{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:41:23Z","timestamp":1773178883720,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006260","name":"Technion-Israel Institute of Technology","doi-asserted-by":"publisher","award":["Elias Fund for Medical Research"],"award-info":[{"award-number":["Elias Fund for Medical Research"]}],"id":[{"id":"10.13039\/501100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006260","name":"Technion-Israel Institute of Technology","doi-asserted-by":"publisher","award":["Polak Fund for Applied Research"],"award-info":[{"award-number":["Polak Fund for Applied Research"]}],"id":[{"id":"10.13039\/501100006260","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ber-Lehmsdorf Foundation"},{"name":"Gerald O. Mann Charitable Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Biomed Eng"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s10439-020-02547-4","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T17:02:34Z","timestamp":1592240554000},"page":"2846-2858","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Rapid Cancer Diagnosis and Early Prognosis of Metastatic Risk Based on Mechanical Invasiveness of Sampled Cells"],"prefix":"10.1007","volume":"48","author":[{"given":"Y.","family":"Merkher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Horesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Abramov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Shleifer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Ben-Ishay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kluger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9670-3418","authenticated-orcid":false,"given":"D.","family":"Weihs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"2547_CR1","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.medengphy.2016.05.013","volume":"38","author":"S Abuhattum","year":"2016","unstructured":"Abuhattum, S., and D. Weihs. Asymmetry in traction forces produced by migrating preadipocytes is bounded to 33. Med. Eng. Phys. 38:834\u2013838, 2016.","journal-title":"Med. Eng. Phys."},{"key":"2547_CR2","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nprot.2006.466","volume":"2","author":"A Albini","year":"2007","unstructured":"Albini, A., and R. Benelli. The chemoinvasion assay: a method to assess tumor and endothelial cell invasion and its modulation. Nat. Protoc. 2:504\u2013511, 2007.","journal-title":"Nat. Protoc."},{"key":"2547_CR3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.medengphy.2019.11.004","volume":"75","author":"MB Alvarez-Elizondo","year":"2020","unstructured":"Alvarez-Elizondo, M. B., C. W. Li, A. Marom, Y.-T. Tung, G. Drillich, Y. Horesh, S. C. Lin, G.-J. Wang, and D. Weihs. Micropatterned topographies reveal measurable differences between cancer and benign cells. Med. Eng. Phys. 75:5\u201312, 2020.","journal-title":"Med. Eng. Phys."},{"key":"2547_CR4","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1089\/ten.tec.2016.0424","volume":"23","author":"MB Alvarez-Elizondo","year":"2017","unstructured":"Alvarez-Elizondo, M. B., and D. Weihs. Cell-gel mechanical interactions as an approach to rapidly and quantitatively reveal invasive subpopulations of metastatic cancer cells. Tissue Eng. Part C Methods 23:180\u2013187, 2017.","journal-title":"Tissue Eng. Part C Methods"},{"key":"2547_CR5","doi-asserted-by":"crossref","unstructured":"Artym, V. V., K. M. Yamada, and S. C. Mueller. ECM degradation assays for analyzing local cell invasion. In: Methods in Molecular Biology (Clifton, N.J.). 