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A refined dissection protocol was used to preserve native curvature and hydration, with the anterior and posterior regions isolated via selective capsular puncture. Force\u2013indentation measurements were performed using calibrated silicon cantilevers and analyzed with the Johnson\u2013Kendall\u2013Roberts (JKR) model to extract local Young\u2019s modulus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Results from over 12,000 force curves revealed that the anterior capsule exhibited significantly higher stiffness (mean 67.9\u00a0kPa, standard deviation 40.1\u00a0kPa) than the posterior (mean 54.1\u00a0kPa, standard deviation 25.2\u00a0kPa;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), with a wider range of stiffness values. AFM topography confirmed comparable surface morphology, ruling out roughness as a confounding factor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight the functional specialization of the lens capsule and the utility of AFM for high-resolution biomechanical characterization. These measurement techniques will be applied to human lens capsules to elucidate age-related changes in capsule properties pertaining to presbyopia, inform surgical strategies, lens capsule modeling, and the design of accommodative intraocular lenses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10439-026-04012-0","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T19:14:52Z","timestamp":1771096492000},"page":"2027-2039","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional Differences in Young\u2019s Modulus of the Porcine Lens Capsule"],"prefix":"10.1007","volume":"54","author":[{"given":"Hoyeon","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles","family":"Cline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongjin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-0997","authenticated-orcid":false,"given":"Hanna","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"key":"4012_CR1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.exer.2008.08.002","volume":"88","author":"BP Danysh","year":"2009","unstructured":"Danysh, B. 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