{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:59:08Z","timestamp":1782935948813,"version":"3.54.5"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Key Research and Development Program of China","award":["No.2023YFC2410404"],"award-info":[{"award-number":["No.2023YFC2410404"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. U2241273"],"award-info":[{"award-number":["No. U2241273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Municipal Natural Science Foundation","award":["No. Z240017"],"award-info":[{"award-number":["No. Z240017"]}]},{"name":"the 111 project, Fundamental Research Funds for the Central Universities","award":["B13003"],"award-info":[{"award-number":["B13003"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Biomed Eng"],"DOI":"10.1007\/s10439-026-04134-5","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:21:19Z","timestamp":1778160079000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploratory Characterization of Adaptive Eye Strategies to High-Acceleration Loading in the Great Spotted Woodpecker"],"prefix":"10.1007","author":[{"given":"Jiazheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3732-0185","authenticated-orcid":false,"given":"Qiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elsheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8328-7569","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8549-3286","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-659X","authenticated-orcid":false,"given":"Lizhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3480-4395","authenticated-orcid":false,"given":"Yubo","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"4134_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.690528","volume":"8","author":"J Zhang","year":"2021","unstructured":"Zhang, J., X. Zhu, Z. Sun, et al. Epidemiology of sports-related eye injuries among athletes in Tianjin. China. Front. Med.8:690528, 2021. https:\/\/doi.org\/10.3389\/fmed.2021.690528.","journal-title":"China. Front. Med."},{"key":"4134_CR2","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1097\/MS9.0000000000000143","volume":"85","author":"B Koirala","year":"2023","unstructured":"Koirala, B., and A. Sapkota. Retinal detachment secondary to bungee jump. Ann. Med. Surg. 85:195\u2013197, 2023. https:\/\/doi.org\/10.1097\/MS9.0000000000000143.","journal-title":"Ann. Med. Surg."},{"key":"4134_CR3","doi-asserted-by":"publisher","first-page":"e388","DOI":"10.1542\/peds.2008-0024","volume":"122","author":"C Day","year":"2008","unstructured":"Day, C., U. Stolz, T. J. Mehan, et al. Diving-related injuries in children <20 years old treated in emergency departments in the United States: 1990\u20132006. Pediatrics. 122:e388\u2013e394, 2008. https:\/\/doi.org\/10.1542\/peds.2008-0024.","journal-title":"Pediatrics"},{"key":"4134_CR4","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1111\/1742-6723.14473","volume":"36","author":"N Dewhurst","year":"2024","unstructured":"Dewhurst, N., D. Tangri, J. Arslan, et al. Ocular trauma in badminton: A 5-year review of badminton-related eye injury emergency department presentations. Emerg. Med. Australas. 36:915\u2013919, 2024. https:\/\/doi.org\/10.1111\/1742-6723.14473.","journal-title":"Emerg. Med. Australas."},{"key":"4134_CR5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1001\/jamaophthalmol.2021.5907","volume":"140","author":"YS Shah","year":"2022","unstructured":"Shah, Y. S., M. Iftikhar, G. A. Justin, et al. A national analysis of ophthalmic features and mortality in abusive head Trauma. JAMA Ophthalmol. 140:227, 2022. https:\/\/doi.org\/10.1001\/jamaophthalmol.2021.5907.","journal-title":"JAMA Ophthalmol."},{"key":"4134_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.pediatrneurol.2021.11.004","volume":"127","author":"R Weiss","year":"2022","unstructured":"Weiss, R., C. H. He, S. Khan, et al. Ocular injuries in pediatric patients admitted with abusive head trauma. Pediatr. Neurol. 127:11\u201318, 2022. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2021.11.004.","journal-title":"Pediatr. Neurol."