{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:13:53Z","timestamp":1791663233127,"version":"4.3.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"FRS-FNRS","award":["T\u00e9l\u00e9vie - 7.4531.14f"],"award-info":[{"award-number":["T\u00e9l\u00e9vie - 7.4531.14f"]}]},{"name":"FRS-FNRS","award":["T\u00e9l\u00e9vie - 7.4602.14"],"award-info":[{"award-number":["T\u00e9l\u00e9vie - 7.4602.14"]}]},{"name":"FRS-FNRS","award":["FRSM - T.0183.13"],"award-info":[{"award-number":["FRSM - T.0183.13"]}]},{"name":"FRS-FNRS","award":["FRSM - T.0183.13"],"award-info":[{"award-number":["FRSM - T.0183.13"]}]},{"name":"National Institutes of Health Program of Excellence in Glycosciences","award":["HL107147"],"award-info":[{"award-number":["HL107147"]}]},{"DOI":"10.13039\/100001209","name":"Knights Templar Eye Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Angiogenesis"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s10456-015-9488-z","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T09:54:48Z","timestamp":1444211688000},"page":"53-65","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis"],"prefix":"10.1007","volume":"19","author":[{"given":"Lauriane","family":"Janssen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mourad","family":"Bekhouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Noel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Leduc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Voz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Peers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Cataldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneel S.","family":"Apte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne","family":"Dubail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Colige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,7]]},"reference":[{"key":"9488_CR1","doi-asserted-by":"crossref","first-page":"31493","DOI":"10.1074\/jbc.R109.052340","volume":"284","author":"SS Apte","year":"2009","unstructured":"Apte SS (2009) A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms. J Biol Chem 284:31493\u201331497","journal-title":"J Biol Chem"},{"issue":"12","key":"9488_CR2","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.bbadis.2011.08.009","volume":"1812","author":"H Stanton","year":"2011","unstructured":"Stanton H, Melrose J, Little CB et al (2011) Proteoglycan degradation by the ADAMTS family of proteinases. Biochim Biophys Acta 1812(12):1616\u20131629","journal-title":"Biochim Biophys Acta"},{"key":"9488_CR3","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1182\/blood.V98.6.1662","volume":"98","author":"K Fujikawa","year":"2001","unstructured":"Fujikawa K, Suzuki H, McMullen B et al (2001) Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family. Blood 98:1662\u20131666","journal-title":"Blood"},{"key":"9488_CR4","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/35097008","volume":"413","author":"GG Levy","year":"2001","unstructured":"Levy GG, Nichols WC, Lian EC et al (2001) Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature 413:488\u2013494","journal-title":"Nature"},{"key":"9488_CR5","doi-asserted-by":"crossref","first-page":"41059","DOI":"10.1074\/jbc.C100515200","volume":"276","author":"X Zheng","year":"2001","unstructured":"Zheng X, Chung D, Takayama TK et al (2001) Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J Biol Chem 276:41059\u201341063","journal-title":"J Biol Chem"},{"key":"9488_CR6","doi-asserted-by":"crossref","first-page":"5756","DOI":"10.1074\/jbc.M105601200","volume":"277","author":"A Colige","year":"2002","unstructured":"Colige A, Vandenberghe I, Thiry M et al (2002) Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3. J Biol Chem 277:5756\u20135766","journal-title":"J Biol Chem"},{"key":"9488_CR7","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1086\/302504","volume":"65","author":"A Colige","year":"1999","unstructured":"Colige A, Sieron AL, Li SW et al (1999) Human Ehlers\u2013Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene. Am J Hum Genet 65:308\u2013317","journal-title":"Am J Hum Genet"},{"key":"9488_CR8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.0022-202X.2004.23406.x","volume":"123","author":"A Colige","year":"2004","unstructured":"Colige A, Nuytinck L, Hausser I et al (2004) Novel types of mutation responsible for the dermatosparactic type of Ehlers\u2013Danlos syndrome (type VIIC) and