{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:21:48Z","timestamp":1778617308641,"version":"3.51.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,5,8]],"date-time":"2011-05-08T00:00:00Z","timestamp":1304812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiogenesis"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1007\/s10456-011-9215-3","type":"journal-article","created":{"date-parts":[[2011,5,7]],"date-time":"2011-05-07T08:34:50Z","timestamp":1304757290000},"page":"321-330","source":"Crossref","is-referenced-by-count":63,"title":["Taurine: a novel tumor marker for enhanced detection of breast cancer among female patients"],"prefix":"10.1007","volume":"14","author":[{"given":"I. M.","family":"El Agouza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. S.","family":"Eissa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"El Houseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia E.","family":"El-Nashar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. M.","family":"Abd El Hameed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,5,8]]},"reference":[{"issue":"3","key":"9215_CR1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.26719\/2003.9.3.448","volume":"9","author":"S Omar","year":"2003","unstructured":"Omar S, Khaled H, Gaafar R, Zekry R, Eissa S, El-Khatib O (2003) Breast cancer in Egypt: a review of disease presentation and detection strategies. East Mediterr Health J 9(3):448\u2013463","journal-title":"East Mediterr Health J"},{"issue":"5","key":"9215_CR2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.breast.2005.07.002","volume":"14","author":"S Boulos","year":"2005","unstructured":"Boulos S, Gadallah M, Neguib S, Essam E, Youssef A et al (2005) Breast screening in the emerging world: high prevalence of breast cancer in Cairo. Breast 14(5):340\u2013346","journal-title":"Breast"},{"issue":"1","key":"9215_CR3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/carcin\/bgg175","volume":"25","author":"J Mobley","year":"2004","unstructured":"Mobley J, Brueggemeier R (2004) Estrogen receptor-mediated regulation of oxidative stress and DNA damage in breast cancer. Carcinogenesis 25(1):3\u20139","journal-title":"Carcinogenesis"},{"issue":"23","key":"9215_CR4","doi-asserted-by":"crossref","first-page":"11123","DOI":"10.1158\/0008-5472.CAN-07-3061","volume":"67","author":"J Lin","year":"2007","unstructured":"Lin J, Manson J, Selhub J, Buring J, Zhang S (2007) Plasma cysteinylgly-cine Llevels and breast cancer risk in women. Cancer Res 67(23):11123\u201311127","journal-title":"Cancer Res"},{"key":"9215_CR5","volume-title":"SEER cancer statistics review, 1973\u20131999","author":"LAG Ries","year":"2002","unstructured":"Ries LAG, Eisner MP, Kosary CL et al (2002) SEER cancer statistics review, 1973\u20131999. National Cancer Institute, Bethesda, MD"},{"key":"9215_CR6","first-page":"563","volume-title":"The breast \u201ccomprehensive management of benign and malignant disorders\u201d","author":"J Folkman","year":"2004","unstructured":"Folkman J (2004) Angiogenesis in breast cancer. In: Bland K, Copland E (eds) The breast \u201ccomprehensive management of benign and malignant disorders\u201d, vol 1, 3rd edn. Saunders, Missouri, pp 563\u2013586","edition":"3"},{"key":"9215_CR7","unstructured":"Folkman J, Kalluri R (2006) Tumor angiogenesis. In: Kufe DW, Bast RC, Hart WN, et al. (Holland- Frei Cancer Medicin) (ONLINE 7th edn) by BC Decker Inc Hamilton. Londn 2006. (AACR) www.bcdecker.com\/cm7 ), pp 161\u2013194"},{"key":"9215_CR8","first-page":"3491","volume":"7","author":"K Heer","year":"2001","unstructured":"Heer K, Kumar H, Read R, Fox N et al (2001) Serum vascular endothelial growth factor in breast cancer its relation with cancer type and estrogen receptor. Clin Cancer Res 7:3491\u20133494","journal-title":"Clin Cancer Res"},{"issue":"1","key":"9215_CR9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/modpathol.3800253","volume":"18","author":"W Choi","year":"2005","unstructured":"Choi