{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:17:58Z","timestamp":1788016678783,"version":"build-2784847793"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Ultrasonics"],"DOI":"10.1007\/s10396-026-01674-0","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:49:01Z","timestamp":1788011341000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The clinical utility and diagnostic performance of transabdominal contrast-enhanced ultrasonography using Sonazoid for pancreatic diseases: a narrative review"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5417-6752","authenticated-orcid":false,"given":"Atsushi","family":"Sofuni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Itoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"1674_CR1","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1148\/radiology.161.3.3024206","volume":"161","author":"Y Matsuda","year":"1986","unstructured":"Matsuda Y, Yabuuchi I. Hepatic tumors: US contrast enhancement with carbon dioxide microbubbles. Radiology. 1986;161:701\u20135.","journal-title":"Radiology"},{"key":"1674_CR2","doi-asserted-by":"publisher","first-page":"431","DOI":"10.2214\/ajr.173.2.10430149","volume":"173","author":"AS Lev-Toaff","year":"1999","unstructured":"Lev-Toaff AS, Langer JE, Rubin DL, et al. Safety and efficacy of a new oral contrast agent for sonography: a phase II trial. AJR Am J Roentgenol. 1999;173:431\u20136.","journal-title":"AJR Am J Roentgenol"},{"key":"1674_CR3","first-page":"50","volume":"51","author":"PN Burns","year":"1996","unstructured":"Burns PN. Harmonic imaging with ultrasound contrast agents. Clin Radiol. 1996;51:50\u20135.","journal-title":"Clin Radiol"},{"key":"1674_CR4","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1055\/s-2000-674","volume":"172","author":"W Kratzer","year":"2000","unstructured":"Kratzer W, K\u00e4chele V, Merkle E, et al. Contrast enhanced power doppler sonography: comparison of various administration forms of the ultrasound contrast agent Levovist. Rofo. 2000;172:443\u20138.","journal-title":"Rofo"},{"key":"1674_CR5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1055\/s-2000-9124","volume":"21","author":"S Rickes","year":"2000","unstructured":"Rickes S, Unkrodt K, Ocran K, et al. Evaluation of Doppler ultrasonography criteria for the differential diagnosis of pancreatic tumors. Ultraschall Med. 2000;21:253\u20138.","journal-title":"Ultraschall Med"},{"key":"1674_CR6","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1080\/003655202761020605","volume":"37","author":"S Rickes","year":"2002","unstructured":"Rickes S, Unkrodt K, Neye H, et al. Differentiation of pancreatic tumors by conventional ultrasound, unenhanced and echo-enhanced power Doppler sonography. Scand J Gastroenterol. 2002;37:1313\u201320.","journal-title":"Scand J Gastroenterol"},{"key":"1674_CR7","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.2214\/ajr.171.5.9798848","volume":"171","author":"RS Shapiro","year":"1998","unstructured":"Shapiro RS, Wagreich J, Persons RB, et al. Tissue harmonic imaging sonography: evaluation of image quality compared with conventional sonography. AJR Am J Roentgenol. 1998;171:1203\u20136.","journal-title":"AJR Am J Roentgenol"},{"key":"1674_CR8","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.2214\/ajr.178.5.1781133","volume":"178","author":"O Oshikawa","year":"2002","unstructured":"Oshikawa O, Tanaka S, Ioka T, et al. Dynamic sonography of pancreatic tumors: comparison with dynamic CT. AJR. 2002;178:1133\u20137.","journal-title":"AJR"},{"key":"1674_CR9","doi-asserted-by":"publisher","first-page":"983","DOI":"10.7863\/jum.2002.21.9.983","volume":"21","author":"Y Ozawa","year":"2002","unstructured":"Ozawa Y, Numata K, Tanaka K, et al. Contrast-enhanced sonography of small pancreatic mass lesions. J Ultrasound Med. 2002;21:983\u201391.","journal-title":"J Ultrasound Med"},{"key":"1674_CR10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1258\/rsmacta.44.1.103","volume":"44","author":"K Takeda","year":"2003","unstructured":"Takeda K, Goto H, Hirooka Y, et al. Contrast enhanced transabdominal ultrasonography in the diagnosis of pancreatic mass lesions. Acta Radiol. 