{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T23:37:29Z","timestamp":1789256249187,"version":"build-2803163510"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T00:00:00Z","timestamp":1676073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T00:00:00Z","timestamp":1676073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K12847"],"award-info":[{"award-number":["19K12847"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K01418"],"award-info":[{"award-number":["16K01418"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006092","name":"the Foundation for Development of the Community","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006092","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008369","name":"Japan Society of Ultrasonics in Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008369","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Ultrasonics"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The safety of acoustic radiation force impulse (ARFI) elastography, which applies higher acoustic power with a longer pulse duration (PD) than conventional diagnostic ultrasound, is yet to be verified. We assessed the ARFI-induced lung injury risk and its relationship with peak rarefactional pressure amplitude (PRPA) and mechanical index (MI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Eighteen and two rabbits were included in the ARFI (0.3-ms push pulses) and sham groups, respectively. A 5.2-MHz linear probe was applied to the subcostal area and aimed at both lungs through the liver for 30 ARFI emissions. The derated PRPA varied among the six ARFI groups\u20140.80\u00a0MPa, 1.13\u00a0MPa, 1.33\u00a0MPa, 1.70\u00a0MPa, 1.91\u00a0MPa, and 2.00\u00a0MPa, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The occurrence of lung hemorrhage and the mean lesion area among all samples in the seven groups were 0\/6, 0\/6, 1\/6 (1.7 mm<jats:sup>2<\/jats:sup>), 4\/6 (8.0 mm<jats:sup>2<\/jats:sup>), 4\/6 (11.2 mm<jats:sup>2<\/jats:sup>), 5\/6 (23.8 mm<jats:sup>2<\/jats:sup>), and 0\/4 (sham), respectively. Logistic regression analysis showed that derated PRPA was significantly associated with lung injury occurrence (odds ratio: 207, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), with the threshold estimated to be 1.1\u00a0MPa (MI, 0.5). Spearman\u2019s rank correlation showed a positive correlation between derated PRPA and lesion area (<jats:italic>r<\/jats:italic>\u2009=\u20090.671, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study demonstrated that the occurrence and severity of ARFI-induced lung hemorrhage increased with a rise in PRPA under clinical conditions in rabbits. This indicates a potential risk of lung injury due to ARFI elastography, especially when ARFI is unintentionally directed to the lungs during liver, heart, or breast examinations.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10396-023-01285-z","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T09:05:36Z","timestamp":1676106336000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acoustic radiation force impulse-induced lung hemorrhage: investigating the relationship with peak rarefactional pressure amplitude and mechanical index in rabbits"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-6159","authenticated-orcid":false,"given":"Noriya","family":"Takayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Sasanuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Rifu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotaka","family":"Nitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwaki","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,11]]},"reference":[{"key":"1285_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.7863\/jum.2000.19.2.85","volume":"19","author":"American Institute of Ultrasound in Medicine","year":"2000","unstructured":"American Institute of Ultrasound in Medicine. 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The Federation; c1993\u20132016 [cited 2014 Nov. 27] Basic concepts of safety of diagnostic ultrasonic equipment. http:\/\/afsumb.org\/safety\/file\/safety_of_ultrasound_equipment4web2014.pdf; p. 16. Accessed 1 Jan 2022."},{"key":"1285_CR9","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1016\/j.ultrasmedbio.2006.03.011","volume":"32","author":"WD O\u2019Brien","year":"2006","unstructured":"O\u2019Brien WD, Yang Y, Simpson DG, et al. Threshold estimation of ultrasound-induced lung hemorrhage in adult rabbits and comparison of thresholds in mice, rats, rabbits and pigs. Ultrasound Med Biol. 2006;32:1793\u2013804.","journal-title":"Ultrasound Med Biol"},{"key":"1285_CR10","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.ultrasmedbio.2003.08.002","volume":"29","author":"WD O\u2019Brien","year":"2003","unstructured":"O\u2019Brien WD, Simpson DG, Frizzell LA, et al. 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