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Hideki Goto has received research grants and speaker fees from Bristol Myers Squibb and Kyowa Kirin, a research grant from SymBio, and speaker fees from Novartis, Chugai Pharmaceutical, and Daiichi Sankyo. Isao Yokota has received a research grant from Nihon Medi-Physics, and speaker fees from Chugai Pharmaceutical and AstraZeneca. Takanori Teshima has received research grants and speaker fees from Chugai Pharmaceutical, Kyowa Kirin, Nippon Shinyaku, Sumitomo Pharma, and Astellas, research grants from Fuji Pharma, Asahi Kasei Pharma, Eisai, Ono Pharmaceutical, Shionogi, Priothera SAS, and Luca Science, speaker fees from AbbVie, Novartis, Bristol-Myers Squibb, Merck Sharp & Dohme, Celgene and Janssen, and participation on a Data Safety Monitoring Board or Advisory Board at Novartis, Meiji Seika Pharma, Daiichi Sankyo, Asahi Kasei Pharma, Astellas, AstraZeneca, Takeda, Janssen, Roche Diagnostics, Sumitomo Pharma, Celgene, and Sanofi. The rest of the authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study was approved by the Institutional Review Board (019\u20130386), and written informed consent was obtained from all study participants in accordance with the World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects, 2013.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical aproval"}}]}}