},{"key":"4134_CR7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0039-6257(96)80025-7","volume":"41","author":"SM Napier","year":"1996","unstructured":"Napier, S. M., R. S. Baker, D. G. Sanford, et al. Eye injuries in athletics and recreation. Surv. Ophthalmol. 41:229\u2013244, 1996. https:\/\/doi.org\/10.1016\/S0039-6257(96)80025-7.","journal-title":"Surv. Ophthalmol."},{"key":"4134_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2022.100129","volume":"2","author":"MR Lam","year":"2022","unstructured":"Lam, M. R., P. Dong, Y. Shokrollahi, et al. Finite element analysis of soccer ball-related ocular and retinal trauma and comparison with abusive head trauma. Ophthalmol. Sci.2:100129, 2022. https:\/\/doi.org\/10.1016\/j.xops.2022.100129.","journal-title":"Ophthalmol. Sci."},{"key":"4134_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-981-13-9741-7","volume-title":"Sports-related eye injuries","author":"H Yan","year":"2020","unstructured":"Yan, H. Sports-related eye injuries. Singapore: Springer Singapore Pte. Limited, p. 1, 2020."},{"key":"4134_CR10","doi-asserted-by":"publisher","first-page":"053","DOI":"10.1385\/FSMP:1:1:053","volume":"1","author":"S Cirovic","year":"2005","unstructured":"Cirovic, S., R. M. Bhola, D. R. Hose, et al. Mechanistic hypothesis for eye injury in infant shaking: an experimental and computational study. Forensic Sci. Med. Pathol. 1:053\u2013060, 2005. https:\/\/doi.org\/10.1385\/FSMP:1:1:053.","journal-title":"Forensic Sci. Med. Pathol."},{"key":"4134_CR11","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3390\/children11050586","volume":"11","author":"K Shahraki","year":"2024","unstructured":"Shahraki, K., and D. W. Suh. An update to biomechanical and biochemical principles of retinal injury in child abuse. Children. 11:586, 2024. https:\/\/doi.org\/10.3390\/children11050586.","journal-title":"Children"},{"key":"4134_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3161\/00016454AO2020.55.1.013","volume":"55","author":"T Kyle","year":"2020","unstructured":"Kyle, T. The structure and function of drumming in the Middle Spotted Woodpecker Dendrocoptes Medius. Acta Ornithol. 55:129\u2013138, 2020. https:\/\/doi.org\/10.3161\/00016454AO2020.55.1.013.","journal-title":"Acta Ornithol."},{"key":"4134_CR13","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1001\/archneur.1979.00500420080011","volume":"36","author":"P May","year":"1979","unstructured":"May, P., J. Fuster, J. Haber, et al. Woodpecker drilling behavior. Arch. Neurol. 36:370, 1979. https:\/\/doi.org\/10.1001\/archneur.1979.00500420080011.","journal-title":"Arch. Neurol."},{"key":"4134_CR14","doi-asserted-by":"publisher","first-page":"350","DOI":"10.2307\/1370276","volume":"100","author":"R Stark","year":"1998","unstructured":"Stark, R., D. Dodenhoff, and E. Johnson. A quantitative analysis of woodpecker drumming. The Condor. 100:350\u2013356, 1998. https:\/\/doi.org\/10.2307\/1370276.","journal-title":"The Condor"},{"key":"4134_CR15","doi-asserted-by":"publisher","first-page":"20140274","DOI":"10.1098\/rsif.2014.0274","volume":"11","author":"N Lee","year":"2014","unstructured":"Lee, N., M. F. Horstemeyer, H. Rhee, et al. Hierarchical multiscale structure\u2013property relationships of the red-bellied woodpecker (Melanerpes carolinus) beak. J. R. Soc. Interface. 11:20140274, 2014. https:\/\/doi.org\/10.1098\/rsif.2014.0274.","journal-title":"J. R. Soc. Interface"},{"key":"4134_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191526","volume":"13","author":"G Farah","year":"2018","unstructured":"Farah, G., D. Siwek, and P. Cummings. Tau accumulations in the brains of woodpeckers. PLoS ONE.13:e0191526, 2018. https:\/\/doi.org\/10.1371\/journal.pone.0191526.","journal-title":"PLoS ONE"},{"key":"4134_CR17","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s11431-020-1754-0","volume":"64","author":"P Xu","year":"2021","unstructured":"Xu, P., Y. Ni, J. Liu, et al. Biological analysis of woodpecker\u2019s brain after impact experiments. Sci. China Technol. Sci. 64:1101\u20131106, 2021. https:\/\/doi.org\/10.1007\/s11431-020-1754-0.","journal-title":"Sci. China Technol. Sci."