2003;44:103\u20136.","journal-title":"Acta Radiol"},{"key":"1674_CR11","doi-asserted-by":"publisher","first-page":"789","DOI":"10.7863\/jum.2003.22.8.789","volume":"22","author":"M Nagase","year":"2003","unstructured":"Nagase M, Furuse J, Ishii H, et al. Evaluation of contrast enhancement patterns in pancreatic tumors by coded harmonic sonographic imaging with a microbubble contrast agent. J Ultrasound Med. 2003;22:789\u201395.","journal-title":"J Ultrasound Med"},{"key":"1674_CR12","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1159\/000071775","volume":"3","author":"B Flath","year":"2003","unstructured":"Flath B, Rickes S, Schweigert M, et al. Differentiation of pancreatic metastasis of a renal cell carcinoma from primary pancreatic carcinoma by echo-enhanced power Doppler sonography. Pancreatology. 2003;3:349\u201351.","journal-title":"Pancreatology"},{"key":"1674_CR13","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s00261-003-0097-8","volume":"29","author":"M D\u2019Onofrio","year":"2004","unstructured":"D\u2019Onofrio M, Mansueto G, Falconi M, et al. Neuroendocrine pancreatic tumor: value of contrast enhanced ultrasonography. Abdom Imaging. 2004;29:246\u201358.","journal-title":"Abdom Imaging"},{"key":"1674_CR14","doi-asserted-by":"publisher","first-page":"199","DOI":"10.7863\/jum.2004.23.2.199","volume":"23","author":"K Numata","year":"2004","unstructured":"Numata K, Ozawa Y, Kobayashi N, et al. Contrast enhanced sonography of autoimmune pancreatitis. Comparison with pathologic findings. J Ultrasound Med. 2004;23:199\u2013206.","journal-title":"J Ultrasound Med"},{"key":"1674_CR15","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1007\/s00330-003-2191-2","volume":"14","author":"C Hohl","year":"2004","unstructured":"Hohl C, Schmidt T, Haage P, et al. Phase-inversion tissue harmonic imaging compared with conventional B-mode ultrasound in the evaluation of pancreatic lesions. Eur Radiol. 2004;14:1109\u201317.","journal-title":"Eur Radiol"},{"key":"1674_CR16","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/00006676-200404000-00024","volume":"28","author":"T Ohshima","year":"2004","unstructured":"Ohshima T, Yamaguchi T, Ishihara T, et al. Evaluation of blood flow in pancreatic ductal carcinoma using contrast-enhanced, wide-band Doppler ultrasonography correlation with tumor characteristics and vascular endothelial growth factor. Pancreas. 2004;28:335\u201343.","journal-title":"Pancreas"},{"key":"1674_CR17","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1136\/gut.2003.029934","volume":"53","author":"M Kitano","year":"2004","unstructured":"Kitano M, Kudo M, Maekawa K, et al. Dynamic imaging of pancreatic diseases by contrast enhanced coded phase inversion harmonic ultrasonography. Gut. 2004;53:854\u20139.","journal-title":"Gut"},{"key":"1674_CR18","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1007\/s00535-005-1578-z","volume":"40","author":"A Sofuni","year":"2005","unstructured":"Sofuni A, Iijima H, Moriyasu F, et al. Differential diagnosis of pancreatic tumors using ultrasound contrast imaging. J Gastroenterol. 2005;40:518\u201325.","journal-title":"J Gastroenterol"},{"key":"1674_CR19","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00535-005-1598-8","volume":"40","author":"K Numata","year":"2005","unstructured":"Numata K, Ozawa Y, Kobayashi N, et al. Contrast-enhanced sonography of pancreatic carcinoma: correlations with pathological findings. J Gastroenterol. 