{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:48:31Z","timestamp":1782834511023,"version":"3.54.5"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:00:00Z","timestamp":1548201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP125886"],"award-info":[{"award-number":["MOP125886"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Biomed Eng"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s10439-018-02188-8","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T13:34:50Z","timestamp":1548336890000},"page":"980-989","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Elevated Microdamage Spatially Correlates with Stress in Metastatic Vertebrae"],"prefix":"10.1007","volume":"47","author":[{"given":"Ayelet","family":"Atkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Samiezadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarete K.","family":"Akens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hardisty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cari M.","family":"Whyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"2188_CR1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S8756-3282(98)00104-5","volume":"23","author":"V Bentolila","year":"1998","unstructured":"Bentolila, V., T. M. Boyce, D. P. Fyhrie, R. Drumb, T. M. Skerry, and M. B. Schaffler. Intracortical remodeling in adult rat long bones after fatigue loading. Bone 23:275\u2013281, 1998.","journal-title":"Bone"},{"key":"2188_CR2","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S8756-3282(97)00015-X","volume":"20","author":"RD Bloebaum","year":"1997","unstructured":"Bloebaum, R. D., J. G. Skedros, E. G. Vajda, K. N. Bachus, and B. R. Constantz. Determining mineral content variations in bone using backscattered electron imaging. Bone 20:485\u2013490, 1997.","journal-title":"Bone"},{"key":"2188_CR3","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1002\/cncr.11138","volume":"97","author":"J-J Body","year":"2003","unstructured":"Body, J.-J., P. Greipp, R. E. Coleman, T. Facon, F. Geurs, J.-P. Fermand, J.-L. Harousseau, A. Lipton, X. Mariette, C. D. Williams, A. Nakanishi, D. Holloway, S. W. Martin, C. R. Dunstan, and P. J. Bekker. A Phase I study of AMGN-0007, a recombinant osteoproteger in construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer 97:887\u2013892, 2003.","journal-title":"Cancer"},{"key":"2188_CR4","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1002\/jor.23248","volume":"34","author":"MV Burke","year":"2016","unstructured":"Burke, M. V., A. Atkins, M. Akens, T. L. Willett, and C. M. Whyne. Osteolytic and mixed cancer metastasis modulates collagen and mineral parameters within rat vertebral bone matrix. J. Orthop. Res. 34:2126\u20132136, 2016.","journal-title":"J. Orthop. Res."},{"key":"2188_CR5","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jmbbm.2016.12.017","volume":"69","author":"M Burke","year":"2017","unstructured":"Burke, M., A. Atkins, A. Kiss, M. Akens, A. Yee, and C. Whyne. The impact of metastasis on the mineral phase of vertebral bone tissue. J. Mech. Behav. Biomed. Mater. 69:75\u201384, 2017.","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"2188_CR6","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jsb.2017.06.008","volume":"199","author":"M Burke","year":"2017","unstructured":"Burke, M., A. Golaraei, A. Atkins, M. Akens, V. Barzda, and C. Whyne. Collagen fibril organization within rat vertebral bone modified with metastatic involvement. J. Struct. Biol. 199:153\u2013164, 2017.","journal-title":"J. Struct. Biol."},{"key":"2188_CR7","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1097\/00002281-199805000-00017","volume":"10","author":"DB Burr","year":"1998","unstructured":"Burr, D. B. The importance of subchondral bone in osteoarthrosis. Curr. Opin. Rheumatol. 10:256\u2013262, 1998.","journal-title":"Curr. Opin. Rheumatol."