{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:36:02Z","timestamp":1783020962753,"version":"3.54.6"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62373070"],"award-info":[{"award-number":["62373070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M670111ZX"],"award-info":[{"award-number":["2020M670111ZX"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019595","name":"Youth and Middle-aged Scientific and Technological Innovation Leading Talents Program of the Corps","doi-asserted-by":"publisher","award":["yxgdrc20210101"],"award-info":[{"award-number":["yxgdrc20210101"]}],"id":[{"id":"10.13039\/501100019595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","award":["KYYJ202004"],"award-info":[{"award-number":["KYYJ202004"]}],"id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-MSX0663"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0663"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Biomed Eng"],"DOI":"10.1007\/s10439-026-04182-x","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:23:33Z","timestamp":1783016613000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Pressure Difference-Based Strategy for Blood Oxygen Control in Membrane Oxygenators: Reduced Modeling, Computational Simulation, and Exploratory In Vivo Evaluation"],"prefix":"10.1007","author":[{"given":"Shiwei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xirong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daidi","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"4182_CR1","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1186\/s13054-015-1155-7","volume":"19","author":"JM Mosier","year":"2015","unstructured":"Mosier, J. M., M. Kelsey, and Y. Raz. Extracorporeal membrane oxygenation (ECMO) for critically ill adults in the emergency department: history, current applications, and future directions. Crit. Care. 19:431, 2015. https:\/\/doi.org\/10.1186\/s13054-015-1155-7.","journal-title":"Crit. Care"},{"issue":"14","key":"4182_CR2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.21037\/atm.2017.06.58","volume":"5","author":"M Parekh","year":"2017","unstructured":"Parekh, M., D. Abrams, and D. Brodie. Extracorporeal techniques in acute respiratory distress syndrome. Ann. Transl. Med. 5(14):296, 2017. https:\/\/doi.org\/10.21037\/atm.2017.06.58.","journal-title":"Ann. Transl. Med."},{"issue":"3","key":"4182_CR3","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.jtcvs.2013.11.007","volume":"147","author":"TP Theruvath","year":"2014","unstructured":"Theruvath, T. P. Historical perspectives of The American Association for Thoracic Surgery: John H. Gibbon, Jr (1903\u20131973). J. Thorac. Cardiovasc. Surg. 147(3):833\u2013836, 2014. https:\/\/doi.org\/10.1016\/j.jtcvs.2013.11.007.","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"1-Suppl","key":"4182_CR4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1177\/02676591241238156","volume":"39","author":"E Tomarchio","year":"2024","unstructured":"Tomarchio, E., F. Momigliano, L. Giosa, P. D. Collins, N. A. Barrett, and L. Camporota. The intricate physiology of veno-venous extracorporeal membrane oxygenation: an overview for clinicians. Perfusion. 39(1-Suppl):49\u201365, 2024. https:\/\/doi.org\/10.1177\/02676591241238156.","journal-title":"Perfusion"},{"issue":"3","key":"4182_CR5","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/MCC.0000000000001259","volume":"31","author":"D Furfaro","year":"2025","unstructured":"Furfaro, D., A. Supady, and D. Abrams. Oxygen delivery and carbon dioxide removal on venovenous extracorporeal membrane oxygenation. Curr. Opin. Crit. Care. 31(3):328\u2013336, 2025. https:\/\/doi.org\/10.1097\/MCC.0000000000001259.","journal-title":"Curr. Opin. Crit. Care"},{"issue":"2","key":"4182_CR6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/00002480-200503000-00216","volume":"51","author":"I Taga","year":"2005","unstructured":"Taga, I., A. Funakubo, T. Higami, T. Kawamura, and Y. Fukui. Study on evaluation of artificial implantable lung design. ASAIO J. 51(2):55, 2005.","journal-title":"ASAIO J."},{"issue":"3","key":"4182_CR7","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1061\/JMCEA3.0000991","volume":"94","author":"MH Weissman","year":"1968","unstructured":"Weissman, M. H., and L. F. Mockros. Gas transfer to blood flowing in coiled circular tubes. J. Eng. Mech. Div. 94(3):857\u2013872, 1968. https:\/\/doi.org\/10.1061\/JMCEA3.0000991.","journal-title":"J. Eng. Mech. Div."},{"key":"4182_CR8","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/BF02474173","volume":"7","author":"MH Weissman","year":"1969","unstructured":"Weissman, M. H., and L. F. Mockros. Oxygen and carbon dioxide transfer in membrane oxygenators. Med. Biol. Eng. 7:169\u2013184, 1969. https:\/\/doi.org\/10.1007\/BF02474173.","journal-title":"Med. Biol. Eng."