2005;40:631\u201340.","journal-title":"J Gastroenterol"},{"key":"1674_CR20","doi-asserted-by":"publisher","first-page":"849","DOI":"10.7863\/jum.2005.24.6.849","volume":"24","author":"M D'Onofrio","year":"2005","unstructured":"D\u2019Onofrio M, Malag\u00f2 R, Vecchiato F, et al. Contrast-enhanced ultrasonography of small solid pseudopapillary tumors of the pancreas. J Ultrasound Med. 2005;24:849\u201354.","journal-title":"J Ultrasound Med"},{"key":"1674_CR21","doi-asserted-by":"publisher","first-page":"4181","DOI":"10.3748\/wjg.v12.i26.4181","volume":"12","author":"M D\u2019Onofrio","year":"2006","unstructured":"D\u2019Onofrio M, Zamboni G, Tognolini A, et al. Mass-forming pancreatitis: value of contrast-enhanced ultrasonography. World J Gastroenterol. 2006;12:4181\u20134.","journal-title":"World J Gastroenterol"},{"key":"1674_CR22","first-page":"584","volume":"7","author":"S Rickes","year":"2006","unstructured":"Rickes S, M\u00f6nkem\u00fcller K, Malfertheiner P. Contrast-enhanced ultrasound in the diagnosis of pancreatic tumors. JOP. 2006;7:584\u201392.","journal-title":"JOP"},{"key":"1674_CR23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00261-006-9010-6","volume":"32","author":"M D'Onofrio","year":"2007","unstructured":"D\u2019Onofrio M, Zamboni G, Faccioli N, et al. Ultrasonography of the pancreas. Contrast-enhanced imaging. Abdom Imaging. 2007;32:171\u201381.","journal-title":"Abdom Imaging"},{"key":"1674_CR24","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.ejrad.2007.02.042","volume":"62","author":"W Yang","year":"2007","unstructured":"Yang W, Chen MH, Yan K, et al. Differential diagnosis of non-functional islet cell tumor and pancreatic carcinoma with sonography. Eur J Radiol. 2007;62:342\u201351.","journal-title":"Eur J Radiol"},{"key":"1674_CR25","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1097\/MPA.0b013e31816c908b","volume":"37","author":"N Faccioli","year":"2008","unstructured":"Faccioli N, D\u2019Onofrio M, Malag\u00f2 R, et al. Resectable pancreatic adenocarcinoma: depiction of tumoral margins at contrast-enhanced ultrasonography. Pancreas. 2008;37:265\u20138.","journal-title":"Pancreas"},{"key":"1674_CR26","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1055\/s-2008-1027555","volume":"29","author":"Y D\u00f6rffel","year":"2008","unstructured":"D\u00f6rffel Y, Wermke W. Neuroendocrine tumors: characterization with contrast-enhanced ultrasonography. Ultraschall Med. 2008;29:506\u201314.","journal-title":"Ultraschall Med"},{"key":"1674_CR27","doi-asserted-by":"publisher","first-page":"7183","DOI":"10.3748\/wjg.14.7183","volume":"14","author":"A Sofuni","year":"2008","unstructured":"Sofuni A, Itoi T, Itokawa F, et al. Usefulness of contrast-enhanced ultrasonography in determining treatment efficacy and outcome after pancreatic cancer chemotherapy. World J Gastroenterol. 2008;14:7183\u201391.","journal-title":"World J Gastroenterol"},{"key":"1674_CR28","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1053\/j.gastro.2009.08.049","volume":"137","author":"S Kersting","year":"2009","unstructured":"Kersting S, Konopke R, Kersting F, et al. Quantitative perfusion analysis of transabdominal contrast-enhanced ultrasonography of pancreatic masses and carcinomas. Gastroenterology. 2009;137:1903\u201311.","journal-title":"Gastroenterology"},{"key":"1674_CR29","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1097\/MPA.0b013e318183ff73","volume":"38","author":"K Tawada","year":"2009","unstructured":"Tawada K, Yamaguchi T, Kobayashi A, et al. Changes in tumor vascularity depicted by contrast-enhanced ultrasonography as a predictor of chemotherapeutic effect in patients with unresectable pancreatic cancer. Pancreas. 