},{"key":"2188_CR8","doi-asserted-by":"crossref","unstructured":"Burr, D. B., and T. Stafford. Validity of the bulk-staining technique to separate artifactual from in vivo bone microdamage. Clin. Orthop. Relat. Res. 260:305\u2013308, 1990. \n                    http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1699696\n                    \n                  .","DOI":"10.1097\/00003086-199011000-00047"},{"key":"2188_CR9","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/aja.1001860208","volume":"186","author":"DB Burr","year":"1989","unstructured":"Burr, D. B., and R. B. Martin. Errors in bone remodeling: toward a unified theory of metabolic bone disease. Am. J. Anat. 186:186\u2013216, 1989.","journal-title":"Am. J. Anat."},{"key":"2188_CR10","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0021-9290(85)90204-0","volume":"18","author":"DB Burr","year":"1985","unstructured":"Burr, D. B., R. B. Martin, M. B. Schaffler, and E. L. Radin. Bone remodeling in response to in vivo fatigue microdamage. J. Biomech. 18:189\u2013200, 1985.","journal-title":"J. Biomech."},{"key":"2188_CR11","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0021-9290(72)90053-X","volume":"5","author":"A Chamay","year":"1972","unstructured":"Chamay, A., and P. Tschantz. Mechanical influences in bone remodeling. Experimental research on Wolff\u2019s law. J. Biomech. 5:173\u2013180, 1972.","journal-title":"J. Biomech."},{"key":"2188_CR12","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.jbiomech.2016.02.034","volume":"49","author":"C Choudhari","year":"2016","unstructured":"Choudhari, C., K. Chan, M. K. Akens, and C. M. Whyne. \u03bcFE models can represent microdamaged regions of healthy and metastatically involved whole vertebrae identified through histology and contrast enhanced \u03bcCT imaging. J. Biomech. 49:1103\u20131110, 2016.","journal-title":"J. Biomech."},{"key":"2188_CR13","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1177\/0954411916658679","volume":"230","author":"C Choudhari","year":"2016","unstructured":"Choudhari, C., R. Herblum, M. K. Akens, S. Moore, M. Hardisty, and C. M. Whyne. Post-euthanasia micro-computed tomography-based strain analysis is able to represent quasi-static in vivo behavior of whole vertebrae. Proc. Inst. Mech. Eng. Part H 230:900\u2013904, 2016.","journal-title":"Proc. Inst. Mech. Eng. Part H"},{"key":"2188_CR14","first-page":"185","volume":"496","author":"H Daims","year":"2011","unstructured":"Daims, H., and M. Wagner. In situ techniques and digital image analysis methods for quantifying spatial localization patterns of nitrifiers and other microorganisms in biofilm and flocs. Elsevier 496:185\u2013215, 2011.","journal-title":"Elsevier"},{"key":"2188_CR15","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1002\/(SICI)1097-0215(19990719)82:2<219::AID-IJC12>3.0.CO;2-#","volume":"82","author":"O Engebraaten","year":"1999","unstructured":"Engebraaten, O., and O. Fodstad. Site-specific experimental metastasis patterns of two human breast cancer cell lines in nude rats. Int. J. Cancer 82:219\u2013225, 1999.","journal-title":"Int. J. Cancer"},{"key":"2188_CR16","first-page":"25","volume":"8","author":"HM Frost","year":"1960","unstructured":"Frost, H. M. Presence of microscopic cracks in vivo in bone. Henry Ford Hosp. Med. Bull. 8:25\u201335, 1960.","journal-title":"Henry Ford Hosp. Med. Bull."},{"key":"2188_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00675618","volume":"52","author":"HM Frost","year":"1993","unstructured":"Frost, H. M. Suggested fundamental concepts in skeletal physiology. Calcif. Tissue Int. 52:1\u20134, 1993.","journal-title":"Calcif. Tissue Int."},{"key":"2188_CR18","unstructured":"Frost, H. M. Bone modeling and skeletal modeling errors. Thomas, 1973, 214pp. \n                    https:\/\/catalogue.nla.gov.au\/Record\/451462\n                    \n                  ."