{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:49:04Z","timestamp":1782236944384,"version":"3.54.5"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL160028"],"award-info":[{"award-number":["R01 HL160028"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD016191"],"award-info":[{"award-number":["S10OD016191"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["EF-2222434"],"award-info":[{"award-number":["EF-2222434"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020415","name":"Additional Ventures","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020415","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Biomed Eng"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10439-026-04006-y","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T17:04:33Z","timestamp":1771347873000},"page":"2129-2147","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Live Imaging-Derived 4D Hemodynamics and Dynamic Tissue Mechanics Across Outflow Tract Morphogenesis"],"prefix":"10.1007","volume":"54","author":[{"given":"Gening","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehyun","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani J.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly E.","family":"Drumm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Lauridsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Esmaily-Moghadam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9309-6296","authenticated-orcid":false,"given":"Jonathan T.","family":"Butcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"4006_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/jcdd6010011","volume":"6","author":"K Courchaine","year":"2019","unstructured":"Courchaine, K., M. J. Gray, K. Beel, K. Thornburg, and S. Rugonyi. 4-D computational modeling of cardiac outflow tract hemodynamics over looping developmental stages in chicken embryos. J. Cardiovasc. Dev. Dis. 6:11, 2019. https:\/\/doi.org\/10.3390\/jcdd6010011.","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"4006_CR2","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1177\/2150135116651114","volume":"7","author":"RH Anderson","year":"2016","unstructured":"Anderson, R. H., S. Mori, D. E. Spicer, N. A. Brown, and T. J. Mohun. Development and morphology of the ventricular outflow tracts. World J. Pediatr. Congenit. Heart Surg. 7:561\u2013577, 2016. https:\/\/doi.org\/10.1177\/2150135116651114.","journal-title":"World J. Pediatr. Congenit. Heart Surg."},{"key":"4006_CR3","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3390\/jcdd8100132","volume":"8","author":"RE Poelmann","year":"2021","unstructured":"Poelmann, R. E., A. C. Gittenberger-de Groot, C. Goerdajal, N. Grewal, M. A. G. De Bakker, and M. K. Richardson. Ventricular septation and outflow tract development in crocodilians result in two aortas with bicuspid semilunar valves. J. Cardiovasc. Dev. Dis. 8:132, 2021. https:\/\/doi.org\/10.3390\/jcdd8100132.","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"4006_CR4","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/wdev.98","volume":"2","author":"Z Neeb","year":"2013","unstructured":"Neeb, Z., J. D. Lajiness, E. Bolanis, and S. J. Conway. Cardiac outflow tract anomalies. WIREs Developmental Biol. 2:499\u2013530, 2013. https:\/\/doi.org\/10.1002\/wdev.98.","journal-title":"WIREs Developmental Biol."},{"key":"4006_CR5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3390\/jcdd8040042","volume":"8","author":"S Stefanovic","year":"2021","unstructured":"Stefanovic, S., H. C. Etchevers, and S. Zaffran. Outflow tract formation\u2014embryonic origins of conotruncal congenital heart disease. J. Cardiovasc. Dev. Dis. 8:42, 2021. https:\/\/doi.org\/10.3390\/jcdd8040042.","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"4006_CR6","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000606","author":"ME Pierpont","year":"2018","unstructured":"Pierpont, M. E., M. Brueckner, W. K. Chung, V. Garg, R. V. Lacro, A. L. McGuire, S. Mital, J. R. Priest, W. T. Pu, A. Roberts, S. M. Ware, B. D. Gelb, and M. W. Russell. Genetic basis for congenital heart disease: revisited: a scientific statement from the American heart association. Circulation. 2018. https:\/\/doi.org\/10.1161\/CIR.0000000000000606.","journal-title":"Circulation"},{"key":"4006_CR7","doi-asserted-by":"publisher","first-page":"e20593","DOI":"10.1097\/MD.0000000000020593","volume":"99","author":"W Wu","year":"2020","unstructured":"Wu, W., J. He, and X. Shao. Incidence and mortality trend of congenital heart disease at the global, regional, and national level, 1990\u20132017. Medicine. 99:e20593, 2020. https:\/\/doi.org\/10.1097\/MD.0000000000020593.","journal-title":"Medicine"},{"key":"4006_CR8","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","volume":"39","author":"JIE Hoffman","year":"2002","unstructured":"Hoffman, J. I. E., and S. Kaplan. The incidence of congenital heart disease. J. Am. Coll. Cardiol. 