W, Lewis M, Lawson D, Yin-Goen Q, Birdsong G et al (2005) Angiogenic, lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters, VEGF-family gene expression. Mod Pathol 18(1):143\u2013152","journal-title":"Mod Pathol"},{"key":"9215_CR10","first-page":"1528","volume":"322","author":"M Parton","year":"2001","unstructured":"Parton M, Smith I (2001) Studies of apoptosis in breast cancer. Cancer Breast BMJ 322:1528\u20131532","journal-title":"Cancer Breast BMJ"},{"issue":"10","key":"9215_CR11","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1054\/bjoc.2001.2115","volume":"85","author":"I Hadjiloucas","year":"2001","unstructured":"Hadjiloucas I, Glimor AP, Bundred J, Streuli H (2001) Assessment of apoptosis in human breast tissue using an antibody against the active form of caspase -3; relation to tumor histopathologyical charechteristics. Br J Cancer 85(10):1522\u201315260","journal-title":"Br J Cancer"},{"issue":"6","key":"9215_CR12","first-page":"1675","volume":"26","author":"H Yang","year":"2005","unstructured":"Yang H, Edgareton S, Thor D (2005) Reconstituation of caspase-3 sensitizes mcf-7 breast cancer cells to radiation. Int J Oncol 26(6):1675\u20131680","journal-title":"Int J Oncol"},{"key":"9215_CR13","doi-asserted-by":"crossref","unstructured":"Ames BN (1983) Dietary carcinogens and anticarcinogens; oxygen radicals and degenerative diseases. Science (Washington, DC) 221:1256\u20131264","DOI":"10.1126\/science.6351251"},{"issue":"6","key":"9215_CR14","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3892\/ijo_32_6_1205","volume":"32","author":"A Daigeler","year":"2008","unstructured":"Daigeler A, Chromik AM, Geisler A, Bulut D, Hilgert C, Krieg A, Klein-Hitpass L, Lehnhardt M, Uhl W, Mittelkotter U (2008) Synergistic apoptotic effects of taurolidine, TRAIL on squamous carcinoma cells of oesophagus. Int J Oncol 32(6):1205\u20131220","journal-title":"Int J Oncol"},{"issue":"9","key":"9215_CR15","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/01.cad.0000176502.40810.b0","volume":"16","author":"A Jacobi","year":"2005","unstructured":"Jacobi A, Menenakos C, Braumann C (2005) Taurolidine a new drug with anti-tumor, anti-angiogenic effects. Anticancer Drugs 16(9):917\u2013921","journal-title":"Anticancer Drugs"},{"issue":"9","key":"9215_CR16","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1248\/bpb.32.1584","volume":"32","author":"Y Sadszuka","year":"2009","unstructured":"Sadszuka Y, Matsuura M, Snobobe T (2009) The effect of taurine, a novel biochemical modulator, on the antitumor activity of Doxorubicin. Biol Pharm Bull 32(9):1584\u20131587","journal-title":"Biol Pharm Bull"},{"key":"9215_CR17","unstructured":"El Agouza I, Eissa S, Mansure M, El Nashare D (2010) The possiblity of antiangiogenetic effect of Taurine in hepatocellular carcinoma: human and expremental evaluation (in press)"},{"key":"9215_CR18","unstructured":"El Agouza IM, El Nashar D (2011) Serum taurine as a marker in endometrial carcinoma. Women Health Care. Accepted June 2011"},{"issue":"10","key":"9215_CR19","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/0731-7085(95)01697-X","volume":"148","author":"GP McMahon","year":"1996","unstructured":"McMahon GP, O\u2019Kennedy R, Kelly MT (1996) High-performance liquid chromatographic determination of ne in human plasma using pre-column extraction and derivatization. Pharm Biomed Anal 148(10):1287\u20131294","journal-title":"Pharm Biomed Anal"},{"key":"9215_CR20","volume-title":"Medical decision making","author":"HC Sox","year":"1988","unstructured":"Sox HC, Blatt MA, Higgins MC, Marton KI (1988) Medical decision making. Butterworths, Boston, MA"},{"issue":"3","key":"9215_CR21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1373\/clinchem.2005.059832","volume":"52","author":"M Duffy","year":"2006","unstructured":"Duffy M (2006) Serum tumor markers in breast cancer: are they of clinical value? Clin Chem 52(3):345\u2013351","journal-title":"Clin