},{"key":"2188_CR19","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1016\/j.jbiomech.2014.06.016","volume":"47","author":"MG Goff","year":"2014","unstructured":"Goff, M. G., K. L. Chang, E. N. Litts, and C. J. Hernandez. The effects of misalignment during in vivo loading of bone: Techniques to detect the proximity of objects in three-dimensional models. J. Biomech. 47:3156\u20133161, 2014.","journal-title":"J. Biomech."},{"key":"2188_CR20","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1007\/s10439-010-0052-0","volume":"38","author":"MR Hardisty","year":"2010","unstructured":"Hardisty, M. R., M. Akens, A. J. Yee, and C. M. Whyne. Image registration demonstrates the growth plate has a variable affect on vertebral strain. Ann. Biomed. Eng. 38:2948\u20132955, 2010.","journal-title":"Ann. Biomed. Eng."},{"key":"2188_CR21","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1002\/jbmr.5650091003","volume":"9","author":"RP Heaney","year":"1994","unstructured":"Heaney, R. P. The bone-remodeling transient: Implications for the interpretation of clinical studies of bone mass change. J. Bone Miner. Res. 9:1515\u20131523, 1994.","journal-title":"J. Bone Miner. Res."},{"key":"2188_CR22","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1002\/jor.22392","volume":"31","author":"R Herblum","year":"2013","unstructured":"Herblum, R., M. Beek, and C. M. Whyne. \u03bcfEA successfully exhibits higher stresses and strains in microdamaged regions of whole vertebrae. J. Orthop. Res. 31:1653\u20131660, 2013.","journal-title":"J. Orthop. Res."},{"key":"2188_CR23","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1118\/1.3703590","volume":"39","author":"S-P Hojjat","year":"2012","unstructured":"Hojjat, S.-P., W. Foltz, L. Wise-Milestone, and C. M. Whyne. Multimodal \u03bcCT\/\u03bcMR based semiautomated segmentation of rat vertebrae affected by mixed osteolytic\/osteoblastic metastases. Med. Phys. 39:2848, 2012.","journal-title":"Med. Phys."},{"key":"2188_CR24","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3171\/2010.3.SPINE09576","volume":"13","author":"S-P Hojjat","year":"2010","unstructured":"Hojjat, S.-P., M. Hardisty,  and C. M. Whyne. Micro-computed tomography-based highly automated 3D segmentation of the rat spine for quantitative analysis of metastatic disease. J. Neurosurg. Spine 13:367\u2013370, 2010.","journal-title":"J. Neurosurg. Spine"},{"key":"2188_CR25","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1007\/s10439-011-0370-x","volume":"39","author":"S-P Hojjat","year":"2011","unstructured":"Hojjat, S.-P., E. Won, M. R. Hardisty, M. K. Akens, L. M. Wise-Milestone, and C. M. Whyne. Non-destructive evaluation of the effects of combined bisphosphonate and photodynamic therapy on bone strain in metastatic vertebrae using image registration. Ann. Biomed. Eng. 39:2816\u20132822, 2011.","journal-title":"Ann. Biomed. Eng."},{"key":"2188_CR26","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.bone.2014.04.012","volume":"64","author":"K Iwata","year":"2014","unstructured":"Iwata, K., T. Mashiba, T. Hitora, Y. Yamagami, and T. Yamamoto. A large amount of microdamages in the cortical bone around fracture site in a patient of atypical femoral fracture after long-term bisphosphonate therapy. Bone 64:183\u2013186, 2014.","journal-title":"Bone"},{"key":"2188_CR27","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.jbiomech.2003.08.010","volume":"37","author":"TS Kaneko","year":"2004","unstructured":"Kaneko, T. S., J. S. Bell, M. R. Pejcic, J. Tehranzadeh, and J. H. Keyak. Mechanical properties, density and quantitative CT scan data of trabecular bone with and without metastases. J. Biomech. 37:523\u2013530, 2004.","journal-title":"J. Biomech."