},{"issue":"1","key":"4182_CR9","first-page":"628","volume":"31","author":"LF Mockros","year":"1985","unstructured":"Mockros, L. F., and R. Leonard. Compact cross-flow tubular oxygenators. ASAIO J. 31(1):628\u2013633, 1985.","journal-title":"ASAIO J."},{"issue":"4","key":"4182_CR10","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1097\/00002480-199440040-00016","volume":"40","author":"SN Vaslef","year":"1994","unstructured":"Vaslef, S. N., L. F. Mockros, R. W. Anderson, and R. J. Leonard. Use of a mathematical model to predict oxygen transfer rates in hollow fiber membrane oxygenators. ASAIO J. 40(4):990\u2013996, 1994.","journal-title":"ASAIO J."},{"issue":"6","key":"4182_CR11","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1007\/s10439-008-9482-3","volume":"36","author":"RG Svitek","year":"2008","unstructured":"Svitek, R. G., and W. J. Federspiel. A mathematical model to predict CO$$_{2}$$ removal in hollow fiber membrane oxygenators. Ann. Biomed. Eng. 36(6):992\u20131003, 2008. https:\/\/doi.org\/10.1007\/s10439-008-9482-3.","journal-title":"Ann. Biomed. Eng."},{"issue":"1\u20132","key":"4182_CR12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0376-7388(00)00512-3","volume":"179","author":"N Matsuda","year":"2000","unstructured":"Matsuda, N., K. Sakai, K.-I. Yamamoto, and H. Iwasaki. Effects of hollow fiber packing fraction on blood flow pattern and gas transfer rate of an intravascular oxygenator (IVOX). J. Membr. Sci. 179(1\u20132):231\u2013241, 2000. https:\/\/doi.org\/10.1016\/S0376-7388(00)00512-3.","journal-title":"J. Membr. Sci."},{"key":"4182_CR13","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s10047-012-0655-3","volume":"15","author":"H Tabesh","year":"2012","unstructured":"Tabesh, H., G. Amoabediny, A. Poorkhalil, A. Khachab, A. Kashefi, and K. Mottaghy. A theoretical model for evaluation of the design of a hollow-fiber membrane oxygenator. J. Artif. Organs. 15:347\u2013356, 2012. https:\/\/doi.org\/10.1007\/s10047-012-0655-3.","journal-title":"J. Artif. Organs"},{"issue":"6","key":"4182_CR14","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1111\/j.1525-1594.2010.01150.x","volume":"35","author":"F Turri","year":"2011","unstructured":"Turri, F., and J. I. Yanagihara. Computer-assisted numerical analysis for oxygen and carbon dioxide mass transfer in blood oxygenators. Artif. Organs. 35(6):579\u2013592, 2011. https:\/\/doi.org\/10.1111\/j.1525-1594.2010.01150.x.","journal-title":"Artif. Organs"},{"key":"4182_CR15","doi-asserted-by":"publisher","unstructured":"Smith, D. J. and H. V. Porumamilla. LQG based robust tracking control of blood gases during extracorporeal membrane oxygenation. In: Proceedings of the American Control Conference, 2011, pp. 324\u2013329. https:\/\/doi.org\/10.1109\/ACC.2011.5991330.","DOI":"10.1109\/ACC.2011.5991330"},{"issue":"4","key":"4182_CR16","doi-asserted-by":"publisher","first-page":"634","DOI":"10.4046\/trd.2025.0076","volume":"88","author":"SY Lim","year":"2025","unstructured":"Lim, S. Y., and M. Schmidt. Optimizing extracorporeal membrane oxygenation gas exchange: key insights for clinical management. Tuberc. Respir. Dis. 88(4):634\u2013642, 2025. https:\/\/doi.org\/10.4046\/trd.2025.0076.","journal-title":"Tuberc. Respir. Dis."},{"issue":"6","key":"4182_CR17","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/j.1525-1594.2009.00890.x","volume":"34","author":"BJE Misgeld","year":"2010","unstructured":"Misgeld, B. J. E., J. Werner, and M. Hexamer. Simultaneous automatic control of oxygen and carbon dioxide blood gases during cardiopulmonary bypass. Artif. Organs. 34(6):503\u2013512, 2010. https:\/\/doi.org\/10.1111\/j.1525-1594.2009.00890.x.","journal-title":"Artif. Organs"},{"issue":"9","key":"4182_CR18","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3390\/membranes15090268","volume":"15","author":"SH Monsefi Estakhrposhti","year":"2025","unstructured":"Monsefi Estakhrposhti, S. H., J. Xu, M. Gf\u00f6hler, and M. Harasek. A validated CFD model for gas exchange in hollow fiber membrane oxygenators: incorporating the Bohr and Haldane effects. Membranes. 15(9):268, 2025. https:\/\/doi.org\/10.3390\/membranes15090268.","journal-title":"Membranes"},{"issue":"9","key":"4182_CR19","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.21037\/jtd.2017.07.93","volume":"9","author":"LM Broman","year":"2017","unstructured":"Broman, L. M. Inter-hospital transports on extracorporeal membrane oxygenation in different health-care systems. J. Thorac. Dis. 9(9):3425\u20133429, 2017. https:\/\/doi.org\/10.21037\/jtd.2017.07.93.","journal-title":"J. Thorac. Dis."},{"issue":"2","key":"4182_CR20","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1177\/02676591241232824","volume":"40","author":"P Chotimol","year":"2024","unstructured":"Chotimol, P., W. Lansdowne, D. Machin, K. Binas, G. D. Angelini, and B. Gibbison. Hypobaric type oxygenators\u2014physics and physiology. Perfusion. 