{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:32:07Z","timestamp":1791311527702,"version":"4.3.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:00:00Z","timestamp":1443484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche (FR)","doi-asserted-by":"publisher","award":["ANR-10-LABX-0034"],"award-info":[{"award-number":["ANR-10-LABX-0034"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche (FR)","doi-asserted-by":"publisher","award":["ANR-06-PHYSIO-039"],"award-info":[{"award-number":["ANR-06-PHYSIO-039"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e9 Paris 13 (FR)"},{"name":"Inserm ITMO IHP","award":["IHP-2012002"],"award-info":[{"award-number":["IHP-2012002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Angiogenesis"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s10456-015-9487-0","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T02:50:57Z","timestamp":1443495057000},"page":"39-52","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Targeting VEGF-A with a vaccine decreases inflammation and joint destruction in experimental arthritis"],"prefix":"10.1007","volume":"19","author":[{"given":"Luca","family":"Semerano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Duvallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Belmellat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Marival","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Schall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eblle","family":"Monteil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Grouard-Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Bernier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lecouvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Hlawaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylviane","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christophe","family":"Boissier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Assier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,29]]},"reference":[{"key":"9487_CR1","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0140-6736(98)05912-1","volume":"353","author":"S Hirohata","year":"1999","unstructured":"Hirohata S, Sakakibara J (1999) Angioneogenesis as a possible elusive triggering factor in rheumatoid arthritis. Lancet 353:1331","journal-title":"Lancet"},{"key":"9487_CR2","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1172\/JCI117753","volume":"95","author":"B Mansson","year":"1995","unstructured":"Mansson B, Carey D, Alini M et al (1995) Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism. J Clin Invest 95:1071\u20131077","journal-title":"J Clin Invest"},{"key":"9487_CR3","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/art.1780340908","volume":"34","author":"CQ Chu","year":"1991","unstructured":"Chu CQ, Field M, Feldmann M, Maini RN (1991) Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis Rheum 34:1125\u20131132","journal-title":"Arthritis Rheum"},{"key":"9487_CR4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/ard.52.3.232","volume":"52","author":"R Madhok","year":"1993","unstructured":"Madhok R, Crilly A, Watson J, Capell HA (1993) Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity. Ann Rheum Dis 52:232\u2013234","journal-title":"Ann Rheum Dis"},{"key":"9487_CR5","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/art.10816","volume":"48","author":"P Miossec","year":"2003","unstructured":"Miossec P (2003) Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy. Arthritis Rheum 48:594\u2013601","journal-title":"Arthritis Rheum"},{"key":"9487_CR6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jbspin.2010.06.004","volume":"78","author":"L Semerano","year":"2011","unstructured":"Semerano L, Clavel G, Assier E, Denys A, Boissier MC (2011) Blood vessels, a potential therapeutic target in rheumatoid arthritis? Joint Bone Spine 78:118\u2013123","journal-title":"Joint Bone Spine"},{"key":"9487_CR7","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/art.30158","volume":"63","author":"JM Kremer","year":"2011","unstructured":"Kremer JM, Blanco R, Brzosko M et al (2011) Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year. Arthritis Rheum 63:609\u2013621","journal-title":"Arthritis Rheum"},{"key":"9487_CR8","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bcmd.2006.12.003","volume":"38","author":"ZK