{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:22:04Z","timestamp":1767892924105,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T00:00:00Z","timestamp":1325635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Biomed Eng"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1007\/s10439-011-0498-8","type":"journal-article","created":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T17:03:53Z","timestamp":1325610233000},"page":"1192-1204","source":"Crossref","is-referenced-by-count":23,"title":["Automated Detection of Dual p16\/Ki67 Nuclear Immunoreactivity in Liquid-Based Pap Tests for Improved Cervical Cancer Risk Stratification"],"prefix":"10.1007","volume":"40","author":[{"given":"Arkadiusz","family":"Gertych","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anika O.","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann E.","family":"Walts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shikha","family":"Bose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,1,4]]},"reference":[{"key":"498_CR1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/dc.20175","volume":"32","author":"S Bose","year":"2005","unstructured":"Bose, S., H. Evans, L. Lantzy, K. Scharre, and E. Youssef. p16(INK4A) is a surrogate biomarker for a subset of human papilloma virus-associated dysplasias of the uterine cervix as determined on the Pap smear. Diagn. Cytopathol. 32:21\u201324, 2005.","journal-title":"Diagn. Cytopathol."},{"key":"498_CR2","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1214\/10-AOS799","volume":"38","author":"ZI Botev","year":"2010","unstructured":"Botev, Z. I., J. F. Grotowski, and D. P. Kroese. Kernel density estimation via diffusion. Ann. Stat. 38:2916\u20132957, 2010.","journal-title":"Ann. Stat."},{"key":"498_CR3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/(SICI)1097-0142(19990815)86:4<715::AID-CNCR22>3.0.CO;2-O","volume":"86","author":"T Byers","year":"1999","unstructured":"Byers, T., J. Mouchawar, J. Marks, B. Cady, N. Lins, G. M. Swanson, D. G. Bal, and H. Eyre. The American Cancer Society challenge goals. How far can cancer rates decline in the U.S. by the year 2015? Cancer 86:715\u2013727, 1999.","journal-title":"Cancer"},{"key":"498_CR4","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1006\/gyno.1996.4602","volume":"64","author":"CJ Dunton","year":"1997","unstructured":"Dunton, C. J., K. H. van Hoeven, A. J. Kovatich, R. E. Oliver, R. Q. Scacheri, J. R. Cater, and J. A. Carlson, Jr. Ki-67 antigen staining as an adjunct to identifying cervical intraepithelial neoplasia. Gynecol. Oncol. 64:451\u2013455, 1997.","journal-title":"Gynecol. Oncol."},{"key":"498_CR5","volume-title":"Computer and Robot Vision","author":"RM Haralick","year":"1992","unstructured":"Haralick, R. M., and L. G. Shapiro. Computer and Robot Vision. Reading, MA: Addison-Wesley, 1992."},{"key":"498_CR6","first-page":"19","volume":"34","author":"D Juric","year":"2010","unstructured":"Juric, D., V. Mahovlic, S. Rajhvajn, A. Ovanin-Rakic, L. Skopljanac-Macina, A. Barisic, I. S. Projic, D. Babic, M. Susa, A. Corusic, and S. Oreskovic. Liquid-based cytology\u2014new possibilities in the diagnosis of cervical lesions. Coll. Antropol. 34:19\u201324, 2010.","journal-title":"Coll. Antropol."},{"key":"498_CR7","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/01.RCT.0000157092.44680.25","volume":"24","author":"A Longatto Filho","year":"2005","unstructured":"Longatto Filho, A., M. L. Utagawa, N. K. Shirata, S. M. Pereira, G. M. Namiyama, C. T. Kanamura, C. Santos Gda, M. A. de Oliveira, A. Wakamatsu, S. Nonogaki, C. Roteli-Martins, C. di Loreto, G. de Mattosinho Castro Ferraz Mda, M. Y. Maeda, V. A. Alves, and K. Syrjanen. Immunocytochemical expression of p16INK4A and Ki-67 in cytologically negative and equivocal pap smears positive for oncogenic human papillomavirus. Int. J. Gynecol. Pathol. 24:118\u2013124, 2005.","journal-title":"Int. J. Gynecol. Pathol."