{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:46:23Z","timestamp":1780987583141,"version":"3.54.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiogenesis"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1007\/s10456-010-9164-2","type":"journal-article","created":{"date-parts":[[2010,3,9]],"date-time":"2010-03-09T23:09:54Z","timestamp":1268176194000},"page":"59-69","source":"Crossref","is-referenced-by-count":9,"title":["VHL and PTEN loss coordinate to promote mouse liver vascular lesions"],"prefix":"10.1007","volume":"13","author":[{"given":"Shufen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie A.","family":"Sanford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Jude","family":"Samulski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Kimryn","family":"Rathmell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,11]]},"reference":[{"issue":"1","key":"9164_CR1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0009-9260(05)81467-9","volume":"45","author":"FP McGrath","year":"1992","unstructured":"McGrath FP et al (1992) Case report: multiple hepatic and pulmonary haemangioblastomas\u2014a new manifestation of von Hippel-Lindau disease. Clin Radiol 45(1):37\u201339","journal-title":"Clin Radiol"},{"issue":"6","key":"9164_CR2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00005792-199711000-00001","volume":"76","author":"ER Maher","year":"1997","unstructured":"Maher ER, Kaelin WG Jr (1997) von Hippel-Lindau disease. Medicine (Baltimore) 76(6):381\u2013391","journal-title":"Medicine (Baltimore)"},{"issue":"21","key":"9164_CR3","first-page":"4804","volume":"55","author":"F Chen","year":"1995","unstructured":"Chen F et al (1995) Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene. Cancer Res 55(21):4804\u20134807","journal-title":"Cancer Res"},{"issue":"1","key":"9164_CR4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/ng0594-85","volume":"7","author":"JR Gnarra","year":"1994","unstructured":"Gnarra JR et al (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet 7(1):85\u201390","journal-title":"Nat Genet"},{"issue":"11","key":"9164_CR5","first-page":"2852","volume":"54","author":"T Shuin","year":"1994","unstructured":"Shuin T et al (1994) Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res 54(11):2852\u20132855","journal-title":"Cancer Res"},{"issue":"12","key":"9164_CR6","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1111\/j.1538-7836.2005.01441.x","volume":"3","author":"WK Rathmell","year":"2005","unstructured":"Rathmell WK, Simon MC (2005) VHL: oxygen sensing and vasculogenesis. J Thromb Haemost 3(12):2627\u20132632","journal-title":"J Thromb Haemost"},{"issue":"1","key":"9164_CR7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ijc.10303","volume":"99","author":"W Brenner","year":"2002","unstructured":"Brenner W et al (2002) Loss of tumor suppressor protein PTEN during renal carcinogenesis. Int J Cancer 99(1):53\u201357","journal-title":"Int J Cancer"},{"issue":"7","key":"9164_CR8","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1073\/pnas.0706790105","volume":"105","author":"BM Emerling","year":"2008","unstructured":"Emerling BM et al (2008) PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proc Natl Acad Sci U S A 105(7):2622\u20132627","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"23","key":"9164_CR9","doi-asserted-by":"crossref","first-page":"8595","DOI":"10.1158\/0008-5472.CAN-04-1430","volume":"64","author":"WK Rathmell","year":"2004","unstructured":"Rathmell WK et al (2004) In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Cancer Res 64(23):8595\u20138603","journal-title":"Cancer Res"},{"issue":"14","key":"9164_CR10","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1038\/onc.2009.12","volume":"28","author":"CM Lee","year":"2009","unstructured":"Lee CM et al (2009) VHL type 2B gene mutation moderates HIF dosage in vitro and in vivo. Oncogene 28(14):1694\u20131705","journal-title":"Oncogene"},{"issue":"17","key":"9164_CR11","doi-asserted-by":"crossref","first-page":"9102","DOI":"10.1073\/pnas.94.17.9102","volume":"94","author":"JR Gnarra","year":"1997","unstructured":"Gnarra JR et al (1997) Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A 94(17):9102\u20139107","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"9164_CR12","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1073\/pnas.98.4.1583","volume":"98","author":"VH Haase","year":"2001","unstructured":"Haase VH et al (2001) Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A 98(4):1583\u20131588","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"9164_CR13","first-page":"5320","volume":"63","author":"W Ma","year":"2003","unstructured":"Ma W et al (2003) Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res 63(17):5320\u20135328","journal-title":"Cancer Res"},{"issue":"9","key":"9164_CR14","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nm1460","volume":"12","author":"M Ding","year":"2006","unstructured":"Ding M et al (2006) Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice. Nat Med 12(9):1081\u20131087","journal-title":"Nat