40(2):273\u2013282, 2024. https:\/\/doi.org\/10.1177\/02676591241232824.","journal-title":"Perfusion"},{"issue":"9","key":"4182_CR21","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1097\/MAT.0000000000002396","volume":"71","author":"D Han","year":"2025","unstructured":"Han, D., J. Zhang, A. Shah, B. P. Griffith, and Z. J. Wu. A new multifunction oxygenator with a dual-chamber gas exchanger to reduce dependence on oxygen supply. ASAIO J. 71(9):719\u2013726, 2025. https:\/\/doi.org\/10.1097\/MAT.0000000000002396.","journal-title":"ASAIO J."},{"key":"4182_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-60513-5_1","volume-title":"Hemorheology and Hemodynamics","author":"A Fasano","year":"2017","unstructured":"Fasano, A., and A. Sequeira. Hemorheology and Hemodynamics. Cham: Springer, pp. 1\u201377, 2017. https:\/\/doi.org\/10.1007\/978-3-319-60513-5_1."},{"issue":"5","key":"4182_CR23","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/BF00585068","volume":"408","author":"H Kiwull-Sch\u00f6ne","year":"1987","unstructured":"Kiwull-Sch\u00f6ne, H., B. G\u00e4rtner, and P. Kiwull. The effects of CO$$_{2}$$ and fixed acid on the O$$_{2}$$-Hb affinity of rabbit and cat blood. Pfl\u00fcgers Arch. 408(5):451\u2013457, 1987. https:\/\/doi.org\/10.1007\/BF00585068.","journal-title":"Pfl\u00fcgers Arch."},{"issue":"2","key":"4182_CR24","first-page":"183","volume":"100","author":"RAB Holland","year":"1995","unstructured":"Holland, R. A. B., et al. Oxygen transport by rabbit embryonic blood: high cooperativity of hemoglobin\u2013oxygen binding. Respir. Physiol. 100(2):183\u2013190, 1995.","journal-title":"Respir. Physiol."},{"issue":"3","key":"4182_CR25","first-page":"599","volume":"46","author":"JW Severinghaus","year":"1979","unstructured":"Severinghaus, J. W. Simple, accurate equations for human blood O$$_{2}$$ dissociation computations. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 46(3):599\u2013602, 1979.","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"4182_CR26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s40981-020-00368-x","volume":"6","author":"K Hirota","year":"2020","unstructured":"Hirota, K., M. Murata, and K. Shingu. A proposal for a new temperature-corrected formula for the oxygen content of blood. JA Clin. Rep. 6:62, 2020. https:\/\/doi.org\/10.1186\/s40981-020-00368-x.","journal-title":"JA Clin. Rep."},{"key":"4182_CR27","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1002\/cphy.c080113","volume":"2","author":"H Mairb\u00e4url","year":"2012","unstructured":"Mairb\u00e4url, H., and R. E. Weber. Oxygen transport by hemoglobin. Compr. Physiol. 2:1463\u20131489, 2012. https:\/\/doi.org\/10.1002\/cphy.c080113.","journal-title":"Compr. Physiol."},{"key":"4182_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2025.109026","author":"S Wang","year":"2025","unstructured":"Wang, S., J. Jiang, J. Hou, X. Liao, Z. Huang, X. Li, J. Zhang, D. Zhong, and P. Yang. Adaptive gas supply system for membrane oxygenator using online model identification and control in normothermic machine perfusion. Comput. Methods Programs Biomed. 2025. https:\/\/doi.org\/10.1016\/j.cmpb.2025.109026.","journal-title":"Comput. Methods Programs Biomed."},{"issue":"1","key":"4182_CR29","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1051\/ject\/2023047","volume":"56","author":"SP Butt","year":"2024","unstructured":"Butt, S. P., N. Razzaq, Y. Saleem, B. Cook, and S. Abdulaziz. Improving ECMO therapy: monitoring oxygenator functionality and identifying key indicators, factors, and considerations for changeout. J. ExtraCorpor. Technol. 56(1):20\u201329, 2024. https:\/\/doi.org\/10.1051\/ject\/2023047.","journal-title":"J. ExtraCorpor. Technol."}],"container-title":["Annals of Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-026-04182-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10439-026-04182-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10439-026-04182-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:23:35Z","timestamp":1783016615000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10439-026-04182-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":29,"alternative-id":["4182"],"URL":"https:\/\/doi.org\/10.1007\/s10439-026-04182-x","relation":{},"ISSN":["0090-6964","1573-9686"],"issn-type":[{"value":"0090-6964","type":"print"},{"value":"1573-9686","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]},"assertion":[{"value":"22 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval was obtained from the Institutional Animal Care and Use Committee (IACUC) of Chongqing Medical University, China. Approval No. IACUC-SAHCQMU-2024-00061.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}