2009;38:30\u20135.","journal-title":"Pancreas"},{"key":"1674_CR30","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1097\/MPA.0b013e31821f57b7","volume":"40","author":"H Matsubara","year":"2011","unstructured":"Matsubara H, Itoh A, Kawashima H, et al. Quantitative perfusion analysis of pancreatic diseases by contrast-enhanced ultrasonography. Pancreas. 2011;40:663\u20137.","journal-title":"Pancreas"},{"key":"1674_CR31","doi-asserted-by":"publisher","first-page":"257","DOI":"10.7863\/jum.2012.31.2.257","volume":"31","author":"SS Tang","year":"2012","unstructured":"Tang SS, Huang LP, Wang Y, et al. Solid pseudopapillary tumors of the pancreas: contrast-enhanced sonographic features. J Ultrasound Med. 2012;31:257\u201363.","journal-title":"J Ultrasound Med"},{"key":"1674_CR32","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.ejrad.2011.01.053","volume":"81","author":"M D'Onofrio","year":"2012","unstructured":"D\u2019Onofrio M, Barbi E, Dietrich CF, et al. Pancreatic multicenter ultrasound study (PAMUS). Eur J Radiol. 2012;81:630\u20138.","journal-title":"Eur J Radiol"},{"key":"1674_CR33","first-page":"B4536","volume":"59","author":"HS Grossjohann","year":"2012","unstructured":"Grossjohann HS. Contrast-enhanced ultrasound for diagnosing, staging and assessment of operability of pancreatic cancer. Dan Med J. 2012;59:B4536.","journal-title":"Dan Med J"},{"key":"1674_CR34","first-page":"233","volume":"1","author":"A Sofuni","year":"2012","unstructured":"Sofuni A, Itoi T, Tsuji S, et al. New advances in contrast-enhanced ultrasonography for pancreatic disease\u2014usefulness of the new generation contrast agent and contrast-enhanced ultrasonographic imaging method. J GHR. 2012;1:233\u201340.","journal-title":"J GHR"},{"key":"1674_CR35","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ejrad.2010.11.027","volume":"81","author":"N Kurihara","year":"2012","unstructured":"Kurihara N, Kawamoto H, Kobayashi Y, et al. Vascular patterns in nodules of intraductal papillary mucinous neoplasms depicted under contrast-enhanced ultrasonography are helpful for evaluating malignant potential. Eur J Radiol. 2012;81:66\u201370.","journal-title":"Eur J Radiol"},{"key":"1674_CR36","first-page":"108","volume":"14","author":"TA Vasile","year":"2012","unstructured":"Vasile TA, Socaciu M, Stan Iuga R, et al. Added value of intravenous contrast-enhanced ultrasound for characterization of cystic pancreatic masses: a prospective study on 37 patients. Med Ultrason. 2012;14:108\u201314.","journal-title":"Med Ultrason"},{"key":"1674_CR37","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3233\/CH-131675","volume":"58","author":"J Rennert","year":"2014","unstructured":"Rennert J, Farkas S, Georgieva M, et al. Identification of early complications following pancreas and renal transplantation using contrast enhanced ultrasound (CEUS)-first results. Clin Hemorheol Microcirc. 2014;58:343\u201352.","journal-title":"Clin Hemorheol Microcirc"},{"key":"1674_CR38","doi-asserted-by":"publisher","first-page":"7419","DOI":"10.3748\/wjg.v19.i42.7419","volume":"19","author":"A Sofuni","year":"2013","unstructured":"Sofuni A, Itoi T, Itokawa F, et al. Real-time virtual sonography visualization and its clinical application in biliopancreatic disease. World J Gastroenterol. 2013;19:7419\u201325.","journal-title":"World J Gastroenterol"},{"key":"1674_CR39","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1055\/s-0034-1385068","volume":"35","author":"M D'Onofrio","year":"2014","unstructured":"D\u2019Onofrio M, Biagioli E, Gerardi C, et al. Diagnostic performance of contrast-enhanced ultrasound (CEUS) and contrast-enhanced endoscopic ultrasound (ECEUS) for the differentiation of pancreatic lesions\u2014a systematic review and meta-analysis. Ultraschall Med. 2014;35:515\u201321.","journal-title":"Ultraschall Med"},{"key":"1674_CR40","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1007\/s00261-014-0135-8","volume":"39","author":"H Miwa","year":"2014","unstructured":"Miwa H, Numata K, Sugimori K, et al. Differential diagnosis of solid pancreatic lesions using contrast-enhanced three-dimensional ultrasonography. Abdom Imaging. 