39:1890\u20131900, 2002. https:\/\/doi.org\/10.1016\/S0735-1097(02)01886-7.","journal-title":"J. Am. Coll. Cardiol."},{"key":"4006_CR9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/uog.26231","volume":"62","author":"BM Jepson","year":"2023","unstructured":"Jepson, B. M., T. D. Metz, T. A. Miller, S. L. Son, Z. Ou, A. P. Presson, A. Nance, and N. M. Pinto. Pregnancy loss in major fetal congenital heart disease: incidence, risk factors and timing. Ultrasound Obstet. Gynecol. 62:75\u201387, 2023. https:\/\/doi.org\/10.1002\/uog.26231.","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"4006_CR10","doi-asserted-by":"publisher","first-page":"a036749","DOI":"10.1101\/cshperspect.a036749","volume":"12","author":"SN Nees","year":"2020","unstructured":"Nees, S. N., and W. K. Chung. Genetic basis of human congenital heart disease. Cold Spring Harb. Perspect. Biol. 12:a036749, 2020. https:\/\/doi.org\/10.1101\/cshperspect.a036749.","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"4006_CR11","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s10237-020-01413-5","volume":"20","author":"HE Salman","year":"2021","unstructured":"Salman, H. E., M. Alser, A. Shekhar, R. A. Gould, F. M. Benslimane, J. T. Butcher, and H. C. Yalcin. Effect of left atrial ligation-driven altered inflow hemodynamics on embryonic heart development: clues for prenatal progression of hypoplastic left heart syndrome. Biomech. Model Mechanobiol. 20:733\u2013750, 2021. https:\/\/doi.org\/10.1007\/s10237-020-01413-5.","journal-title":"Biomech. Model Mechanobiol."},{"key":"4006_CR12","doi-asserted-by":"publisher","first-page":"H1728","DOI":"10.1152\/ajpheart.00495.2010","volume":"299","author":"HC Yalcin","year":"2010","unstructured":"Yalcin, H. C., A. Shekhar, N. Nishimura, A. A. Rane, C. B. Schaffer, and J. T. Butcher. Two-photon microscopy-guided femtosecond-laser photoablation of avian cardiogenesis: noninvasive creation of localized heart defects. American Journal of Physiology-Heart and Circulatory Physiology. 299:H1728\u2013H1735, 2010. https:\/\/doi.org\/10.1152\/ajpheart.00495.2010.","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"351\u2013354","key":"4006_CR13","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1126\/science.abc6229","volume":"374","author":"H Fukui","year":"1979","unstructured":"Fukui, H., R.W.-Y. Chow, J. Xie, Y. Y. Foo, C. H. Yap, N. Minc, N. Mochizuki, and J. Vermot. Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces. Science. 374(351\u2013354):2021, 1979. https:\/\/doi.org\/10.1126\/science.abc6229.","journal-title":"Science"},{"key":"4006_CR14","doi-asserted-by":"publisher","first-page":"e1000246","DOI":"10.1371\/journal.pbio.1000246","volume":"7","author":"J Vermot","year":"2009","unstructured":"Vermot, J., A. S. Forouhar, M. Liebling, D. Wu, D. Plummer, M. Gharib, and S. E. Fraser. Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart. PLoS Biol. 7:e1000246, 2009. https:\/\/doi.org\/10.1371\/journal.pbio.1000246.","journal-title":"PLoS Biol"},{"key":"4006_CR15","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83209","author":"M Wang","year":"2023","unstructured":"Wang, M., B. Y. Lin, S. Sun, C. Dai, F. Long, and J. T. Butcher. Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction. Elife. 2023. https:\/\/doi.org\/10.7554\/eLife.83209.","journal-title":"Elife"},{"key":"4006_CR16","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.devcel.2017.09.023","volume":"43","author":"LM Goddard","year":"2017","unstructured":"Goddard, L. M., A.-L. Duchemin, H. Ramalingan, B. Wu, M. Chen, S. Bamezai, J. Yang, L. Li, M. P. Morley, T. Wang, M. Scherrer-Crosbie, D. B. Frank, K. A. Engleka, S. C. Jameson, E. E. Morrisey, T. J. Carroll, B. Zhou, J. Vermot, and M. L. Kahn. Hemodynamic forces sculpt developing heart valves through a KLF2-WNT9B paracrine signaling axis. Dev. Cell. 43:274-289.e5, 2017. https:\/\/doi.org\/10.1016\/j.devcel.2017.09.023.","journal-title":"Dev. Cell"},{"key":"4006_CR17","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1002\/dvdy.419","volume":"251","author":"DH Pham","year":"2022","unstructured":"Pham, D. H., C. R. Dai, B. Y. Lin, and J. T. Butcher. Local fluid shear stress operates a molecular switch to drive fetal semilunar valve extension. Dev. Dyn. 251:481\u2013497, 2022. https:\/\/doi.org\/10.1002\/dvdy.419.","journal-title":"Dev. Dyn."},{"key":"4006_CR18","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1007\/s10439-012-0574-8","volume":"40","author":"KN Bharadwaj","year":"2012","unstructured":"Bharadwaj, K. N., C. Spitz, A. Shekhar, H. C. Yalcin, and J. T. Butcher. Computational fluid dynamics of developing avian outflow tract heart valves. Ann. Biomed. Eng. 40:2212\u20132227, 2012. https:\/\/doi.org\/10.1007\/s10439-012-0574-8.","journal-title":"Ann. Biomed. Eng."