{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:53:05Z","timestamp":1779148385151,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2016YFC1101603"],"award-info":[{"award-number":["2016YFC1101603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370043"],"award-info":[{"award-number":["81370043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671823"],"award-info":[{"award-number":["81671823"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","award":["PAPD"],"award-info":[{"award-number":["PAPD"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Biomed Eng"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s10439-018-2011-0","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T13:22:08Z","timestamp":1522416128000},"page":"1013-1025","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Genipin-Cross-Linked Chitosan Nerve Conduits Containing TNF-\u03b1 Inhibitors for Peripheral Nerve Repair"],"prefix":"10.1007","volume":"46","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changmei","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"2011_CR1","first-page":"G579","volume":"263","author":"P Akerman","year":"1992","unstructured":"Akerman, P., P. Cote, S. Q. Yang, C. McClain, S. Nelson, G. J. Bagby, et al. Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am. J. Physiol. 263:G579\u2013G585, 1992.","journal-title":"Am. J. Physiol."},{"key":"2011_CR2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1006\/exnr.1995.1095","volume":"136","author":"AM Avellino","year":"1995","unstructured":"Avellino, A. M., D. Hart, A. T. Dailey, M. MacKinnon, D. Ellegala, and M. Kliot. Differential macrophage responses in the peripheral and central nervous system during wallerian degeneration of axons. Exp. Neurol. 136:183\u2013198, 1995.","journal-title":"Exp. Neurol."},{"key":"2011_CR3","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.hcl.2017.04.005","volume":"33","author":"B Battiston","year":"2017","unstructured":"Battiston, B., P. Titolo, D. Ciclamini, and B. Panero. Peripheral nerve defects: overviews of practice in Europe. Hand Clin. 33:545\u2013550, 2017.","journal-title":"Hand Clin."},{"key":"2011_CR4","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.pneurobio.2015.06.001","volume":"131","author":"V Chiono","year":"2015","unstructured":"Chiono, V., and C. Tonda-Turo. Trends in the design of nerve guidance channels in peripheral nerve tissue engineering. Prog. Neurobiol. 131:87\u2013104, 2015.","journal-title":"Prog. Neurobiol."},{"key":"2011_CR5","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1126\/science.274.5291.1379","volume":"274","author":"DE Cressman","year":"1996","unstructured":"Cressman, D. E., L. E. Greenbaum, R. A. DeAngelis, G. Ciliberto, E. E. Furth, V. Poli, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science. 274:1379\u20131383, 1996.","journal-title":"Science."},{"key":"2011_CR6","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.msec.2016.04.048","volume":"65","author":"K Dalamagkas","year":"2016","unstructured":"Dalamagkas, K., M. Tsintou, and A. Seifalian. Advances in peripheral nervous system regenerative therapeutic strategies: a biomaterials approach. Mater. Sci. Eng. C. 65:425\u2013432, 2016.","journal-title":"Mater. Sci. Eng. C."},{"key":"2011_CR7","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.conb.2014.05.001","volume":"27","author":"MR Freeman","year":"2014","unstructured":"Freeman, M. R. Signaling mechanisms regulating Wallerian degeneration. Curr. Opin. Neurobiol. 27:224\u2013231, 2014.","journal-title":"Curr. Opin. Neurobiol."},{"key":"2011_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-12-420045-6.00001-8","volume":"109","author":"S Gnavi","year":"2013","unstructured":"Gnavi, S., C. Barwig, T. Freier, K. Haastert-Talini, C. Grothe, and S. Geuna. The use of chitosan-based scaffolds to enhance regeneration in the nervous system. Int. Rev. Neurobiol. 