{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:09:08Z","timestamp":1767856148865,"version":"3.49.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["14PRE18080005"],"award-info":[{"award-number":["14PRE18080005"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center for Pediatric Innovation"},{"DOI":"10.13039\/100006778","name":"Georgia Institute of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006778","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The John and Mary Brock Discovery Fund"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Biomed Eng"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s10439-016-1550-5","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T18:26:52Z","timestamp":1453400812000},"page":"2339-2350","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["A Predictive Model of High Shear Thrombus Growth"],"prefix":"10.1007","volume":"44","author":[{"given":"Marmar","family":"Mehrabadi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren D. C.","family":"Casa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrus K.","family":"Aidun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Ku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,21]]},"reference":[{"key":"1550_CR1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s13239-010-0011-9","volume":"1","author":"JF Antaki","year":"2010","unstructured":"Antaki, J. F., M. R. Ricci, J. E. Verkaik, S. T. Snyder, T. M. Maul, et al. PediaFlow\u2122 Maglev ventricular assist device: a prescriptive design approach. Cardiovasc. Eng. Technol. 1:104\u2013121, 2010.","journal-title":"Cardiovasc. Eng. Technol."},{"key":"1550_CR2","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1161\/01.CIR.78.6.1431","volume":"78","author":"L Badimon","year":"1988","unstructured":"Badimon, L., J. J. Badimon, V. T. Turitto, S. Vallabhajosula, and V. Fuster. Platelet thrombus formation on collagen type I. A model of deep vessel injury. Influence of blood rheology, von Willebrand factor, and blood coagulation. Circulation 78:1431\u20131442, 1988.","journal-title":"Circulation"},{"key":"1550_CR3","volume-title":"The Hemodynamics during Thrombosis and Impact on Thrombus Growth","author":"DL Bark","year":"2010","unstructured":"Bark, D. L. The Hemodynamics during Thrombosis and Impact on Thrombus Growth. Atlanta, GA: Mech. Eng., Georgia Institute of Technology, 2010."},{"key":"1550_CR4","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1016\/j.jbiomech.2010.07.011","volume":"43","author":"DL Bark","year":"2010","unstructured":"Bark, D. L., and D. N. Ku. Wall shear over high degree stenoses pertinent to atherothrombosis. J. Biomech. 43:2970\u20132977, 2010.","journal-title":"J. Biomech."},{"key":"1550_CR5","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1002\/bit.24537","volume":"109","author":"DL Bark","year":"2012","unstructured":"Bark, D. L., A. N. Para, and D. N. Ku. Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation. Biotechnol. Bioeng. 109:2642\u20132650, 2012.","journal-title":"Biotechnol. Bioeng."},{"key":"1550_CR6","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1161\/01.ATV.14.12.1984","volume":"14","author":"RM Barstad","year":"1994","unstructured":"Barstad, R. M., H. Roald, Y. Cui, V. Turitto, and K. Sakariassen. A perfusion chamber developed to investigate thombus formation and shear profiles in flowing native human blood at the apex of a well-defined stenosis. Atertio. Thromb. Vasc. Biol. 14:1984\u20131991, 1994.","journal-title":"Atertio. Thromb. Vasc. Biol."},{"key":"1550_CR7","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/j.1538-7836.2004.00661.x","volume":"2","author":"A Bernardo","year":"2004","unstructured":"Bernardo, A., A. L. Bergeron, C. W. Sun, P. Guchhait, M. A. Cruz, et al. Von Willebrand factor present in fibrillar collagen enhances platelet adhesion to collagen and collagen-induced platelet aggregation. J. Thromb. Haemost. 2:660\u2013669, 2004.","journal-title":"J. Thromb. Haemost."},{"key":"1550_CR8","first-page":"466","volume":"310","author":"JM Bland","year":"1995","unstructured":"Bland, J. M., and D. G. Altman. Statistics notes: calculating correlation coefficients with repeated observations: Part 1\u2014correlation within subjects. BMJ 310:466, 1995.","journal-title":"BMJ"},{"key":"1550_CR9","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.jvs.2014.12.050","volume":"61","author":"LDC Casa","year":"2015","unstructured":"Casa, L. D. C., D. H. Deaton, and D. N. Ku. Role of high shear rate in thrombosis. J. Vasc. Surg. 61:1068\u20131080, 2015.","journal-title":"J. Vasc. Surg."