{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:22:41Z","timestamp":1778732561688,"version":"3.51.4"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2012-2472"],"award-info":[{"award-number":["2012-2472"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Angiogenesis"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1007\/s10456-019-09679-9","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T11:04:18Z","timestamp":1567595058000},"page":"553-567","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Revascularization after angiogenesis inhibition favors new sprouting over abandoned vessel reuse"],"prefix":"10.1007","volume":"22","author":[{"given":"Anthony","family":"Mukwaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierfrancesco","family":"Mirabelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Lennikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthukumar","family":"Thangavelu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Ntzouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lasse","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Peebo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1079-4361","authenticated-orcid":false,"given":"Neil","family":"Lagali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"issue":"20","key":"9679_CR1","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1056\/NEJMoa1102673","volume":"364","author":"Group, C.R.","year":"2011","unstructured":"Group, C.R. (2011) Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med 364(20):1897\u20131908","journal-title":"N Engl J Med"},{"issue":"1","key":"9679_CR2","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ophtha.2014.07.041","volume":"122","author":"K Berg","year":"2015","unstructured":"Berg K et al (2015) Comparison of ranibizumab and bevacizumab for neovascular age-related macular degeneration according to LUCAS treat-and-extend protocol. Ophthalmology 122(1):146\u2013152","journal-title":"Ophthalmology"},{"issue":"2","key":"9679_CR3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1177\/112067210801800215","volume":"18","author":"A Mirshahi","year":"2008","unstructured":"Mirshahi A et al (2008) Bevacizumab-augmented retinal laser photocoagulation in proliferative diabetic retinopathy: a randomized double-masked clinical trial. Eur J Ophthalmol 18(2):263\u2013269","journal-title":"Eur J Ophthalmol"},{"issue":"7","key":"9679_CR4","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1097\/ICO.0b013e3182775f8d","volume":"32","author":"G Ferrari","year":"2013","unstructured":"Ferrari G et al (2013) Topical ranibizumab as a treatment of corneal neovascularization. Cornea 32(7):992","journal-title":"Cornea"},{"issue":"4","key":"9679_CR5","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1001\/archophthalmol.2009.18","volume":"127","author":"MH Dastjerdi","year":"2009","unstructured":"Dastjerdi MH et al (2009) Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, noncomparative study. Arch Ophthalmol 127(4):381\u2013389","journal-title":"Arch Ophthalmol"},{"issue":"242","key":"9679_CR6","doi-asserted-by":"publisher","first-page":"242ra84-242ra84","DOI":"10.1126\/scitranslmed.3008455","volume":"6","author":"L Xu","year":"2014","unstructured":"Xu L et al (2014) COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models. Sci Transl Med 6(242):242ra84-242ra84","journal-title":"Sci Transl Med"},{"key":"9679_CR7","unstructured":"Wang Z et al (2015) Broad targeting of angiogenesis for cancer prevention and therapy. In Seminars in cancer biology. Elsevier"},{"issue":"19","key":"9679_CR8","doi-asserted-by":"publisher","first-page":"12905","DOI":"10.1074\/jbc.M900280200","volume":"284","author":"D-K Chang","year":"2009","unstructured":"Chang D-K et al (2009) Antiangiogenic targeting liposomes increase therapeutic efficacy for solid tumors. J Biol Chem 284(19):12905\u201312916","journal-title":"J Biol Chem"},{"key":"9679_CR9","doi-asserted-by":"publisher","first-page":"12680","DOI":"10.1038\/ncomms12680","volume":"7","author":"Y Yang","year":"2016","unstructured":"Yang Y et al (2016) Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism. Nat Commun 7:12680","journal-title":"Nat Commun"},{"issue":"19","key":"9679_CR10","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1056\/NEJMra0706596","volume":"358","author":"RS Kerbel","year":"2008","unstructured":"Kerbel RS (2008) Tumor angiogenesis. N Engl J Med 