109:1\u201362, 2013.","journal-title":"Int. Rev. Neurobiol."},{"key":"2011_CR9","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1083\/jcb.201503019","volume":"210","author":"JA Gomez-Sanchez","year":"2015","unstructured":"Gomez-Sanchez, J. A., L. Carty, M. Iruarrizaga-Lejarreta, M. Palomo-Irigoyen, M. Varela-Rey, M. Griffith, et al. Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves. J. Cell Biol. 210:153\u2013168, 2015.","journal-title":"J. Cell Biol."},{"key":"2011_CR10","doi-asserted-by":"publisher","first-page":"6143","DOI":"10.1016\/j.biomaterials.2014.04.064","volume":"35","author":"X Gu","year":"2014","unstructured":"Gu, X., F. Ding, and D. F. Williams. Neural tissue engineering options for peripheral nerve regeneration. Biomaterials. 35:6143\u20136156, 2014.","journal-title":"Biomaterials."},{"key":"2011_CR11","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.pneurobio.2010.11.002","volume":"93","author":"X Gu","year":"2011","unstructured":"Gu, X., F. Ding, Y. Yang, and J. Liu. Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration. Prog. Neurobiol. 93:204\u2013230, 2011.","journal-title":"Prog. Neurobiol."},{"key":"2011_CR12","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nature07039","volume":"453","author":"GC Gurtner","year":"2008","unstructured":"Gurtner, G. C., S. Werner, Y. Barrandon, and M. T. Longaker. Wound repair and regeneration. Nature. 453:314\u2013321, 2008.","journal-title":"Nature."},{"key":"2011_CR13","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.neuron.2016.04.022","volume":"90","author":"Z He","year":"2016","unstructured":"He, Z., and Y. Jin. Intrinsic control of axon regeneration. Neuron. 90:437\u2013451, 2016.","journal-title":"Neuron."},{"key":"2011_CR14","first-page":"339","volume":"48","author":"EA Huebner","year":"2009","unstructured":"Huebner, E. A., and S. M. Strittmatter. Axon regeneration in the peripheral and central nervous systems. Results Probl. Cell Differ. 48:339\u2013351, 2009.","journal-title":"Results Probl. Cell Differ."},{"key":"2011_CR15","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1002\/glia.23200","volume":"65","author":"SY Jang","year":"2017","unstructured":"Jang, S. Y., B. A. Yoon, Y. K. Shin, S. H. Yun, Y. R. Jo, Y. Y. Choi, et al. Schwann cell dedifferentiation-associated demyelination leads to exocytotic myelin clearance in inflammatory segmental demyelination. Glia. 65:1848\u20131862, 2017.","journal-title":"Glia."},{"key":"2011_CR16","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nature17039","volume":"529","author":"M Karin","year":"2016","unstructured":"Karin, M., and H. Clevers. Reparative inflammation takes charge of tissue regeneration. Nature. 529:307\u2013315, 2016.","journal-title":"Nature."},{"key":"2011_CR17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.biomaterials.2015.11.063","volume":"81","author":"RA Koppes","year":"2016","unstructured":"Koppes, R. A., S. Park, T. Hood, X. Jia, N. Abdolrahim Poorheravi, A. H. Achyuta, et al. Thermally drawn fibers as nerve guidance scaffolds. Biomaterials. 81:27\u201335, 2016.","journal-title":"Biomaterials."},{"key":"2011_CR18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1742-2094-7-27","volume":"7","author":"L Leung","year":"2010","unstructured":"Leung, L., and C. M. Cahill. TNF-alpha and neuropathic pain\u2013a review. J. Neuroinflamm. 7:27, 2010.","journal-title":"J. Neuroinflamm."},{"key":"2011_CR19","doi-asserted-by":"publisher","first-page":"16888","DOI":"10.1038\/srep16888","volume":"5","author":"S Li","year":"2015","unstructured":"Li, S., C. Xue, Y. Yuan, R. Zhang, Y. Wang, Y. Wang, et al. The transcriptional landscape of dorsal root ganglia after sciatic nerve transection. Sci. Rep. 5:16888, 2015.","journal-title":"Sci. Rep."