},{"key":"4006_CR19","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3390\/jcdd2020108","volume":"2","author":"V Menon","year":"2015","unstructured":"Menon, V., J. Eberth, R. Goodwin, and J. Potts. Altered hemodynamics in the embryonic heart affects outflow valve development. J. Cardiovasc. Dev. Dis. 2:108\u2013124, 2015. https:\/\/doi.org\/10.3390\/jcdd2020108.","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"4006_CR20","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s10237-015-0720-y","volume":"15","author":"S Goenezen","year":"2016","unstructured":"Goenezen, S., V. K. Chivukula, M. Midgett, L. Phan, and S. Rugonyi. 4D subject-specific inverse modeling of the chick embryonic heart outflow tract hemodynamics. Biomech. Model Mechanobiol. 15:723\u2013743, 2016. https:\/\/doi.org\/10.1007\/s10237-015-0720-y.","journal-title":"Biomech. Model Mechanobiol."},{"key":"4006_CR21","doi-asserted-by":"publisher","first-page":"e40869","DOI":"10.1371\/journal.pone.0040869","volume":"7","author":"A Liu","year":"2012","unstructured":"Liu, A., X. Yin, L. Shi, P. Li, K. L. Thornburg, R. Wang, and S. Rugonyi. Biomechanics of the chick embryonic heart outflow tract at HH18 using 4D optical coherence tomography imaging and computational modeling. PLoS One. 7:e40869, 2012. https:\/\/doi.org\/10.1371\/journal.pone.0040869.","journal-title":"PLoS One"},{"key":"4006_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jcdd3010001","volume":"3","author":"V Chivukula","year":"2015","unstructured":"Chivukula, V., S. Goenezen, A. Liu, and S. Rugonyi. Effect of outflow tract banding on embryonic cardiac hemodynamics. J. Cardiovasc. Dev. Dis. 3:1, 2015. https:\/\/doi.org\/10.3390\/jcdd3010001.","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"4006_CR23","doi-asserted-by":"publisher","first-page":"a037218","DOI":"10.1101\/cshperspect.a037218","volume":"12","author":"JG Wittig","year":"2020","unstructured":"Wittig, J. G., and A. M\u00fcnsterberg. The chicken as a model organism to study heart development. Cold Spring Harb. Perspect. Biol. 12:a037218, 2020. https:\/\/doi.org\/10.1101\/cshperspect.a037218.","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"4006_CR24","doi-asserted-by":"publisher","DOI":"10.3791\/57763","author":"V Messerschmidt","year":"2018","unstructured":"Messerschmidt, V., Z. Bailey, K. I. Baek, Y. Ding, J. J. Hsu, R. Bryant, R. Li, T. K. Hsiai, and J. Lee. Light-sheet fluorescence microscopy to capture 4-dimensional images of the effects of modulating shear stress on the developing zebrafish heart. J. Vis. Exp. 2018. https:\/\/doi.org\/10.3791\/57763.","journal-title":"J. Vis. Exp."},{"key":"4006_CR25","doi-asserted-by":"publisher","first-page":"e72924","DOI":"10.1371\/journal.pone.0072924","volume":"8","author":"J Lee","year":"2013","unstructured":"Lee, J., M. E. Moghadam, E. Kung, H. Cao, T. Beebe, Y. Miller, B. L. Roman, C.-L. Lien, N. C. Chi, A. L. Marsden, and T. K. Hsiai. Moving domain computational fluid dynamics to interface with an embryonic model of cardiac morphogenesis. PLoS One. 8:e72924, 2013. https:\/\/doi.org\/10.1371\/journal.pone.0072924.","journal-title":"PLoS One"},{"issue":"751\u2013753","key":"4006_CR26","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1126\/science.1123775","volume":"312","author":"AS Forouhar","year":"1979","unstructured":"Forouhar, A. S., M. Liebling, A. Hickerson, A. Nasiraei-Moghaddam, H.-J. Tsai, J. R. Hove, S. E. Fraser, M. E. Dickinson, and M. Gharib. The embryonic vertebrate heart tube is a dynamic suction pump. Science. 312(751\u2013753):2006, 1979. https:\/\/doi.org\/10.1126\/science.1123775.","journal-title":"Science"},{"key":"4006_CR27","doi-asserted-by":"publisher","first-page":"e1005828","DOI":"10.1371\/journal.pcbi.1005828","volume":"13","author":"V Vedula","year":"2017","unstructured":"Vedula, V., J. Lee, H. Xu, C.-C.J. Kuo, T. K. Hsiai, and A. L. Marsden. A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling. PLoS Comput. Biol. 13:e1005828, 2017. https:\/\/doi.org\/10.1371\/journal.pcbi.1005828.","journal-title":"PLoS Comput. Biol."},{"key":"4006_CR28","doi-asserted-by":"publisher","first-page":"18072","DOI":"10.1038\/s41598-019-54061-w","volume":"9","author":"S Ho","year":"2019","unstructured":"Ho, S., W. X. Chan, N. Phan-Thien, and C. H. Yap. Organ dynamics and hemodynamic of the whole hh25 avian embryonic heart, revealed by ultrasound biomicroscopy, boundary tracking, and flow simulations. Sci. Rep. 9:18072, 2019. https:\/\/doi.org\/10.1038\/s41598-019-54061-w.","journal-title":"Sci. Rep."},{"key":"4006_CR29","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1007\/s10237-019-01132-6","volume":"18","author":"S Ho","year":"2019","unstructured":"Ho, S., W. X. Chan, S. Rajesh, N. Phan-Thien, and C. H. Yap. Fluid dynamics and forces in the HH25 avian embryonic outflow tract. Biomech. Model Mechanobiol. 18:1123\u20131137, 2019. https:\/\/doi.org\/10.1007\/s10237-019-01132-6.","journal-title":"Biomech. Model Mechanobiol."