/ThoracResPract.2024.23109","author":"AN Emecen","year":"2024","unstructured":"Emecen AN, K\u0131ran P, \u00c7a\u011flayan D (2024) Influential factors of tuberculosis notification rates in Turkey: A provincial-level spatial analysis. Thoracic Research and Practice. https:\/\/doi.org\/10.5152\/ThoracResPract.2024.23109","journal-title":"Thoracic Research and Practice"},{"key":"1792_CR11","doi-asserted-by":"publisher","unstructured":"Fei, X., Chen, X., Wang, Y., Chen, G., Li, P., Yu, S., & Bai, S. (2022). Epidemic trend of Kaschin-Beck disease in Gansu Province from 2004 to 2018.\u00a0Chinese Journal of Endemiology, pp.139\u2013143. https:\/\/doi.org\/10.3760\/cma.j.cn231583-20210408-00115","DOI":"10.3760\/cma.j.cn231583-20210408-00115"},{"key":"1792_CR12","doi-asserted-by":"publisher","first-page":"107535","DOI":"10.1016\/j.aap.2024.107535","volume":"200","author":"WT Gedamu","year":"2024","unstructured":"Gedamu WT, Plank-Wiedenbeck U, Wodajo BT (2024) A spatial autocorrelation analysis of road traffic crash by severity using Moran\u2019s I spatial statistics: A comparative study of Addis Ababa and Berlin cities. Accident Analysis & Prevention 200:107535. https:\/\/doi.org\/10.1016\/j.aap.2024.107535","journal-title":"Accident Analysis & Prevention"},{"issue":"11","key":"1792_CR13","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1016\/j.joca.2014.07.023","volume":"22","author":"X Guo","year":"2014","unstructured":"Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ (2014) Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease. Osteoarthritis and Cartilage 22(11):1774\u20131783. https:\/\/doi.org\/10.1016\/j.joca.2014.07.023","journal-title":"Osteoarthritis and Cartilage"},{"key":"1792_CR14","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s12011-019-1642-9","volume":"191","author":"Y Guo","year":"2019","unstructured":"Guo Y, Zhou Y, Yan S, Qu C, Wang L, Guo X, Han J (2019) Decreased expression of CHST-12, CHST-13, and UST in the proximal interphalangeal joint cartilage of school-age children with Kashin-Beck disease: an endemic osteoarthritis in China caused by selenium deficiency. Biological Trace Element Research 191:276\u2013285. https:\/\/doi.org\/10.1007\/s12011-019-1642-9","journal-title":"Biological Trace Element Research"},{"key":"1792_CR15","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.healthplace.2013.10.008","volume":"25","author":"G Harling","year":"2014","unstructured":"Harling G, Castro MC (2014) A spatial analysis of social and economic determinants of tuberculosis in Brazil. Health & Place 25:56\u201367. https:\/\/doi.org\/10.1016\/j.healthplace.2013.10.008","journal-title":"Health & Place"},{"key":"1792_CR16","unstructured":"Hu M Q, Zhou H X, Tu Z W, Tang X Y.(2015). Spatial-temporal pattern and meteorological factors of schistosomiasis in Hubei Province[J]. Chinese Journal of Disease Control & Prevention, 19(11): 1101\u20131104"},{"key":"1792_CR17","doi-asserted-by":"publisher","unstructured":"Jia, Y., Han, S., Hou, J., Wang, R., Li, G., Su, S., Qi, L., Wang, Y., Du, L., Sun, H., & Hao, S. (2022). Spatial epidemiological analysis of Keshan disease in China.\u00a0Annals of Global Health,\u00a088(1). https:\/\/doi.org\/10.5334\/aogh.3836","DOI":"10.5334\/aogh.3836"},{"key":"1792_CR18","doi-asserted-by":"publisher","unstructured":"Jiang, T., Pu, Z., Wang, O., Chen, Z., Gao, J., Tan, H., Liu, T., Wang, J., Lin, J., Huang, J., & Huo, J. (2023). Analysis of diet structure of Kashin-beck disease area in Chamdo-Lhorong of Tibet in 2021.