},{"key":"2011_CR20","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1523\/JNEUROSCI.2235-16.2016","volume":"37","author":"Y Liu","year":"2017","unstructured":"Liu, Y., L. J. Zhou, J. Wang, D. Li, W. J. Ren, J. Peng, et al. TNF-alpha differentially regulates synaptic plasticity in the hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury. J. Neurosci. 37:871\u2013881, 2017.","journal-title":"J. Neurosci."},{"key":"2011_CR21","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1002\/glia.20766","volume":"56","author":"R Martini","year":"2008","unstructured":"Martini, R., S. Fischer, R. Lopez-Vales, and S. David. Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease. Glia. 56:1566\u20131577, 2008.","journal-title":"Glia."},{"key":"2011_CR22","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.tins.2011.09.002","volume":"34","author":"C Mc Guire","year":"2011","unstructured":"Mc Guire, C., R. Beyaert, and G. van Loo. Death receptor signalling in central nervous system inflammation and demyelination. Trends Neurosci. 34:619\u2013628, 2011.","journal-title":"Trends Neurosci."},{"key":"2011_CR23","first-page":"1941","volume":"63","author":"A Pabari","year":"2010","unstructured":"Pabari, A., S. Y. Yang, A. M. Seifalian, and A. Mosahebi. Modern surgical management of peripheral nerve gap. JPRAS. 63:1941\u20131948, 2010.","journal-title":"JPRAS."},{"key":"2011_CR24","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.biomaterials.2015.01.055","volume":"49","author":"CJ Pateman","year":"2015","unstructured":"Pateman, C. J., A. J. Harding, A. Glen, C. S. Taylor, C. R. Christmas, P. P. Robinson, et al. Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair. Biomaterials. 49:77\u201389, 2015.","journal-title":"Biomaterials."},{"key":"2011_CR25","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.aanat.2011.03.001","volume":"193","author":"S Raimondo","year":"2011","unstructured":"Raimondo, S., M. Fornaro, P. Tos, B. Battiston, M. G. Giacobini-Robecchi, and S. Geuna. Perspectives in regeneration and tissue engineering of peripheral nerves. Ann. Anat. 193:334\u2013340, 2011.","journal-title":"Ann. Anat."},{"key":"2011_CR26","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1126\/science.aad9272","volume":"352","author":"K Sadtler","year":"2016","unstructured":"Sadtler, K., K. Estrellas, B. W. Allen, M. T. Wolf, H. Fan, A. J. Tam, et al. Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells. Science. 352:366\u2013370, 2016.","journal-title":"Science."},{"key":"2011_CR27","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1016\/j.ijbiomac.2016.02.043","volume":"93","author":"PR Sivashankari","year":"2016","unstructured":"Sivashankari, P. R., and M. Prabaharan. Prospects of chitosan-based scaffolds for growth factor release in tissue engineering. Int. J. Biol. Macromol. 93:1382\u20131389, 2016.","journal-title":"Int. J. Biol. Macromol."},{"key":"2011_CR28","doi-asserted-by":"publisher","first-page":"4264","DOI":"10.1016\/j.biomaterials.2012.02.043","volume":"33","author":"EC Spivey","year":"2012","unstructured":"Spivey, E. C., Z. Z. Khaing, J. B. Shear, and C. E. Schmidt. The fundamental role of subcellular topography in peripheral nerve repair therapies. Biomaterials. 33:4264\u20134276, 2012.","journal-title":"Biomaterials."},{"key":"2011_CR29","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.biomaterials.2017.01.044","volume":"124","author":"X Tang","year":"2017","unstructured":"Tang, X., H. Qin, X. Gu, and X. Fu. China\u2019s landscape in regenerative medicine. Biomaterials. 124:78\u201394, 2017.","journal-title":"Biomaterials."},{"key":"2011_CR30","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s11010-013-1614-x","volume":"378","author":"X Tang","year":"2013","unstructured":"Tang, X., Y. Wang, S. Zhou, T. Qian, and X. Gu. Signaling pathways regulating dose-dependent dual effects of TNF-alpha on primary cultured Schwann cells. Mol. Cell Biochem. 378:237\u2013246, 2013.","journal-title":"Mol. Cell Biochem."