},{"key":"4134_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026490","volume":"6","author":"L Wang","year":"2011","unstructured":"Wang, L., J. T. Cheung, F. Pu, et al. Why do woodpeckers resist head impact injury: a biomechanical investigation. PLoS ONE.6:e26490, 2011. https:\/\/doi.org\/10.1371\/journal.pone.0026490.","journal-title":"PLoS ONE"},{"key":"4134_CR19","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1007\/s11427-013-4523-z","volume":"56","author":"L Wang","year":"2013","unstructured":"Wang, L., S. Lu, X. Liu, et al. Biomechanism of impact resistance in the woodpecker\u2019s head and its application. Sci. China Life Sci. 56:715\u2013719, 2013. https:\/\/doi.org\/10.1007\/s11427-013-4523-z.","journal-title":"Sci. China Life Sci."},{"key":"4134_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2016.03.030","volume":"37","author":"J-Y Jung","year":"2016","unstructured":"Jung, J.-Y., S. E. Naleway, N. A. Yaraghi, et al. Structural analysis of the tongue and hyoid apparatus in a woodpecker. Acta Biomater. 37:1\u201313, 2016. https:\/\/doi.org\/10.1016\/j.actbio.2016.03.030.","journal-title":"Acta Biomater."},{"key":"4134_CR21","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1007\/s11427-011-4242-2","volume":"54","author":"L Wang","year":"2011","unstructured":"Wang, L., H. Zhang, and Y. Fan. Comparative study of the mechanical properties, micro-structure, and composition of the cranial and beak bones of the great spotted woodpecker and the lark bird. Sci. China Life Sci. 54:1036\u20131041, 2011. https:\/\/doi.org\/10.1007\/s11427-011-4242-2.","journal-title":"Sci. China Life Sci."},{"key":"4134_CR22","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1155\/2013\/924564","volume":"1\u20136","author":"L Wang","year":"2013","unstructured":"Wang, L., X. Niu, Y. Ni, et al. Effect of microstructure of spongy bone in different parts of woodpecker\u2019s skull on resistance to impact injury. J. Nanomater. 1\u20136:2013, 2013. https:\/\/doi.org\/10.1155\/2013\/924564.","journal-title":"J. Nanomater."},{"key":"4134_CR23","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/sj.eye.6702163","volume":"21","author":"T Wygnanski-Jaffe","year":"2007","unstructured":"Wygnanski-Jaffe, T., C. J. Murphy, C. Smith, et al. Protective ocular mechanisms in woodpeckers. Eye. 21:83\u201389, 2007. https:\/\/doi.org\/10.1038\/sj.eye.6702163.","journal-title":"Eye"},{"key":"4134_CR24","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1007\/s11427-019-1664-1","volume":"63","author":"S Lu","year":"2020","unstructured":"Lu, S., X. Fan, S. Liu, et al. Biomechanism of resistance to retinal injury in woodpecker\u2019s eyes. Sci. China Life Sci. 63:592\u2013598, 2020. https:\/\/doi.org\/10.1007\/s11427-019-1664-1.","journal-title":"Sci. China Life Sci."},{"key":"4134_CR25","volume-title":"My year with the woodpeackers","author":"H Sielmann","year":"1959","unstructured":"Sielmann, H. My year with the woodpeackers. London: Barrie and Rockliff, 1959."},{"key":"4134_CR26","doi-asserted-by":"publisher","first-page":"280","DOI":"10.11606\/issn.1678-4456.bjvras.2016.109045","volume":"53","author":"DG Pinto","year":"2016","unstructured":"Pinto, D. G., G. D. Cruz, R. H. F. Teixeira, et al. Histological analysis of the eyeball of neotropical birds of prey Caracara Plancus, Falco Sparverius, Rupornis Magnirostris, Megascops Choliba and Athene Cunicularia. Braz. J. Vet. Res. Anim. Sci. 53:280, 2016. https:\/\/doi.org\/10.11606\/issn.1678-4456.bjvras.2016.109045.","journal-title":"Braz. J. Vet. Res. Anim. Sci."},{"key":"4134_CR27","doi-asserted-by":"publisher","first-page":"4993179","DOI":"10.1155\/vmi\/4993179","volume":"2025","author":"M Masoudifard","year":"2025","unstructured":"Masoudifard, M., O. Zehtabvar, A. Shahbazi, et al. Anatomical study of the scleral ring and Scleral Ossicles of the Ostrich (Struthio camelus) with gross anatomical methods and diagnostic imaging techniques. Vet. Med. Int. 2025:4993179, 2025. https:\/\/doi.org\/10.1155\/vmi\/4993179.","journal-title":"Vet. Med. Int."