{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:46:51Z","timestamp":1792082811644,"version":"4.4.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","award":["IP-2014-09-3752"],"award-info":[{"award-number":["IP-2014-09-3752"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["681103"],"award-info":[{"award-number":["681103"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Biomed Eng"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s10439-020-02712-9","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T21:09:24Z","timestamp":1609967364000},"page":"1572-1586","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of Chitosan-Based Scaffolds Seeded with Sheep Nasal Chondrocytes for Cartilage Tissue Engineering"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-331X","authenticated-orcid":false,"given":"Anamarija","family":"Rogina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Pu\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucija","family":"\u0160tefan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Ivkovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Urli\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marica","family":"Ivankovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrvoje","family":"Ivankovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"issue":"9","key":"2712_CR1","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1002\/term.372","volume":"5","author":"ML Alves da Silva","year":"2011","unstructured":"Alves da Silva, M. L., A. Martins, A. R. Costa-Pinto, V. M. Correlo, P. Sol, M. Bhattacharya, S. Faria, R. L. Reis, and N. M. Neves. Chondrogenic differentiation of human bone marrow mesenchymal stem cells in chitosan-based scaffolds using a flow-perfusion bioreactor. J. Tissue. Eng. Regen. Med. 5(9):722\u2013732, 2011.","journal-title":"J. Tissue. Eng. Regen. Med."},{"issue":"3","key":"2712_CR2","doi-asserted-by":"publisher","first-page":"5643","DOI":"10.1016\/j.actbio.2012.10.029","volume":"9","author":"IF Amaral","year":"2013","unstructured":"Amaral, I. F., I. Neiva, F. Ferreira da Silva, S. R. Sousa, A. M. Piloto, C. D. F. Lopes, M. A. Barbosa, C. J. Kirkpatrick, and A. P. Pego. Endothelialization of chitosan porous conduits via immobilization of a recombinant fibronectin fragment (rhFNIII7-10). Acta Biomater. 9(3):5643\u20135652, 2013.","journal-title":"Acta Biomater."},{"issue":"2","key":"2712_CR3","doi-asserted-by":"publisher","first-page":"e24791","DOI":"10.4161\/biom.24791","volume":"3","author":"IF Amaral","year":"2013","unstructured":"Amaral, I. F., S. R. Sousa, I. Neiva, L. Marcos-Silva, C. J. Kirkpatrick, M. A. Barbosa, and A. P. Pego. Kinetics and isotherm of fibronectin adsorption to three-dimensional porous chitosan scaffolds explored by 125I-radiolabelling. Biomatter. 3(2):e24791, 2013.","journal-title":"Biomatter."},{"issue":"29","key":"2712_CR4","doi-asserted-by":"publisher","first-page":"5465","DOI":"10.1016\/j.biomaterials.2009.06.056","volume":"30","author":"IF Amaral","year":"2009","unstructured":"Amaral, I. F., R. E. Unger, S. Fuchs, A. M. Mendonca, S. R. Sousa, M. A. Barbosa, A. P. Pego, and C. J. Kirkpatrick. Fibronectin-mediated endothelialisation of chitosan porous matrices. Biomaterials. 30(29):5465\u20135475, 2009.","journal-title":"Biomaterials."},{"issue":"7","key":"2712_CR5","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1007\/s10439-020-02522-z","volume":"48","author":"D Barati","year":"2020","unstructured":"Barati, D., C. Gegg, and F. Yang. Nanoparticle-mediated TGF-\u03b2 release from microribbon-based hydrogels accelerates stem cell-based cartilage formation in vivo. Ann. Biomed. Eng. 48(7):1971\u20131981, 2020.","journal-title":"Ann. Biomed. Eng."