},{"key":"2188_CR28","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/0021-9290(94)90053-1","volume":"27","author":"TM Keaveny","year":"1994","unstructured":"Keaveny, T. M., X. E. Guo, E. F. Wachtel, T. A. McMahon, and W. C. Hayes. Trabecular bone exhibits fully linear elastic behavior and yields at low strains. J. Biomech. 27:1127\u20131136, 1994.","journal-title":"J. Biomech."},{"key":"2188_CR29","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1359\/jbmr.2000.15.10.1981","volume":"15","author":"JH Kinney","year":"2000","unstructured":"Kinney, J. H., D. L. Haupt, M. Balooch, A. J. C. Ladd, J. T. Ryaby, and N. E. Lane. Three-dimensional morphometry of the L6 vertebra in the ovariectomized rat model of osteoporosis: biomechanical implications. J. Bone Miner. Res. 15:1981\u20131991, 2000.","journal-title":"J. Bone Miner. Res."},{"key":"2188_CR30","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/S0021-9290(98)00108-0","volume":"31","author":"AJ Ladd","year":"1998","unstructured":"Ladd, A. J., and J. H. Kinney. Numerical errors and uncertainties in finite-element modeling of trabecular bone. J. Biomech. 31:941\u2013945, 1998.","journal-title":"J. Biomech."},{"key":"2188_CR31","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.bone.2010.10.160","volume":"48","author":"MD Landrigan","year":"2011","unstructured":"Landrigan, M. D., J. Li, T. L. Turnbull, D. B. Burr, G. L. Niebur, and R. K. Roeder. Contrast-enhanced micro-computed tomography of fatigue microdamage accumulation in human cortical bone. Bone 48:443\u2013450, 2011.","journal-title":"Bone"},{"key":"2188_CR32","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1080\/10426911003748137","volume":"25","author":"M Lau","year":"2010","unstructured":"Lau, M., K. Lau, Y. Y. Yeo, C. A. Yeung, and J. Lee. Measurement of bovine bone properties through surface indentation technique. Mater. Manuf. Process. 25:324\u2013328, 2010.","journal-title":"Mater. Manuf. Process."},{"key":"2188_CR33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev-matsci-070909-104427","volume":"40","author":"ME Launey","year":"2010","unstructured":"Launey, M. E., M. J. Buehler, and R. O. Ritchie. On the mechanistic origins of toughness in bone. Annual. Rev. Mater. Res. 40:25\u201353, 2010.","journal-title":"Annual. Rev. Mater. Res."},{"key":"2188_CR34","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1046\/j.1469-7580.2002.00123.x","volume":"201","author":"TC Lee","year":"2002","unstructured":"Lee, T. C., A. Staines, and D. Taylor. Bone adaptation to load: microdamage as a stimulus for bone remodelling. J. Anat. 201:437\u2013446, 2002.","journal-title":"J. Anat."},{"key":"2188_CR35","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jmbbm.2007.06.002","volume":"1","author":"H Leng","year":"2008","unstructured":"Leng, H., X. Wang, R. D. Ross, G. L. Niebur, and R. K. Roeder. Micro-computed tomography of fatigue microdamage in cortical bone using a barium sulfate contrast agent. J. Mech. Behav. Biomed. Mater. 1:68\u201375, 2008.","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"2188_CR36","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1082::AID-CNCR20>3.0.CO;2-Z","volume":"88","author":"A Lipton","year":"2000","unstructured":"Lipton, A., R. L. Theriault, G. N. Hortobagyi, J. Simeone, R. D. Knight, K. Mellars, D. J. Reitsma, M. Heffernan, and J. J. Seaman. Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases. Cancer 88:1082\u20131090, 2000.","journal-title":"Cancer"},{"key":"2188_CR37","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1002\/jor.22373","volume":"31","author":"VCK Lo","year":"2013","unstructured":"Lo, V. C. K., M. K. Akens, L. Wise-Milestone, A. J. M. Yee, B. C. Wilson, and C. M. Whyne. The benefits of photodynamic therapy on vertebral bone are maintained and enhanced by combination treatment with bisphosphonates and radiation therapy. J. Orthop. Res. 31:1398\u20131405, 2013.","journal-title":"J. Orthop. Res."