Chem"},{"issue":"6","key":"9215_CR22","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3171\/jns.2005.102.6.1055","volume":"102","author":"R Rodak","year":"2005","unstructured":"Rodak R, Kubota H, Ishihara H, Eugster HP, Konu D, Mohler H et al (2005) Induction of reactive oxygen intermediates-dependent programmed cell death in human malignant ex vivo glioma cells, inhibition of the vascular endothelial growth factor production by taurolidine. J Neurosurg 102(6):1055\u20131068","journal-title":"J Neurosurg"},{"key":"9215_CR23","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1200\/JCO.2001.19.6.1865","volume":"19","author":"C Bast","year":"2001","unstructured":"Bast C, Ravdin P, Hayes F, Bates S, Fritsche H, Jessup M et al (2001) Update of recommendations for the use of tumor markers in breast and colorectal cancer: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol 19:1865\u20131878","journal-title":"J Clin Oncol"},{"issue":"6","key":"9215_CR24","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1177\/030089160509100613","volume":"91","author":"J Martinez-Trufero","year":"2005","unstructured":"Martinez-Trufero J, de Lobera AR, Lao J, Puertolas T, Artal-Cortes A et al (2005) Serum markers and prognosis in locally advanced breast cancer. Tumor 91(6):522\u2013530","journal-title":"Tumor"},{"issue":"1","key":"9215_CR25","first-page":"99","volume":"12","author":"M Sorak","year":"2007","unstructured":"Sorak M, Arsenijevi\u0107 S, Luki\u0107 G, Arsenijevi\u0107 N, Risti\u0107 P et al (2007) Relations-hip of serum levels of tumor markers with tissue expression of gene products in ovarian carcinoma. J BUON 12(1):99\u2013104","journal-title":"J BUON"},{"key":"9215_CR26","unstructured":"Ragaz J, Miller K, Badve S, et al. (2004) Advers association of expressed vascular endothelial growth factor (VEGF), Her-2, Cox-2, uPA and EMSY with long-term outcome of stage I-III breast cancer. J Clin Oncol 22(Suppl 14S):524"},{"key":"9215_CR27","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1200\/JCO.2005.12.017","volume":"23","author":"P Schneider","year":"2005","unstructured":"Schneider P, Miller D (2005) Overview: VEGF and angiogenesis in breast cancer \u201cAngiogenesis, the process of new blood vessel formation, plays a central role in both local tumor growth and distant metastasis in breast cancer\u201d. J Clin Oncol 23:1782\u20131790","journal-title":"J Clin Oncol"},{"key":"9215_CR28","first-page":"101","volume":"5","author":"G Gasparini","year":"1999","unstructured":"Gasparini G, Toi M, Miceli R et al (1999) Clinical relivance of vascular endothelial growth factor and thiamdine phosphorlase in patient with node-positive breast cancer trated with ither adiuvant chemotherapy or hormone therapy. Cancer J Sci Am 5:101\u2013111","journal-title":"Cancer J Sci Am"},{"key":"9215_CR29","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1200\/JCO.2000.18.7.1423","volume":"18","author":"B Linderholm","year":"2000","unstructured":"Linderholm B, Grankvist K, Wilking N, Johansson M, Tavelin B, Henriksson R (2000) Correlation of vascular endothelial growth factor content with recurrences, survival, and first relapse site in primary node-positive breast carcinoma after adjuvant treatment. J Clin Oncol 18:1423\u20131431","journal-title":"J Clin Oncol"},{"key":"9215_CR30","first-page":"5407","volume":"61","author":"JA Foekens","year":"2001","unstructured":"Foekens JA, Peters HA, Grebenchtchikov N et al (2001) High tumor levels of vascular endothelial growth factor predict poor response to systemic therapy in advanced breast cancer. Cancer Res 61:5407\u20135414","journal-title":"Cancer Res"},{"key":"9215_CR31","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1158\/1078-0432.CCR-0951-3","volume":"10","author":"E Konecny","year":"2004","unstructured":"Konecny E, Meng G, Untch M et al (2004) Association between Her-2\/neu and vascular endothelial rowth factor expression predicts clinical outcome in primary breast patients. Clin