},{"key":"4134_CR28","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s11064-015-1801-0","volume":"41","author":"AR Jayakumar","year":"2016","unstructured":"Jayakumar, A. R., L. K. Bak, K. V. Rama Rao, et al. Neuronal cell death induced by mechanical percussion trauma in cultured neurons is not preceded by alterations in glucose, lactate and glutamine metabolism. Neurochem. Res. 41:307\u2013315, 2016. https:\/\/doi.org\/10.1007\/s11064-015-1801-0.","journal-title":"Neurochem. Res."},{"key":"4134_CR29","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1089\/neu.2010.1602","volume":"29","author":"J Ji","year":"2012","unstructured":"Ji, J., Y. Y. Tyurina, M. Tang, et al. Mitochondrial injury after mechanical stretch of cortical neurons in vitro: biomarkers of apoptosis and selective peroxidation of anionic phospholipids. J. Neurotrauma. 29:776\u2013788, 2012. https:\/\/doi.org\/10.1089\/neu.2010.1602.","journal-title":"J. Neurotrauma"},{"key":"4134_CR30","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1080\/09168451.2014.932664","volume":"78","author":"X Quan","year":"2014","unstructured":"Quan, X., K. Guo, Y. Wang, et al. Mechanical compression insults induce nanoscale changes of membrane-skeleton arrangement which could cause apoptosis and necrosis in dorsal root ganglion neurons. Biosci. Biotechnol. Biochem. 78:1631\u20131639, 2014. https:\/\/doi.org\/10.1080\/09168451.2014.932664.","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"4134_CR31","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/978-3-7091-6475-4_60","volume-title":"Intracranial pressure and neuromonitoring in brain injury","author":"C Heuvel","year":"1998","unstructured":"Heuvel, C., S. Lewis, M. Wong, et al. Diffuse neuronal perikaryon amyloid precursor protein immunoreactivity in a focal head impact model. In: Intracranial pressure and neuromonitoring in brain injury, edited by A. Marmarou, R. Bullock, C. Avezaat, A. Baethmann, D. Becker, M. Brock, J. Hoff, H. Nagai, H.-J. Reulen, G. Teasdale, et al., . Vienna: Springer Vienna, 1998, pp. 209\u2013211. https:\/\/doi.org\/10.1007\/978-3-7091-6475-4_60."},{"key":"4134_CR32","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1089\/neu.1995.12.269","volume":"12","author":"GL Li","year":"1995","unstructured":"Li, G. L., M. Farooque, A. Holtz, et al. Changes of \u03b2-amyloid precursor protein after compression trauma to the spinal cord: an experimental study in the rat using immunohistochemistry. J. Neurotrauma. 12:269\u2013277, 1995. https:\/\/doi.org\/10.1089\/neu.1995.12.269.","journal-title":"J. Neurotrauma"},{"key":"4134_CR33","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00415-025-13117-w","volume":"272","author":"J Lin","year":"2025","unstructured":"Lin, J., H. Li, L. Jiang, et al. Novel strategies for targeting tau oligomers in neurodegenerative diseases. J. Neurol. 272:383, 2025. https:\/\/doi.org\/10.1007\/s00415-025-13117-w.","journal-title":"J. Neurol."},{"key":"4134_CR34","doi-asserted-by":"publisher","first-page":"5155","DOI":"10.1007\/s12035-023-03387-8","volume":"60","author":"Z Waheed","year":"2023","unstructured":"Waheed, Z., J. Choudhary, F. H. Jatala, et al. The role of tau proteoforms in health and disease. Mol. Neurobiol. 60:5155\u20135166, 2023. https:\/\/doi.org\/10.1007\/s12035-023-03387-8.","journal-title":"Mol. Neurobiol."},{"key":"4134_CR35","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/neu.10269","volume":"58","author":"N Arimura","year":"2004","unstructured":"Arimura, N., C. Menager, Y. Fukata, et al. Role of CRMP-2 in neuronal polarity. J. Neurobiol. 58:34\u201347, 2004. https:\/\/doi.org\/10.1002\/neu.10269.","journal-title":"J. Neurobiol."