{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:33:55Z","timestamp":1765233235722,"version":"3.37.3"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Biomed Eng"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s10439-021-02899-5","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:04:44Z","timestamp":1641513884000},"page":"29-38","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Influence of Valve Leaflet Stiffness Variability on Aortic Wall Shear Stress"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-1002","authenticated-orcid":false,"given":"Alexandros","family":"Rosakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morteza","family":"Gharib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"2899_CR1","first-page":"457","volume":"5","author":"AJ Barker","year":"2012","unstructured":"Barker, A. J., M. Markl, J. B\u00fcrk, R. Lorenz, J. Bock, S. Bauer, J. Schulz-Menger, and F. von Knobelsdorff-Brenkenhoff. Bicuspid aortic valve is associated with altered wall shear stress in the ascending aorta. Circulation. 5:457\u2013466, 2012","journal-title":"Circulation"},{"key":"2899_CR2","first-page":"e523","volume":"118","author":"RO Bonow","year":"2008","unstructured":"Bonow, R. O., B. A. Carabello, K. Chatterjee, A. C. de Leon, D. P. Faxon, M. D. Freed, W. H. Gaasch, B. W. Lytle, R. A. Nishimura, P. T. O\u2019Gara, R. A. O\u2019Rourke, C. M. Otto, P. M. Shah, and J. S. Shanewise. 2008 Focused update incorporated into the ACC\/AHA 2006 guidelines for the management of patients with valvular heart disease. Circulation. 118:e523\u2013e661, 2008","journal-title":"Circulation"},{"key":"2899_CR3","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jbiomech.2018.02.017","volume":"71","author":"GM Bosi","year":"2018","unstructured":"Bosi, G. M., C. Capelli, M. H. Cheang, N. Delahunty, M. Mullen, A. M. Taylor, and S. Schievano. Population-specific material properties of the implantation site for transcatheter aortic valve replacement finite element simulations. J. Biomech. 71:236\u2013244, 2018","journal-title":"J. Biomech."},{"key":"2899_CR4","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/s13239-017-0309-y","volume":"8","author":"M B\u00fcsen","year":"2017","unstructured":"B\u00fcsen, M., C. Arenz, M. Neidlin, S. Liao, T. Schmitz-Rode, U. Steinseifer, and S. J. Sonntag. Development of an in vitro PIV setup for preliminary investigation of the effects of aortic compliance on flow patterns and hemodynamics. Cardiovasc. Eng. Technol. 8:368\u2013377, 2017","journal-title":"Cardiovasc. Eng. Technol."},{"key":"2899_CR5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/labinvest.3700215","volume":"85","author":"KS Cunningham","year":"2005","unstructured":"Cunningham, K. S., and A. I. Gotlieb. The role of shear stress in the pathogenesis of atherosclerosis. Lab. Investig. 85:9\u201323, 2005","journal-title":"Lab. Investig."},{"key":"2899_CR6","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1097\/MAT.0000000000000107","volume":"60","author":"EM Groves","year":"2014","unstructured":"Groves, E. M., A. Falahatpisheh, J. L. Su, and A. Kheradvar. The effects of positioning of transcatheter aortic valves on fluid dynamics of the aortic root. ASAIO J. 60:545\u2013552, 2014","journal-title":"ASAIO J."},{"key":"2899_CR7","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1109\/JBHI.2014.2322934","volume":"18","author":"U G\u00fclan","year":"2014","unstructured":"G\u00fclan, U., B. L\u00fcthi, M. Holzner, A. Liberzon, A. Tsinober, and W. Kinzelbach. Experimental investigation of the influence of the aortic stiffness on hemodynamics in the ascending aorta. IEEE J. Biomed. Health Inf. 18:1775\u20131780, 2014","journal-title":"IEEE J. Biomed. Health Inf."},{"key":"2899_CR8","doi-asserted-by":"publisher","first-page":"2000032","DOI":"10.1002\/anbr.202000032","volume":"1","author":"C Jenney","year":"2021","unstructured":"Jenney, C., P. Millson, D. W. Grainger, R. Grubbs, P. Gunatillake, S. J. McCarthy, J. Runt, and J. Beith. Assessment of a siloxane poly(urethane-urea) elastomer designed for implantable heart valve leaflets. Adv. NanoBiomed Res. 1:2000032, 2021","journal-title":"Adv. NanoBiomed Res."},{"key":"2899_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/MAT.0000000000001296","volume":"67","author":"C-S Jhun","year":"2021","unstructured":"Jhun, C.-S., R. Newswanger, J. P. Cysyk, S. Ponnaluri, B. Good, K. B. Manning, and G. Rosenberg. Dynamics of blood flows in aortic stenosis: mild, moderate, and severe. ASAIO J. 67:1, 2021","journal-title":"ASAIO J."},{"key":"2899_CR10","doi-asserted-by":"publisher","first-page":"035017","DOI":"10.1088\/0960-1317\/24\/3\/035017","volume":"24","author":"ID Johnston","year":"2014","unstructured":"Johnston, I. D., D. K. McCluskey, C. K. L. Tan, and M. C. Tracey. Mechanical characterization of bulk Sylgard 184 for microfluidics and microengineering. J. Micromech. Microeng. 24:035017, 2014","journal-title":"J. Micromech. Microeng."