{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:45:30Z","timestamp":1774385130119,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["DPI-2017-83911R"],"award-info":[{"award-number":["DPI-2017-83911R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008431","name":"Consejer\u00eda de Educaci\u00f3n, Junta de Castilla y Le\u00f3n","doi-asserted-by":"crossref","award":["VA081G18"],"award-info":[{"award-number":["VA081G18"]}],"id":[{"id":"10.13039\/501100008431","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Biomed Eng"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s10439-020-02702-x","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T21:03:43Z","timestamp":1609880623000},"page":"1507-1520","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Boundary-Condition Analysis of an Idealized Left Atrium Model"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6570-6624","authenticated-orcid":false,"given":"Jorge","family":"Due\u00f1as-Pamplona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1565-9337","authenticated-orcid":false,"given":"Jos\u00e9","family":"Sierra-Pallares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2986-7228","authenticated-orcid":false,"given":"Javier","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7038-7517","authenticated-orcid":false,"given":"Francisco","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-2438","authenticated-orcid":false,"given":"Jorge","family":"Munoz-Paniagua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"2702_CR1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3389\/fphys.2019.00237","volume":"10","author":"AM Aguado","year":"2019","unstructured":"Aguado, A. M., A. L. Olivares, C. Yagu\u00eb, E. Silva, M. Nu\u00f1ez-Garci\u00e1, \u00c1. Fernandez-Quilez, J. Mill, I. Genua, D. Arzamendi, T. De Potter, X. Freixa, and O. Camara. In silico optimization of left atrial appendage occluder implantation using interactive and modeling tools. Front. Physiol. 10:237, 2019.","journal-title":"Front. Physiol."},{"key":"2702_CR2","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1136\/hrt.82.5.547","volume":"82","author":"NM Al-Saady","year":"1999","unstructured":"Al-Saady, N. M., O. A. Obel, and A. J. Camm. Left atrial appendage: structure, function, and role in thromboembolism. Heart 82:547\u2013554, 1999.","journal-title":"Heart"},{"key":"2702_CR3","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s10554-016-1044-4","volume":"33","author":"W Bai","year":"2017","unstructured":"Bai, W., Z. Chen, H. Tang, H. Wang, W. Cheng, and L. Rao. Assessment of the left atrial appendage structure and morphology: comparison of real-time three-dimensional transesophageal echocardiography and computed tomography. Int. J. Cardiovasc. Imaging 33:623\u2013633, 2017.","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"2702_CR4","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1146\/annurev-fluid-010814-014728","volume":"47","author":"J Bermejo","year":"2015","unstructured":"Bermejo, J., P. Mart\u00ednez-Legazpi, and J. C. del \u00c1lamo. The clinical assessment of intraventricular flows. Annu. Rev. Fluid Mech. 47:315\u2013342, 2015.","journal-title":"Annu. Rev. Fluid Mech."},{"key":"2702_CR5","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1161\/CIRCULATIONAHA.118.034187","volume":"138","author":"LD Biase","year":"2018","unstructured":"Biase, L. D., A. Natale, and J. Romero. Thrombogenic and arrhythmogenic roles of the left atrial appendage in atrial fibrillation clinical implications. Circulation 138:2036\u20132050, 2018.","journal-title":"Circulation"},{"key":"2702_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcvm.2018.00034","volume":"5","author":"GM Bosi","year":"2018","unstructured":"Bosi, G. M., A. Cook, R. Rai, L. J. Menezes, S. Schievano, R. Torii, and G. Burriesci. Computational fluid dynamic analysis of the left atrial appendage to predict thrombosis risk. Front. Cardiovasc. Med. 5:1\u20138, 2018.","journal-title":"Front. Cardiovasc. Med."},{"key":"2702_CR7","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1007\/s00348-011-1042-1","volume":"50","author":"NA Buchmann","year":"2011","unstructured":"Buchmann, N. A., C. Atkinson, M. C. Jeremy, and J. Soria. Tomographic particle image velocimetry investigation of the flow in a modeled human carotid artery bifurcation. Exp. Fluids 50:1131\u20131151, 2011.","journal-title":"Exp. Fluids"},{"key":"2702_CR8","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1161\/01.CIR.0000132470.78896.A8","volume":"109","author":"Y-M Cha","year":"2004","unstructured":"Cha, Y.-M., M. M. Redfield, W.