},{"key":"498_CR8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1109\/TPAMI.2003.1217601","volume":"25","author":"G Loy","year":"2003","unstructured":"Loy, G., and A. Zelinsky. Fast radial symmetry for detecting points of interest. IEEE Trans. Pattern Anal. Mach. Intell. 25:959\u2013973, 2003.","journal-title":"IEEE Trans. Pattern Anal. Mach. Intell."},{"key":"498_CR9","first-page":"45","volume":"13","author":"NA Mat-Isa","year":"2005","unstructured":"Mat-Isa, N. A. Automated edge detection technique for Pap smear images using moving K-means clustering and modified seed based region growing algorithm. Int. J. Comput. Internet Manag. 13:45\u201359, 2005.","journal-title":"Int. J. Comput. Internet Manag."},{"key":"498_CR10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/cncr.22580","volume":"111","author":"JL Meyer","year":"2007","unstructured":"Meyer, J. L., D. W. Hanlon, B. T. Andersen, O. F. Rasmussen, and K. Bisgaard. Evaluation of p16INK4a expression in ThinPrep cervical specimens with the CINtec p16INK4a assay: correlation with biopsy follow-up results. Cancer 111:83\u201392, 2007.","journal-title":"Cancer"},{"key":"498_CR11","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7326\/0003-4819-132-10-200005160-00009","volume":"132","author":"K Nanda","year":"2000","unstructured":"Nanda, K., D. C. McCrory, E. R. Myers, L. A. Bastian, V. Hasselblad, J. D. Hickey, and D. B. Matchar. Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review. Ann. Intern. Med. 132:810\u2013819, 2000.","journal-title":"Ann. Intern. Med."},{"key":"498_CR12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-6413-1-4","volume":"1","author":"R Nayar","year":"2004","unstructured":"Nayar, R., and D. Solomon. Second edition of \u2018The Bethesda System for reporting cervical cytology\u2019\u2014atlas, website, and Bethesda interobserver reproducibility project. Cytojournal 1:4, 2004.","journal-title":"Cytojournal"},{"key":"498_CR13","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1109\/34.56205","volume":"12","author":"P Perona","year":"1990","unstructured":"Perona, P., and J. Malik. Scale-space and edge detection using anisotropic diffusion. IEEE Trans. Pattern Anal. Mach. Intell. 12:629\u2013639, 1990.","journal-title":"IEEE Trans. Pattern Anal. Mach. Intell."},{"key":"498_CR14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1109\/TITB.2010.2087030","volume":"15","author":"ME Plissiti","year":"2011","unstructured":"Plissiti, M. E., C. Nikou, and A. Charchanti. Automated detection of cell nuclei in pap smear images using morphological reconstruction and clustering. IEEE Trans. Inf. Technol. Biomed. 15:233\u2013241, 2011.","journal-title":"IEEE Trans. Inf. Technol. Biomed."},{"key":"498_CR15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/1097-0142(195603\/04)9:2<385::AID-CNCR2820090225>3.0.CO;2-I","volume":"9","author":"JW Reagan","year":"1956","unstructured":"Reagan, J. W., and M. J. Hamonic. The cellular pathology in carcinoma in situ; a cytohistopathological correlation. Cancer 9:385\u2013402, 1956.","journal-title":"Cancer"},{"key":"498_CR16","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/ijc.21489","volume":"118","author":"S Sahebali","year":"2006","unstructured":"Sahebali, S., C. E. Depuydt, G. A. Boulet, M. Arbyn, L. M. Moeneclaey, A. J. Vereecken, E. A. Van Marck, and J. J. Bogers. Immunocytochemistry in liquid-based cervical cytology: analysis of clinical use following a cross-sectional study. Int. J. Cancer 118:1254\u20131260, 2006.","journal-title":"Int. J. Cancer"},{"key":"498_CR17","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1136\/jcp.56.9.681","volume":"56","author":"S Sahebali","year":"2003","unstructured":"Sahebali, S., C. E. Depuydt, K. Segers, A. J. Vereecken, E. Van Marck, and J. J. Bogers. Ki-67 immunocytochemistry in liquid based cervical cytology: useful as an adjunctive tool? J. Clin. Pathol. 56:681\u2013686, 2003.","journal-title":"J. Clin. Pathol."