},{"key":"2899_CR11","first-page":"1","volume":"142","author":"Q Li","year":"2019","unstructured":"Li, Q., F. Hegner, and C. H. Bruecker. Comparative study of wall-shear stress at the ascending aorta for different mechanical heart valve prostheses. J. Biomech. Eng. 142:1, 2019","journal-title":"J. Biomech. Eng."},{"key":"2899_CR12","first-page":"e003626","volume":"8","author":"D Maragiannis","year":"2015","unstructured":"Maragiannis, D., M. S. Jackson, S. R. Igo, R. C. Schutt, P. Connell, J. Grande-Allen, C. M. Barker, S. M. Chang, M. J. Reardon, W. A. Zoghbi, and S. H. Little. Replicating patient-specific severe aortic valve stenosis with functional 3D modeling. Circulation. 8:e003626, 2015","journal-title":"Circulation"},{"key":"2899_CR13","doi-asserted-by":"publisher","first-page":"rjz127","DOI":"10.1093\/jscr\/rjz127","volume":"2019","author":"H Nagamine","year":"2019","unstructured":"Nagamine, H., Y. Date, T. Takagi, and Y. Kawase. Ascending aortic aneurysm exposed to direct impingement of eccentric flow jets through a tilting-disc valve prosthesis. J. Surg. Case Rep. 2019:rjz127, 2019","journal-title":"J. Surg. Case Rep."},{"key":"2899_CR14","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4330\/wjc.v2.i6.135","volume":"2","author":"S Nathaniel","year":"2010","unstructured":"Nathaniel, S., S. Saligram, and A. L. Innasimuthu. Aortic stenosis: an update. World J. Cardiol. 2:135\u2013139, 2010","journal-title":"World J. Cardiol."},{"key":"2899_CR15","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1002\/jbm.a.34939","volume":"102","author":"T Pham","year":"2014","unstructured":"Pham, T., and W. Sun. Material properties of aged human mitral valve leaflets. J. Biomed. Mater. Res. A. 102:2692\u20132703, 2014","journal-title":"J. Biomed. Mater. Res. A"},{"key":"2899_CR16","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"CA Schneider","year":"2012","unstructured":"Schneider, C. A., W. S. Rasband, and K. W. Eliceiri. NIH image to ImageJ: 25 years of image analysis. Nature Methods. 9:671\u2013675, 2012","journal-title":"Nature Methods"},{"key":"2899_CR17","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.ejcts.2011.02.007","volume":"39","author":"H-H Sievers","year":"2011","unstructured":"Sievers, H.-H., and H. L. Sievers. Aortopathy in bicuspid aortic valve disease \u2014 genes or hemodynamics? Or Scylla and Charybdis? Eur. J. Cardio-Thorac. Surg. 39:803\u2013804, 2011","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"2899_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5334\/jors.bl","volume":"2","author":"W Thielicke","year":"2014","unstructured":"Thielicke, W., and E. J. Stamhuis. PIVlab \u2013 towards user-friendly, affordable and accurate digital particle image velocimetry in MATLAB. J. Open Res. Softw. 2:1, 2014","journal-title":"J. Open Res. Softw."},{"key":"2899_CR19","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1007\/s10439-016-1577-7","volume":"44","author":"K Vahidkhah","year":"2016","unstructured":"Vahidkhah, K., D. Cordasco, M. Abbasi, L. Ge, E. Tseng, P. Bagchi, and A. N. Azadani. Flow-induced damage to blood cells in aortic valve stenosis. Ann. Biomed. Eng. 44:2724\u20132736, 2016","journal-title":"Ann. Biomed. Eng."},{"key":"2899_CR20","doi-asserted-by":"crossref","first-page":"e005959","DOI":"10.1161\/JAHA.117.005959","volume":"6","author":"P van Ooij","year":"2021","unstructured":"van Ooij, P., M. Markl, J. D. Collins, J. C. Carr, C. Rigsby, R. O. Bonow, S. C. Malaisrie, P. M. McCarthy, P. W. M. Fedak, and A. J. Barker. Aortic valve stenosis alters expression of regional aortic wall shear stress: new insights from a 4-dimensional flow magnetic resonance imaging study of 571 subjects. J. Am. Heart Assoc. 6:e005959, 2021","journal-title":"J. Am. Heart Assoc."},{"key":"2899_CR21","first-page":"e004038","volume":"9","author":"F von Knobelsdorff-Brenkenhoff","year":"2016","unstructured":"von Knobelsdorff-Brenkenhoff, F., A. Karunaharamoorthy, R. F. Trauzeddel, A. J. Barker, E. Blaszczyk, M. Markl, and J. Schulz-Menger. Evaluation of aortic blood flow and wall shear stress in aortic stenosis and its association with left ventricular remodeling. Circulation. 9:e004038, 2016","journal-title":"Circulation"},{"key":"2899_CR22","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/BF00190388","volume":"10","author":"CE Willert","year":"1991","unstructured":"Willert, C. E., and M. Gharib. Digital particle image velocimetry. Exp. Fluids. 10:181\u2013193, 1991","journal-title":"Exp. Fluids"}],"container-title":["Annals of Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-021-02899-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10439-021-02899-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-021-02899-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T05:30:34Z","timestamp":1674365434000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10439-021-02899-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["2899"],"URL":"https:\/\/doi.org\/10.1007\/s10439-021-02899-5","relation":{},"ISSN":["0090-6964","1573-9686"],"issn-type":[{"type":"print","value":"0090-6964"},{"type":"electronic","value":"1573-9686"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"15 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}