\u00a0Wei Sheng yan jiu= Journal of Hygiene Research,\u00a052(6), pp.943\u2013949. https:\/\/doi.org\/10.19813\/j.cnki.weishengyanjiu.2023.06.014","DOI":"10.19813\/j.cnki.weishengyanjiu.2023.06.014"},{"issue":"1","key":"1792_CR19","doi-asserted-by":"publisher","first-page":"e0190505","DOI":"10.1371\/journal.pone.0190505","volume":"13","author":"W Lian","year":"2018","unstructured":"Lian W, Liu H, Song Q, Liu YQ, Sun LY, Deng Q, Wang SP, Cao YH, Zhang XY, Jiang YY, Lv HY (2018) Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey. Plos One 13(1):e0190505. https:\/\/doi.org\/10.1371\/journal.pone.0190505","journal-title":"Plos One"},{"issue":"9","key":"1792_CR20","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1302\/2046-3758.99.BJR-2019-0247.R1","volume":"9","author":"M Ma","year":"2020","unstructured":"Ma M, Liang X, Wang X, Zhang L, Cheng S, Guo X, Zhang F, Wen Y (2020) The molecular mechanism study of COMP involved in the articular cartilage damage of Kashin-Beck disease. Bone & Joint Research 9(9):578\u2013586. https:\/\/doi.org\/10.1302\/2046-3758.99.BJR-2019-0247.R1","journal-title":"Bone & Joint Research"},{"key":"1792_CR21","doi-asserted-by":"publisher","unstructured":"Morrison, C.N., Mair, C.F., Bates, L., Duncan, D.T., Branas, C.C., Bushover, B.R., Mehranbod, C.A., Gobaud, A.N., Uong, S., Forrest, S., & Roberts, L. (2024). Defining Spatial Epidemiology: A Systematic Review and Re-Orientation. Epidemiology, pp.10\u20131097.https:\/\/doi.org\/10.1097\/EDE.0000000000001738","DOI":"10.1097\/EDE.0000000000001738"},{"issue":"10","key":"1792_CR22","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1097\/OLQ.0b013e3181b6ac93","volume":"36","author":"K Owusu-Edusei","year":"2009","unstructured":"Owusu-Edusei K, Chesson HW (2009) Using spatial regression methods to examine the association between county-level racial\/ethnic composition and reported cases of chlamydia and gonorrhea: An illustration with data from the state of Texas. Sexually Transmitted Diseases 36(10):657\u2013664. https:\/\/doi.org\/10.1097\/OLQ.0b013e3181b6ac93","journal-title":"Sexually Transmitted Diseases"},{"issue":"1\u20132","key":"1792_CR23","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.chemgeo.2009.10.011","volume":"269","author":"LL Stillings","year":"2010","unstructured":"Stillings LL, Amacher MC (2010) Kinetics of selenium release in mine waste from the Meade Peak phosphatic shale, Phosphoria formation, Wooley Valley, Idaho, USA. Chemical Geology 269(1\u20132):113\u2013123","journal-title":"Chemical Geology"},{"key":"1792_CR24","doi-asserted-by":"publisher","unstructured":"Su, L., Liang, C., Yang, X., & Liu, Y. (2018). Influence factors analysis of provincial divorce rate spatial distribution in China.\u00a0Discrete Dynamics in Nature and Society,\u00a02018. https:\/\/doi.org\/10.1155\/2018\/6903845","DOI":"10.1155\/2018\/6903845"},{"issue":"9","key":"1792_CR25","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3390\/toxins15090533","volume":"15","author":"D Sun","year":"2023","unstructured":"Sun D, Chasseur C, Mathieu F, Lechanteur J, Van Antwerpen P, Rasschaert J, Fontaine V, Delporte C (2023) Untargeted metabolomics approach correlated enniatin B mycotoxin presence in cereals with Kashin-Beck disease endemic regions of China. Toxins 15(9):533. https:\/\/doi.org\/10.3390\/toxins15090533","journal-title":"Toxins"},{"key":"1792_CR26","doi-asserted-by":"publisher","first-page":"100359","DOI":"10.1016\/j.sste.2020.100359","volume":"34","author":"F Tran","year":"2020","unstructured":"Tran F, Morrison C (2020) Income inequality and suicide in the United States: a spatial analysis of 1684 US counties using geographically weighted regression. Spatial and Spatio-Temporal Epidemiology 34:100359. https:\/\/doi.org\/10.1016\/j.sste.2020.100359","journal-title":"Spatial and Spatio-Temporal Epidemiology"},{"key":"1792_CR27","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.sste.2015.12.003","volume":"16","author":"N Wabiri","year":"2016","unstructured":"Wabiri N, Shisana O, Zuma K, Freeman J (2016) Assessing the spatial nonstationarity in relationship between local patterns of HIV infections and the covariates in South Africa: A geographically weighted regression analysis. Spatial and Spatio-Temporal Epidemiology 16:88\u201399. https:\/\/doi.org\/10.1016\/j.sste.2015.12.003","journal-title":"Spatial and Spatio-Temporal Epidemiology"},{"key":"1792_CR28","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.18306\/dlkxjz.2020.10.007","volume":"39","author":"J