Otrock","year":"2007","unstructured":"Otrock ZK, Makarem JA, Shamseddine AI (2007) Vascular endothelial growth factor family of ligands and receptors: review. Blood Cells Mol Dis 38:258\u2013268","journal-title":"Blood Cells Mol Dis"},{"key":"9487_CR9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10456-006-9055-8","volume":"9","author":"M Shibuya","year":"2006","unstructured":"Shibuya M (2006) Vascular endothelial growth factor receptor-1 (VEGFR-1\/Flt-1): a dual regulator for angiogenesis. Angiogenesis 9:225","journal-title":"Angiogenesis"},{"key":"9487_CR10","first-page":"202","volume":"17","author":"G Clavel","year":"2006","unstructured":"Clavel G, Valvason C, Yamaoka K et al (2006) Relationship between angiogenesis and inflammation in experimental arthritis. Eur Cytokine Netw 17:202","journal-title":"Eur Cytokine Netw"},{"key":"9487_CR11","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1136\/ard.2007.083915","volume":"67","author":"G Clavel","year":"2008","unstructured":"Clavel G, Marchiol-Fournigault C, Renault G et al (2008) Ultrasound and Doppler micro-imaging in a model of rheumatoid arthritis in mice. Ann Rheum Dis 67:1765\u20131772","journal-title":"Ann Rheum Dis"},{"key":"9487_CR12","doi-asserted-by":"crossref","first-page":"5922","DOI":"10.4049\/jimmunol.164.11.5922","volume":"164","author":"J Lu","year":"2000","unstructured":"Lu J, Kasama T, Kobayashi K et al (2000) Vascular endothelial growth factor expression and regulation of murine collagen-induced arthritis. J Immunol 164:5922\u20135927","journal-title":"J Immunol"},{"key":"9487_CR13","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.4049\/jimmunol.171.9.4853","volume":"171","author":"M Bandt De","year":"2003","unstructured":"De Bandt M, Ben Mahdi MH, Ollivier V et al (2003) Blockade of vascular endothelial growth factor receptor I (VEGF-RI), but not VEGF-RII, suppresses joint destruction in the K\/BxN model of rheumatoid arthritis. J Immunol 171:4853\u20134859","journal-title":"J Immunol"},{"key":"9487_CR14","doi-asserted-by":"crossref","first-page":"19442","DOI":"10.1073\/pnas.0604827103","volume":"103","author":"H Buanec Le","year":"2006","unstructured":"Le Buanec H, Delavall\u00e9e L, Bessis N et al (2006) TNFalpha kinoid vaccination-induced neutralizing antibodies to TNFalpha protect mice from autologous TNFalpha-driven chronic and acute inflammation. Proc Natl Acad Sci USA 103:19442\u201319447","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR15","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1136\/ard.2007.079137","volume":"67","author":"L Delavall\u00e9e","year":"2008","unstructured":"Delavall\u00e9e L, Le Buanec H, Bessis N et al (2008) Early and long-lasting protection from arthritis in tumour necrosis factor alpha (TNFalpha) transgenic mice vaccinated against TNFalpha. Ann Rheum Dis 67:1332\u20131338","journal-title":"Ann Rheum Dis"},{"key":"9487_CR16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/cei.12040","volume":"172","author":"L Semerano","year":"2013","unstructured":"Semerano L, Biton J, Delavall\u00e9e L et al (2013) Protection from articular damage by passive or active anti-tumour necrosis factor (TNF)-\u03b1 immunotherapy in human TNF-\u03b1 transgenic mice depends on anti-TNF-\u03b1 antibody levels. Clin Exp Immunol 172:54\u201362","journal-title":"Clin Exp Immunol"},{"key":"9487_CR17","doi-asserted-by":"crossref","first-page":"e51780","DOI":"10.1371\/journal.pone.0051780","volume":"8","author":"L Amit","year":"2013","unstructured":"Amit L, Ben-Aharon I, Vidal L, Leibovici L, Stemmer SM (2013) The impact of Bevacizumab (Avastin) on survival in metastatic solid tumors\u2013a meta-analysis and systematic review. PLoS One 8:e51780","journal-title":"PLoS One"},{"key":"9487_CR18","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1073\/pnas.0611022104","volume":"104","author":"FH Rad","year":"2007","unstructured":"Rad FH, Le Buanec H, Paturance S et al (2007) VEGF kinoid vaccine, a therapeutic approach against tumor angiogenesis and metastases. Proc Natl Acad Sci USA 104:2837\u20132842","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR19","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0969-2126(97)00284-0","volume":"5","author":"YA Muller","year":"1997","unstructured":"Muller YA, Christinger HW, Keyt BA, de