Cancer Res 10:1706\u20131716","journal-title":"Clin Cancer Res"},{"issue":"6","key":"9215_CR32","first-page":"1675","volume":"26","author":"H Yang","year":"2005","unstructured":"Yang H, Edgareton S, Thor D (2005) Reconstituation of caspase-3 sensitizes mcf-7 breast cancer cells to radiation. Int J Oncol 26(6):1675\u20131680","journal-title":"Int J Oncol"},{"issue":"2","key":"9215_CR33","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/jcp.20149","volume":"202","author":"B Faraglia","year":"2005","unstructured":"Faraglia B, Bonsignore A, Scaldaferri F, Boninsegna A, Cittadini A (2005) Caspase-3 inhibits the growth of breast cancer cells independent of protease activity. J Cell Physiol 202(2):478\u2013482","journal-title":"J Cell Physiol"},{"key":"9215_CR34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0962-8924(97)01215-4","volume":"8","author":"J Antwerp Van","year":"1998","unstructured":"Van Antwerp J, Martin J, Verma M, Green R (1998) Inhibition of TNF-induced apoptosis by NF-kappa B. Trends Cell Biol 8:107\u2013111","journal-title":"Trends Cell Biol"},{"issue":"1","key":"9215_CR35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/011542659501000119","volume":"10","author":"V Sardisia","year":"1995","unstructured":"Sardisia V (1995) Role of antioxidant in health maintenance. Natur Clin Pract 10(1):19\u201325","journal-title":"Natur Clin Pract"},{"key":"9215_CR36","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1136\/bmj.330.7500.1095","volume":"330","author":"GJ Fuchs","year":"2005","unstructured":"Fuchs GJ (2005) Antioxidants for children with kwashiorkor. BMJ 330:1095\u20131096","journal-title":"BMJ"},{"key":"9215_CR37","volume-title":"Free radicals in biology and medicine, ed 4","author":"B Halliwell","year":"2006","unstructured":"Halliwell B, Gutteridge J (2006) Free radicals in biology and medicine, ed 4. Clarendon Press, Oxford, JMC"},{"key":"9215_CR38","first-page":"738","volume":"25","author":"M Percival","year":"1998","unstructured":"Percival M (1998) Antioxidant. Clin Nutr Insights 25:738","journal-title":"Clin Nutr Insights"},{"key":"9215_CR39","first-page":"6816","volume":"61","author":"P Calabresi","year":"2001","unstructured":"Calabresi P, Goulette F, Darnowski J (2001) Taurolidine: cytotoxic and mechanistic evaluation of a novel antineoplastic agent. Cancer Res 61:6816\u20136821","journal-title":"Cancer Res"},{"key":"9215_CR40","unstructured":"Stendel R, Stoltenburg-Didinger G, Al Keikh CL, Wattrodt M, Brock M (2002) The effect of taurolidine on brain tumor cells. Anticancer Res 22(2A): 809\u2013814"},{"key":"9215_CR41","doi-asserted-by":"crossref","first-page":"7655","DOI":"10.1158\/1078-0432.CCR-0196-03","volume":"10","author":"L Nici","year":"2004","unstructured":"Nici L, Monfils B, Calabresi P (2004) The effects of taurolidine, a novel antineoplastic agent, on human malignant mesothelioma. Clin Cancer Res 10:7655\u20137661","journal-title":"Clin Cancer Res"},{"issue":"9","key":"9215_CR42","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1007\/s001250100631","volume":"44","author":"I Obrosova","year":"2001","unstructured":"Obrosova I, Minchenko A, Marinescu V et al (2001) Antioxidant attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats. Diabetologia 44(9):1102\u20131110","journal-title":"Diabetologia"},{"key":"9215_CR43","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0891-5849(02)01005-5","volume":"33","author":"N Maulik","year":"2002","unstructured":"Maulik N, Das D (2002) Redox signaling in vascular angiogenesis. Free Radic Biol Med 33:1047\u20131060","journal-title":"Free Radic Biol Med"},{"key":"9215_CR44","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/bcr315","volume":"3","author":"N Brown","year":"2001","unstructured":"Brown N, Bicknell R (2001) Hypoxia and oxidative stress in breast cancer: oxidative stress\u2014its effects on the growth, metastatic potential and response to therapy of breast cancer. Breast Cancer Res 3:323\u2013327. doi: 