},{"issue":"25","key":"2712_CR6","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.1016\/j.biomaterials.2011.04.061","volume":"32","author":"N Bhardwaj","year":"2011","unstructured":"Bhardwaj, N., Q. T. Nguyen, A. C. Chen, D. L. Kaplan, R. L. Sah, and S. C. Kundu. Potential of 3-D tissue constructs engineered from bovine chondrocytes\/silk fibroin-chitosan for in vitro cartilage tissue engineering. Biomaterials. 32(25):5773\u20135781, 2011.","journal-title":"Biomaterials."},{"key":"2712_CR7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/1097-4636(200107)56:1<74::AID-JBM1070>3.0.CO;2-M","volume":"56","author":"RS Bhati","year":"2001","unstructured":"Bhati, R. S., D. P. Mukherjee, K. J. McCarty, S. H. Rogers, D. F. Smith, and S. W. Shalaby. The growth of chondrocytes into a fibronectin-coated biodegradable scaffold. J. Biomed. Mater. Res. 56:74\u201382, 2001.","journal-title":"J. Biomed. Mater. Res."},{"issue":"3","key":"2712_CR8","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s10616-015-9895-4","volume":"68","author":"I Bru\u017eauskaite","year":"2016","unstructured":"Bru\u017eauskaite, I., D. Bironaite, E. Bagdonas, and E. Bernontiene. Scaffolds and cells for tissue regeneration: different scaffold pore sizes\u2013different cell effects. Cytotechnology. 68(3):355\u2013369, 2016.","journal-title":"Cytotechnology."},{"issue":"10","key":"2712_CR9","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.joca.2012.06.016","volume":"20","author":"MM Caron","year":"2012","unstructured":"Caron, M. M., P. J. Emans, M. M. Coolsen, L. Voss, D. A. M. Surtel, A. Cremers, L. W. van Rhijn, and T. J. M. Weltin. Redifferentiation of dedifferentiated human articular chondrocytes: comparison of 2D and 3D cultures. Osteoarthritis Cartilage. 20(10):1170\u20131178, 2012.","journal-title":"Osteoarthritis Cartilage."},{"issue":"1","key":"2712_CR10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1089\/ten.teb.2018.0119","volume":"25","author":"A Cheng","year":"2019","unstructured":"Cheng, A., Z. Schwartz, A. Kahn, X. Li, Z. Shao, M. Sun, Y. Ao, B. D. Boyan, and H. Chen. Advances in porous scaffold design for bone and cartilage tissue engineering and regeneration. Tissue Eng. Part B 25(1):14\u201329, 2019.","journal-title":"Tissue Eng. Part B"},{"issue":"7","key":"2712_CR11","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1089\/ten.tec.2010.0467","volume":"17","author":"CR Correia","year":"2011","unstructured":"Correia, C. R., L. S. Moreira-Teixeira, L. Moroni, R. L. Reis, C. A. van Blitterswijk, M. Karperien, and J. F. Mano. Chitosan scaffolds containing hyaluronic acid for cartilage tissue engineering. Tissue Eng Part C Methods. 17(7):717\u2013730, 2011.","journal-title":"Tissue Eng Part C Methods."},{"issue":"4","key":"2712_CR12","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/term.248","volume":"4","author":"CA Cust\u00f3dio","year":"2010","unstructured":"Cust\u00f3dio, C. A., C. M. Alves, R. L. Reis, and J. F. Mano. Immobilization of fibronectin in chitosan substrates improves cell adhesion and proliferation. J. Tissue. Eng. Regen. Med. 4(4):316\u2013323, 2010.","journal-title":"J. Tissue. Eng. Regen. Med."},{"key":"2712_CR13","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s10439-019-02348-4","volume":"1","author":"L De Moor","year":"2020","unstructured":"De Moor, L., E. Beyls, and H. Declercq. Scaffold free microtissue formation for enhanced cartilage repair. Ann. Biomed. Eng. 1:298\u2013311, 2020.","journal-title":"Ann. Biomed. Eng."},{"key":"2712_CR14","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1177\/0885328209355332","volume":"25","author":"R El-Ayoubi","year":"2011","unstructured":"El-Ayoubi, R., C. DeGrandpr\u00e9, R. Di Raddo, and A. M. Yousefi. Design and dynamic culture of 3D-scaffolds for cartilage tissue engineering. J. Biomater. Appl. 25:429\u2013444, 2011.","journal-title":"J. Biomater. Appl."