Vos AM (1997) The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding. Structure\u00a05:1325\u20131328","journal-title":"Structure"},{"key":"9487_CR20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/art.27243","volume":"62","author":"JS Kong","year":"2010","unstructured":"Kong JS, Yoo SA, Kim JW et al (2010) Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis. Arthritis Rheum 62:179","journal-title":"Arthritis Rheum"},{"key":"9487_CR21","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/j.lfs.2006.08.005","volume":"79","author":"A Starzec","year":"2006","unstructured":"Starzec A, Vassy R, Martin A et al (2006) Antiangiogenic and antitumor activities of peptide inhibiting the vascular endothelial growth factor binding to neuropilin-1. Life Sci 79:2370\u20132371","journal-title":"Life Sci"},{"key":"9487_CR22","doi-asserted-by":"crossref","first-page":"12153","DOI":"10.1074\/jbc.M008055200","volume":"276","author":"S Iyer","year":"2001","unstructured":"Iyer S, Leonidas DD, Swaminathan GJ et al (2001) The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution. J Biol Chem 276:12153\u201312161","journal-title":"J Biol Chem"},{"key":"9487_CR23","doi-asserted-by":"crossref","first-page":"11082","DOI":"10.1074\/jbc.M111.331140","volume":"287","author":"MW Parker","year":"2012","unstructured":"Parker MW, Xu P, Li X, Vander Kooi CW (2012) Structural basis for selective vascular endothelial growth factor-A (VEGF-A) binding to neuropilin-1. J Biol Chem 287:11082\u201311089","journal-title":"J Biol Chem"},{"key":"9487_CR24","doi-asserted-by":"crossref","first-page":"31582","DOI":"10.1074\/jbc.272.50.31582","volume":"272","author":"S Soker","year":"1997","unstructured":"Soker S, Gollamudi-Payne S, Fidder H, Charmahelli H, Klagsbrun M (1997) Inhibition of vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation by a peptide corresponding to the exon 7-encoded domain of VEGF165. J Biol Chem 272:31582\u201331588","journal-title":"J Biol Chem"},{"key":"9487_CR25","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1002\/eji.200535235","volume":"35","author":"A Miellot","year":"2005","unstructured":"Miellot A, Zhu R, Diem S et al (2005) Activation of invariant NK T cells protects against experimental rheumatoid arthritis by an IL-10-dependent pathway. Eur J Immunol 35:3704\u20133713","journal-title":"Eur J Immunol"},{"key":"9487_CR26","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1182\/blood-2006-04-016030","volume":"108","author":"M Murakami","year":"2006","unstructured":"Murakami M, Iwai S, Hiratsuka S et al (2006) Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes\/macrophages. Blood 108:1849\u20131856","journal-title":"Blood"},{"key":"9487_CR27","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3858\/emm.2010.42.9.059","volume":"42","author":"EH Nam","year":"2010","unstructured":"Nam EH, Park SR, Kim PH (2010) TGF-beta1 induces mouse dendritic cells to express VEGF and its receptor (Flt-1) under hypoxic conditions. Exp Mol Med 42:606\u2013613","journal-title":"Exp Mol Med"},{"key":"9487_CR28","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.4049\/jimmunol.177.8.5727","volume":"177","author":"WU Kim","year":"2006","unstructured":"Kim WU, Kang SS, Yoo SA et al (2006) Interaction of vascular endothelial growth factor 165 with neuropilin-1 protects rheumatoid synoviocytes from apoptotic death by regulating Bcl-2 expression and Bax translocation. J Immunol 177:5727\u20135735","journal-title":"J Immunol"},{"key":"9487_CR29","doi-asserted-by":"crossref","first-page":"e25156","DOI":"10.4161\/onci.25156","volume":"2","author":"M Terme","year":"2013","unstructured":"Terme M, Tartour E, Taieb J (2013) VEGFA\/VEGFR2-targeted therapies prevent the VEGFA-induced proliferation of regulatory T cells in cancer. Oncoimmunology 2:e25156","journal-title":"Oncoimmunology"},{"key":"9487_CR30","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1084\/jem.20111497","volume":"209","author":"W Hansen","year":"2013","unstructured":"Hansen W, Hutzler M, Abel S et al (2013) Neuropilin 1 deficiency on CD4\u00a0+\u00a0Foxp3\u00a0+\u00a0regulatory T cells impairs mouse melanoma growth. J Exp Med 209:2001\u20132006","journal-title":"J Exp Med"},{"key":"9487_CR31","doi-asserted-by":"crossref","unstructured":"Terme M, Pernot S, Marcheteau E et al (2013) VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer. Cancer Res 73:539\u2013539","DOI":"10.1158\/0008-5472.CAN-12-2325"},{"key":"9487_CR32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jbspin.2008.08.002","volume":"76","author":"MC Boissier","year":"2009","unstructured":"Boissier MC, Assier E, Biton J et al (2009) Regulatory T cells (Treg) in rheumatoid arthritis. Joint Bone Spine 76:10\u201314","journal-title":"Joint Bone Spine"},{"key":"9487_CR33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1084\/jem.20061531","volume":"204","author":"S Nadkarni","year":"2007","unstructured":"Nadkarni S, Mauri C, Ehrenstein MR (2007) Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. J Exp Med 204:33\u201339","journal-title":"J Exp Med"},{"key":"9487_CR34","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.4049\/jimmunol.1003372","volume":"186","author":"J Biton","year":"2011","unstructured":"Biton J, Semerano L, Delavall\u00e9e L et al (2011) Interplay between TNF and regulatory T cells in a TNF-driven murine model of arthritis. J Immunol 186:3899","journal-title":"J Immunol"},{"key":"9487_CR35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jbspin.2011.09.017","volume":"79","author":"J Biton","year":"2012","unstructured":"Biton J, Boissier MC, Bessis N (2012) TNF\u03b1: activator or inhibitor of regulatory T cells? Joint Bone Spine 79:119\u2013123","journal-title":"Joint Bone Spine"},{"key":"9487_CR36","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nm.3085","volume":"19","author":"H Nie","year":"2013","unstructured":"Nie H, Zheng Y, Li R et al (2013) Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-\u03b1 in rheumatoid arthritis. Nat Med 19:322\u2013328","journal-title":"Nat Med"},{"key":"9487_CR37","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/art.38246","volume":"66","author":"A Thiolat","year":"2014","unstructured":"Thiolat A, Semerano L, Pers YM et al (2014) Interleukin-6 receptor blockade enhances CD39\u00a0+\u00a0regulatory T cell development in rheumatoid arthritis and in experimental arthritis. Arthritis Rheumatol 66:273\u2013283","journal-title":"Arthritis Rheumatol"},{"key":"9487_CR38","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1093\/annonc\/mdr432","volume":"23","author":"J Cortes","year":"2012","unstructured":"Cortes J, Calvo V, Ramirez-Merino N et al (2012) Adverse events risk associated with bevacizumab addition to breast cancer chemotherapy: a meta-analysis. Ann Oncol 23:1130\u20131137","journal-title":"Ann Oncol"},{"key":"9487_CR39","doi-asserted-by":"crossref","first-page":"8024","DOI":"10.1073\/pnas.141224798","volume":"98","author":"D Zagury","year":"2001","unstructured":"Zagury D, Burny A, Gallo RC (2001) Toward a new generation of vaccines: the anti-cytokine therapeutic vaccines. Proc Natl Acad Sci USA 98:8024\u20138029","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR40","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1016\/j.vaccine.2005.03.030","volume":"23","author":"SM Bertin-Maghit","year":"2005","unstructured":"Bertin-Maghit SM, Capini CJ, Bessis N et al (2005) Improvement of collagen-induced arthritis by active immunization against murine IL-1beta peptides designed by molecular modelling. Vaccine 23:4228\u20134235","journal-title":"Vaccine"},{"key":"9487_CR41","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1016\/j.vaccine.2004.01.064","volume":"22","author":"CJ Capini","year":"2004","unstructured":"Capini CJ, Bertin-Maghit SM, Bessis N et al (2004) Active immunization against murine TNFalpha peptides in mice: generation of endogenous antibodies cross-reacting with the native cytokine and in vivo protection. Vaccine 22:3144\u20133153","journal-title":"Vaccine"},{"key":"9487_CR42","doi-asserted-by":"crossref","first-page":"9329","DOI":"10.1016\/j.vaccine.2011.09.134","volume":"29","author":"RA Ratsimandresy","year":"2011","unstructured":"Ratsimandresy RA, Duvallet E, Assier E et al (2011) Active immunization against IL-23p19 improves experimental arthritis. Vaccine 29:9329\u20139336","journal-title":"Vaccine"},{"key":"9487_CR43","doi-asserted-by":"crossref","first-page":"R85","DOI":"10.1186\/ar4265","volume":"15","author":"YS Hah","year":"2013","unstructured":"Hah YS, Koh YJ, Lim HS et al (2013) Double-antiangiogenic protein DAAP targeting vascular endothelial growth factor A