},{"key":"4134_CR36","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s12017-024-08805-1","volume":"26","author":"Y Wang","year":"2024","unstructured":"Wang, Y., S. Harada, Y. Goshima, et al. Inhibition of CRMP2 phosphorylation suppresses microglia activation in the retina and optic nerve and promotes optic nerve regeneration after optic nerve injury. NeuroMolecular Med. 26:37, 2024. https:\/\/doi.org\/10.1007\/s12017-024-08805-1.","journal-title":"NeuroMolecular Med."},{"key":"4134_CR37","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s12192-020-01159-0","volume":"26","author":"S Demyanenko","year":"2021","unstructured":"Demyanenko, S., V. Nikul, S. Rodkin, et al. Exogenous recombinant HSP70 mediates neuroprotection after photothrombotic stroke. Cell Stress Chaperones. 26:103\u2013114, 2021. https:\/\/doi.org\/10.1007\/s12192-020-01159-0.","journal-title":"Cell Stress Chaperones"},{"key":"4134_CR38","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf248","author":"Y Wei","year":"2025","unstructured":"Wei, Y., D. Li, R. Yang, et al. TIA1-mediated stress granules promote neurodegeneration by sequestering HSP70 mRNA in C9orf72 mice. Brain. 2025. https:\/\/doi.org\/10.1093\/brain\/awaf248.","journal-title":"Brain"},{"key":"4134_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2022.101760","volume":"25","author":"P Cheng","year":"2022","unstructured":"Cheng, P., H.-Y. Liao, and H.-H. Zhang. The role of Wnt\/mTOR signaling in spinal cord injury. J. Clin. Orthop. Trauma.25:101760, 2022. https:\/\/doi.org\/10.1016\/j.jcot.2022.101760.","journal-title":"J. Clin. Orthop. Trauma"},{"key":"4134_CR40","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.3390\/ijms23052814","volume":"23","author":"M Villa-Gonz\u00e1lez","year":"2022","unstructured":"Villa-Gonz\u00e1lez, M., G. Mart\u00edn-L\u00f3pez, and M. J. P\u00e9rez-\u00c1lvarez. Dysregulation of mTOR signaling after brain ischemia. Int. J. Mol. Sci. 23:2814, 2022. https:\/\/doi.org\/10.3390\/ijms23052814.","journal-title":"Int. J. Mol. Sci."},{"key":"4134_CR41","doi-asserted-by":"publisher","first-page":"3240","DOI":"10.1002\/dvdy.21754","volume":"237","author":"TA Franz-Odendaal","year":"2008","unstructured":"Franz-Odendaal, T. A. Toward understanding the development of scleral ossicles in the chicken. Gallus Gallus. Dev. Dyn. 237:3240\u20133251, 2008. https:\/\/doi.org\/10.1002\/dvdy.21754.","journal-title":"Gallus Gallus. Dev. Dyn."},{"key":"4134_CR42","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1002\/jmor.1050310302","volume":"31","author":"JR Slonaker","year":"1918","unstructured":"Slonaker, J. R. A physiological study of the anatomy of the eye and its accessory parts of the English sparrow (Passer Domesticus). J. Morphol. 31:351\u2013459, 1918. https:\/\/doi.org\/10.1002\/jmor.1050310302.","journal-title":"J. Morphol."},{"key":"4134_CR43","doi-asserted-by":"publisher","first-page":"5461","DOI":"10.1002\/adfm.201301121","volume":"23","author":"Q Fu","year":"2013","unstructured":"Fu, Q., E. Saiz, M. N. Rahaman, et al. Toward strong and tough glass and ceramic scaffolds for bone repair. Adv. Funct. Mater. 23:5461\u20135476, 2013. https:\/\/doi.org\/10.1002\/adfm.201301121.","journal-title":"Adv. Funct. Mater."},{"key":"4134_CR44","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1111\/ahe.12927","volume":"52","author":"D Korkmaz","year":"2023","unstructured":"Korkmaz, D., I. Demircioglu, I. S. Harem, et al. Macroscopic and microscopic comparison of pecten oculi in different avian species. Anat. Histol. Embryol. 52:696\u2013708, 2023. https:\/\/doi.org\/10.1111\/ahe.12927.","journal-title":"Anat. Histol. Embryol."},{"key":"4134_CR45","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/968652","volume":"2013","author":"MO Dayan","year":"2013","unstructured":"Dayan, M. O., and T. Ozayd\u0131n. A comparative morphometrical study of the pecten oculi in different avian species. Sci. World J.2013:968652, 2013. https:\/\/doi.org\/10.1155\/2013\/968652.","journal-title":"Sci. World J."},{"key":"4134_CR46","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/jez.2866","volume":"343","author":"MMA Abumandour","year":"2025","unstructured":"Abumandour, M. M. A., and B. G. Hanafy. Ultrastructural and SEM-EDX analysis characterizations of the pecten oculi of the Eurasian stone-curlew (Burhinus oedicnemus): new insights to its migratory adaptations with northern Egyptian coast. J. Exp. Zool. Part Ecol. Integr. Physiol. 