},{"key":"2188_CR38","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1115\/1.1503792","volume":"124","author":"AM Makiyama","year":"2002","unstructured":"Makiyama, A. M., S. Vajjhala, and L. J. Gibson. Analysis of crack growth in a 3D voronoi structure: a model for fatigue in low density trabecular bone. J. Biomech. Eng. 124:512, 2002.","journal-title":"J. Biomech. Eng."},{"key":"2188_CR39","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.tem.2010.01.010","volume":"21","author":"SC Manolagas","year":"2010","unstructured":"Manolagas, S. C., and A. M. Parfitt. What old means to bone. Trends Endocrinol. Metab. 21:369\u2013374, 2010.","journal-title":"Trends Endocrinol. Metab."},{"key":"2188_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S8756-3282(99)00241-0","volume":"26","author":"R Martin","year":"2000","unstructured":"Martin, R. Toward a unifying theory of bone remodeling. Bone 26:1\u20136, 2000.","journal-title":"Bone"},{"key":"2188_CR41","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/8756-3282(93)90235-3","volume":"14","author":"S Mori","year":"1993","unstructured":"Mori, S., and D. B. Burr. Increased intracortical remodeling following fatigue damage. Bone 14:103\u2013109, 1993.","journal-title":"Bone"},{"key":"2188_CR42","first-page":"268","volume":"108","author":"JM Morris","year":"1968","unstructured":"Morris, J. M. Fatigue fractures. Calif. Med. 108:268\u2013274, 1968.","journal-title":"Calif. Med."},{"key":"2188_CR43","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.jbiomech.2004.05.013","volume":"38","author":"S Nagaraja","year":"2005","unstructured":"Nagaraja, S., T. L. Couse, and R. E. Guldberg. Trabecular bone microdamage and microstructural stresses under uniaxial compression. J. Biomech. 38:707\u2013716, 2005.","journal-title":"J. Biomech."},{"key":"2188_CR44","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.bone.2006.10.028","volume":"40","author":"S Nagaraja","year":"2007","unstructured":"Nagaraja, S., A. S. P. Lin, and R. E. Guldberg. Age-related changes in trabecular bone microdamage initiation. Bone 40:973\u2013980, 2007.","journal-title":"Bone"},{"key":"2188_CR45","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.bone.2008.04.009","volume":"43","author":"A Nazarian","year":"2008","unstructured":"Nazarian, A., B. D. Snyder, D. Zurakowski, and R. M\u00fcller. Quantitative micro-computed tomography: a non-invasive method to assess equivalent bone mineral density. Bone 43:302\u2013311, 2008.","journal-title":"Bone"},{"key":"2188_CR46","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1115\/1.2800865","volume":"121","author":"GL Niebur","year":"1999","unstructured":"Niebur, G. L., J. C. Yuen, A. C. Hsia, and T. M. Keaveny. Convergence behavior of high-resolution finite element models of trabecular bone. J. Biomech. Eng. 121:629, 1999.","journal-title":"J. Biomech. Eng."},{"key":"2188_CR47","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S8756-3282(97)00004-5","volume":"20","author":"TL Norman","year":"1997","unstructured":"Norman, T. L., and Z. Wang. Microdamage of human cortical bone: Incidence and morphology in long bones. Bone 20:375\u2013379, 1997.","journal-title":"Bone"},{"key":"2188_CR48","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S8756-3282(98)00112-4","volume":"23","author":"P Roschger","year":"1998","unstructured":"Roschger, P., P. Fratzl, J. Eschberger, and K. Klaushofer. Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 23:319\u2013326, 1998.","journal-title":"Bone"},{"key":"2188_CR49","first-page":"75","volume":"9","author":"P Roschger","year":"1995","unstructured":"Roschger, P., H. Plenk, K. Klaushofer, and J. Eschberger. A new scanning electron microscopy approach to the quantification of bone mineral distribution: backscattered electron image grey-levels correlated to calcium K alpha-line intensities. Scanning Microsc. 9:75\u201386, 1995; (discussion 86\u201388).","journal-title":"Scanning Microsc."