and angiopoietins attenuates collagen-induced arthritis. Arthritis Res Ther 15:R85","journal-title":"Arthritis Res Ther"},{"key":"9487_CR44","doi-asserted-by":"crossref","first-page":"9784","DOI":"10.1073\/pnas.89.20.9784","volume":"89","author":"RO Williams","year":"1992","unstructured":"Williams RO, Feldmann M, Maini RN (1992) Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 89:9784","journal-title":"Proc Natl Acad Sci USA"},{"key":"9487_CR45","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.bone.2004.07.004","volume":"35","author":"N Saidenberg-Kermanac\u2019h","year":"2004","unstructured":"Saidenberg-Kermanac\u2019h N, Corrado A, Lemeiter D et al (2004) TNF-a antibodies and osteoprotegerin decrease systemic bone loss associated with inflammation through distinct mechanisms in collagen-induced arthritis. Bone 35:1200\u20131207","journal-title":"Bone"},{"key":"9487_CR46","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1007\/s10753-013-9687-y","volume":"36","author":"Y Wang","year":"2013","unstructured":"Wang Y, Da G, Li H et al (2013) Avastin exhibits therapeutic effects on collagen-induced arthritis in rat model. Inflammation 36:1460\u20131467","journal-title":"Inflammation"},{"key":"9487_CR47","doi-asserted-by":"crossref","first-page":"R178","DOI":"10.1186\/ar3142","volume":"12","author":"T Nagai","year":"2010","unstructured":"Nagai T, Sato M, Kutsuna T et al (2010) Intravenous administration of anti-vascular endothelial growth factor humanized monoclonal antibody bevacizumab improves articular cartilage repair. Arthritis Res Ther 12:R178","journal-title":"Arthritis Res Ther"},{"key":"9487_CR48","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1167\/iovs.07-1175","volume":"49","author":"L Yu","year":"2008","unstructured":"Yu L, Wu X, Cheng Z et al (2008) Interaction between bevacizumab and murine VEGF-A: a reassessment. Invest Ophthalmol Vis Sci 49:522\u2013527","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9487_CR49","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10067-008-1075-x","volume":"28","author":"ST Choi","year":"2009","unstructured":"Choi ST, Kim JH, Seok JY et al (2009) Therapeutic effect of anti-vascular endothelial growth factor receptor I antibody in the established collagen-induced arthritis mouse model. Clin Rheumatol 28:333\u2013337","journal-title":"Clin Rheumatol"},{"key":"9487_CR50","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.4049\/jimmunol.174.9.5846","volume":"174","author":"SA Yoo","year":"2005","unstructured":"Yoo SA, Bae DG, Ryoo JW et al (2005) Arginine-rich anti-vascular endothelial growth factor (anti-VEGF) hexapeptide inhibits collagen-induced arthritis and VEGF-stimulated productions of TNF-alpha and IL-6 by human monocytes. J Immunol 174:5846\u20135855","journal-title":"J Immunol"},{"key":"9487_CR51","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1186\/ar2897","volume":"11","author":"L Delavall\u00e9e","year":"2009","unstructured":"Delavall\u00e9e L, Semerano L, Assier E et al (2009) Active immunization to tumor necrosis factor-alpha is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis. Arthritis Res Ther 11:R195","journal-title":"Arthritis Res Ther"},{"key":"9487_CR52","doi-asserted-by":"crossref","first-page":"e113465","DOI":"10.1371\/journal.pone.0113465","volume":"9","author":"P Durez","year":"2014","unstructured":"Durez P, Vandepapeliere P, Miranda P et al (2014) Therapeutic vaccination with TNF-kinoid in TNF antagonist-resistant rheumatoid arthritis: a phase II randomized, controlled clinical trial. PLoS One 9:e113465","journal-title":"PLoS One"}],"container-title":["Angiogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-015-9487-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10456-015-9487-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-015-9487-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T13:26:30Z","timestamp":1559136390000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10456-015-9487-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,29]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["9487"],"URL":"https:\/\/doi.org\/10.1007\/s10456-015-9487-0","relation":{},"ISSN":["0969-6970","1573-7209"],"issn-type":[{"value":"0969-6970","type":"print"},{"value":"1573-7209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,29]]}}}