2014;39:988\u201399.","journal-title":"Abdom Imaging"},{"key":"1674_CR41","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/j.ultrasmedbio.2015.01.015","volume":"41","author":"Y Wei","year":"2015","unstructured":"Wei Y, Yu XL, Liang P, et al. Guiding and controlling percutaneous pancreas biopsies with contrast-enhanced ultrasound: target lesions are not localized on B-mode ultrasound. Ultrasound Med Biol. 2015;41:1561\u20139.","journal-title":"Ultrasound Med Biol"},{"key":"1674_CR42","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1055\/s-0041-103847","volume":"53","author":"F Vitali","year":"2015","unstructured":"Vitali F, Pfeifer L, Janson C, et al. Quantitative perfusion analysis in pancreatic contrast enhanced ultrasound (DCE-US)\u2014a promising tool for the differentiation between autoimmune pancreatitis and pancreatic cancer. Z Gastroenterol. 2015;53:1175\u201381.","journal-title":"Z Gastroenterol"},{"key":"1674_CR43","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.ultrasmedbio.2015.12.008","volume":"42","author":"Y Wang","year":"2016","unstructured":"Wang Y, Yan K, Fan Z, et al. Contrast-enhanced ultrasonography of pancreatic carcinoma: correlation with pathologic findings. Ultrasound Med Biol. 2016;42:891\u20138.","journal-title":"Ultrasound Med Biol"},{"key":"1674_CR44","doi-asserted-by":"publisher","first-page":"163","DOI":"10.11152\/mu.2013.2066.182.ceu","volume":"18","author":"LZ Lin","year":"2016","unstructured":"Lin LZ, Li F, Liu Y, et al. Contrast-enhanced ultrasound for differential diagnosis of pancreatic mass lesions-a meta-analysis. Med Ultrason. 2016;18:163\u20139.","journal-title":"Med Ultrason"},{"key":"1674_CR45","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007463","volume":"96","author":"L Ran","year":"2017","unstructured":"Ran L, Zhao W, Zhao Y, et al. Value of contrast-enhanced ultrasound in differential diagnosis of solid lesions of pancreas (SLP): a systematic review and a meta-analysis. Medicine (Baltimore). 2017;96:e7463.","journal-title":"Medicine (Baltimore)"},{"key":"1674_CR46","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.2147\/OTT.S125497","volume":"10","author":"X Sun","year":"2017","unstructured":"Sun X, Zhou F, Liu F, et al. Discrimination of serous cystadenoma from mucinous cystadenoma in the pancreas with contrast-enhanced ultrasonography: a prospective study in 61 patients. Onco Targets Ther. 2017;10:1283\u201394.","journal-title":"Onco Targets Ther"},{"key":"1674_CR47","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/jum.14363","volume":"37","author":"Y Wang","year":"2018","unstructured":"Wang Y, Yan K, Fan Z, et al. Clinical value of contrast-enhanced ultrasound enhancement patterns for differentiating focal pancreatitis from pancreatic carcinoma: a comparison study with conventional ultrasound. J Ultrasound Med. 2018;37:551\u20139.","journal-title":"J Ultrasound Med"},{"key":"1674_CR48","first-page":"5698140","volume":"2019","author":"Y Wang","year":"2019","unstructured":"Wang Y, Wang Y, Fan Z, et al. The value of contrast-enhanced ultrasound classification in diagnosis of pancreatic cystic lesions. BioMed Res Int. 2019;2019:5698140.","journal-title":"BioMed Res Int"},{"key":"1674_CR49","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s10396-019-00975-x","volume":"47","author":"S Hashimoto","year":"2020","unstructured":"Hashimoto S, Hirooka Y, Kawabe N, et al. Role of transabdominal ultrasonography in the diagnosis of pancreatic cystic lesions. J Med Ultrason. 