},{"issue":"4","key":"2712_CR15","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S1063-4584(05)80075-5","volume":"2","author":"A Frazer","year":"1994","unstructured":"Frazer, A., R. A. Bunning, M. Thavarajah, J. M. Seid, and R. G. Russell. Studies on type II collagen and aggrecan production in human articular chondrocytes in vitro and effects of transforming growth factor-beta and interleukin-1beta. Osteoarthritis Cartilage. 2(4):235\u2013245, 1994.","journal-title":"Osteoarthritis Cartilage."},{"issue":"5","key":"2712_CR16","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1039\/c2ib00139j","volume":"4","author":"C Gonz\u00e1lez-Garc\u00eda","year":"2012","unstructured":"Gonz\u00e1lez-Garc\u00eda, C., D. Moratal, R. O. Oreffo, M. J. Dalby, and M. Salmer\u00f3n-S\u00e1nchez. Surface mobility regulates skeletal stem cell differentiation. Integr. Biol. (Camb) 4(5):531\u2013539, 2012.","journal-title":"Integr. Biol. (Camb)"},{"key":"2712_CR17","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.actbio.2005.12.007","volume":"2","author":"DJ Griffon","year":"2006","unstructured":"Griffon, D. J., M. R. Sedighi, D. V. Schaeffer, J. A. Eurell, and A. L. Johnson. Chitosan scaffolds: interconnective pore size and cartilage engineering. Acta Biomater. 2:313\u2013320, 2006.","journal-title":"Acta Biomater."},{"issue":"9","key":"2712_CR18","doi-asserted-by":"publisher","first-page":"4888","DOI":"10.1016\/S0021-9258(18)34609-X","volume":"257","author":"F Grinnell","year":"1982","unstructured":"Grinnell, F., and M. K. Feld. Fibronectin adsorption on hydrophilic and hydrophobic surfaces detected by antibody binding and analyzed during cell adhesion in serum-containing medium. J. Biol. Chem. 257(9):4888\u20134893, 1982.","journal-title":"J. Biol. Chem."},{"issue":"23\u201324","key":"2712_CR19","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.1089\/ten.tea.2013.0702","volume":"20","author":"A Gupta","year":"2014","unstructured":"Gupta, A., S. Bhat, P. R. Jagdale, B. P. Chaudhari, L. Lidgren, K. C. Gupta, and A. Kumar. Evaluation of three-dimensional chitosan-agarose-gelatin cryogel scaffold for the repair of subchondral cartilage defects: an in vivo study in a rabbit model. Tissue Eng Part A. 20(23\u201324):3101\u20133111, 2014.","journal-title":"Tissue Eng Part A."},{"issue":"15","key":"2712_CR20","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1016\/j.carres.2007.06.009","volume":"342","author":"KC Gupta","year":"2007","unstructured":"Gupta, K. C., and F. H. Jabrail. Glutaraldehyde cross-linked chitosan microspheres for controlled release of centchroman. Carbohydr. Res. 342(15):2244\u20132252, 2007.","journal-title":"Carbohydr. Res."},{"key":"2712_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4236\/jbise.2012.51003","volume":"5","author":"T Han","year":"2012","unstructured":"Han, T., N. Nwe, T. Furuike, S. Tokura, and H. Tamura. Methods of N-acetylated chitosan scaffolds and its in vitro biodegradation by lysozyme. J. Biomed. Sci. Eng. 5:15\u201323, 2012.","journal-title":"J. Biomed. Sci. Eng."},{"issue":"2","key":"2712_CR22","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.joca.2009.08.007","volume":"18","author":"T Hao","year":"2010","unstructured":"Hao, T., N. Wen, J. K. Cao, H. B. Wang, S. H. Lu, T. Liu, Q. X. Lin, C. M. Duan, and C. Y. Wang. The support of matrix accumulation and the promotion of sheep articular cartilage defects repair in vivo by chitosan hydrogels. Osteoarthritis Cartilage. 18(2):257\u2013265, 2010.","journal-title":"Osteoarthritis Cartilage."},{"issue":"1","key":"2712_CR23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1097\/00005537-200301000-00005","volume":"113","author":"MR Homicz","year":"2003","unstructured":"Homicz, M. R., S. H. Chia, B. L. Schumacher, K. Masuda, E. J. Thonar, R. L. Sah, and D. Watson. Human septal chondrocyte redifferentiation in alginate, polyglycolic acid scaffold, and monolayer culture. Laryngoscope. 