{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:45:55Z","timestamp":1785527155357,"version":"3.56.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Ultrasonics"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the role of ultrasound screening for fetal structural abnormalities at 20 and 30\u00a0weeks\u2019 gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included women with singleton pregnancies who underwent routine ultrasound screening at our hospital between May 2014 and April 2021. Participants received two ultrasound screening examinations: at 20 and 30\u00a0weeks\u2019 gestation. We evaluated the frequency and details of fetal structural abnormalities identified during each examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 10,560 pregnant women underwent ultrasound screening at 20 and 30\u00a0weeks\u2019 gestation and delivered at our hospital. Structural abnormalities were observed in 142 (1.3%) women; of note, screening examinations at 20 and 30\u00a0weeks detected 42.3% and 23.9% of cases, respectively. Routine point-of-care ultrasound examinations performed between 20 and 30\u00a0weeks and beyond 30\u00a0weeks detected 8.5% and 6.3% of cases, respectively, with 19.0% of cases identified after birth. Cleft lip and palate and ventricular septal defects (VSDs) were the most common abnormalities detected at the 20-week ultrasound screening. At the 30-week ultrasound screening, in addition to hydronephrosis, VSD, and vascular rings, which were also detected at the 20-week ultrasound screening, diaphragmatic hernia, ovarian cysts, achondroplasia, duodenal atresia, and meconium peritonitis, which could be apparent later in pregnancy, were detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The 20-week ultrasound screening revealed common fetal structural abnormalities, and the 30-week ultrasound screening detected fetal structural abnormalities that failed to be detected during the 20-week ultrasound screening and became apparent later in pregnancy. Adding a 30-week ultrasound screening provides enhanced diagnostic details in comparison to 20-week screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10396-025-01609-1","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:33:30Z","timestamp":1765640010000},"page":"301-309","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Detection of fetal structural abnormalities at 20 and 30 weeks: a retrospective study of prenatal ultrasound screening"],"prefix":"10.1007","volume":"53","author":[{"given":"Yuki","family":"Kamihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8728-5576","authenticated-orcid":false,"given":"Katsusuke","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Muromoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Sugibayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Sago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,13]]},"reference":[{"key":"1609_CR1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.siny.2017.11.005","volume":"23","author":"L Edwards","year":"2018","unstructured":"Edwards L, Hui L. First and second trimester screening for fetal structural anomalies. Semin Fetal Neonatal Med. 2018;23:102\u201311.","journal-title":"Semin Fetal Neonatal Med"},{"key":"1609_CR2","doi-asserted-by":"crossref","unstructured":"Committee on Practice Bulletins\u2014Obstetrics and the American Institute of Ultrasound in Medicine. Practice Bulletin No. 175: ultrasound in pregnancy. Obstet Gynecol. 2016;128:e241-e56.","DOI":"10.1097\/AOG.0000000000001815"},{"key":"1609_CR3","unstructured":"National Health Service (NHS), NHS fetal anomaly screening programme (FASP). Fetal anomaly screening programme handbook [Online]. NHS: London; 2015. https:\/\/www.gov.uk\/government\/publications\/fetal-anomaly-screening-programme-handbook\/overview. Accessed 2 Jan 2025."},{"key":"1609_CR4","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1002\/uog.24888","volume":"59","author":"LJ Salomon","year":"2022","unstructured":"Salomon LJ, Alfirevic Z, Berghella V, et al. ISUOG Practice Guidelines (updated): performance of the routine mid-trimester fetal ultrasound scan. Ultrasound Obstet Gynecol. 2022;59:840\u201356.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1609_CR5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/1471-0528.16468","volume":"128","author":"L Drukker","year":"2021","unstructured":"Drukker L, Bradburn E, Rodriguez GB, et al. How often do we identify fetal abnormalities during routine third-trimester ultrasound? A systematic review and meta-analysis. BJOG. 2021;128:259\u201369.","journal-title":"BJOG"},{"key":"1609_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/jog.15438","volume":"49","author":"A Itakura","year":"2023","unstructured":"Itakura A, Shoji S, Shigeru A, et al. Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology and Japan Association of Obstetricians and Gynecologists 2020 edition. J Obstet Gynaecol Res. 2023;49:5\u201353.","journal-title":"J Obstet Gynaecol Res"},{"key":"1609_CR7","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2023.2167075","volume":"36","author":"S Tokoro","year":"2023","unstructured":"Tokoro S, Koshida S, Tsuji S, et al. Insufficient antenatal identification of fetal growth restriction leading to intrauterine fetal death: a regional population-based study in Japan. J Matern Fetal Neonatal Med. 2023;36:2167075.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"1609_CR8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/uog.27538","volume":"63","author":"A Khalil","year":"2024","unstructured":"Khalil A, Sotiriadis A, D\u2019Antonio F, et al. ISUOG Practice Guidelines: performance of third-trimester obstetric ultrasound scan. Ultrasound Obstet Gynecol. 2024;63:131\u201347.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1609_CR9","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1002\/uog.6446","volume":"34","author":"G Romosan","year":"2009","unstructured":"Romosan G, Henriksson E, Rylander A, et al. Diagnostic performance of routine ultrasound screening for fetal abnormalities in an unselected Swedish population in 2000-2005. Ultrasound Obstet Gynecol. 2009;34:526\u201333.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1609_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.05.052","volume":"223","author":"L Drukker","year":"2020","unstructured":"Drukker L, Cavallaro A, Salim I, et al. How often do we incidentally find a fetal abnormality at the routine third-trimester growth scan? A population-based study. Am J Obstet Gynecol. 2020;223:919.e1-.e13.","journal-title":"Am J Obstet Gynecol"},{"key":"1609_CR11","volume":"2015","author":"M Whitworth","year":"2015","unstructured":"Whitworth M, Bricker L, Mullan C. Ultrasound for fetal assessment in early pregnancy. Cochrane Database Syst Rev. 2015;2015:Cd007058.","journal-title":"Cochrane Database Syst Rev"},{"key":"1609_CR12","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1186\/s12887-019-1877-9","volume":"19","author":"S Tsuchiya","year":"2019","unstructured":"Tsuchiya S, Tsuchiya M, Momma H, et al. Association of cleft lip and palate on mother-to-infant bonding: a cross-sectional study in the Japan Environment and Children\u2019s Study (JECS). BMC Pediatr. 2019;19:505.","journal-title":"BMC Pediatr"},{"key":"1609_CR13","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/pd.6128","volume":"42","author":"L Gordin Kopylov","year":"2022","unstructured":"Gordin Kopylov L, Dekel N, Maymon R, et al. Prenatally diagnosed isolated perimembranous ventricular septal defect: genetic and clinical implications. Prenat Diagn. 2022;42:461\u20138.","journal-title":"Prenat Diagn"},{"key":"1609_CR14","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1007\/s00246-023-03219-5","volume":"45","author":"I Milligan","year":"2024","unstructured":"Milligan I, Border W, Sachdeva R, et al. Contemporary outcomes in fetuses diagnosed with vascular rings. Pediatr Cardiol. 2024;45:1559\u201364.","journal-title":"Pediatr Cardiol"},{"key":"1609_CR15","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/uog.17546","volume":"51","author":"DIP Buca","year":"2018","unstructured":"Buca DIP, Khalil A, Rizzo G, et al. Outcome of prenatally diagnosed fetal heterotaxy: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018;51:323\u201330.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1609_CR16","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1590\/1516-3180.2019.026906082019","volume":"137","author":"FF Dulgheroff","year":"2019","unstructured":"Dulgheroff FF, Peixoto AB, Petrini CG, et al. Fetal structural anomalies diagnosed during the first, second and third trimesters of pregnancy using ultrasonography: a retrospective cohort study. Sao Paulo Med J. 2019;137:391\u2013400.","journal-title":"Sao Paulo Med J"},{"key":"1609_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/uog.187","volume":"22","author":"R Chaoui","year":"2003","unstructured":"Chaoui R. The four-chamber view: four reasons why it seems to fail in screening for cardiac abnormalities and suggestions to improve detection rate. Ultrasound Obstet Gynecol. 