2009, pp. 211\u2013219.","DOI":"10.1007\/978-1-59745-413-1_15"},{"key":"2547_CR6","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s12029-015-9724-1","volume":"46","author":"A Carrato","year":"2015","unstructured":"Carrato, A., A. Falcone, M. Ducreux, J. W. Valle, A. Parnaby, K. Djazouli, K. Alnwick-Allu, A. Hutchings, C. Palaska, and I. Parthenaki. A systematic review of the burden of pancreatic cancer in Europe: real-world impact on survival, quality of life and costs. J. Gastrointest. Cancer 46:201\u2013211, 2015.","journal-title":"J. Gastrointest. Cancer"},{"key":"2547_CR7","doi-asserted-by":"crossref","unstructured":"Casciani, F., G. Marchegiani, G. Malleo, C. Bassi, and R. Salvia. Pancreatic cancer in the era of neoadjuvant therapy: a narrative overview. Chirurgia (Bucur) 113:307, 2018.","DOI":"10.21614\/chirurgia.113.3.307"},{"key":"2547_CR8","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/nnano.2007.388","volume":"2","author":"SE Cross","year":"2007","unstructured":"Cross, S. E., Y. S. Jin, J. Rao, and J. K. Gimzewski. Nanomechanical analysis of cells from cancer patients. Nat. Nanotechnol. 2:780\u2013783, 2007.","journal-title":"Nat. Nanotechnol."},{"key":"2547_CR9","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1097\/MPA.0b013e3181c15963","volume":"39","author":"EL Deer","year":"2010","unstructured":"Deer, E. L., J. Gonzalez-Hernandez, J. D. Coursen, J. E. Shea, J. Ngatia, C. L. Scaife, M. A. Firpo, and S. J. Mulvihill. Phenotype and genotype of pancreatic cancer cell lines. Pancreas 39:425\u2013435, 2010.","journal-title":"Pancreas"},{"key":"2547_CR10","doi-asserted-by":"publisher","first-page":"043010","DOI":"10.1088\/1367-2630\/17\/4\/043010","volume":"17","author":"L Dvir","year":"2015","unstructured":"Dvir, L., R. Nissim, M. B. Alvarez-Elizondo, and D. Weihs. Quantitative measures to reveal coordinated cytoskeleton-nucleus reorganization during in vitro invasion of cancer cells. New J. Phys. 17:043010, 2015.","journal-title":"New J. Phys."},{"key":"2547_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10544-017-0234-8","volume":"19","author":"H Eslami Amirabadi","year":"2017","unstructured":"Eslami Amirabadi, H., S. Saheb Ali, J. P. Frimat, R. Luttge, and J. M. J. Den Toonder. A novel method to understand tumor cell invasion: integrating extracellular matrix mimicking layers in microfluidic chips by \u201cselective curing\u201d. Biomed. Microdevices 19:1\u201311, 2017.","journal-title":"Biomed. Microdevices"},{"key":"2547_CR12","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/nrc1075","volume":"3","author":"P Friedl","year":"2003","unstructured":"Friedl, P., and K. Wolf. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat. Rev. Cancer 3:362\u2013374, 2003.","journal-title":"Nat. Rev. Cancer"},{"key":"2547_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1083\/jcb.200909003","volume":"188","author":"P Friedl","year":"2010","unstructured":"Friedl, P., and K. Wolf. Plasticity of cell migration: a multiscale tuning model. J. Cell Biol. 188:11\u201319, 2010.","journal-title":"J. Cell Biol."},{"key":"2547_CR14","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s00397-013-0694-6","volume":"52","author":"N Gal","year":"2013","unstructured":"Gal, N., D. Lechtman-Goldstein, and D. Weihs. Particle tracking in living cells: a review of the mean square displacement method and beyond. Rheol. Acta 52:425\u2013443, 2013.","journal-title":"Rheol. Acta"},{"key":"2547_CR15","doi-asserted-by":"publisher","first-page":"3689","DOI":"10.1529\/biophysj.104.045476","volume":"88","author":"J Guck","year":"2005","unstructured":"Guck, J., S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Kas, S. Ulvick, and C. Bilby. Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence. Biophys. J. 88:3689\u20133698, 2005.","journal-title":"Biophys. J."},{"key":"2547_CR16","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1109\/RBME.2009.2034865","volume":"2","author":"MN Gurcan","year":"2009","unstructured":"Gurcan, M. N., L. E. Boucheron, A. Can, A. Madabhushi, N. M. Rajpoot, and B. Yener. Histopathological image analysis: a review. IEEE Rev. Biomed. Eng. 2:147\u2013171, 2009.","journal-title":"IEEE Rev. Biomed. Eng."