113(1):25\u201332, 2003.","journal-title":"Laryngoscope."},{"key":"2712_CR24","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.carbpol.2013.04.073","volume":"97","author":"K Huanbutta","year":"2013","unstructured":"Huanbutta, K., K. Cheewatanakornkool, K. Terada, J. Nunthanid, and P. Sriamornsak. Impact of salt form and molecular weight of chitosan on swelling and drug release from chitosan matrix tablets. Carbohydr. Polym. 97:26\u201333, 2013.","journal-title":"Carbohydr. Polym."},{"issue":"18","key":"2712_CR25","doi-asserted-by":"publisher","first-page":"4487","DOI":"10.3390\/ijms20184487","volume":"20","author":"Y Huang","year":"2019","unstructured":"Huang, Y., D. Seitz, F. K\u00f6nig, P. E. M\u00fcller, V. Jansson, and R. M. Klar. Induction of articular chondrogenesis by chitosan\/hyaluronic-acid-based biomimetic matrices using human adipose-derived stem cells. Int. J. Mol. Sci. 20(18):4487, 2019.","journal-title":"Int. J. Mol. Sci."},{"key":"2712_CR26","first-page":"159","volume-title":"Chitosan based biomaterials","author":"JA Jennings","year":"2016","unstructured":"Jennings, J. A. Controlling chitosan degradation in vitro and in vivo\u201d. In: Chitosan based biomaterials, Vol. 1, edited by J. A. Jennings, and J. D. Bumgargner. Sawston: Woodhead, 2016, pp. 159\u2013182."},{"key":"2712_CR27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s13770-019-00231-w","volume":"17","author":"JH Jeon","year":"2020","unstructured":"Jeon, J. H., B. G. Yun, M. J. Lim, S. J. Kim, M. H. Lim, J. Y. Lim, S. H. Park, and S. W. Kim. Rapid cartilage regeneration of spheroids composed of human nasal septum-derived chondrocyte in rat osteochondral defect model. Tissue Eng. Regen. Med. 17:81\u201390, 2020.","journal-title":"Tissue Eng. Regen. Med."},{"key":"2712_CR28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/B978-0-12-396983-5.00005-3","volume-title":"Natural and Synthetic Biomedical Polymers","author":"T Jiang","year":"2014","unstructured":"Jiang, T., R. James, S. G. Kumbar, and C. T. Laurencin. Chitosan as a biomaterial: Structure, properties and applications in tissue engineering and drug delivery. In: Natural and Synthetic Biomedical Polymers, edited by G. Kumbar, C. T. Laurencin, and M. Deng. Amsterdam: Elsevier Science, 2014, pp. 91\u2013113."},{"issue":"5","key":"2712_CR29","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1089\/10763270260424178","volume":"8","author":"W Kafienah","year":"2002","unstructured":"Kafienah, W., M. Jakob, O. D\u00e9marteau, A. Frazer, M. D. Barker, I. Martin, and A. P. Hollander. Three-dimensional tissue engineering of hyaline cartilage: comparison of adult nasal and articular chondrocytes. Tissue Eng. 8(5):817\u2013826, 2002.","journal-title":"Tissue Eng."},{"issue":"6","key":"2712_CR30","doi-asserted-by":"publisher","first-page":"759","DOI":"10.2217\/rme.14.40","volume":"9","author":"RH Kalkreuth","year":"2014","unstructured":"Kalkreuth, R. H., J. P. Kr\u00fcger, S. Lau, P. Niemeyer, M. Endres, P. C. Kreuz, and C. Kaps. Fibronectin stimulates migration and proliferation, but not chondrogenic differentiation of human subchondral progenitor cells. Regen Med. 9(6):759\u2013773, 2014.","journal-title":"Regen Med."},{"issue":"1","key":"2712_CR31","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2009.09.004","volume":"62","author":"T Kean","year":"2010","unstructured":"Kean, T., and M. Thanou. Biodegradation, biodistribution and toxicity of chitosan. Adv. Drug. Deliv. Rev. 62(1):3\u201311, 2010.","journal-title":"Adv. Drug. Deliv. Rev."