},{"key":"4006_CR30","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1007\/s10439-017-1882-9","volume":"45","author":"S Ho","year":"2017","unstructured":"Ho, S., G. X. Y. Tan, T. J. Foo, N. Phan-Thien, and C. H. Yap. Organ dynamics and fluid dynamics of the HH25 chick embryonic cardiac ventricle as revealed by a novel 4D high-frequency ultrasound imaging technique and computational flow simulations. Ann. Biomed. Eng. 45:2309\u20132323, 2017. https:\/\/doi.org\/10.1007\/s10439-017-1882-9.","journal-title":"Ann. Biomed. Eng."},{"key":"4006_CR31","doi-asserted-by":"publisher","DOI":"10.3791\/68206","author":"D Zhang","year":"2025","unstructured":"Zhang, D., and S. E. Lindsey. Rapid whole-mount high-resolution imaging of small animal vasculature for quantitative studies. J. Vis. Exp. 2025. https:\/\/doi.org\/10.3791\/68206.","journal-title":"J. Vis. Exp."},{"key":"4006_CR32","doi-asserted-by":"publisher","DOI":"10.1242\/dev.162578","author":"SE Lindsey","year":"2018","unstructured":"Lindsey, S. E., J. T. Butcher, and I. E. Vignon-Clementel. Cohort-based multiscale analysis of hemodynamic-driven growth and remodeling of the embryonic pharyngeal arch arteries. Development. 2018. https:\/\/doi.org\/10.1242\/dev.162578.","journal-title":"Development"},{"key":"4006_CR33","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1007\/s10439-021-02802-2","volume":"49","author":"SE Lindsey","year":"2021","unstructured":"Lindsey, S. E., I. E. Vignon-Clementel, and J. T. Butcher. Assessing early cardiac outflow tract adaptive responses through combined experimental-computational manipulations. Ann. Biomed. Eng. 49:3227\u20133242, 2021. https:\/\/doi.org\/10.1007\/s10439-021-02802-2.","journal-title":"Ann. Biomed. Eng."},{"key":"4006_CR34","doi-asserted-by":"publisher","first-page":"20150652","DOI":"10.1098\/rsif.2015.0652","volume":"12","author":"M Midgett","year":"2015","unstructured":"Midgett, M., V. K. Chivukula, C. Dorn, S. Wallace, and S. Rugonyi. Blood flow through the embryonic heart outflow tract during cardiac looping in HH13\u2013HH18 chicken embryos. J. R. Soc. Interface. 12:20150652, 2015. https:\/\/doi.org\/10.1098\/rsif.2015.0652.","journal-title":"J. R. Soc. Interface"},{"key":"4006_CR35","doi-asserted-by":"publisher","first-page":"19943","DOI":"10.1073\/pnas.1106954108","volume":"108","author":"K Balachandran","year":"2011","unstructured":"Balachandran, K., P. W. Alford, J. Wylie-Sears, J. A. Goss, A. Grosberg, J. Bischoff, E. Aikawa, R. A. Levine, and K. K. Parker. Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proc. Natl. Acad. Sci. 108:19943\u201319948, 2011. https:\/\/doi.org\/10.1073\/pnas.1106954108.","journal-title":"Proc. Natl. Acad. Sci."},{"key":"4006_CR36","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1002\/dvdy.21958","volume":"238","author":"BJ Damon","year":"2009","unstructured":"Damon, B. J., M. C. R\u00e9mond, M. R. Bigelow, T. C. Trusk, W. Xie, R. Perucchio, D. Sedmera, S. Denslow, and R. P. Thompson. Patterns of muscular strain in the embryonic heart wall. Dev. Dyn. 238:1535\u20131546, 2009. https:\/\/doi.org\/10.1002\/dvdy.21958.","journal-title":"Dev. Dyn."},{"key":"4006_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00318","author":"SE Lindsey","year":"2014","unstructured":"Lindsey, S. E. Mechanical regulation of cardiac development. Front. Physiol. 2014. https:\/\/doi.org\/10.3389\/fphys.2014.00318.","journal-title":"Front. Physiol."},{"key":"4006_CR38","doi-asserted-by":"publisher","DOI":"10.4172\/2168-9873.S11-001","author":"S Rugonyi","year":"2013","unstructured":"Rugonyi, S. Strain-induced tissue growth laws: applications to embryonic cardiovascular development. J. Appl. Mech. Eng. 2013. https:\/\/doi.org\/10.4172\/2168-9873.S11-001.","journal-title":"J. Appl. Mech. Eng."},{"key":"4006_CR39","doi-asserted-by":"publisher","DOI":"10.3791\/2154","author":"HC Yalcin","year":"2010","unstructured":"Yalcin, H. C., A. Shekhar, A. A. Rane, and J. T. Butcher. An ex-ovo chicken embryo culture system suitable for imaging and microsurgery applications. J. Vis. Exp. 2010. https:\/\/doi.org\/10.3791\/2154.","journal-title":"J. Vis. Exp."},{"key":"4006_CR40","doi-asserted-by":"publisher","first-page":"H755","DOI":"10.1152\/ajpheart.1993.264.3.H755","volume":"264","author":"B Cuneo","year":"1993","unstructured":"Cuneo, B., S. Hughes, and D. W. Benson. Heart rate perturbation in the stage 17\u201327 chick embryo: effect on stroke volume and aortic flow. Am. J. Physiology-Heart Circ. Physiol. 264:H755\u2013H759, 1993. https:\/\/doi.org\/10.1152\/ajpheart.1993.264.3.H755.","journal-title":"Am. J. Physiology-Heart Circ. Physiol."},{"key":"4006_CR41","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1161\/01.RES.65.6.1665","volume":"65","author":"N Hu","year":"1989","unstructured":"Hu, N., and E. B. Clark. Hemodynamics of the stage 12 to stage 29 chick embryo. Circ. Res. 65:1665\u20131670, 1989. https:\/\/doi.org\/10.1161\/01.RES.65.6.1665.","journal-title":"Circ. Res."