10.1186\/bcr315","journal-title":"Breast Cancer Res"},{"issue":"3","key":"9215_CR45","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0009-9120(02)00450-2","volume":"36","author":"N Ilhan","year":"2003","unstructured":"Ilhan N, Ilhan N (2003) Vascular endothelial growth factor and oxidative damage in cancer. Clin Biochem 36(3):225\u2013228","journal-title":"Clin Biochem"},{"key":"9215_CR46","first-page":"63","volume":"17","author":"B Nespereira","year":"2003","unstructured":"Nespereira B, Perez-Ilzarbe M, Fermandez P, Fuentes A et al (2003) Vitamin E and C dowenregulat VEGF and VEGFR-2 expression in apolipoprotein-E-deficient. Atherosclerosis 17:63\u201373","journal-title":"Atherosclerosis"},{"key":"9215_CR47","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/BF00052180","volume":"6","author":"CB Ambrosone","year":"1995","unstructured":"Ambrosone CB, Marshall JR, Vena JE, Laughlin R, Graham S et al (1995) Interaction of family history of breast cancer and dietary antioxidants with breast cancer risk. Cancer Causes Control 6:407\u2013415","journal-title":"Cancer Causes Control"},{"key":"9215_CR48","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/jnci\/88.6.340","volume":"88","author":"L Freudenheim","year":"1996","unstructured":"Freudenheim L, Marshall R, Vena E, Laughlin R, Brasure R et al (1996) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients. J Natl Cancer Inst 88:340\u2013348","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"9215_CR49","first-page":"409","volume":"22","author":"C Abramjuk","year":"2009","unstructured":"Abramjuk C, Bueschges M, Schnorr J, Jung K, Staack A, Lein M (2009) Divergent effects of taurolidine as potential anti-neoplastic agent: inhibition of bladder carcinoma cells in vitro and promotion of bladder tumor in vivo. Oncol Rep 22(2):409\u2013414","journal-title":"Oncol Rep"},{"key":"9215_CR50","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1477-7819-7-32","volume":"7","author":"C Braumann","year":"2009","unstructured":"Braumann C, Gutt CN, Scheele J, Menenakos C, Williams W, Muller JM, Jacobi CA (2009) Taurolidin reduces the tumor stimulating cytokine interleukin-1beta in patients with respectable gastrointestinal cancer: a multicentre prospective randomized trial. World J Surg Oncol 7:32","journal-title":"World J Surg Oncol"},{"key":"9215_CR51","unstructured":"Hoksch B, Rufer B, Gazdhar A, Bilici M, Beshay M, Gugger M, Schmid RA (2009) Taurolidin in the prevention and therapy of lung metastasis. Eur J Cardiothorac Surg 36(6):1058-1063. Epub 2009 Oct 21"},{"key":"9215_CR52","unstructured":"Aceto N, Bertino P, Barbone D, Tassi G, Manozo L, Porta C, Mutti L, Guadino G (2009) Taurilidine and Oxidative stress: a rationale for local treatment of methothelioma. Eur Respir J. 34(6):1399-1407. Epub 200 May 21"},{"issue":"1","key":"9215_CR53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3233\/CBM-2009-0115","volume":"6","author":"S Srivastava","year":"2010","unstructured":"Srivastava S, Roy R, Siggh S, Kumar P, Alela D, Sankhwar SN, Goel A, Sonkar AA (2010) Taurine-apossible fingerprint biomarker in non-muscle invasive bladder cancer: a pilot study by 1H NMR spectroscopy. Cancer Biomarker 6(1):11\u201320","journal-title":"Cancer Biomarker"}],"container-title":["Angiogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-011-9215-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10456-011-9215-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-011-9215-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T21:51:11Z","timestamp":1637617871000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10456-011-9215-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,8]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["9215"],"URL":"https:\/\/doi.org\/10.1007\/s10456-011-9215-3","relation":{},"ISSN":["0969-6970","1573-7209"],"issn-type":[{"value":"0969-6970","type":"print"},{"value":"1573-7209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,8]]}}}