},{"issue":"4","key":"2712_CR32","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/term.2787","volume":"13","author":"JP Kruger","year":"2019","unstructured":"Kruger, J. P., S. Hondke, S. Lau, and M. Endres. Characterization of plasma fibronectin for migration, proliferation, and differentiation on human articular chondrocytes. Tissue Eng. Regen. Med. 13(4):537\u2013545, 2019.","journal-title":"Tissue Eng. Regen. Med."},{"key":"2712_CR33","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.reth.2020.03.014","volume":"14","author":"IC Lin","year":"2020","unstructured":"Lin, I. C., T. J. Wang, C. L. Wu, D. H. Lu, Y. R. Chen, and K. C. Yang. Chitosan-cartilage extracellular matrix hybrid scaffold induces chondrogenic differentiation to adipose-derived stem cells. Regen. Therapy. 14:238\u2013244, 2020.","journal-title":"Regen. Therapy."},{"issue":"8","key":"2712_CR34","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1002\/art.1780360811","volume":"36","author":"RF Loeser","year":"1993","unstructured":"Loeser, R. F. Integrin-mediated attachment of articular chondrocytes to extracellular matrix proteins. Arthritis Rheum. 36(8):1103\u20131110, 1993.","journal-title":"Arthritis Rheum."},{"key":"2712_CR35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.matbio.2014.08.007","volume":"39","author":"RF Loeser","year":"2014","unstructured":"Loeser, R. F. Integrins and chondrocyte-matrix interactions in articular cartilage. Matrix Biol. 39:11\u201316, 2014.","journal-title":"Matrix Biol."},{"issue":"3","key":"2712_CR36","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3727\/096368916X693464","volume":"26","author":"TJ Lu","year":"2017","unstructured":"Lu, T. J., F. Y. Chiu, H. Y. Chiu, M. C. Chang, and S. C. Hung. Chondrogenic differentiation of mesenchymal stem cells in three-dimensional chitosan film culture. Cell Transplant. 26(3):417\u2013427, 2017.","journal-title":"Cell Transplant."},{"issue":"1","key":"2712_CR37","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrrheum.2014.157","volume":"11","author":"EA Makris","year":"2015","unstructured":"Makris, E. A., A. H. Gomoll, K. N. Malizos, J. C. Hu, and K. A. Athanasiou. Repair and tissue engineering techniques for articular cartilage. Nat. Rev. Rheumatol. 11(1):21\u201334, 2015.","journal-title":"Nat. Rev. Rheumatol."},{"key":"2712_CR38","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.carbpol.2015.06.084","volume":"132","author":"A Mart\u00ednez","year":"2015","unstructured":"Mart\u00ednez, A., M. D. Blanco, N. Davidenko, and R. E. Cameron. Tailoring chitosan\/collagen scaffolds for tissue engineering: effect of tissue composition and different crosslinking agents on scaffold properties. Carbohydr. Polym. 132:606\u2013619, 2015.","journal-title":"Carbohydr. Polym."},{"key":"2712_CR39","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1053\/j.otsm.2018.06.008","volume":"26","author":"G Merkely","year":"2018","unstructured":"Merkely, G., J. Ackermann, and C. Lattermann. Articular cartilage defects: incidence, diagnosis, and natural history. Oper. Tech. Sports Med. 26:156\u2013161, 2018.","journal-title":"Oper. Tech. Sports Med."},{"issue":"11","key":"2712_CR40","doi-asserted-by":"publisher","first-page":"7609","DOI":"10.1021\/acsomega.7b01303","volume":"2","author":"V Moulisov\u00e1","year":"2017","unstructured":"Moulisov\u00e1, V., S. Poveda-Reyes, E. Sanmart\u00edn-Masi\u00e1, L. Quintanilla-Sierra, M. Salmer\u00f3n-S\u00e1nchez, and G. GallegoFerrer. Hybrid protein-glycosaminoglycan hydrogels promote chondrogenic stem cell differentiation. ACS Omega. 2(11):7609\u20137620, 2017.","journal-title":"ACS Omega."},{"issue":"10055","key":"2712_CR41","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1016\/S0140-6736(16)31658-0","volume":"388","author":"M Mumme","year":"2016","unstructured":"Mumme, M., A. Barbero, S. Miot, A. Wixmerten, S. Feliciano, F. Wolf, A. M. Asnaghi, D. Baumhoer, O. Bieri, M. Kretzschmar, G. Pagenstert, M. Haug, D. J. Schaefer, I. Martin, and M. Jakob. Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial. Lancet. 388(10055):1985\u20131994, 2016.","journal-title":"Lancet."},{"issue":"21\u201322","key":"2712_CR42","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1089\/ten.tea.2016.0159","volume":"22","author":"M Mumme","year":"2016","unstructured":"Mumme, M., A. Steinitz, K. M. Nuss, K. Klein, S. Feliciano, P. Kronen, M. Jakob, B. von Rechenberg, I. Martin, A. Barbero, and K. Pelttari. Regenerative potential of tissue-engineered nasal chondrocytes in goat articular cartilage defects. Tissue Eng. Part. A. 22(21\u201322):1286\u20131295, 2016.","journal-title":"Tissue Eng. Part. A."},{"issue":"2","key":"2712_CR43","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.carbpol.2008.11.002","volume":"76","author":"RAA Muzzarelli","year":"2009","unstructured":"Muzzarelli, R. A. A. Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone. Carbohydr. Polym. 76(2):167\u2013182, 2009.","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"2712_CR44","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2500\/105065898782102972","volume":"12","author":"A Naumann","year":"1998","unstructured":"Naumann, A., N. Rotter, J. Buj\u00eda, and J. Aigner. Tissue engineering of autologous cartilage transplants for rhinology. Am J Rhinol. 12(1):59\u201363, 1998.","journal-title":"Am J Rhinol."},{"issue":"3","key":"2712_CR45","first-page":"223","volume":"14","author":"MM Nava","year":"2016","unstructured":"Nava, M. M., L. Draghi, C. Giordano, and R. Pietrabissa. The effect of scaffold pore size in cartilage tissue engineering. J. Appl. Biomater. Func. Mater. 14(3):223\u2013229, 2016.","journal-title":"J. Appl. Biomater. Func. Mater."},{"issue":"4","key":"2712_CR46","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1002\/jbm.a.32909","volume":"95","author":"A Ode","year":"2010","unstructured":"Ode, A., G. N. Duda, J. D. Glaeser, G. Matziolis, S. Frauenschuh, C. Perka, C. J. Wilson, and G. Kasper. Toward biomimetic materials in bone regeneration: functional behavior of mesenchymal stem cells on a broad spectrum of extracellular matrix components. J. Biomed. Mater. Res. A. 95(4):1114\u20131124, 2010.","journal-title":"J. Biomed. Mater. Res. A."},{"key":"2712_CR47","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1016\/j.carres.2005.07.022","volume":"340","author":"D Ren","year":"2005","unstructured":"Ren, D., H. Yi, W. Wang, and X. Ma. The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation. Carbohydr. Res. 340:2403\u20132410, 2005.","journal-title":"Carbohydr. Res."},{"key":"2712_CR48","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.carbpol.2018.06.029","volume":"197","author":"A Ressler","year":"2018","unstructured":"Ressler, A., J. R\u00f3denas-Rochina, M. Ivankovi\u0107, H. Ivankovi\u0107, A. Rogina, and G. Gallego Ferrer. Injectable chitosan-hydroxyapatite hydrogels promote the osteogenic differentiation of mesenchymal stem cells. Carbohydr. Polym. 197:469\u2013477, 2018.","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"2712_CR49","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1007\/s10439-019-02381-3","volume":"48","author":"A Rouhollahi","year":"2020","unstructured":"Rouhollahi, A., O. Ilegbusi, S. Florczyk, K. Xu, and H. Foroosh. Effect of mold geometry on pore size in freeze-cast chitosan-alginate scaffolds for tissue engineering. Ann. Biomed. Eng. 48(3):1090\u20131102, 2020.","journal-title":"Ann. Biomed. Eng."},{"issue":"1","key":"2712_CR50","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/BF00047692","volume":"3","author":"E Ruoslahti","year":"1984","unstructured":"Ruoslahti, E. Fibronectin in cell adhesion and invasion. Cancer Metastasis Rev. 3(1):43\u201351, 1984.","journal-title":"Cancer Metastasis Rev."