},{"key":"1550_CR10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10544-013-9811-7","volume":"16","author":"LDC Casa","year":"2014","unstructured":"Casa, L. D. C., and D. N. Ku. Geometric design of microfluidic chambers: platelet adhesion versus accumulation. Biomed. Microdevices 16:115\u2013126, 2014.","journal-title":"Biomed. Microdevices"},{"key":"1550_CR11","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s13239-014-0180-z","volume":"5","author":"LDC Casa","year":"2014","unstructured":"Casa, L. D. C., and D. N. Ku. High shear thrombus formation under pulsatile and steady flow. Cardiovasc. Eng. Technol. 5:154\u2013163, 2014.","journal-title":"Cardiovasc. Eng. Technol."},{"key":"1550_CR12","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.thromres.2012.11.020","volume":"131","author":"S Cito","year":"2013","unstructured":"Cito, S., M. D. Mazzeo, and L. Badimon. A review of macroscopic thrombus modeling methods. Thromb. Res. 131:116\u2013124, 2013.","journal-title":"Thromb. Res."},{"key":"1550_CR13","unstructured":"DuMouchel, W. H., and F. L. O\u2019Brien, Integrating a Robust Option into a Multiple Regression Computing Environment., Computer Science and Statistics: Proceedings of the 21st Symposium on the Interface., American Statistical Association, Alexandria, VA, 1989."},{"key":"1550_CR14","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1056\/NEJM199506083322306","volume":"332","author":"FH Epstein","year":"1995","unstructured":"Epstein, F. H., J. Lefkovits, E. F. Plow, and E. J. Topol. Mechanisms of disease: platelet glycoprotein IIb\/IIIa receptors in cardiovascular medicine. New Engl. J. Med. 332:1553\u20131559, 1995.","journal-title":"New Engl. J. Med."},{"key":"1550_CR15","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1080\/09537100120039370","volume":"12","author":"C Escudero","year":"2001","unstructured":"Escudero, C., M. Santos, J. Buj\u00e1n, M. Fuente, N. G. Honduvilla, et al. Optical aggregometry versus the PFA-100: experimental studies in pigs treated with propofol. Platelets 12:133\u2013137, 2001.","journal-title":"Platelets"},{"key":"1550_CR16","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1182\/blood-2011-10-388140","volume":"120","author":"MH Flamm","year":"2012","unstructured":"Flamm, M. H., T. V. Colace, M. S. Chatterjee, H. Jing, S. Zhou, et al. Multiscale prediction of patient-specific platelet function under flow. Blood 120:190\u2013198, 2012.","journal-title":"Blood"},{"key":"1550_CR17","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/BF02367081","volume":"22","author":"J Hellums","year":"1994","unstructured":"Hellums, J. 1993 Whitaker Lecture: biorheology in thrombosis research. Ann. Biomed. Eng. 22:445\u2013455, 1994.","journal-title":"Ann. Biomed. Eng."},{"key":"1550_CR18","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1080\/03610927708827533","volume":"6","author":"PW Holland","year":"1977","unstructured":"Holland, P. W., and R. E. Welsch. Robust regression using iteratively reweighted least-squares. Commun. Stat. 6:813\u2013827, 1977.","journal-title":"Commun. Stat."},{"key":"1550_CR19","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1160\/TH13-09-0800","volume":"111","author":"V Huck","year":"2014","unstructured":"Huck, V., M. F. Schneider, C. Gorzelanny, and S. W. Schneider. The various states of von Willebrand factor and their function in physiology and pathophysiology. Thromb. Haemost. 111:598\u2013609, 2014.","journal-title":"Thromb. Haemost."},{"key":"1550_CR20","first-page":"273","volume-title":"Vascular Disease: Surgical & Interventional Therapy","author":"JV Hunter","year":"1994","unstructured":"Hunter, J. V., and J. K. Chin. Carotid Angiography. In: Vascular Disease: Surgical & Interventional Therapy, edited by D. E. Strandness Jr, and Van Breda. New York: Churchill Livingstone, 1994, pp. 273\u2013287."