343:35\u201347, 2025. https:\/\/doi.org\/10.1002\/jez.2866.","journal-title":"J. Exp. Zool. Part Ecol. Integr. Physiol."},{"key":"4134_CR47","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/s0074-7696(08)62417-1","volume":"187","author":"H Wolburg","year":"1999","unstructured":"Wolburg, H., S. Liebner, A. Reichenbach, et al. The pecten oculi of the chicken: a model system for vascular differentiation and barrier maturation. Int. Rev. Cytol. 187:111\u2013159, 1999. https:\/\/doi.org\/10.1016\/s0074-7696(08)62417-1.","journal-title":"Int. Rev. Cytol."},{"key":"4134_CR48","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0304-3940(93)90398-5","volume":"160","author":"SM Gentleman","year":"1993","unstructured":"Gentleman, S. M., M. J. Nash, C. J. Sweeting, et al. \u03b2-Amyloid precursor protein (\u03b2-APP) as a marker for axonal injury after head injury. Neurosci. Lett. 160:139\u2013144, 1993. https:\/\/doi.org\/10.1016\/0304-3940(93)90398-5.","journal-title":"Neurosci. Lett."},{"key":"4134_CR49","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3390\/biomedicines12030520","volume":"12","author":"L De Macedo Filho","year":"2024","unstructured":"De Macedo Filho, L., L. F. Figueredo, G. A. Villegas-Gomez, et al. Pathophysiology-based management of secondary injuries and insults in TBI. Biomedicines. 12:520, 2024. https:\/\/doi.org\/10.3390\/biomedicines12030520.","journal-title":"Biomedicines"},{"key":"4134_CR50","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.wneu.2024.01.084","volume":"185","author":"TJ Orr","year":"2024","unstructured":"Orr, T. J., E. Lesha, A. H. Kramer, et al. Traumatic brain injury: a comprehensive review of biomechanics and molecular pathophysiology. World Neurosurg. 185:74\u201388, 2024. https:\/\/doi.org\/10.1016\/j.wneu.2024.01.084.","journal-title":"World Neurosurg."},{"key":"4134_CR51","doi-asserted-by":"publisher","first-page":"30851","DOI":"10.1074\/jbc.M110.110957","volume":"285","author":"AD Alonso","year":"2010","unstructured":"Alonso, A. D., J. Di Clerico, B. Li, et al. Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. J. Biol. Chem. 285:30851\u201330860, 2010. https:\/\/doi.org\/10.1074\/jbc.M110.110957.","journal-title":"J. Biol. Chem."},{"key":"4134_CR52","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13024-017-0199-3","volume":"12","author":"M Chiasseu","year":"2017","unstructured":"Chiasseu, M., L. Alarcon, N. Belforte, et al. Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer\u2019s disease. Mol. Neurodegener. 12:58\u201358, 2017. https:\/\/doi.org\/10.1186\/s13024-017-0199-3.","journal-title":"Mol. Neurodegener."},{"key":"4134_CR53","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1021\/acschemneuro.0c00307","volume":"11","author":"R Khanna","year":"2020","unstructured":"Khanna, R., A. Moutal, S. Perez-Miller, et al. Druggability of CRMP2 for neurodegenerative diseases. ACS Chem. Neurosci. 11:2492\u20132505, 2020. https:\/\/doi.org\/10.1021\/acschemneuro.0c00307.","journal-title":"ACS Chem. Neurosci."},{"key":"4134_CR54","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1080\/02656730500069955","volume":"21","author":"TB Franklin","year":"2005","unstructured":"Franklin, T. B., A. M. Krueger-Naug, D. B. Clarke, et al. The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system. Int. J. Hyperth. 21:379\u2013392, 2005. https:\/\/doi.org\/10.1080\/02656730500069955.","journal-title":"Int. J. Hyperth."},{"key":"4134_CR55","doi-asserted-by":"publisher","first-page":"1230436","DOI":"10.3389\/fnmol.2023.1230436","volume":"16","author":"AA Venediktov","year":"2023","unstructured":"Venediktov, A. A., O. Y. Bushueva, V. A. Kudryavtseva, et al. Closest horizons of HSP70 engagement to manage neurodegeneration. Front. Mol. Neurosci. 16:1230436, 2023. https:\/\/doi.org\/10.3389\/fnmol.2023.1230436.","journal-title":"Front. Mol. Neurosci."