},{"key":"2188_CR50","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1007\/s00223-006-0035-1","volume":"79","author":"M Saito","year":"2006","unstructured":"Saito, M., K. Fujii, and K. Marumo. Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls. Calcif. Tissue Int. 79:160\u2013168, 2006.","journal-title":"Calcif. Tissue Int."},{"key":"2188_CR51","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/8756-3282(95)00370-3","volume":"17","author":"MB Schaffler","year":"1995","unstructured":"Schaffler, M. B., K. Choi, and C. Milgrom. Aging and matrix microdamage accumulation in human compact bone. Bone 17:521\u2013525, 1995.","journal-title":"Bone"},{"key":"2188_CR52","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0020-7403(99)00031-4","volume":"42","author":"G Schaffner","year":"2000","unstructured":"Schaffner, G., X.-D. E. Guo, M. J. Silva, and L. J. Gibson. Modelling fatigue damage accumulation in two-dimensional Voronoi honeycombs. Int. J. Mech. Sci. 42:645\u2013656, 2000.","journal-title":"Int. J. Mech. Sci."},{"key":"2188_CR53","unstructured":"Toma, S., A. Venturino, G. Sogno, C. Formica, B. Bignotti, S. Bonassi, and R. Palumbo. Metastatic bone tumors: Nonsurgical treatment. Outcome and survival. Clin. Orthop. Relat. Res. 295:246\u2013251, 1993. \n                    https:\/\/europepmc.org\/abstract\/med\/8403656\n                    \n                  ."},{"key":"2188_CR54","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1016\/j.jbiomech.2014.06.022","volume":"47","author":"TL Turnbull","year":"2014","unstructured":"Turnbull, T. L., A. P. Baumann, and R. K. Roeder. Fatigue microcracks that initiate fracture are located near elevated intracortical porosity but not elevated mineralization. J. Biomech. 47:3135\u20133142, 2014.","journal-title":"J. Biomech."},{"key":"2188_CR55","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S8756-3282(99)00253-7","volume":"26","author":"D Vashishth","year":"2000","unstructured":"Vashishth, D., J. Koontz, S. J. Qiu, D. Lundin-Cannon, Y. N. Yeni, M. B. Schaffler, and D. P. Fyhrie. In vivo diffuse damage in human vertebral trabecular bone. Bone 26:147\u2013152, 2000.","journal-title":"Bone"},{"key":"2188_CR56","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1359\/jbmr.2000.15.1.60","volume":"15","author":"O Verborgt","year":"2000","unstructured":"Verborgt, O., G. J. Gibson, and M. B. Schaffler. Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J. Bone Miner. Res. 15:60\u201367, 2000.","journal-title":"J. Bone Miner. Res."},{"key":"2188_CR57","doi-asserted-by":"publisher","first-page":"3497","DOI":"10.1007\/s00520-013-1932-2","volume":"21","author":"R Moos von","year":"2013","unstructured":"von Moos, R., J.-J. Body, B. Egerdie, A. Stopeck, J. E. Brown, D. Damyanov, L. J. Fallowfield, G. Marx, C. S. Cleeland, D. L. Patrick, F. G. Palazzo, Y. Qian, A. Braun, and K. Chung. Pain and health-related quality of life in patients with advanced solid tumours and bone metastases: integrated results from three randomized, double-blind studies of denosumab and zoledronic acid. Support. Care Cancer 21:3497\u20133507, 2013.","journal-title":"Support. Care Cancer"},{"key":"2188_CR58","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1016\/j.jbiomech.2007.05.009","volume":"40","author":"X Wang","year":"2007","unstructured":"Wang, X., D. B. Masse, H. Leng, K. P. Hess, R. D. Ross, R. K. Roeder, and G. L. Niebur. Detection of trabecular bone microdamage by micro-computed tomography. J. Biomech. 40:3397\u20133403, 2007.","journal-title":"J. Biomech."