},{"key":"4006_CR42","doi-asserted-by":"publisher","DOI":"10.3791\/57089","author":"A Dittrich","year":"2018","unstructured":"Dittrich, A., M. M. Thygesen, and H. Lauridsen. 2D and 3D echocardiography in the axolotl (Ambystoma Mexicanum). J. Vis. Exp. 2018. https:\/\/doi.org\/10.3791\/57089.","journal-title":"J. Vis. Exp."},{"key":"4006_CR43","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","volume":"30","author":"A Fedorov","year":"2012","unstructured":"Fedorov, A., R. Beichel, J. Kalpathy-Cramer, J. Finet, J.-C. Fillion-Robin, S. Pujol, C. Bauer, D. Jennings, F. Fennessy, M. Sonka, J. Buatti, S. Aylward, J. V. Miller, S. Pieper, and R. Kikinis. 3D Slicer as an image computing platform for the quantitative imaging network. Magn. Reson. Imaging. 30:1323\u20131341, 2012. https:\/\/doi.org\/10.1016\/j.mri.2012.05.001.","journal-title":"Magn. Reson. Imaging"},{"key":"4006_CR44","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.cmpb.2019.02.011","volume":"171","author":"C Pinter","year":"2019","unstructured":"Pinter, C., A. Lasso, and G. Fichtinger. Polymorph segmentation representation for medical image computing. Comput. Methods Programs Biomed. 171:19\u201326, 2019. https:\/\/doi.org\/10.1016\/j.cmpb.2019.02.011.","journal-title":"Comput. Methods Programs Biomed"},{"key":"4006_CR45","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.cma.2014.11.033","volume":"286","author":"M Esmaily-Moghadam","year":"2015","unstructured":"Esmaily-Moghadam, M., Y. Bazilevs, and A. L. Marsden. A bi-partitioned iterative algorithm for solving linear systems arising from incompressible flow problems. Comput. Methods Appl. Mech. Eng. 286:40\u201362, 2015. https:\/\/doi.org\/10.1016\/j.cma.2014.11.033.","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"4006_CR46","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1007\/s00466-013-0868-1","volume":"52","author":"M Esmaily-Moghadam","year":"2013","unstructured":"Esmaily-Moghadam, M., Y. Bazilevs, and A. L. Marsden. A new preconditioning technique for implicitly coupled multidomain simulations with applications to hemodynamics. Comput. Mech. 52:1141\u20131152, 2013. https:\/\/doi.org\/10.1007\/s00466-013-0868-1.","journal-title":"Comput. Mech."},{"key":"4006_CR47","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jcp.2012.07.035","volume":"244","author":"M Esmaily-Moghadam","year":"2013","unstructured":"Esmaily-Moghadam, M., I. E. Vignon-Clementel, R. Figliola, and A. L. Marsden. A modular numerical method for implicit 0D\/3D coupling in cardiovascular finite element simulations. J. Comput. Phys. 244:63\u201379, 2013. https:\/\/doi.org\/10.1016\/j.jcp.2012.07.035.","journal-title":"J. Comput. Phys."},{"key":"4006_CR48","first-page":"2008","volume":"129\u2013136","author":"P Cignoni","year":"2008","unstructured":"Cignoni, P., M. Callieri, M. Corsini, M. Dellepiane, F. Ganovelli, and G. Ranzuglia. MeshLab: an open-source mesh processing tool. Eurographics Italian chapter conference. 129\u2013136:2008, 2008.","journal-title":"Eurographics Italian chapter conference"},{"key":"4006_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1145\/2629697","volume":"41","author":"H Si","year":"2015","unstructured":"Si, H. TetGen, a delaunay-based quality tetrahedral mesh generator. ACM Trans. Math. Softv. 41:1\u201336, 2015. https:\/\/doi.org\/10.1145\/2629697.","journal-title":"ACM Trans. Math. Softv"},{"key":"4006_CR50","doi-asserted-by":"publisher","DOI":"10.1115\/1.4050170","author":"D Jia","year":"2021","unstructured":"Jia, D., M. Peroni, T. Khalapyan, and M. Esmaily. An efficient assisted bidirectional glenn design with lowered superior vena cava pressure for stage-one single ventricle patients. J. Biomech. Eng. 2021. https:\/\/doi.org\/10.1115\/1.4050170.","journal-title":"J. Biomech. Eng."},{"key":"4006_CR51","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.jtcvs.2014.10.035","volume":"149","author":"M Esmaily-Moghadam","year":"2015","unstructured":"Esmaily-Moghadam, M., T.-Y. Hsia, and A. L. Marsden. The assisted bidirectional glenn: a novel surgical approach for first-stage single-ventricle heart palliation. J. Thorac. Cardiovasc. Surg. 149:699\u2013705, 2015. https:\/\/doi.org\/10.1016\/j.jtcvs.2014.10.035.","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"4006_CR52","doi-asserted-by":"publisher","DOI":"10.1115\/1.4006814","author":"M Esmaily Moghadam","year":"2012","unstructured":"Esmaily Moghadam, M., F. Migliavacca, I. E. Vignon-Clementel, T.-Y. Hsia, and A. L. Marsden. Optimization of shunt placement for the Norwood surgery using multi-domain modeling. J. Biomech. Eng. 2012. https:\/\/doi.org\/10.1115\/1.4006814.","journal-title":"J. Biomech. Eng."},{"key":"4006_CR53","doi-asserted-by":"publisher","first-page":"074903","DOI":"10.1103\/l8wc-6l8g","volume":"10","author":"D Jia","year":"2025","unstructured":"Jia, D., and M. Esmaily. Introducing a harmonic balance Navier-Stokes finite element solver to accelerate cardiovascular simulations. Phys. Rev. Fluids. 