},{"key":"2547_CR17","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.1021\/acs.nanolett.8b04720","volume":"19","author":"AW Holle","year":"2019","unstructured":"Holle, A. W., N. Govindan Kutty Devi, K. Clar, A. Fan, T. Saif, R. Kemkemer, and J. P. Spatz. Cancer cells invade confined microchannels via a self-directed mesenchymal-to-amoeboid transition. Nano Lett. 19:2280\u20132290, 2019.","journal-title":"Nano Lett."},{"key":"2547_CR18","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/bcr2889","volume":"13","author":"DL Holliday","year":"2011","unstructured":"Holliday, D. L., and V. Speirs. Choosing the right cell line for breast cancer research. Breast Cancer Res. 13:215, 2011.","journal-title":"Breast Cancer Res."},{"key":"2547_CR19","doi-asserted-by":"publisher","first-page":"e33476","DOI":"10.1371\/journal.pone.0033476","volume":"7","author":"TM Koch","year":"2012","unstructured":"Koch, T. M., S. Munster, N. Bonakdar, J. P. Butler, and B. Fabry. 3D Traction forces in cancer cell invasion. PLoS ONE 7:e33476, 2012.","journal-title":"PLoS ONE"},{"key":"2547_CR20","doi-asserted-by":"publisher","first-page":"e32572","DOI":"10.1371\/journal.pone.0032572","volume":"7","author":"CM Kraning-Rush","year":"2012","unstructured":"Kraning-Rush, C. M., J. P. Califano, and C. A. Reinhart-King. Cellular traction stresses increase with increasing metastatic potential. PLoS ONE 7:e32572, 2012.","journal-title":"PLoS ONE"},{"key":"2547_CR21","doi-asserted-by":"publisher","first-page":"035022","DOI":"10.1088\/1367-2630\/15\/3\/035022","volume":"15","author":"R Kristal-Muscal","year":"2013","unstructured":"Kristal-Muscal, R., L. Dvir, and D. Weihs. Metastatic cancer cells tenaciously indent impenetrable, soft substrates. New J. Phys. 15:035022, 2013.","journal-title":"New J. Phys."},{"key":"2547_CR22","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","volume":"139","author":"KR Levental","year":"2009","unstructured":"Levental, K. R., H. Yu, L. Kass, J. N. Lakins, M. Egeblad, J. T. Erler, S. F. T. Fong, K. Csiszar, A. Giaccia, W. Weninger, M. Yamauchi, D. L. Gasser, and V. M. Weaver. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139:891\u2013906, 2009.","journal-title":"Cell"},{"issue":"12","key":"2547_CR23","first-page":"1509","volume":"4","author":"X Li","year":"2012","unstructured":"Li, X., A. V. Valadez, P. Zuo, and Z. Nie. Microfluidic 3D cell culture: potential application for tissue-based bioassays. Bioassays. 4(12):1509\u20131525, 2012.","journal-title":"Bioassays."},{"issue":"4","key":"2547_CR24","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.biotechadv.2017.04.001","volume":"35","author":"SB Liang","year":"2017","unstructured":"Liang, S. B., and L. W. Fu. Application of single-cell technology in cancer research. Biotechnol. Adv. 35(4):443\u2013449, 2017.","journal-title":"Biotechnol. Adv."},{"key":"2547_CR25","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1109\/TIT.1982.1056489","volume":"28","author":"S Lloyd","year":"1982","unstructured":"Lloyd, S. Least squares quantization in PCM. IEEE Trans. Inf. Theory 28:129\u2013137, 1982.","journal-title":"IEEE Trans. Inf. Theory"},{"key":"2547_CR26","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s10237-016-0864-4","volume":"16","author":"S Massalha","year":"2017","unstructured":"Massalha, S., and D. Weihs. Metastatic breast cancer cells adhere strongly on varying stiffness substrates, initially without adjusting their morphology. Biomech. Model. Mechanobiol. 16:961\u2013970, 2017.","journal-title":"Biomech. Model. Mechanobiol."},{"key":"2547_CR27","doi-asserted-by":"publisher","first-page":"044002","DOI":"10.1088\/2057-1739\/aa8c0b","volume":"3","author":"Y Merkher","year":"2017","unstructured":"Merkher, Y., M. B. Alvarez-Elizondo, and D. Weihs. Taxol reduces synergistic, mechanobiological invasiveness of metastatic cells. Converg. Sci. Phys. Oncol. 3:044002, 2017.","journal-title":"Converg. Sci. Phys. Oncol."