},{"key":"2188_CR59","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/8756-3282(96)88871-5","volume":"19","author":"TE Wenzel","year":"1996","unstructured":"Wenzel, T. E., M. B. Schaffler, and D. P. Fyhrie. In vivo trabecular microcracks in human vertebral bone. Bone 19:89\u201395, 1996.","journal-title":"Bone"},{"key":"2188_CR60","first-page":"652","volume":"28","author":"CM Whyne","year":"2003","unstructured":"Whyne, C. M., S. S. Hu, and J. C. Lotz. Burst fracture in the metastatically involved spine: development, validation, and parametric analysis of a three-dimensional poroelastic finite-element model. Spine (Phila. Pa. 1976) 28:652\u2013660, 2003.","journal-title":"Spine (Phila. Pa. 1976)"},{"key":"2188_CR61","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1002\/jor.21577","volume":"30","author":"L Wise-Milestone","year":"2012","unstructured":"Wise-Milestone, L., M. K. Akens, T. J. Rosol, S.-P. Hojjat, M. D. Grynpas, and C. M. Whyne. Evaluating the effects of mixed osteolytic\/osteoblastic metastasis on vertebral bone quality in a new rat model. J. Orthop. Res. 30:817\u2013823, 2012.","journal-title":"J. Orthop. Res."},{"key":"2188_CR62","doi-asserted-by":"crossref","unstructured":"Won, E., L. Wise-Milestone, M. K. Akens, S. Burch, A. J. M. Yee, B. C. Wilson, and C. M. Whyne. Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissue. Breast Cancer Res. Treat. 124:111\u2013119, 2010. \n                    http:\/\/www.springerlink.com\/index\/5291524844350527.pdf\n                    \n                  .","DOI":"10.1007\/s10549-009-0712-7"},{"key":"2188_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00007632-199001000-00001","volume":"15","author":"DA Wong","year":"1990","unstructured":"Wong, D. A., V. L. Fornasier, and I. MacNab. Spinal metastases: the obvious, the occult, and the impostors. Spine (Phila. Pa. 1976) 15:1\u20134, 1990.","journal-title":"Spine (Phila. Pa. 1976)"},{"key":"2188_CR64","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/S0736-0266(01)00053-5","volume":"19","author":"OC Yeh","year":"2001","unstructured":"Yeh, O. C., and T. M. Keaveny. Relative roles of microdamage and microfracture in the mechanical behavior of trabecular bone. J. Orthop. Res. 19:1001\u20131007, 2001.","journal-title":"J. Orthop. Res."},{"key":"2188_CR65","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/bonekey.2015.112","volume":"4","author":"EA Zimmermann","year":"2015","unstructured":"Zimmermann, E. A., B. Busse, and R. O. Ritchie. The fracture mechanics of human bone: influence of disease and treatment. Bonekey Rep. 4:743, 2015.","journal-title":"Bonekey Rep."},{"key":"2188_CR66","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1106\/5JUJ-TFJ3-JVVA-3RJ0","volume":"15","author":"P Zioupos","year":"2001","unstructured":"Zioupos, P. Ageing human bone: factors affecting its biomechanical properties and the role of collagen. J. Biomater. Appl. 15:187\u2013229, 2001.","journal-title":"J. Biomater. Appl."},{"key":"2188_CR67","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/S0021-9290(99)00111-6","volume":"32","author":"PK Zysset","year":"1999","unstructured":"Zysset, P. K., X. E. Guo, C. E. Hoffler, K. E. Moore, and S. A. Goldstein. Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur. J. Biomech. 32:1005\u20131012, 1999.","journal-title":"J. Biomech."}],"container-title":["Annals of Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-018-02188-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10439-018-02188-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-018-02188-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T19:22:55Z","timestamp":1579720975000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10439-018-02188-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,23]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["2188"],"URL":"https:\/\/doi.org\/10.1007\/s10439-018-02188-8","relation":{},"ISSN":["0090-6964","1573-9686"],"issn-type":[{"value":"0090-6964","type":"print"},{"value":"1573-9686","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,23]]},"assertion":[{"value":"3 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}