10:074903, 2025. https:\/\/doi.org\/10.1103\/l8wc-6l8g.","journal-title":"Phys. Rev. Fluids"},{"key":"4006_CR54","doi-asserted-by":"publisher","first-page":"e82703","DOI":"10.1371\/journal.pone.0082703","volume":"8","author":"AI Hassaballah","year":"2013","unstructured":"Hassaballah, A. I., M. A. Hassan, A. N. Mardi, and M. Hamdi. An inverse finite element method for determining the tissue compressibility of human left ventricular wall during the cardiac cycle. PLoS One. 8:e82703, 2013. https:\/\/doi.org\/10.1371\/journal.pone.0082703.","journal-title":"PLoS One"},{"key":"4006_CR55","doi-asserted-by":"publisher","first-page":"H407","DOI":"10.1152\/ajpheart.1986.250.3.H407","volume":"250","author":"EB Clark","year":"1986","unstructured":"Clark, E. B., N. Hu, J. L. Dummett, G. K. Vandekieft, C. Olson, and R. Tomanek. Ventricular function and morphology in chick embryo from stages 18 to 29. Am. J. Physiol.-Heart Circ. Physiol. 250:H407\u2013H413, 1986. https:\/\/doi.org\/10.1152\/ajpheart.1986.250.3.H407.","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"4006_CR56","doi-asserted-by":"publisher","first-page":"H55","DOI":"10.1152\/ajpheart.1989.257.1.H55","volume":"257","author":"EB Clark","year":"1989","unstructured":"Clark, E. B., N. Hu, P. Frommelt, G. K. Vandekieft, J. L. Dummett, and R. J. Tomanek. Effect of increased pressure on ventricular growth in stage 21 chick embryos. Am. J. Physiol.-Heart Circ. Physiol. 257:H55\u2013H61, 1989. https:\/\/doi.org\/10.1152\/ajpheart.1989.257.1.H55.","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"4006_CR57","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1203\/00006450-199104000-00002","volume":"29","author":"N Hu","year":"1991","unstructured":"Hu, N., D. M. Connuck, B. B. Keller, and E. B. Clark. diastolic filling characteristics in the stage 12 to 27 chick embryo ventricle. Pediatr. Res. 29:334\u2013337, 1991. https:\/\/doi.org\/10.1203\/00006450-199104000-00002.","journal-title":"Pediatr. Res."},{"key":"4006_CR58","doi-asserted-by":"crossref","unstructured":"Ahrens, J. P., B. Geveci, and C. C. Law. ParaView: An End-User Tool for Large-Data Visualization. , 2005.at <https:\/\/api.semanticscholar.org\/CorpusID:56558637>","DOI":"10.1016\/B978-012387582-2\/50038-1"},{"key":"4006_CR59","doi-asserted-by":"crossref","unstructured":"Wickham, H. ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag New York, 2016.at <https:\/\/ggplot2.tidyverse.org>","DOI":"10.1007\/978-3-319-24277-4_9"},{"key":"4006_CR60","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13973","author":"RH Anderson","year":"2023","unstructured":"Anderson, R. H., W. H. Lamers, J. P. J. M. Hikspoors, T. J. Mohun, S. D. Bamforth, B. Chaudhry, L. Eley, J. Kerwin, M. Crosier, and D. J. Henderson. Development of the arterial roots and ventricular outflow tracts. J. Anat. 2023. https:\/\/doi.org\/10.1111\/joa.13973.","journal-title":"J. Anat."},{"key":"4006_CR61","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1002\/mrm.24802","volume":"71","author":"R Lorenz","year":"2014","unstructured":"Lorenz, R., J. Bock, A. J. Barker, F. von Knobelsdorff-Brenkenhoff, W. Wallis, J. G. Korvink, M. M. Bissell, J. Schulz-Menger, and M. Markl. 4D flow magnetic resonance imaging in bicuspid aortic valve disease demonstrates altered distribution of aortic blood flow helicity. Magn. Reson. Med. 71:1542\u20131553, 2014. https:\/\/doi.org\/10.1002\/mrm.24802.","journal-title":"Magn. Reson. Med."},{"key":"4006_CR62","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/dvdy.22512","volume":"240","author":"HC Yalcin","year":"2011","unstructured":"Yalcin, H. C., A. Shekhar, T. C. McQuinn, and J. T. Butcher. Hemodynamic patterning of the avian atrioventricular valve. Dev. Dyn. 240:23\u201335, 2011. https:\/\/doi.org\/10.1002\/dvdy.22512.","journal-title":"Dev. Dyn."},{"key":"4006_CR63","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1161\/CIRCRESAHA.107.155630","volume":"101","author":"L Song","year":"2007","unstructured":"Song, L., W. Yan, X. Chen, C. Deng, Q. Wang, and K. Jiao. Myocardial Smad4 Is essential for cardiogenesis in mouse embryos. Circ. Res. 101:277\u2013285, 2007. https:\/\/doi.org\/10.1161\/CIRCRESAHA.107.155630.","journal-title":"Circ. Res."},{"key":"4006_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/gene.10152","volume":"35","author":"SJ Conway","year":"2003","unstructured":"Conway, S. J., A. Kruzynska-Frejtag, P. L. Kneer, M. Machnicki, and S. V. Koushik. What cardiovascular defect does my prenatal mouse mutant have, and why? Genesis. 35:1\u201321, 2003. https:\/\/doi.org\/10.1002\/gene.10152.","journal-title":"Genesis."