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This study validated a finite element (<jats:italic>in silico<\/jats:italic>) model based on an ITAP design and investigated implant stem stiffness influence on periprosthetic femoral bone strain. Results showed good agreement in the validation of the <jats:italic>in silico<\/jats:italic> model against the <jats:italic>in vitro<\/jats:italic> results using uniaxial strain gauges and Digital Image Correlation (DIC). Using Strain Energy Density (SED) thresholds as the stimulus for adaptive bone remodelling, the validated model illustrated that: (a) bone apposition increased and resorption decreased with increasing implant stem flexibility in early stance; (b) bone apposition decreased (mean change\u2009=\u2009\u2212\u20099.8%) and resorption increased (mean change\u2009=\u200920.3%) from distal to proximal in most stem stiffness models in early stance. By engineering the flow of force through the implant\/bone (e.g. by changing material properties) these results demonstrate how periprosthetic bone remodelling, thus aseptic loosening, can be managed. 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