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Aged (300 day-old) female wildtype (WT), <jats:italic>Dcn<\/jats:italic>\n            <jats:sup>\n              <jats:italic>flox\/flox<\/jats:italic>\n            <\/jats:sup> (I-<jats:italic>Dcn<\/jats:italic>\n            <jats:sup>\n              <jats:italic>-\/-<\/jats:italic>\n            <\/jats:sup>), <jats:italic>Bgn<\/jats:italic>\n            <jats:sup>\n              <jats:italic>flox\/flox<\/jats:italic>\n            <\/jats:sup> (I-<jats:italic>Bgn<\/jats:italic>\n            <jats:sup>\n              <jats:italic>-\/-<\/jats:italic>\n            <\/jats:sup>), and compound <jats:italic>Dcn<\/jats:italic>\n            <jats:sup>\n              <jats:italic>flox\/flox<\/jats:italic>\n            <\/jats:sup>\n            <jats:italic>\/Bgn<\/jats:italic>\n            <jats:sup>\n              <jats:italic>flox\/flox<\/jats:italic>\n            <\/jats:sup> (I-<jats:italic>Dcn<\/jats:italic>\n            <jats:sup>\n              <jats:italic>-\/-<\/jats:italic>\n            <\/jats:sup>\n            <jats:italic>\/Bgn<\/jats:italic>\n            <jats:sup>\n              <jats:italic>-\/-<\/jats:italic>\n            <\/jats:sup>) mice with a tamoxifen (TM) inducible Cre underwent a bilateral patellar tendon injury (PT). Cre excision of the conditional alleles was induced at 5\u00a0days (samples collected at 3 and 6\u00a0weeks) or 21\u00a0days post-injury (samples collected at 6\u00a0weeks). Scar tissue area, collagen architecture, gene expression and mechanical properties were assessed during re-establishment of tendon architecture after injury. Fibril diameter distribution was impacted by both decorin and biglycan knockdown at 3 and 6\u00a0weeks compared to WT. Although early healing appeared to be delayed in the I-<jats:italic>Bgn<\/jats:italic>\n            <jats:sup>\n              <jats:italic>-\/-<\/jats:italic>\n            <\/jats:sup> tendons (larger scar tissue area at 3\u00a0weeks), no differences in failure properties were detected. By 6\u00a0weeks, in the I-<jats:italic>Dcn<\/jats:italic>\n            <jats:sup>\n              <jats:italic>-\/-<\/jats:italic>\n            <\/jats:sup> tendons, we observed a better recovery of viscoelastic properties compared to the WT tendons (reduced stress relaxation and increased dynamic modulus) when the knockdown was induced early. This could be explained by the increased expression of other matrix proteins, such as elastin whose gene expression was increased at 3\u00a0weeks in the I-<jats:italic>Dcn<\/jats:italic>\n            <jats:sup>\n              <jats:italic>-\/-<\/jats:italic>\n            <\/jats:sup> tendons. Despite an impact on collagen fibrillogenesis, decorin and\/or biglycan knockdown did not produce a detectable effect on quasi-static properties after patellar tendon injury. However, early decorin knockdown resulted in better recovery of viscoelastic properties. Mechanisms underlying this result remained to be clarified in further studies.<\/jats:p>","DOI":"10.1007\/s10439-024-03612-y","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T15:59:39Z","timestamp":1732895979000},"page":"622-633","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Decorin Knockdown Improves Aged Tendon Healing by Enhancing Recovery of Viscoelastic Properties, While Biglycan May Not"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-0073","authenticated-orcid":false,"given":"Christelle","family":"Darrieutort-Laffite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie N.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney A.","family":"Nuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D","family":"Eekhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis J.","family":"Soslowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"issue":"8","key":"3612_CR1","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.2106\/JBJS.E.00835","volume":"88","author":"K Yamaguchi","year":"2006","unstructured":"Yamaguchi, K., K. 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