},{"issue":"8","key":"2712_CR51","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1016\/j.biomaterials.2010.11.057","volume":"32","author":"M Salmer\u00f3n-S\u00e1nchez","year":"2011","unstructured":"Salmer\u00f3n-S\u00e1nchez, M., P. Rico, D. Moratal, T. T. Lee, J. E. Schwarzbauer, and A. J. Garc\u00eda. Role of material-driven fibronectin fibrillogenesis in cell differentiation. Biomaterials. 32(8):2099\u20132105, 2011.","journal-title":"Biomaterials."},{"key":"2712_CR52","doi-asserted-by":"publisher","first-page":"5246584","DOI":"10.1155\/2016\/5246584","volume":"2016","author":"D Salzig","year":"2016","unstructured":"Salzig, D., J. Leber, K. Merkewitz, M. C. Lange, N. K\u00f6ster, and P. Czermak. Attachment, growth, and detachment of human mesenchymal stem cells in a chemically defined medium. Stem Cells International. 2016:5246584, 2016.","journal-title":"Stem Cells International."},{"key":"2712_CR53","first-page":"1","volume-title":"Biological Interactions on Materials Surfaces: Understanding and Controlling Protein, Cell, and Tissue Responses","author":"DR Schmidt","year":"2009","unstructured":"Schmidt, D. R., H. Waldbeck, and W. J. Kao. Protein adsorption to biomaterials. In: Biological Interactions on Materials Surfaces: Understanding and Controlling Protein, Cell, and Tissue Responses, edited by D. A. Puleo, and R. Bizios. New York: Springer, 2009, pp. 1\u201318."},{"issue":"3\u20134","key":"2712_CR54","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1089\/ten.tea.2011.0234","volume":"18","author":"C Scotti","year":"2012","unstructured":"Scotti, C., A. Osmokrovic, F. Wolf, S. Miot, G. M. Peretti, A. Barbero, and I. Martin. Response of human engineered cartilage based on articular or nasal chondrocytes to interleukin-1\u03b2 and low oxygen. Tissue Eng Part A. 18(3\u20134):362\u2013372, 2012.","journal-title":"Tissue Eng Part A."},{"key":"2712_CR55","doi-asserted-by":"publisher","first-page":"100215","DOI":"10.1016\/j.bcdf.2020.100215","volume":"22","author":"F Sharifi","year":"2020","unstructured":"Sharifi, F., S. Irani, G. Azadegan, M. Pezeshki-Modaress, M. Zandi, and M. Saeed. Co-electrospun gelatin-chondroitin sulfate\/polycaprolactone nanofibrous scaffolds for cartilage tissue engineering. Bioact. Carbohydr. Diet. Fibre 22:100215, 2020.","journal-title":"Bioact. Carbohydr. Diet. Fibre"},{"issue":"3","key":"2712_CR56","doi-asserted-by":"publisher","first-page":"206","DOI":"10.2174\/187794680503160223163623","volume":"5","author":"DS Silva","year":"2016","unstructured":"Silva, D. S., J. A. M. Delezuk, F. A. La Porta, E. Longo, and S. P. Campana-Filho. Comparison of experimental and theoretical data on the structural and electronic characterization of chitin and chitosan. Curr. Phys. Chem. 5(3):206\u2013213, 2016.","journal-title":"Curr. Phys. Chem."},{"issue":"24","key":"2712_CR57","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.1016\/S0142-9612(00)00126-5","volume":"21","author":"JK Suh","year":"2000","unstructured":"Suh, J. K., and H. W. Matthew. Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. Biomaterials. 21(24):2589\u20132598, 2000.","journal-title":"Biomaterials."},{"key":"2712_CR58","doi-asserted-by":"publisher","first-page":"9310318","DOI":"10.1155\/2019\/9310318","volume":"2019","author":"I Ta\u00efhi","year":"2019","unstructured":"Ta\u00efhi, I., A. Nassif, J. Isaac, B. P. Fournier, and F. Ferr\u00e9. Head to knee: cranial neural crest-derived cells as promising candidates for human cartilage repair. Stem Cells Int. 2019:9310318, 2019.","journal-title":"Stem Cells Int."