2020;47:389\u201399.","journal-title":"J Med Ultrason"},{"key":"1674_CR50","first-page":"1571","volume":"12","author":"Y Sun","year":"2020","unstructured":"Sun Y, Yang S, Qi E, et al. Comparative diagnostic evaluation with contrast-enhanced ultrasound, computed tomography and magnetic resonance imaging in patients with pancreatic cystic neoplasms. Cancer Manag Res. 2020;12:1571\u201380.","journal-title":"Cancer Manag Res"},{"key":"1674_CR51","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s10396-019-00968-w","volume":"47","author":"A Sofuni","year":"2020","unstructured":"Sofuni A, Tsuchiya T, Itoi T. Ultrasound diagnosis of pancreatic solid tumors. J Med Ultrason. 2020;47:359\u201376.","journal-title":"J Med Ultrason"},{"key":"1674_CR52","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1016\/j.ultrasmedbio.2020.04.016","volume":"46","author":"S Tanaka","year":"2020","unstructured":"Tanaka S, Fukuda J, Nakao M, et al. Effectiveness of contrast-enhanced ultrasonography for the characterization of small and early stage pancreatic adenocarcinoma. Ultrasound Med Biol. 2020;46:2245\u201353.","journal-title":"Ultrasound Med Biol"},{"key":"1674_CR53","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.1016\/j.ultrasmedbio.2021.08.005","volume":"47","author":"Y Yamashita","year":"2021","unstructured":"Yamashita Y, Shimokawa T, Ashida R, et al. Value of low-mechanical-index contrast-enhanced transabdominal ultrasound for diagnosis of pancreatic cancer: a meta-analysis. Ultrasound Med Biol. 2021;47:3315\u201322.","journal-title":"Ultrasound Med Biol"},{"key":"1674_CR54","doi-asserted-by":"publisher","first-page":"4304","DOI":"10.21037\/qims-24-154","volume":"14","author":"Z Yuan","year":"2024","unstructured":"Yuan Z, Li J, Yang L, et al. The differential diagnosis of pancreatic cystic neoplasms with conventional ultrasound and contrast-enhanced ultrasound. Quant Imaging Med Surg. 2024;14:4304\u201315.","journal-title":"Quant Imaging Med Surg"},{"key":"1674_CR55","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1055\/s-2007-963785","volume":"29","author":"EFSUMB Study Group","year":"2008","unstructured":"EFSUMB Study Group. Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS)\u2014update 2008. Ultraschall Med. 2008;29:28\u201344.","journal-title":"Ultraschall Med"},{"key":"1674_CR56","first-page":"627","volume":"114","author":"K Yamaguchi","year":"2016","unstructured":"Yamaguchi K. Clinical practice guidelines for pancreatic cancer 2016 from the Japan Pancreas Society. Nihon Shokakibyo Gakkai Zasshi. 2016;114:627\u201336.","journal-title":"Nihon Shokakibyo Gakkai Zasshi"}],"container-title":["Journal of Medical Ultrasonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10396-026-01674-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10396-026-01674-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10396-026-01674-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:02:13Z","timestamp":1788015733000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10396-026-01674-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":56,"alternative-id":["1674"],"URL":"https:\/\/doi.org\/10.1007\/s10396-026-01674-0","relation":{},"ISSN":["1346-4523","1613-2254"],"issn-type":[{"value":"1346-4523","type":"print"},{"value":"1613-2254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,29]]},"assertion":[{"value":"14 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Atsushi Sofuni, Shuntaro Mukai, Hiroyuki Kojima, and Kazumasa Nagai declare that they have no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from all patients for being included in the study.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}