},{"key":"1550_CR21","first-page":"273","volume":"44","author":"DN Ku","year":"2007","unstructured":"Ku, D. N., and C. J. Flannery. Development of a flow-through system to create occluding thrombus. Biorheology 44:273\u2013284, 2007.","journal-title":"Biorheology"},{"key":"1550_CR22","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s00580-010-1171-6","volume":"21","author":"C Leuser","year":"2011","unstructured":"Leuser, C., S. Schlottmann, R. Siekmann, M. Heidt, A. Moritz, et al. Use of the platelet function analyser PFA-100\u2122 in juvenile pigs. Comp. Clin. Pathol. 21:761\u2013767, 2011.","journal-title":"Comp. Clin. Pathol."},{"key":"1550_CR23","volume-title":"Microfluidic System for Thrombosis Under Multiple Shear Rates and Platelet Therapies","author":"M Li","year":"2013","unstructured":"Li, M. Microfluidic System for Thrombosis Under Multiple Shear Rates and Platelet Therapies. Atlanta, GA: Biomed. Eng, Georgia Institute of Technology, 2013."},{"key":"1550_CR24","doi-asserted-by":"publisher","first-page":"e82493","DOI":"10.1371\/journal.pone.0082493","volume":"9","author":"M Li","year":"2014","unstructured":"Li, M., N. A. Hotaling, D. N. Ku, and C. R. Forest. Microfluidic thrombosis under multiple shear rates and antiplatelet therapy doses. PLoS One 9:e82493, 2014.","journal-title":"PLoS One"},{"key":"1550_CR25","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1039\/c2lc21145a","volume":"12","author":"M Li","year":"2012","unstructured":"Li, M., D. Ku, and C. Forest. Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood. Lab Chip 12:1355\u20131362, 2012.","journal-title":"Lab Chip"},{"key":"1550_CR26","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/nm.1955","volume":"15","author":"WS Nesbitt","year":"2009","unstructured":"Nesbitt, W. S., E. Westein, F. J. Tovar-Lopez, E. Tolouei, A. Mitchell, et al. A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat. Med. 15:665\u2013673, 2009.","journal-title":"Nat. Med."},{"key":"1550_CR27","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1097\/MAT.0b013e31815d6898","volume":"54","author":"M Nobili","year":"2008","unstructured":"Nobili, M., J. Sheriff, U. Morbiducci, A. Redaelli, and D. Bluestein. Platelet activation due to hemodynamic shear stresses: damage accumulation model and comparison to in vitro measurements. ASAIO J. 54:64\u201372, 2008.","journal-title":"ASAIO J."},{"key":"1550_CR28","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.thromres.2013.02.018","volume":"131","author":"AN Para","year":"2013","unstructured":"Para, A. N., and D. N. Ku. A low-volume, single pass in vitro system of high shear thrombosis in a stenosis. Thromb. Res. 131:418\u2013424, 2013.","journal-title":"Thromb. Res."},{"key":"1550_CR29","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1159\/000091648","volume":"43","author":"RS Reneman","year":"2006","unstructured":"Reneman, R. S., T. Arts, and A. P. G. Hoeks. Wall shear stress\u2014an important determinant of endothelial cell function and structure\u2014in the arterial system in vivo. J. Vasc. Res. 43:251\u2013269, 2006.","journal-title":"J. Vasc. Res."},{"key":"1550_CR30","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1161\/CIRCINTERVENTIONS.111.965426","volume":"5","author":"JW Rowley","year":"2010","unstructured":"Rowley, J. W., A. V. Finn, P. A. French, L. K. Jennings, D. Bluestein, et al. Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses. Circ. Cardiovasc. Interv. 5:296\u2013304, 2010.","journal-title":"Circ. Cardiovasc. Interv."},{"key":"1550_CR31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1160\/TH07-04-0279","volume":"98","author":"ZM Ruggeri","year":"2007","unstructured":"Ruggeri, Z. M.\u00a0Von Willebrand factor: looking back and looking forward. Thromb. Haemost. 98:55\u201362, 2007.","journal-title":"Thromb. Haemost."},{"key":"1550_CR32","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0092-8674(00)80983-6","volume":"84","author":"B Savage","year":"1996","unstructured":"Savage, B., E. Saldivar, and Z. M. Ruggeri. Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. Cell 84:289\u2013297, 1996.","journal-title":"Cell"},{"key":"1550_CR33","unstructured":"Siemens, PFA-100\u00ae System: Getting Started Guide, 2008."},{"key":"1550_CR34","volume-title":"Vascular Diseases: Surgical and Interventional Therapy","author":"DE Strandness","year":"1993","unstructured":"Strandness, D. E., and A. van Breda. Vascular Diseases: Surgical and Interventional Therapy. London: Churchill Livingstone, 1993."