-K. Shen, and B. J. Gersh. Atrial fibrillation and ventricular dysfunction: a vicious electromechanical cycle. Circulation 109:2839\u20132843, 2004.","journal-title":"Circulation"},{"key":"2702_CR9","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.pcad.2017.04.003","volume":"59","author":"A Chanda","year":"2017","unstructured":"Chanda, A. and J. P. Reilly. Left atrial appendage occlusion for stroke prevention. Prog. Cardiovasc. Dis. 59:626\u2013635, 2017.","journal-title":"Prog. Cardiovasc. Dis."},{"key":"2702_CR10","doi-asserted-by":"crossref","unstructured":"Charonko, J. J., P. P. Vlachos. Estimation of uncertainty bounds for individual particle image velocimetry measurements from cross-correlation peak ratio. Meas. Sci. Technol. 24, 2013.","DOI":"10.1088\/0957-0233\/24\/6\/065301"},{"key":"2702_CR11","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.compfluid.2014.01.030","volume":"94","author":"C Chnafa","year":"2014","unstructured":"Chnafa, C., S. Mendez, and F. Nicoud. Image-based large-eddy simulation in a realistic left heart. Comput. Fluids 94:173\u2013187, 2014.","journal-title":"Comput. Fluids"},{"key":"2702_CR12","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ijcard.2008.11.055","volume":"140","author":"L Christiaens","year":"2010","unstructured":"Christiaens, L., N. Varroud-Vial, P. Ardilouze, S. Ragot, J. Mergy, B. Bonnet, D. Herpin, and J. Allal. Real three-dimensional assessment of left atrial and left atrial appendage volumes by 64-slice spiral computed tomography in individuals with or without cardiovascular disease. Int. J. Cardiol. 140:189\u2013196, 2010.","journal-title":"Int. J. Cardiol."},{"key":"2702_CR13","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s13239-012-0099-1","volume":"3","author":"SK Dahl","year":"2012","unstructured":"Dahl, S. K., E. Thomassen, L. R. Hellevik, and B. Skallerud. Impact of Pulmonary Venous Locations on the Intra-Atrial Flow and the Mitral Valve Plane Velocity Profile. Cardiovasc. Eng. Technol. 3:269\u2013281, 2012.","journal-title":"Cardiovasc. Eng. Technol."},{"key":"2702_CR14","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.jacc.2012.04.032","volume":"60","author":"L Di Biase","year":"2012","unstructured":"Di Biase, L., P.\u00a0Santangeli, M.\u00a0Anselmino, P.\u00a0Mohanty, I.\u00a0Salvetti, S.\u00a0Gili, R.\u00a0Horton, J.\u00a0E. Sanchez, R.\u00a0Bai, S.\u00a0Mohanty, A.\u00a0Pump, M.\u00a0CerecedaBrantes, G.\u00a0J. Gallinghouse, J.\u00a0D. Burkhardt, F.\u00a0Cesarani, M.\u00a0Scaglione, A.\u00a0Natale, and F.\u00a0Gaita. Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study. J. Am. Coll. Cardiol. 60:531\u2013538, 2012.","journal-title":"J. Am. Coll. Cardiol."},{"key":"2702_CR15","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1136\/heart.86.4.448","volume":"86","author":"A Fyrenius","year":"2001","unstructured":"Fyrenius, A., L. Wigstr\u00f6m, T. Ebbers, M. Karlsson, J. Engvall, and A. F. Bolger. Three dimensional flow in the human left atrium. Heart 86:448\u2013455, 2001.","journal-title":"Heart"},{"key":"2702_CR16","doi-asserted-by":"publisher","first-page":"e3100","DOI":"10.1002\/cnm.3100","volume":"34","author":"G Garc\u00eda-Isla","year":"2018","unstructured":"Garc\u00eda-Isla, G., A. L. Olivares, E. Silva, M. Nu\u00f1ez-Garcia, C. Butakoff, D. Sanchez-Quintana, H. G. Morales, X. Freixa, J. Noailly, T. De Potter, and O. Camara. Sensitivity analysis of geometrical parameters to study haemodynamics and thrombus formation in the left atrial appendage. Int. J. Numer. Methods Biomed. Eng. 34:e3100, 2018.","journal-title":"Int. J. Numer. Methods Biomed. Eng."},{"key":"2702_CR17","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","volume":"285","author":"AS Go","year":"2001","unstructured":"Go, A. S., E. M. Hylek, K. A. Phillips, Y. Chang, L. E. Henault, J. V. Selby, and D. E. Singer. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the anticoagulation and risk factors in atrial fibrillation study. JAMA 285:2370\u20132375, 2001.","journal-title":"JAMA"},{"key":"2702_CR18","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jacc.2013.08.1631","volume":"63","author":"DR Holmes","year":"2014","unstructured":"Holmes, D. R., D. R. Lakkireddy, R. P. Whitlock, R. Waksman, and M. J. Mack. Left atrial appendage occlusion: opportunities and challenges. J. Am. Coll. Cardiol. 63:291\u2013298, 2014.","journal-title":"J. Am. Coll. Cardiol."},{"key":"2702_CR19","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s10439-018-02153-5","volume":"47","author":"J Lantz","year":"2019","unstructured":"Lantz, J., V. Gupta, L. Henriksson, M. Karlsson, A. Persson, C. J. Carlh\u00e4ll, and T. Ebbers. Impact of pulmonary venous inflow on cardiac flow simulations: comparison with in vivo 4D Flow MRI. Ann. Biomed. Eng. 47:413\u2013424, 2019.","journal-title":"Ann. Biomed. Eng."