},{"key":"4006_CR65","doi-asserted-by":"publisher","first-page":"e19186","DOI":"10.1371\/journal.pone.0019186","volume":"6","author":"MC Mak","year":"2011","unstructured":"Mak, M. C., K. M. Lam, P. K. Chan, Y. B. Lau, W. H. Tang, P. K. K. Yeung, B. C. B. Ko, S. M. S. Chung, and S. K. Chung. Embryonic lethality in mice lacking the nuclear factor of activated t cells 5 protein due to impaired cardiac development and function. PLoS One. 6:e19186, 2011. https:\/\/doi.org\/10.1371\/journal.pone.0019186.","journal-title":"PLoS One"},{"key":"4006_CR66","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1002\/dvdy.20468","volume":"233","author":"BJ Martinsen","year":"2005","unstructured":"Martinsen, B. J. Reference guide to the stages of chick heart embryology. Dev. Dyn. 233:1217\u20131237, 2005. https:\/\/doi.org\/10.1002\/dvdy.20468.","journal-title":"Dev. Dyn."},{"key":"4006_CR67","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1161\/CIRCRESAHA.107.148684","volume":"100","author":"JT Butcher","year":"2007","unstructured":"Butcher, J. T., T. C. McQuinn, D. Sedmera, D. Turner, and R. R. Markwald. transitions in early embryonic atrioventricular valvular function correspond with changes in cushion biomechanics that are predictable by tissue composition. Circ. Res. 100:1503\u20131511, 2007. https:\/\/doi.org\/10.1161\/CIRCRESAHA.107.148684.","journal-title":"Circ. Res."},{"key":"4006_CR68","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1002\/uog.6362","volume":"33","author":"AM Oosterbaan","year":"2009","unstructured":"Oosterbaan, A. M., N. T. C. Ursem, P. C. Struijk, J. G. Bosch, A. F. W. van der Steen, and E. A. P. Steegers. Doppler flow velocity waveforms in the embryonic chicken heart at developmental stages corresponding to 5\u20138 weeks of human gestation. Ultrasound Obstet. Gynecol. 33:638\u2013644, 2009. https:\/\/doi.org\/10.1002\/uog.6362.","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"4006_CR69","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.808999","author":"S Chen","year":"2022","unstructured":"Chen, S., H. Zhang, Q. Hou, Y. Zhang, and A. Qiao. Multiscale modeling of vascular remodeling induced by wall shear stress. Front. Physiol. 2022. https:\/\/doi.org\/10.3389\/fphys.2021.808999.","journal-title":"Front. Physiol."},{"key":"4006_CR70","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1203\/00006450-199307000-00011","volume":"34","author":"MLA Broekhuizen","year":"1993","unstructured":"Broekhuizen, M. L. A., F. Mast, P. C. Struijk, W. Van Der Bie, P. G. H. Mulder, A. C. Gittenberger-De Groot, and J. W. Wladimiroff. Hemodynamic parameters of stage 20 to stage 35 chick embryo. Pediatr. Res. 34:44\u201346, 1993. https:\/\/doi.org\/10.1203\/00006450-199307000-00011.","journal-title":"Pediatr. Res."},{"key":"4006_CR71","doi-asserted-by":"publisher","DOI":"10.1242\/dev.196519","author":"D Bassen","year":"2021","unstructured":"Bassen, D., M. Wang, D. Pham, S. Sun, R. Rao, R. Singh, and J. Butcher. Hydrostatic mechanical stress regulates growth and maturation of the atrioventricular valve. Development. 2021. https:\/\/doi.org\/10.1242\/dev.196519.","journal-title":"Development"},{"key":"4006_CR72","doi-asserted-by":"publisher","first-page":"a037465","DOI":"10.1101\/cshperspect.a037465","volume":"12","author":"TJ Mohun","year":"2020","unstructured":"Mohun, T. J., and R. H. Anderson. 3D Anatomy of the developing heart: understanding ventricular septation. Cold Spring Harb. Perspect. Biol. 12:a037465, 2020. https:\/\/doi.org\/10.1101\/cshperspect.a037465.","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"4006_CR73","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1161\/01.RES.0000262688.14288.b8","volume":"100","author":"MS Rana","year":"2007","unstructured":"Rana, M. S., N. C. A. Horsten, S. Tesink-Taekema, W. H. Lamers, A. F. M. Moorman, and M. J. B. van den Hoff. Trabeculated right ventricular free wall in the chicken heart forms by ventricularization of the myocardium initially forming the outflow tract. Circ. Res. 100:1000\u20131007, 2007. https:\/\/doi.org\/10.1161\/01.RES.0000262688.14288.b8.","journal-title":"Circ. Res."},{"key":"4006_CR74","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1007\/s10439-009-9682-5","volume":"37","author":"Y Wang","year":"2009","unstructured":"Wang, Y., O. Dur, M. J. Patrick, J. P. Tinney, K. Tobita, B. B. Keller, and K. Pekkan. Aortic arch morphogenesis and flow modeling in the chick embryo. Ann. Biomed. Eng. 37:1069\u20131081, 2009. https:\/\/doi.org\/10.1007\/s10439-009-9682-5.","journal-title":"Ann. Biomed. Eng."},{"key":"4006_CR75","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/ar.23942","volume":"302","author":"J Ryvlin","year":"2019","unstructured":"Ryvlin, J., S. E. Lindsey, and J. T. Butcher. Systematic analysis of the smooth muscle wall phenotype of the pharyngeal arch arteries during their reorganization into the great vessels and its association with hemodynamics. Anat. Rec. 302:153\u2013162, 2019. https:\/\/doi.org\/10.1002\/ar.23942.","journal-title":"Anat. Rec."