common polymorphisms in the ADAMTS2 gene. J Invest Dermatol 123:656\u2013663","journal-title":"J Invest Dermatol"},{"key":"9488_CR9","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/hep.21868","volume":"46","author":"F Kesteloot","year":"2007","unstructured":"Kesteloot F, Desmouli\u00e8re A, Leclercq I et al (2007) ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice. Hepatology 46:1620\u20131631","journal-title":"Hepatology"},{"key":"9488_CR10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/bj3550271","volume":"355","author":"SW Li","year":"2001","unstructured":"Li SW, Arita M, Fertala A et al (2001) Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility. Biochem J 355:271\u2013278","journal-title":"Biochem J"},{"key":"9488_CR11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00109-007-0284-0","volume":"86","author":"TP Hofer","year":"2008","unstructured":"Hofer TP, Frankenberger M, Mages J et al (2008) Tissue-specific induction of ADAMTS2 in monocytes and macrophages by glucocorticoids. J Mol Med 86:323\u2013332","journal-title":"J Mol Med"},{"key":"9488_CR12","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1007\/s00018-010-0431-6","volume":"67","author":"J Dubail","year":"2010","unstructured":"Dubail J, Kesteloot F, Deroanne C et al (2010) ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity. Cell Mol Life Sci 67:4213\u20134232","journal-title":"Cell Mol Life Sci"},{"key":"9488_CR13","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1182\/blood-2012-07-442038","volume":"120","author":"A Arning","year":"2012","unstructured":"Arning A, Hiersche M, Witten A et al (2012) A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke. Blood 120:5231\u20135236","journal-title":"Blood"},{"key":"9488_CR14","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1242\/dev.02308","volume":"133","author":"C Goff Le","year":"2006","unstructured":"Le Goff C, Somerville RP, Kesteloot F et al (2006) Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis. Development 133:1587\u20131596","journal-title":"Development"},{"issue":"19","key":"9488_CR15","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1161\/CIRCULATIONAHA.113.002779","volume":"129","author":"M Jeltsch","year":"2014","unstructured":"Jeltsch M, Jha SK, Tvorogov D et al (2014) CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated VEGF-C activation. Circulation 129(19):1962\u20131971","journal-title":"Circulation"},{"key":"9488_CR16","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1242\/dev.100495","volume":"141","author":"L Guen Le","year":"2014","unstructured":"Le Guen L, Karpanen T, Schulte D et al (2014) Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis. Development 141:1239\u20131249","journal-title":"Development"},{"key":"9488_CR17","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1161\/CIRCRESAHA.111.250738","volume":"109","author":"FL Bos","year":"2011","unstructured":"Bos FL, Caunt M, Peterson-Maduro J et al (2011) CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo. Circ Res 109:486\u2013491","journal-title":"Circ Res"},{"key":"9488_CR18","doi-asserted-by":"crossref","first-page":"31502","DOI":"10.1074\/jbc.M103466200","volume":"276","author":"RJ Fernandes","year":"2001","unstructured":"Fernandes RJ, Hirohata S, Engle JM et al (2001) Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis. J Biol Chem 276:31502\u201331509","journal-title":"J Biol Chem"},{"key":"9488_CR19","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nature04480","volume":"438","author":"K Alitalo","year":"2005","unstructured":"Alitalo K, Tammela T, Petrova TV (2005) Lymphangiogenesis in development and human disease. Nature 438:946\u2013953","journal-title":"Nature"},{"key":"9488_CR20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/ATVBAHA.109.196618","volume":"30","author":"G D\u2019Amico","year":"2010","unstructured":"D\u2019Amico G, Korhonen EA, Waltari M et al (2010) Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report. Arterioscler Thromb Vasc Biol 30:207\u2013209","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"9488_CR21","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1093\/emboj\/17.10.2846","volume":"17","author":"C Gunes","year":"1998","unstructured":"Gunes C, Heuchel R, Georgiev O et al (1998) Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J 17:2846\u20132854","journal-title":"EMBO