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Osseointegration is usually evaluated in vivo studies, which, however, do not reproduce the mechanically driven adaptation process. This study aims to develop an\n                    <jats:italic>in silico<\/jats:italic>\n                    model to predict implant osseointegration and the effect of induced micromotion on long-term stability, including a calibration of the material osteoinductivity with conventional in vivo studies. A Finite Element model of the tibia implanted with pins was generated, exploiting bone-to-implant contact measures of cylindrical titanium alloys implanted in rabbits\u2019 tibiae. The evolution of the contact status between bone and implant was modeled using a finite state machine, which updated the contact state at each iteration based on relative micromotion, shear and tensile stresses, and bone-to-implant distance. The model was calibrated with\n                    <jats:italic>in vivo<\/jats:italic>\n                    data by identifying the maximum bridgeable gap. Afterward, a push-out test was simulated to predict the axial load that caused the macroscopic mobilization of the pin. The bone-implant bridgeable gap ranged between 50\u00a0\u03bcm and 80\u00a0\u03bcm. Predicted push-out strength ranged from 19 N to 21 N (5.4\u00a0MPa\u20133.4\u00a0MPa) depending on final bone-to-implant contact. Push-out strength agrees with experimental measurements from a previous animal study (4\u2009\u00b1\u20091\u00a0MPa), carried out using the same implant material, coated, or uncoated. This method can partially replace\n                    <jats:italic>in vivo<\/jats:italic>\n                    studies and predict the long-term stability of cementless hip stems.\n                  <\/jats:p>","DOI":"10.1007\/s10439-024-03588-9","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T10:02:52Z","timestamp":1723197772000},"page":"34-47","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Calibration of Aseptic Loosening Simulation for Coatings Osteoinductive Effect"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6541-9914","authenticated-orcid":false,"given":"Sofia","family":"Baroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3111-2609","authenticated-orcid":false,"given":"Sara","family":"Oliviero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9927-2393","authenticated-orcid":false,"given":"Antonino Amedeo","family":"La Mattina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3778-4406","authenticated-orcid":false,"given":"Melania","family":"Maglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-4839","authenticated-orcid":false,"given":"Lucia","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3732-3570","authenticated-orcid":false,"given":"Milena","family":"Fini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-1530","authenticated-orcid":false,"given":"Marco","family":"Viceconti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"3588_CR1","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.joca.2014.04.009","volume":"22","author":"C Pabinger","year":"2014","unstructured":"Pabinger, C., and A. 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