},{"key":"4006_CR76","doi-asserted-by":"publisher","first-page":"e86878","DOI":"10.1371\/journal.pone.0086878","volume":"9","author":"CH Yap","year":"2014","unstructured":"Yap, C. H., X. Liu, and K. Pekkan. Characterizaton of the vessel geometry, flow mechanics and wall shear stress in the great arteries of wildtype prenatal mouse. PLoS One. 9:e86878, 2014. https:\/\/doi.org\/10.1371\/journal.pone.0086878.","journal-title":"PLoS One"},{"key":"4006_CR77","doi-asserted-by":"publisher","first-page":"e60271","DOI":"10.1371\/journal.pone.0060271","volume":"8","author":"WJ Kowalski","year":"2013","unstructured":"Kowalski, W. J., O. Dur, Y. Wang, M. J. Patrick, J. P. Tinney, B. B. Keller, and K. Pekkan. Critical transitions in early embryonic aortic arch patterning and hemodynamics. PLoS One. 8:e60271, 2013. https:\/\/doi.org\/10.1371\/journal.pone.0060271.","journal-title":"PLoS One"},{"key":"4006_CR78","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1161\/01.CIR.46.2.375","volume":"46","author":"DA Goor","year":"1972","unstructured":"Goor, D. A., R. Dische, and C. W. Lillehei. The conotruncus. Circulation. 46:375\u2013384, 1972. https:\/\/doi.org\/10.1161\/01.CIR.46.2.375.","journal-title":"Circulation"},{"key":"4006_CR79","doi-asserted-by":"publisher","unstructured":"del Monte-Nieto, G., and R. P. Harvey. Embryology of the Heart. In: Skin and the Heart. Cham: Springer International Publishing, 2021, pp. 11\u201330. https:\/\/doi.org\/10.1007\/978-3-030-54779-0_2","DOI":"10.1007\/978-3-030-54779-0_2"},{"key":"4006_CR80","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1136\/heart.89.9.1110","volume":"89","author":"RH Anderson","year":"2003","unstructured":"Anderson, R. H. Development of the heart: (3) Formation of the ventricular outflow tracts, arterial valves, and intrapericardial arterial trunks. Heart. 89:1110\u20131118, 2003. https:\/\/doi.org\/10.1136\/heart.89.9.1110.","journal-title":"Heart"},{"key":"4006_CR81","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/s42003-021-02285-w","volume":"4","author":"CA Dessalles","year":"2021","unstructured":"Dessalles, C. A., C. Leclech, A. Castagnino, and A. I. Barakat. Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology. Commun. Biol. 4:764, 2021. https:\/\/doi.org\/10.1038\/s42003-021-02285-w.","journal-title":"Commun. Biol."},{"key":"4006_CR82","doi-asserted-by":"publisher","first-page":"4229","DOI":"10.1038\/s41467-021-24383-3","volume":"12","author":"I Andreu","year":"2021","unstructured":"Andreu, I., B. Falcones, S. Hurst, N. Chahare, X. Quiroga, A.-L. Le Roux, Z. Kechagia, A. E. M. Beedle, A. Elosegui-Artola, X. Trepat, R. Farr\u00e9, T. Betz, I. Almendros, and P. Roca-Cusachs. The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening. Nat. Commun. 12:4229, 2021. https:\/\/doi.org\/10.1038\/s41467-021-24383-3.","journal-title":"Nat. Commun."},{"key":"4006_CR83","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/j.1749-6632.1965.tb49419.x","volume":"127","author":"FJ Haberich","year":"1965","unstructured":"Haberich, F. J. The functional separation of venous and arterial blood in the univentricular frog heart. Ann. N Y Acad. Sci. 127:459\u2013476, 1965. https:\/\/doi.org\/10.1111\/j.1749-6632.1965.tb49419.x.","journal-title":"Ann. N Y Acad. Sci."},{"key":"4006_CR84","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1007\/s00246-022-02870-8","volume":"43","author":"AF Corno","year":"2022","unstructured":"Corno, A. F., Z. Zhou, S. C. Uppu, S. Huang, B. Marino, D. M. Milewicz, and J. D. Salazar. The Secrets of the Frogs Heart. Pediatr. Cardiol. 43:1471\u20131480, 2022. https:\/\/doi.org\/10.1007\/s00246-022-02870-8.","journal-title":"Pediatr. Cardiol."},{"key":"4006_CR85","doi-asserted-by":"publisher","first-page":"e0188048","DOI":"10.1371\/journal.pone.0188048","volume":"12","author":"SL Meyer","year":"2017","unstructured":"Meyer, S. L., M. R. Jongbloed, S. Y. Ho, M. M. Bartelings, K. P. McCarthy, H. Uemura, and T. Ebels. Intracardiac anatomical relationships and potential for streaming in double inlet left ventricles. PLoS One. 12:e0188048, 2017. https:\/\/doi.org\/10.1371\/journal.pone.0188048.","journal-title":"PLoS One"}],"container-title":["Annals of Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-026-04006-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10439-026-04006-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-026-04006-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:13:31Z","timestamp":1782234811000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10439-026-04006-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":85,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["4006"],"URL":"https:\/\/doi.org\/10.1007\/s10439-026-04006-y","relation":{},"ISSN":["0090-6964","1573-9686"],"issn-type":[{"value":"0090-6964","type":"print"},{"value":"1573-9686","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]},"assertion":[{"value":"8 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing or financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}