358(19):2039\u20132049","journal-title":"N Engl J Med"},{"issue":"4","key":"9679_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nrclinonc.2011.21","volume":"8","author":"JM Ebos","year":"2011","unstructured":"Ebos JM, Kerbel RS (2011) Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol 8(4):210","journal-title":"Nat Rev Clin Oncol"},{"issue":"11","key":"9679_CR12","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1097\/IAE.0000000000000846","volume":"35","author":"D Huang","year":"2015","unstructured":"Huang D et al (2015) OCT Angiography of time course of choroidal neovascularization in response to anti-angiogenic treatment. Retina (Philadelphia, PA) 35(11):2260","journal-title":"Retina (Philadelphia, PA)"},{"issue":"10","key":"9679_CR13","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1161\/ATVBAHA.111.230235","volume":"31","author":"I Moreno-Miralles","year":"2011","unstructured":"Moreno-Miralles I et al (2011) BMPER regulates retinal angiogenesis in vivo in a mouse model of oxygen-induced retinopathy. Arterioscler Thromb Vasc Biol 31(10):2216","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"9679_CR14","doi-asserted-by":"publisher","first-page":"5466","DOI":"10.1167\/iovs.14-14380","volume":"55","author":"Y Qi","year":"2014","unstructured":"Qi Y et al (2014) Retinal ischemia\/reperfusion injury is mediated by Toll-like receptor 4 activation of NLRP3 inflammasomes. Invest Ophthalmol Vis Sci 55(9):5466\u20135475","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"9679_CR15","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1755-3768.2009.01622.x","volume":"89","author":"G Schmidinger","year":"2011","unstructured":"Schmidinger G et al (2011) Repeated intravitreal bevacizumab (Avastin\u00ae) treatment of persistent new vessels in proliferative diabetic retinopathy after complete panretinal photocoagulation. Acta Ophthalmol 89(1):76\u201381","journal-title":"Acta Ophthalmol"},{"issue":"7","key":"9679_CR16","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1001\/jamaophthalmol.2013.2120","volume":"131","author":"VP Shah","year":"2013","unstructured":"Shah VP, Freund KB (2013) Growth of type 1 neovascularization following cessation of anti-vascular endothelial growth factor therapy as a possible explanation for treatment resistance. JAMA Ophthalmol 131(7):967\u2013969","journal-title":"JAMA Ophthalmol"},{"issue":"3","key":"9679_CR17","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/eye.2015.240","volume":"30","author":"T Padhi","year":"2016","unstructured":"Padhi T et al (2016) Serial evaluation of retinal vascular changes in infants treated with intravitreal bevacizumab for aggressive posterior retinopathy of prematurity in zone I. Eye 30(3):392","journal-title":"Eye"},{"issue":"4","key":"9679_CR18","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/IAE.0b013e31804a7af2","volume":"27","author":"Y Matsumoto","year":"2007","unstructured":"Matsumoto Y et al (2007) Rebound macular edema following bevacizumab (Avastin) therapy for retinal venous occlusive disease. Retina 27(4):426\u2013431","journal-title":"Retina"},{"issue":"9","key":"9679_CR19","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1093\/annonc\/mdn540","volume":"19","author":"W Cacheux","year":"2008","unstructured":"Cacheux W et al (2008) Reversible tumor growth acceleration following bevacizumab interruption in metastatic colorectal cancer patients scheduled for surgery. Ann Oncol 19(9):1659\u20131661","journal-title":"Ann Oncol"},{"issue":"14","key":"9679_CR20","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.1158\/1078-0432.CCR-12-0002","volume":"18","author":"AW Griffioen","year":"2012","unstructured":"Griffioen AW et al (2012) Rapid angiogenesis onset after discontinuation of sunitinib treatment of renal cell carcinoma patients. Clinical Cancer Res 18(14):3961\u20133971","journal-title":"Clinical Cancer Res"},{"issue":"3","key":"9679_CR21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/COC.0b013e3181a650a6","volume":"33","author":"DB La Vine","year":"2010","unstructured":"La Vine DB et al (2010) Frequent dose interruptions are required for patients receiving oral kinase inhibitor therapy for advanced renal cell carcinoma. Am J Clin Oncol 33(3):217\u2013220","journal-title":"Am J Clin Oncol"},{"key":"9679_CR22","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ctrv.2016.12.002","volume":"53","author":"H Abdel-Qadir","year":"2017","unstructured":"Abdel-Qadir