Med"},{"issue":"12","key":"9164_CR15","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1038\/emboj.2008.96","volume":"27","author":"IJ Frew","year":"2008","unstructured":"Frew IJ et al (2008) pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation. EMBO J 27(12):1747\u20131757","journal-title":"EMBO J"},{"issue":"16","key":"9164_CR16","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/sj.gt.3301514","volume":"8","author":"DM McCarty","year":"2001","unstructured":"McCarty DM et al (2001) Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis. Gene Ther 8(16):1248\u20131254","journal-title":"Gene Ther"},{"issue":"26","key":"9164_CR17","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1038\/sj.gt.3302134","volume":"10","author":"DM McCarty","year":"2003","unstructured":"McCarty DM et al (2003) Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo. Gene Ther 10(26):2112\u20132118","journal-title":"Gene Ther"},{"issue":"5","key":"9164_CR18","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/oxfordjournals.jbchem.a021860","volume":"122","author":"K Araki","year":"1997","unstructured":"Araki K et al (1997) Efficiency of recombination by Cre transient expression in embryonic stem cells: comparison of various promoters. J Biochem (Tokyo) 122(5):977\u2013982","journal-title":"J Biochem (Tokyo)"},{"issue":"6","key":"9164_CR19","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/sj.gt.3300938","volume":"6","author":"S Zolotukhin","year":"1999","unstructured":"Zolotukhin S et al (1999) Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther 6(6):973\u2013985","journal-title":"Gene Ther"},{"issue":"4","key":"9164_CR20","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1159\/000077378","volume":"96","author":"S Takeda","year":"2004","unstructured":"Takeda S et al (2004) Successful gene transfer using adeno-associated virus vectors into the kidney: comparison among adeno-associated virus serotype 1\u20135 vectors in vitro and in vivo. Nephron Exp Nephrol 96(4):e119\u2013e126","journal-title":"Nephron Exp Nephrol"},{"issue":"7051","key":"9164_CR21","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature03918","volume":"436","author":"Z Chen","year":"2005","unstructured":"Chen Z et al (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436(7051):725\u2013730","journal-title":"Nature"},{"issue":"1","key":"9164_CR22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1586\/14737140.8.1.63","volume":"8","author":"WK Rathmell","year":"2008","unstructured":"Rathmell WK, Chen S (2008) VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment. Expert Rev Anticancer Ther 8(1):63\u201373","journal-title":"Expert Rev Anticancer Ther"},{"issue":"3","key":"9164_CR23","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/ncb1699","volume":"10","author":"AP Young","year":"2008","unstructured":"Young AP et al (2008) VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. Nat Cell Biol 10(3):361\u2013369","journal-title":"Nat Cell Biol"},{"issue":"4","key":"9164_CR24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0092-8674(00)80674-1","volume":"100","author":"A Di Cristofano","year":"2000","unstructured":"Di Cristofano A, Pandolfi PP (2000) The multiple roles of PTEN in tumor suppression. Cell 100(4):387\u2013390","journal-title":"Cell"},{"issue":"4","key":"9164_CR25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1101\/gad.14.4.391","volume":"14","author":"W Zundel","year":"2000","unstructured":"Zundel W et al (2000) Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 14(4):391\u2013396","journal-title":"Genes Dev"},{"issue":"1","key":"9164_CR26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0959-437X(02)00010-2","volume":"13","author":"W Kim","year":"2003","unstructured":"Kim W, Kaelin WG Jr (2003) The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer. Curr Opin Genet Dev 13(1):55\u201360","journal-title":"Curr Opin Genet Dev"},{"issue":"1","key":"9164_CR27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng1494","volume":"37","author":"K Inoki","year":"2005","unstructured":"Inoki K et al (2005) Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 37(1):19\u201324","journal-title":"Nat Genet"},{"issue":"50","key":"9164_CR28","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1038\/sj.onc.1209085","volume":"24","author":"DA Altomare","year":"2005","unstructured":"Altomare DA, Testa JR (2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene 24(50):7455\u20137464","journal-title":"Oncogene"}],"container-title":["Angiogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-010-9164-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10456-010-9164-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-010-9164-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T23:01:35Z","timestamp":1685487695000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10456-010-9164-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["9164"],"URL":"https:\/\/doi.org\/10.1007\/s10456-010-9164-2","relation":{},"ISSN":["0969-6970","1573-7209"],"issn-type":[{"value":"0969-6970","type":"print"},{"value":"1573-7209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}