},{"issue":"13\u201314","key":"2712_CR59","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1089\/ten.tea.2017.0322","volume":"24","author":"T Tao","year":"2018","unstructured":"Tao, T., Y. Li, C. Gui, Y. Ma, Y. Ge, H. Dai, K. Zhang, J. Du, Y. Gao, Y. Jiang, and J. Gui. Fibronectin enhances cartilage repair by activating progenitor cells through integrin \u03b15\u03b21 receptor. Tissue Eng. Part. A. 24(13\u201314):1112\u20131124, 2018.","journal-title":"Tissue Eng. Part. A."},{"issue":"12","key":"2712_CR60","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1002\/sctm.17-0181","volume":"6","author":"F Taraballi","year":"2017","unstructured":"Taraballi, F., G. Bauza, P. McCulloch, J. Harris, and E. Tasciotti. Concise review: biomimetic functionalization of biomaterials to stimulate the endogenous healing process of cartilage and bone tissue. Stem Cells Transl. Med. 6(12):2186\u20132196, 2017.","journal-title":"Stem Cells Transl. Med."},{"issue":"10","key":"2712_CR61","doi-asserted-by":"publisher","first-page":"e109568","DOI":"10.1371\/journal.pone.0109568","volume":"9","author":"MM Villa","year":"2014","unstructured":"Villa, M. M., L. Wang, D. W. Rowe, and M. Wei. Effects of cell-attachment and extracellular matrix on bone formation in vivo in collagen-hydroxyapatite scaffolds. PLoS One. 9(10):e109568, 2014.","journal-title":"PLoS One."},{"issue":"4","key":"2712_CR62","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1002\/bit.22137","volume":"102","author":"C Vinatier","year":"2009","unstructured":"Vinatier, C., O. Gauthier, A. Fatimi, C. Merceron, M. Masson, A. Moreau, F. Moreau, B. Fellah, P. Weiss, and J. Guicheux. An injectable cellulose-based hydrogel for the transfer of autologous nasal chondrocytes in articular cartilage defects. Biotechnol. Bioeng. 102(4):1259\u20131267, 2009.","journal-title":"Biotechnol. Bioeng."},{"issue":"3","key":"2712_CR63","first-page":"586","volume":"81","author":"S Yamane","year":"2007","unstructured":"Yamane, S., N. Iwasaki, Y. Kasahara, K. Harada, T. Majima, K. Monde, S. Nishimura, and A. Minami. Effect of pore size on in vitro cartilage formation using chitosan-based hyaluronic acid hybrid polymer fibers. Journal of Medical Biomaterials Research: Part A 81(3):586\u2013593, 2007.","journal-title":"Journal of Medical Biomaterials Research: Part A"},{"key":"2712_CR64","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.msec.2015.06.046","volume":"56","author":"Q Yao","year":"2015","unstructured":"Yao, Q., W. Li, S. Yu, L. Ma, D. Jin, A. R. Boccaccini, and Y. Liu. Multifunctional chitosan\/polyvynil pyrrolidone\/45S5 Bioglass\u00ae scaffolds for MC3T3-E1 cell stimulation and drug release. Mater. Sci. Eng. C. 56:473\u2013480, 2015.","journal-title":"Mater. Sci. Eng. C."},{"issue":"1\u20132","key":"2712_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1615\/CritRevBiomedEng.v37.i1-2.10","volume":"37","author":"L Zhang","year":"2009","unstructured":"Zhang, L., J. Hu, and K. A. Athanasiou. The role of tissue engineering in articular cartilage repair and regeneration. Crit. Rev. Biomed. Eng. 37(1\u20132):1\u201357, 2009.","journal-title":"Crit. Rev. Biomed. Eng."}],"container-title":["Annals of Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-020-02712-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10439-020-02712-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-020-02712-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T20:54:00Z","timestamp":1674852840000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10439-020-02712-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,6]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2712"],"URL":"https:\/\/doi.org\/10.1007\/s10439-020-02712-9","relation":{},"ISSN":["0090-6964","1573-9686"],"issn-type":[{"value":"0090-6964","type":"print"},{"value":"1573-9686","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,6]]},"assertion":[{"value":"16 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}