H et al (2017) Cardiovascular toxicity of angiogenesis inhibitors in treatment of malignancy: a systematic review and meta-analysis. Cancer Treat Rev 53:120\u2013127","journal-title":"Cancer Treat Rev"},{"key":"9679_CR23","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.2147\/DDDT.S115121","volume":"10","author":"S Yang","year":"2016","unstructured":"Yang S, Zhao J, Sun X (2016) Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review. Drug Des Dev Ther 10:1857","journal-title":"Drug Des Dev Ther"},{"issue":"8","key":"9679_CR24","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/nrc2442","volume":"8","author":"G Bergers","year":"2008","unstructured":"Bergers G, Hanahan D (2008) Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8(8):592","journal-title":"Nat Rev Cancer"},{"issue":"10","key":"9679_CR25","doi-asserted-by":"publisher","first-page":"e018289","DOI":"10.1136\/bmjopen-2017-018289","volume":"7","author":"W Hollingworth","year":"2017","unstructured":"Hollingworth W et al (2017) A longitudinal study to assess the frequency and cost of antivascular endothelial therapy, and inequalities in access, in England between 2005 and 2015. BMJ Open 7(10):e018289","journal-title":"BMJ Open"},{"issue":"2","key":"9679_CR26","first-page":"313","volume":"77","author":"R Vracko","year":"1974","unstructured":"Vracko R (1974) Basal lamina scaffold-anatomy and significance for maintenance of orderly tissue structure: a review. Am J Pathol 77(2):313","journal-title":"Am J Pathol"},{"issue":"2","key":"9679_CR27","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1083\/jcb.55.2.406","volume":"55","author":"R Vracko","year":"1972","unstructured":"Vracko R, Benditt EP (1972) Basal lamina: the scaffold for orderly cell replacement: observations on regeneration of injured skeletal muscle fibers and capillaries. J Cell Biol 55(2):406\u2013419","journal-title":"J Cell Biol"},{"issue":"6","key":"9679_CR28","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/S0002-9394(14)74395-8","volume":"103","author":"AR Irvine","year":"1987","unstructured":"Irvine AR, Wood IS (1987) Radiation retinopathy as an experimental model for ischemic proliferative retinopathy and rubeosis iridis. Am J Ophthalmol 103(6):790\u2013797","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"9679_CR29","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/0014-4835(75)90216-X","volume":"20","author":"A Hamilton","year":"1975","unstructured":"Hamilton A et al (1975) Retinal new vessel formation following experimental vein occlusion. Exp Eye Res 20(6):493\u2013497","journal-title":"Exp Eye Res"},{"issue":"40","key":"9679_CR30","doi-asserted-by":"publisher","first-page":"11237","DOI":"10.1073\/pnas.1605431113","volume":"113","author":"R Mar\u00edn-Juez","year":"2016","unstructured":"Mar\u00edn-Juez R et al (2016) Fast revascularization of the injured area is essential to support zebrafish heart regeneration. Proc Natl Acad Sci USA 113(40):11237\u201311242","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"9679_CR31","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.tranon.2018.01.017","volume":"11","author":"S Becherirat","year":"2018","unstructured":"Becherirat S et al (2018) Discontinuous schedule of bevacizumab in colorectal cancer induces accelerated tumor growth and phenotypic changes. Transl Oncol 11(2):406\u2013415","journal-title":"Transl Oncol"},{"issue":"10","key":"9679_CR32","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1172\/JCI24612","volume":"116","author":"MR Mancuso","year":"2006","unstructured":"Mancuso MR et al (2006) Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest 116(10):2610\u20132621","journal-title":"J Clin Invest"},{"issue":"1","key":"9679_CR33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ophtha.2017.07.014","volume":"125","author":"R Silva","year":"2018","unstructured":"Silva R et al (2018) Treat-and-extend versus monthly regimen in neovascular age-related macular degeneration: results with ranibizumab from the TREND study. Ophthalmology 125(1):57\u201365","journal-title":"Ophthalmology"},{"issue":"4","key":"9679_CR34","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1172\/JCI42405","volume":"121","author":"T Cascone","year":"2011","unstructured":"Cascone T et al (2011) Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor\u2013resistant human lung adenocarcinoma. J Clin Invest 121(4):1313\u20131328","journal-title":"J