J"},{"key":"9488_CR22","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1128\/MCB.23.12.4371-4385.2003","volume":"23","author":"KL Stenvers","year":"2003","unstructured":"Stenvers KL, Tursky ML, Harder KW et al (2003) Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol 23:4371\u20134385","journal-title":"Mol Cell Biol"},{"key":"9488_CR23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1101\/gad.14.2.152","volume":"14","author":"AM Reimold","year":"2000","unstructured":"Reimold AM, Etkin A, Clauss I et al (2000) An essential role in liver development for transcription factor XBP-1. Genes Dev 14:152\u2013157","journal-title":"Genes Dev"},{"key":"9488_CR24","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1073\/pnas.081082098","volume":"98","author":"K Chan","year":"2001","unstructured":"Chan K, Han XD, Kan YW (2001) An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci USA 98:4611\u20134616","journal-title":"Proc Natl Acad Sci USA"},{"key":"9488_CR25","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/ng.484","volume":"41","author":"M Alders","year":"2009","unstructured":"Alders M, Hogan BM, Gjini E et al (2009) Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans. Nat Genet 41:1272\u20131274","journal-title":"Nat Genet"},{"key":"9488_CR26","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1182\/blood-2012-10-462689","volume":"121","author":"Z Zou","year":"2013","unstructured":"Zou Z, Enis DR, Bui H et al (2013) The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood 121:3228\u20133236","journal-title":"Blood"},{"key":"9488_CR27","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1242\/jcs.082875","volume":"124","author":"F Hua","year":"2011","unstructured":"Hua F, Mu R, Liu J et al (2011) TRIB3 interacts with SMAD3 promoting tumor cell migration and invasion. J Cell Sci 124:3235\u20133246","journal-title":"J Cell Sci"},{"key":"9488_CR28","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/path.4131","volume":"229","author":"S Bhattacharyya","year":"2013","unstructured":"Bhattacharyya S, Fang F, Tourtellotte W, Varga J (2013) Egr-1: new conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis). J Pathol 229:286\u2013297","journal-title":"J Pathol"},{"key":"9488_CR29","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/373699a0","volume":"373","author":"C Schmidt","year":"1995","unstructured":"Schmidt C, Bladt F, Goedecke S et al (1995) Scatter factor\/hepatocyte growth factor is essential for liver development. Nature 373:699\u2013702","journal-title":"Nature"},{"key":"9488_CR30","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/373702a0","volume":"373","author":"Y Uehara","year":"1995","unstructured":"Uehara Y, Minowa O, Mori C et al (1995) Placental defect and embryonic lethality in mice lacking hepatocyte growth factor\/scatter factor. Nature 373:702\u2013705","journal-title":"Nature"},{"key":"9488_CR31","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.celrep.2015.01.049","volume":"10","author":"J Han","year":"2015","unstructured":"Han J, Calvo CF, Kang TH et al (2015) Vascular endothelial growth factor receptor 3 controls neural stem\u00a0cell\u00a0activation in mice and humans. Cell Rep 10:1158\u20131172","journal-title":"Cell Rep"},{"key":"9488_CR32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ydbio.2008.01.023","volume":"316","author":"M Hirashima","year":"2008","unstructured":"Hirashima M, Sano K, Morisada T et al (2008) Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. Dev Biol 316:149\u2013159","journal-title":"Dev Biol"},{"key":"9488_CR33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W Huang da","year":"2009","unstructured":"da Huang W, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44\u201357","journal-title":"Nat Protoc"}],"container-title":["Angiogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-015-9488-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10456-015-9488-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-015-9488-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T19:31:47Z","timestamp":1653247907000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10456-015-9488-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["9488"],"URL":"https:\/\/doi.org\/10.1007\/s10456-015-9488-z","relation":{},"ISSN":["0969-6970","1573-7209"],"issn-type":[{"value":"0969-6970","type":"print"},{"value":"1573-7209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,7]]}}}