},{"key":"2702_CR20","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.amjcard.2017.06.005","volume":"120","author":"GY Lip","year":"2017","unstructured":"Lip, G. Y., N. Al-Saady, J. Jin, M. Sun, M. Melino, S. M. Winters, D. Zamoryakhin, and A. Goette. Anticoagulation control in warfarin-treated patients undergoing cardioversion of atrial fibrillation (from the edoxaban versus enoxaparin-warfarin in patients undergoing cardioversion of atrial fibrillation trial). Am. J. Cardiol. 120:792\u2013796, 2017.","journal-title":"Am. J. Cardiol."},{"key":"2702_CR21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1006\/jtbi.1997.0564","volume":"191","author":"C Loudon","year":"1998","unstructured":"Loudon, C. and A. Tordesillas. The use of the dimensionless Womersley number to characterize the unsteady nature of internal flow. J. Theor. Biol. 191:63\u201378, 1998.","journal-title":"J. Theor. Biol."},{"key":"2702_CR22","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/j.hrthm.2016.03.042","volume":"13","author":"F Lupercio","year":"2016","unstructured":"Lupercio, F., J.\u00a0CarlosRuiz, D.\u00a0F. Briceno, J.\u00a0Romero, P.\u00a0A. Villablanca, C.\u00a0Berardi, R.\u00a0Faillace, A.\u00a0Krumerman, J.\u00a0D. Fisher, K.\u00a0Ferrick, M.\u00a0Garcia, A.\u00a0Natale, and L.\u00a0Di Biase. Left atrial appendage morphology assessment for risk stratification of embolic stroke in patients with atrial fibrillation: a meta-analysis. Heart Rhythm 13:1402\u20131409, 2016.","journal-title":"Heart Rhythm"},{"key":"2702_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2018.01938","volume":"9","author":"A Masci","year":"2019","unstructured":"Masci, A., L. Barone, L. Ded\u00e8, M. Fedele, C. Tomasi, A. Quarteroni, and C. Corsi. The impact of left atrium appendage morphology on stroke risk assessment in atrial fibrillation: a computational fluid dynamics study. Front. Physiol. 9:1\u201311, 2019.","journal-title":"Front. Physiol."},{"key":"2702_CR24","doi-asserted-by":"publisher","first-page":"3284","DOI":"10.1007\/s10439-016-1590-x","volume":"44","author":"T Otani","year":"2016","unstructured":"Otani, T., A. Al-Issa, A. Pourmorteza, E. R. McVeigh, S. Wada, and H. Ashikaga. A computational framework for personalized blood flow analysis in the human left atrium. Ann. Biomed. Eng. 44:3284\u20133294, 2016.","journal-title":"Ann. Biomed. Eng."},{"key":"2702_CR25","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1002\/cphy.c140047","volume":"5","author":"J Pellman","year":"2015","unstructured":"Pellman, J. and F. Sheikh. Atrial fibrillation: mechanisms, therapeutics, and future directions. Compr. Physiol. 5:649\u2013665, 2015.","journal-title":"Compr. Physiol."},{"key":"2702_CR26","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1161\/CIRCULATIONAHA.112.000920","volume":"127","author":"SM Singh","year":"2013","unstructured":"Singh, S. M., A. Micieli, and H. C. Wijeysundera. Economic evaluation of percutaneous left atrial appendage occlusion, dabigatran, and warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. Circulation 127:2414\u20132423, 2013.","journal-title":"Circulation"},{"key":"2702_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1115\/1.4031487","volume":"137","author":"V Vedula","year":"2015","unstructured":"Vedula, V., R. George, L. Younes, and R. Mittal. Hemodynamics in the left atrium and its effect on ventricular flow patterns. J. Biomech. Eng. 137:1\u20138, 2015.","journal-title":"J. Biomech. Eng."},{"key":"2702_CR28","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/BF00190388","volume":"10","author":"CE Willert","year":"1991","unstructured":"Willert, C. E. and M. Gharib. Digital particle image velocimetry. Exp. Fluids 10:181\u2013193, 1991.","journal-title":"Exp. Fluids"},{"key":"2702_CR29","doi-asserted-by":"publisher","first-page":"742","DOI":"10.3389\/fphys.2018.00742","volume":"9","author":"L Zhong","year":"2018","unstructured":"Zhong, L., J. M. Zhang, B. Su, R. S. Tan, J. C. Allen, and G. S. Kassab. Application of patient-specific computational fluid dynamics in coronary and intra-cardiac flow simulations: challenges and opportunities. Front. Physiol. 9:742, 2018.","journal-title":"Front. Physiol."}],"container-title":["Annals of Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-020-02702-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10439-020-02702-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-020-02702-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T17:11:11Z","timestamp":1621530671000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10439-020-02702-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2702"],"URL":"https:\/\/doi.org\/10.1007\/s10439-020-02702-x","relation":{},"ISSN":["0090-6964","1573-9686"],"issn-type":[{"value":"0090-6964","type":"print"},{"value":"1573-9686","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,5]]},"assertion":[{"value":"22 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}