},{"key":"1550_CR35","first-page":"H1787","volume":"265","author":"J Strony","year":"1993","unstructured":"Strony, J., A. Beaudoin, D. Brands, and B. Adelman. Analysis of shear stress and hemodynamic factors in a model of coronary artery stenosis and thrombosis. Am. J. Physiol. 265:H1787\u2013H1796, 1993.","journal-title":"Am. J. Physiol."},{"key":"1550_CR36","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1182\/blood-2014-01-550343","volume":"124","author":"M Tomaiuolo","year":"2014","unstructured":"Tomaiuolo, M., T. J. Stalker, J. D. Welsh, S. L. Diamond, T. Sinno, et al. A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment. Blood 124:1816\u20131824, 2014.","journal-title":"Blood"},{"key":"1550_CR37","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1007\/s10439-012-0558-8","volume":"40","author":"W Wang","year":"2012","unstructured":"Wang, W., and M. R. King. Multiscale modeling of platelet adhesion and thrombus growth. Ann. Biomed. Eng. 40:2345\u20132354, 2012.","journal-title":"Ann. Biomed. Eng."},{"key":"1550_CR38","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1161\/ATVBAHA.110.213397","volume":"31","author":"Z Xu","year":"2011","unstructured":"Xu, Z., M. Kamocka, M. Alber, and E. D. Rosen. Computational approaches to studying thrombus development. Atertio. Thromb. Vasc. Biol. 31:500\u2013505, 2011.","journal-title":"Atertio. Thromb. Vasc. Biol."},{"key":"1550_CR39","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/j.bpj.2009.12.4331","volume":"98","author":"Z Xu","year":"2010","unstructured":"Xu, Z., J. Lioi, J. Mu, M. M. Kamocka, X. Liu, et al. A multiscale model of venous thrombus formation with surface-mediated control of blood coagulation cascade. Biophys. J. 98:1723\u20131732, 2010.","journal-title":"Biophys. J."},{"key":"1550_CR40","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1007\/s10439-011-0502-3","volume":"40","author":"B Yun","year":"2012","unstructured":"Yun, B., J. Wu, H. Simon, S. SArgunon, F. Sotiropoulos, et al. A numerical investigation of blood damage in the hinge area of aortic bileaflet mechanical heart valves during the leakage phase. Ann. Biomed. Eng. 40:1468\u20131485, 2012.","journal-title":"Ann. Biomed. Eng."},{"key":"1550_CR41","first-page":"77","volume":"10","author":"A Zydney","year":"1988","unstructured":"Zydney, A., and C. Colton. Augmented solute transport in the shear flow of a concentrated suspension. Physicochem. Hydrodyn. 10:77\u201396, 1988.","journal-title":"Physicochem. Hydrodyn."}],"updated-by":[{"DOI":"10.1007\/s10439-019-02396-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000}}],"container-title":["Annals of Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-016-1550-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10439-016-1550-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-016-1550-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-016-1550-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T21:27:34Z","timestamp":1600291654000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10439-016-1550-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,21]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["1550"],"URL":"https:\/\/doi.org\/10.1007\/s10439-016-1550-5","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s10439-019-02396-w","asserted-by":"object"}]},"ISSN":["0090-6964","1573-9686"],"issn-type":[{"value":"0090-6964","type":"print"},{"value":"1573-9686","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,21]]},"assertion":[{"value":"4 October 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2019","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This erratum is to correct the heading of column 2 (titled \ufffd\ufffd\ufffdb\ufffd\ufffd\ufffd) in Table\ufffd\ufffd1, which was missing proper units. The heading for that column was revised to include proper units, reading \ufffd\ufffd\ufffdb (\ufffd\ufffd 10\ufffd\ufffd\ufffd6 s)\ufffd\ufffd\ufffd.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2019","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This erratum is to correct the heading of column 2 (titled \ufffd\ufffd\ufffdb\ufffd\ufffd\ufffd) in Table\ufffd\ufffd1, which was missing proper units. The heading for that column was revised to include proper units, reading \ufffd\ufffd\ufffdb (\ufffd\ufffd 10\ufffd\ufffd\ufffd6 s)\ufffd\ufffd\ufffd.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}}]}}