2003;22:3\u201310.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1609_CR18","doi-asserted-by":"publisher","first-page":"659","DOI":"10.7863\/jum.1993.12.11.659","volume":"12","author":"GR DeVore","year":"1993","unstructured":"DeVore GR, Medearis AL, Bear MB, et al. Fetal echocardiography: factors that influence imaging of the fetal heart during the second trimester of pregnancy. J Ultrasound Med. 1993;12:659\u201363.","journal-title":"J Ultrasound Med"},{"key":"1609_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.01.001","volume":"222","author":"JJ Byrne","year":"2020","unstructured":"Byrne JJ, Morgan JL, Twickler DM, et al. Utility of follow-up standard sonography for fetal anomaly detection. Am J Obstet Gynecol. 2020;222:615.e1-.e9.","journal-title":"Am J Obstet Gynecol"},{"key":"1609_CR20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/pd.4989","volume":"37","author":"S Wada","year":"2017","unstructured":"Wada S, Jwa SC, Yumoto Y, et al. The prognostic factors and outcomes of primary fetal hydrothorax with the effects of fetal intervention. Prenat Diagn. 2017;37:184\u201392.","journal-title":"Prenat Diagn"},{"key":"1609_CR21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1056\/NEJMoa2027030","volume":"385","author":"JA Deprest","year":"2021","unstructured":"Deprest JA, Nicolaides KH, Benachi A, et al. Randomized trial of fetal surgery for severe left diaphragmatic hernia. N Engl J Med. 2021;385:107\u201318.","journal-title":"N Engl J Med"},{"key":"1609_CR22","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1080\/14767058.2021.1874338","volume":"35","author":"O Demirci","year":"2022","unstructured":"Demirci O, Eri\u00e7 \u00d6zdemir M, Kumru P, et al. Clinical significance of prenatal double bubble sign on perinatal outcome and literature review. J Matern Fetal Neonatal Med. 2022;35:1841\u20137.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"1609_CR23","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/j.jpedsurg.2008.02.060","volume":"43","author":"P Galinier","year":"2008","unstructured":"Galinier P, Carfagna L, Juricic M, et al. Fetal ovarian cysts management and ovarian prognosis: a report of 82 cases. J Pediatr Surg. 2008;43:2004\u20139.","journal-title":"J Pediatr Surg"},{"key":"1609_CR24","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S2352-4642(23)00265-1","volume":"8","author":"R Savarirayan","year":"2024","unstructured":"Savarirayan R, Wilcox WR, Harmatz P, et al. Vosoritide therapy in children with achondroplasia aged 3-59 months: a multinational, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Child Adolesc Health. 2024;8:40\u201350.","journal-title":"Lancet Child Adolesc Health"},{"key":"1609_CR25","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s00467-005-2100-9","volume":"21","author":"G Sidhu","year":"2006","unstructured":"Sidhu G, Beyene J, Rosenblum ND. Outcome of isolated antenatal hydronephrosis: a systematic review and meta-analysis. Pediatr Nephrol. 2006;21:218\u201324.","journal-title":"Pediatr Nephrol"}],"container-title":["Journal of Medical Ultrasonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10396-025-01609-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10396-025-01609-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10396-025-01609-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:09:19Z","timestamp":1785521359000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10396-025-01609-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,13]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["1609"],"URL":"https:\/\/doi.org\/10.1007\/s10396-025-01609-1","relation":{},"ISSN":["1346-4523","1613-2254"],"issn-type":[{"value":"1346-4523","type":"print"},{"value":"1613-2254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,13]]},"assertion":[{"value":"26 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article was originally published under the subscription model but it is now published under an Open Access license.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest associated with this study.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board for Clinical Research of the National Center for Child Health and Development (approval number: 2022-220). Informed consent was obtained via an opt-out form on the website.","order":2,"name":"Ethics","label":"Statement of ethics","group":{"name":"EthicsHeading","label":"Declarations"}}]}}