},{"key":"498_CR18","volume-title":"Advances in Kernel Methods: Support Vector Learning","author":"B Sch\u00f6lkopf","year":"1999","unstructured":"Sch\u00f6lkopf, B., C. J. C. Burges, and A. J. Smola. Advances in Kernel Methods: Support Vector Learning. Cambridge, MA: MIT, 1999."},{"key":"498_CR19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","volume":"182","author":"T Scholzen","year":"2000","unstructured":"Scholzen, T., and J. Gerdes. The Ki-67 protein: from the known and the unknown. J. Cell. Physiol. 182:311\u2013322, 2000.","journal-title":"J. Cell. Physiol."},{"key":"498_CR20","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/labinvest.2010.72","volume":"90","author":"JM Schubert","year":"2010","unstructured":"Schubert, J. M., B. Bird, K. Papamarkakis, M. Miljkovic, K. Bedrossian, N. Laver, and M. Diem. Spectral cytopathology of cervical samples: detecting cellular abnormalities in cytologically normal cells. Lab. Invest. 90:1068\u20131077, 2010.","journal-title":"Lab. Invest."},{"key":"498_CR21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/cncr.23286","volume":"114","author":"AM Siddiqi","year":"2008","unstructured":"Siddiqi, A. M., H. Li, F. Faruque, W. Williams, K. Lai, M. Hughson, S. Bigler, J. Beach, and W. Johnson. Use of hyperspectral imaging to distinguish normal, precancerous, and cancerous cells. Cancer 114:13\u201321, 2008.","journal-title":"Cancer"},{"key":"498_CR22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1525-1497.2004.21107.x","volume":"19","author":"BE Sirovich","year":"2004","unstructured":"Sirovich, B. E., and H. G. Welch. The frequency of Pap smear screening in the United States. J. Gen. Intern. Med. 19:243\u2013250, 2004.","journal-title":"J. Gen. Intern. Med."},{"key":"498_CR23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1142\/S1469026810002860","volume":"9","author":"P Sobervilla","year":"2010","unstructured":"Sobervilla, P., E. Montseny, F. Vaschetto, and E. Lerma. Fuzzy-based analysis of microscopic color cervical Pap smear images: nuclei detection. Int. J. Comput. Intell. Appl. 9:187\u2013206, 2010.","journal-title":"Int. J. Comput. Intell. Appl."},{"key":"498_CR24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ctrv.2008.10.005","volume":"35","author":"I Tsoumpou","year":"2009","unstructured":"Tsoumpou, I., M. Arbyn, M. Kyrgiou, N. Wentzensen, G. Koliopoulos, P. Martin-Hirsch, V. Malamou-Mitsi, and E. Paraskevaidis. p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis. Cancer Treat. Rev. 35:210\u2013220, 2009.","journal-title":"Cancer Treat. Rev."},{"key":"498_CR25","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.humpath.2008.12.005","volume":"40","author":"AE Walts","year":"2009","unstructured":"Walts, A. E., and S. Bose. p16, Ki-67, and BD ProExC immunostaining: a practical approach for diagnosis of cervical intraepithelial neoplasia. Hum. Pathol. 40:957\u2013964, 2009.","journal-title":"Hum. Pathol."},{"key":"498_CR26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1109\/TSMCB.2007.912940","volume":"38","author":"SF Yang-Mao","year":"2008","unstructured":"Yang-Mao, S. F., Y. K. Chan, and Y. P. Chu. Edge enhancement nucleus and cytoplast contour detector of cervical smear images. IEEE Trans. Syst. Man. Cybern. B: Cybern. 38:353\u2013366, 2008.","journal-title":"IEEE Trans. Syst. Man. Cybern. B: Cybern."}],"container-title":["Annals of Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-011-0498-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10439-011-0498-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-011-0498-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T16:58:25Z","timestamp":1559149105000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10439-011-0498-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,4]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["498"],"URL":"https:\/\/doi.org\/10.1007\/s10439-011-0498-8","relation":{},"ISSN":["0090-6964","1573-9686"],"issn-type":[{"value":"0090-6964","type":"print"},{"value":"1573-9686","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,4]]}}}