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Because disease outcomes are thought to be influenced by haemodynamic quantities such as pressure and wall shear stress (WSS), their analysis\n                    <jats:italic>via<\/jats:italic>\n                    numerical simulations may provide valuable clinical insights. Major aortic branches are routinely included in simulations but minor branches are virtually always neglected, despite being implicated in TBAD progression and the development of complications. As minor branches are estimated to carry about 7\u201321% of cardiac output, neglecting them may affect simulation accuracy. We present the first simulation of TBAD with all pairs of intercostal, subcostal and lumbar arteries, using 4D-flow MRI (4DMR) to inform patient-specific boundary conditions. Compared to an equivalent\u00a0case without minor branches, their inclusion improved agreement with 4DMR velocities, reduced time-averaged WSS (TAWSS)\u00a0and transmural pressure and elevated oscillatory shear in regions where FL dilatation and calcification were observed\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\u00a0Minor branch inclusion\u00a0resulted in differences of 60-75% in these metrics of potential clinical relevance,  indicating a need to account for minor branch flow loss if simulation\u00a0accuracy  is sought.\n                  <\/jats:p>","DOI":"10.1007\/s10439-023-03175-4","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T16:03:58Z","timestamp":1679846638000},"page":"1627-1644","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The Influence of Minor Aortic Branches in Patient-Specific Flow Simulations of Type-B Aortic Dissection"],"prefix":"10.1007","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9112-9568","authenticated-orcid":false,"given":"C.","family":"Stokes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Haupt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Muthurangu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"von Tengg-Kobligk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Balabani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"D\u00edaz-Zuccarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"3175_CR1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s10237-020-01396-3","volume":"20","author":"M Andersson","year":"2021","unstructured":"Andersson, M., and M. 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