},{"key":"4134_CR56","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1111\/j.1471-4159.2007.04829.x","volume":"103","author":"AR Cole","year":"2007","unstructured":"Cole, A. R., W. Noble, L. V. Aalten, et al. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer\u2019s disease progression. J. Neurochem. 103:1132\u20131144, 2007. https:\/\/doi.org\/10.1111\/j.1471-4159.2007.04829.x.","journal-title":"J. Neurochem."},{"key":"4134_CR57","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1083\/jcb.200505078","volume":"171","author":"KA Ryan","year":"2005","unstructured":"Ryan, K. A., and S. W. Pimplikar. Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. J. Cell Biol. 171:327\u2013335, 2005. https:\/\/doi.org\/10.1083\/jcb.200505078.","journal-title":"J. Cell Biol."},{"key":"4134_CR58","doi-asserted-by":"publisher","first-page":"6736","DOI":"10.1007\/s12035-019-1568-4","volume":"56","author":"A Moutal","year":"2019","unstructured":"Moutal, A., K. A. White, A. Chefdeville, et al. Dysregulation of CRMP2 post-translational modifications drive its pathological functions. Mol Neurobiol. 56:6736\u20136755, 2019. https:\/\/doi.org\/10.1007\/s12035-019-1568-4.","journal-title":"Mol Neurobiol"},{"key":"4134_CR59","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.2174\/1570159X18666201116145507","volume":"19","author":"S Mylvaganam","year":"2021","unstructured":"Mylvaganam, S., R. Earnshaw, G. Heymann, et al. C-terminus of Hsp70 interacting protein (CHIP) and neurodegeneration: lessons from the bench and bedside. Curr. Neuropharmacol. 19:1038\u20131068, 2021. https:\/\/doi.org\/10.2174\/1570159X18666201116145507.","journal-title":"Curr. Neuropharmacol."},{"key":"4134_CR60","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s12974-022-02607-7","volume":"19","author":"L Xu","year":"2022","unstructured":"Xu, L., M. Li, A. Wei, et al. Treadmill exercise promotes E3 ubiquitin ligase to remove amyloid \u03b2 and P-tau and improve cognitive ability in APP\/PS1 transgenic mice. J. Neuroinflam. 19:243, 2022. https:\/\/doi.org\/10.1186\/s12974-022-02607-7.","journal-title":"J. Neuroinflam."},{"key":"4134_CR61","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41556-018-0205-1","volume":"21","author":"J Kim","year":"2019","unstructured":"Kim, J., and K.-L. Guan. mTOR as a central hub of nutrient signalling and cell growth. Nat. Cell Biol. 21:63\u201371, 2019. https:\/\/doi.org\/10.1038\/s41556-018-0205-1.","journal-title":"Nat. Cell Biol."},{"key":"4134_CR62","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","volume":"168","author":"RA Saxton","year":"2017","unstructured":"Saxton, R. A., and D. M. Sabatini. mTOR Signaling in growth, metabolism, and disease. Cell. 168:960\u2013976, 2017. https:\/\/doi.org\/10.1016\/j.cell.2017.02.004.","journal-title":"Cell"},{"key":"4134_CR63","doi-asserted-by":"publisher","first-page":"175628642311877","DOI":"10.1177\/17562864231187770","volume":"16","author":"K Melanis","year":"2023","unstructured":"Melanis, K., M. I. Stefanou, K. M. Themistoklis, et al. mTOR pathway - a potential therapeutic target in stroke. Ther Adv Neurol Disord. 16:17562864231187770, 2023. https:\/\/doi.org\/10.1177\/17562864231187770.","journal-title":"Ther Adv Neurol Disord"}],"container-title":["Annals of Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-026-04134-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10439-026-04134-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-026-04134-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:15:45Z","timestamp":1782929745000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10439-026-04134-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":63,"alternative-id":["4134"],"URL":"https:\/\/doi.org\/10.1007\/s10439-026-04134-5","relation":{},"ISSN":["0090-6964","1573-9686"],"issn-type":[{"value":"0090-6964","type":"print"},{"value":"1573-9686","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"assertion":[{"value":"26 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}