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Ultrasound images of these AAAs were collected longitudinally over a period of 56\u00a0days to evaluate AAA growth over time. We semi-quantitatively assessed elastin degradation and inflammation from Movat\u2019s pentachrome and H&amp;E-stained samples, respectively. Additionally, we assessed extracellular matrix composition and elastin quality through Movat\u2019s pentachrome stained samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mice subjected to elastase\u2009+\u2009BAPN exhibited continuous and significant AAA growth over time. Mice with ILT had more significant expansion over the length of the study (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). From histology, ILT samples showed more elastin damage, greater collagen and proteoglycan accumulation, and greater inflammation than aneurysms without ILT. From scanning electron microscopy, we confirmed the presence of fibrin sheets and abnormally shaped red blood cells (polyhedrocytes) within ILT. We also observed that tissue samples with greater inflammation were correlated with more elastin damage. Increased aortic expansion and wall damage may create hemodynamic conditions conducive to initiation of ILT deposition: endothelial damage and reduced blood flow.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Understanding the relationship between ILT formation, aortic wall degradation, and inflammation could help refine clinical strategies for monitoring and treating AAAs. These data suggest that work focused on modulating inflammation and ILT formation could offer promising pathways for non-surgical intervention in AAA treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10439-026-04249-9","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:35:38Z","timestamp":1783690538000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Murine Abdominal Aortic Aneurysm Intraluminal Thrombus Composition and Structure"],"prefix":"10.1007","author":[{"given":"Cortland H.","family":"Johns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke E.","family":"Schepers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle M. 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