},{"key":"2011_CR31","doi-asserted-by":"publisher","first-page":"3860","DOI":"10.1016\/j.biomaterials.2012.02.008","volume":"33","author":"X Tang","year":"2012","unstructured":"Tang, X., C. Xue, Y. Wang, F. Ding, Y. Yang, and X. Gu. Bridging peripheral nerve defects with a tissue engineered nerve graft composed of an in vitro cultured nerve equivalent and a silk fibroin-based scaffold. Biomaterials. 33:3860\u20133867, 2012.","journal-title":"Biomaterials."},{"key":"2011_CR32","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12974-015-0331-7","volume":"12","author":"N Tzekova","year":"2015","unstructured":"Tzekova, N., A. Heinen, S. Bunk, C. Hermann, H. P. Hartung, B. Reipert, et al. Immunoglobulins stimulate cultured Schwann cell maturation and promote their potential to induce axonal outgrowth. J. Neuroinflamm. 12:107, 2015.","journal-title":"J. Neuroinflamm."},{"key":"2011_CR33","doi-asserted-by":"publisher","first-page":"11993","DOI":"10.1073\/pnas.1001948107","volume":"107","author":"ME Vargas","year":"2010","unstructured":"Vargas, M. E., J. Watanabe, S. J. Singh, W. H. Robinson, and B. A. Barres. Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury. PNAS. 107:11993\u201311998, 2010.","journal-title":"PNAS."},{"key":"2011_CR34","doi-asserted-by":"publisher","first-page":"e43436","DOI":"10.1371\/journal.pone.0043436","volume":"7","author":"Y Wang","year":"2012","unstructured":"Wang, Y., X. Tang, B. Yu, Y. Gu, Y. Yuan, D. Yao, et al. Gene network revealed involvements of Birc2, Birc3 and Tnfrsf1a in anti-apoptosis of injured peripheral nerves. PLoS ONE. 7:e43436, 2012.","journal-title":"PLoS ONE."},{"key":"2011_CR35","doi-asserted-by":"publisher","first-page":"518","DOI":"10.4103\/1673-5374.211182","volume":"12","author":"KM Wong","year":"2017","unstructured":"Wong, K. M., E. Babetto, and B. Beirowski. Axon degeneration: make the Schwann cell great again. Neural Regen. Res. 12:518\u2013524, 2017.","journal-title":"Neural Regen. Res."},{"key":"2011_CR36","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.ejpb.2011.06.008","volume":"79","author":"Y Yang","year":"2011","unstructured":"Yang, Y., W. Zhao, J. He, Y. Zhao, F. Ding, and X. Gu. Nerve conduits based on immobilization of nerve growth factor onto modified chitosan by using genipin as a crosslinking agent. Eur. J. Pharm. Biopharm. 79:519\u2013525, 2011.","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"2011_CR37","first-page":"22","volume":"11","author":"S Yi","year":"2017","unstructured":"Yi, S., X. Tang, J. Yu, J. Liu, F. Ding, and X. Gu. Microarray and qPCR analyses of wallerian degeneration in rat sciatic nerves. Front. Cell. Neurosci. 11:22, 2017.","journal-title":"Front. Cell. Neurosci."},{"key":"2011_CR38","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.biomaterials.2017.02.026","volume":"134","author":"Y Zhao","year":"2017","unstructured":"Zhao, Y., Y. Wang, J. Gong, L. Yang, C. Niu, X. Ni, et al. Chitosan degradation products facilitate peripheral nerve regeneration by improving macrophage-constructed microenvironments. Biomaterials. 134:64\u201377, 2017.","journal-title":"Biomaterials."}],"container-title":["Annals of Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10439-018-2011-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-018-2011-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-018-2011-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T06:23:13Z","timestamp":1589869393000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10439-018-2011-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,30]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["2011"],"URL":"https:\/\/doi.org\/10.1007\/s10439-018-2011-0","relation":{},"ISSN":["0090-6964","1573-9686"],"issn-type":[{"value":"0090-6964","type":"print"},{"value":"1573-9686","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,30]]},"assertion":[{"value":"23 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}