Wang","year":"2020","unstructured":"Wang J, Li HR, Yang LS (2020) Selenium levels in the environment, food, and human hair in Kashin-Beck disease endemic areas of the Qinghai-Tibet Plateau. Prog. Geogr 39:1677\u20131686","journal-title":"Prog. Geogr"},{"key":"1792_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12889-021-10407-6","volume":"21","author":"J Wang","year":"2021","unstructured":"Wang J, Wang X, Li H, Yang L, Li Y, Kong C (2021) Spatial distribution and determinants of health loss from Kashin-Beck disease in Bin County, Shaanxi Province, China. BMC Public Health 21:1\u20139. https:\/\/doi.org\/10.1186\/s12889-021-10407-6","journal-title":"BMC Public Health"},{"key":"1792_CR30","doi-asserted-by":"publisher","unstructured":"Wang, W., Wang, L., Deng, Q., Cai, Y., Wu, X., & Sun, L. (2019). The levels of urine CTX-II, C2C, and PYD in children patients with Kashin-Beck disease in Qinghai Province of China.\u00a0Journal of Orthopaedic Surgery and Research,\u00a014, pp.1\u20137.https:\/\/doi.org\/10.1186\/s13018-018-1057-x","DOI":"10.1186\/s13018-018-1057-x"},{"key":"1792_CR31","doi-asserted-by":"publisher","unstructured":"Wang, J., Liu, X., **g, Z., & Yang, J. (2023). Spatial and temporal clustering analysis of pulmonary tuberculosis and its associated risk factors in southwest China.\u00a0Geospatial Health,\u00a018(1). https:\/\/doi.org\/10.4081\/gh.2023.1169","DOI":"10.4081\/gh.2023.1169"},{"key":"1792_CR32","doi-asserted-by":"publisher","unstructured":"Wang, J., Fang, F., Wang, J., Yue, P., Wang, S., & Xu, Y. (2024). Evolutionary characteristics and influencing factors of wheat production risk in Gansu Province of China under the background of climate change.\u00a0Theoretical and Applied Climatology, pp.1\u201327. https:\/\/doi.org\/10.1007\/s00704-024-04931-9","DOI":"10.1007\/s00704-024-04931-9"},{"key":"1792_CR33","doi-asserted-by":"publisher","unstructured":"Yu, O.I., & Ya, A.E. (2022). The Impact of the Coronavirus Crisis on the European Union: A Spatial Autocorrelation Analysis.\u00a0Siberian Historical Research-Sibirskie Istoricheskie Issledovaniya (2), pp.121\u2013131. https:\/\/doi.org\/10.17223\/2312461X\/36\/7","DOI":"10.17223\/2312461X\/36\/7"},{"key":"1792_CR34","doi-asserted-by":"publisher","first-page":"096032712312194","DOI":"10.1177\/09603271231219480","volume":"42","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Fang Q, Liu Y, Zhang D, He Y, Liu F, Sun K, Chen J (2023a) Increased FGFR3 is involved in T-2 toxin-induced lesions of hypertrophic cartilage associated with endemic osteoarthritis. Human & Experimental Toxicology 42:09603271231219480. https:\/\/doi.org\/10.1177\/09603271231219480","journal-title":"Human & Experimental Toxicology"},{"key":"1792_CR35","doi-asserted-by":"publisher","first-page":"138493","DOI":"10.1016\/j.chemosphere.2023.138493","volume":"326","author":"R Zhang","year":"2023","unstructured":"Zhang R, Yang Y, Deji Y, Li H, Li Y, Nima C, Gong H (2023b) Factors influencing the spatial distribution and individual variation in urinary fluoride levels in Tibet, China. Chemosphere 326:138493","journal-title":"Chemosphere"}],"container-title":["EcoHealth"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10393-026-01792-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10393-026-01792-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10393-026-01792-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:05:29Z","timestamp":1789538729000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10393-026-01792-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["1792"],"URL":"https:\/\/doi.org\/10.1007\/s10393-026-01792-8","relation":{},"ISSN":["1612-9210"],"issn-type":[{"value":"1612-9210","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"assertion":[{"value":"2 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Research did not involve human participants and\/or animals.","order":2,"name":"Ethics","label":"Ethics Approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}