},{"key":"2547_CR28","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1007\/s10439-017-1814-8","volume":"45","author":"Y Merkher","year":"2017","unstructured":"Merkher, Y., and D. Weihs. Proximity of metastatic cells enhances their mechanobiological invasiveness. Ann. Biomed. Eng. 45:1399\u20131406, 2017.","journal-title":"Ann. Biomed. Eng."},{"key":"2547_CR29","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1002\/path.1716","volume":"205","author":"M Nystr\u00f6m","year":"2005","unstructured":"Nystr\u00f6m, M., G. Thomas, M. Stone, I. Mackenzie, I. Hart, and J. Marshall. Development of a quantitative method to analyse tumour cell invasion in organotypic culture. J. Pathol. 205:468\u2013475, 2005.","journal-title":"J. Pathol."},{"key":"2547_CR30","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1002\/cam4.459","volume":"4","author":"RD Peixoto","year":"2015","unstructured":"Peixoto, R. D., C. Speers, C. E. McGahan, D. J. Renouf, D. F. Schaeffer, and H. F. Kennecke. Prognostic factors and sites of metastasis in unresectable locally advanced pancreatic cancer. Cancer Med. 4:1171\u20131177, 2015.","journal-title":"Cancer Med."},{"key":"2547_CR31","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1158\/0008-5472.CAN-14-0155","volume":"74","author":"L Rahib","year":"2014","unstructured":"Rahib, L., B. D. Smith, R. Aizenberg, A. B. Rosenzweig, J. M. Fleshman, and L. M. Matrisian. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 74:2913\u20132921, 2014.","journal-title":"Cancer Res."},{"key":"2547_CR32","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1471-2407-13-36","volume":"13","author":"M Riihimaki","year":"2013","unstructured":"Riihimaki, M., H. Thomsen, A. Hemminki, K. Sundquist, K. Hemminki, M. Riihim\u00e4ki, H. Thomsen, A. Hemminki, K. Sundquist, K. Hemminki, M. Riihimaki, H. Thomsen, A. Hemminki, K. Sundquist, and K. Hemminki. Comparison of survival of patients with metastases from known versus unknown primaries: survival in metastatic cancer. BMC Cancer 13:36, 2013.","journal-title":"BMC Cancer"},{"key":"2547_CR33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1023\/A:1018436407280","volume":"15","author":"AM Sieuwerts","year":"1997","unstructured":"Sieuwerts, A. M., J. G. Klijn, and J. A. Foekens. Assessment of the invasive potential of human gynecological tumor cell lines with the in vitro Boyden chamber assay: influences of the ability of cells to migrate through the filter membrane. Clin. Exp. Metastasis 15:53\u201362, 1997.","journal-title":"Clin. Exp. Metastasis"},{"key":"2547_CR34","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1002\/ijc.26027","volume":"128","author":"JP Sleeman","year":"2011","unstructured":"Sleeman, J. P., I. Nazarenko, and W. Thiele. Do all roads lead to Rome? Routes to metastasis development. Int. J. Cancer 128:2511\u20132526, 2011.","journal-title":"Int. J. Cancer"},{"key":"2547_CR35","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/S1470-2045(16)00172-8","volume":"17","author":"M Suker","year":"2016","unstructured":"Suker, M., B. R. Beumer, E. Sadot, L. Marthey, J. E. Faris, E. A. Mellon, B. F. El-Rayes, A. Wang-Gillam, J. Lacy, P. J. Hosein, S. Y. Moorcraft, T. Conroy, F. Hohla, P. Allen, J. Taieb, T. S. Hong, R. Shridhar, I. Chau, C. H. van Eijck, and B. G. Koerkamp. FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis. Lancet Oncol. 17:801\u2013810, 2016.","journal-title":"Lancet Oncol."},{"key":"2547_CR36","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.addr.2014.07.002","volume":"79\u201380","author":"KE Sung","year":"2014","unstructured":"Sung, K. E., and D. J. Beebe. Microfluidic 3D models of cancer. Adv. Drug Deliv. Rev. 79\u201380:68\u201378, 2014.","journal-title":"Adv. Drug Deliv. Rev."},{"key":"2547_CR37","doi-asserted-by":"publisher","first-page":"5075","DOI":"10.1158\/0008-5472.CAN-11-0247","volume":"71","author":"V Swaminathan","year":"2011","unstructured":"Swaminathan, V., K. Mythreye, E. T. O\u2019Brien, A. Berchuck, G. C. Blobe, and R. Superfine. Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines. Cancer Res. 71:5075\u20135080, 2011.","journal-title":"Cancer Res."},{"key":"2547_CR38","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1186\/1471-2407-13-453","volume":"13","author":"Y Teng","year":"2013","unstructured":"Teng, Y., X. Xie, S. Walker, D. T. White, J. S. Mumm, and J. K. Cowell. Evaluating human cancer cell metastasis in zebrafish. BMC Cancer 13:453, 2013.","journal-title":"BMC Cancer"},{"key":"2547_CR39","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/bioengineering5020029","volume":"5","author":"YC Toh","year":"2018","unstructured":"Toh, Y. C., A. Raja, H. Yu, and D. Van Noort. A 3D microfluidic model to recapitulate cancer cell migration and invasion. Bioengineering 5:10, 2018.","journal-title":"Bioengineering"},{"key":"2547_CR40","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.biomaterials.2011.09.049","volume":"33","author":"HH Truong","year":"2012","unstructured":"Truong, H. H., J. de Sonneville, V. P. S. S. Ghotra, J. Xiong, L. Price, P. C. W. W. Hogendoorn, H. H. Spaink, B. van de Water, and E. H. J. J. Danen. Automated microinjection of cell-polymer suspensions in 3D ECM scaffolds for high-throughput quantitative cancer invasion screens. Biomaterials 33:181\u2013188, 2012.","journal-title":"Biomaterials"},{"key":"2547_CR41","doi-asserted-by":"publisher","DOI":"10.3791\/52686","author":"M Vinci","year":"2015","unstructured":"Vinci, M., C. Box, and S. A. Eccles. Three-dimensional (3D) tumor spheroid invasion assay. J. Vis. Exp 2015. https:\/\/doi.org\/10.3791\/52686.","journal-title":"J. Vis. Exp"},{"key":"2547_CR42","doi-asserted-by":"publisher","first-page":"3358","DOI":"10.1038\/s41598-019-40041-7","volume":"9","author":"JW Wei","year":"2019","unstructured":"Wei, J. W., L. J. Tafe, Y. A. Linnik, L. J. Vaickus, N. Tomita, and S. Hassanpour. Pathologist-level classification of histologic patterns on resected lung adenocarcinoma slides with deep neural networks. Sci. Rep. 9:3358, 2019.","journal-title":"Sci. Rep."},{"key":"2547_CR43","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nrc1670","volume":"5","author":"B Weigelt","year":"2005","unstructured":"Weigelt, B., J. L. Peterse, and L. J. van\u2019t Veer. Breast cancer metastasis markers and models. Nat. Rev. Cancer 5:591\u2013602, 2005.","journal-title":"Nat. Rev. Cancer"},{"key":"2547_CR44","unstructured":"Weihs, D., and Y. Merkher. A device and method for determining cell indention activity, Patent pending. Patent: PCT\/IL2019\/050463, 2019."},{"key":"2547_CR45","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41551-019-0400-9","volume":"3","author":"CL Yankaskas","year":"2019","unstructured":"Yankaskas, C. L., K. N. Thompson, C. D. Paul, M. I. Vitolo, P. Mistriotis, A. Mahendra, V. K. Bajpai, D. J. Shea, K. M. Manto, A. C. Chai, N. Varadarajan, et al. A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens. Nat. Biomed. Eng. 3:452\u2013465, 2019.","journal-title":"Nat. Biomed. Eng."}],"container-title":["Annals of Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-020-02547-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10439-020-02547-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-020-02547-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T23:56:23Z","timestamp":1623714983000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10439-020-02547-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,15]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2547"],"URL":"https:\/\/doi.org\/10.1007\/s10439-020-02547-4","relation":{},"ISSN":["0090-6964","1573-9686"],"issn-type":[{"value":"0090-6964","type":"print"},{"value":"1573-9686","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,15]]},"assertion":[{"value":"2 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}