Clin Invest"},{"issue":"10","key":"9679_CR35","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1038\/onc.2010.503","volume":"30","author":"J Welti","year":"2011","unstructured":"Welti J et al (2011) Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib. Oncogene 30(10):1183","journal-title":"Oncogene"},{"issue":"40","key":"9679_CR36","doi-asserted-by":"publisher","first-page":"10090","DOI":"10.1158\/0008-5472.CAN-10-0489","volume":"70","author":"F Shojaei","year":"2010","unstructured":"Shojaei F et al (2010) HGF\/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors. Cancer Res 70(40):10090\u201310100","journal-title":"Cancer Res"},{"issue":"3","key":"9679_CR37","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.cell.2007.08.038","volume":"131","author":"C Fischer","year":"2007","unstructured":"Fischer C et al (2007) Anti-PlGF inhibits growth of VEGF (R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 131(3):463\u2013475","journal-title":"Cell"},{"issue":"4","key":"9679_CR38","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.ccr.2005.09.005","volume":"8","author":"O Casanovas","year":"2005","unstructured":"Casanovas O et al (2005) Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8(4):299\u2013309","journal-title":"Cancer Cell"},{"issue":"1","key":"9679_CR39","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40942-017-0084-9","volume":"3","author":"T Cabral","year":"2017","unstructured":"Cabral T et al (2017) Retinal and choroidal angiogenesis: a review of new targets. Int J Retina Vitr 3(1):31","journal-title":"Int J Retina Vitr"},{"issue":"12","key":"9679_CR40","doi-asserted-by":"publisher","first-page":"3657","DOI":"10.1158\/1078-0432.CCR-06-0818","volume":"12","author":"B Peruzzi","year":"2006","unstructured":"Peruzzi B, Bottaro DP (2006) Targeting the c-Met signaling pathway in cancer. Clin Cancer Res 12(12):3657\u20133660","journal-title":"Clin Cancer Res"},{"issue":"1","key":"9679_CR41","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/ijc.27666","volume":"132","author":"YJ Kim","year":"2013","unstructured":"Kim YJ et al (2013) Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1\u03b1. Int J Cancer 132(1):29\u201341","journal-title":"Int J Cancer"},{"issue":"21","key":"9679_CR42","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","volume":"285","author":"J Folkman","year":"1971","unstructured":"Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285(21):1182\u20131186","journal-title":"N Engl J Med"},{"issue":"11","key":"9679_CR43","first-page":"1383","volume":"9","author":"M Korey","year":"1977","unstructured":"Korey M, Peyman G, Berkowitz R (1977) The effect of hypertonic ointments on corneal alkali burns. Ann Ophthalmol 9(11):1383\u20131387","journal-title":"Ann Ophthalmol"},{"issue":"8","key":"9679_CR44","first-page":"1625","volume":"37","author":"BM Kenyon","year":"1996","unstructured":"Kenyon BM et al (1996) A model of angiogenesis in the mouse cornea. Invest Ophthalmol Vis Sci 37(8):1625\u20131632","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"9679_CR45","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/0002-9394(79)90245-9","volume":"87","author":"TA Deutsch","year":"1979","unstructured":"Deutsch TA, Hughes WF (1979) Suppressive effects of indomethacin on thermally induced neovascularization of rabbit corneas. Am J Ophthalmol 87(4):536\u2013540","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"9679_CR46","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1167\/iovs.09-4407","volume":"51","author":"BB Peebo","year":"2010","unstructured":"Peebo BB et al (2010) Cellular-level characterization of lymph vessels in live, unlabeled corneas by in vivo confocal microscopy. Invest Ophthalmol Vis Sci 51(2):830\u2013835","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9679_CR47","doi-asserted-by":"publisher","first-page":"32137","DOI":"10.1038\/srep32137","volume":"6","author":"A Mukwaya","year":"2016","unstructured":"Mukwaya A et al (2016) Factors regulating capillary remodeling in a reversible model of inflammatory corneal angiogenesis. Sci Rep 6:32137","journal-title":"Sci Rep"},{"issue":"3","key":"9679_CR48","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s10456-011-9223-3","volume":"14","author":"BB Peebo","year":"2011","unstructured":"Peebo BB et al (2011) Cellular level characterization of capillary regression in inflammatory angiogenesis using an in vivo corneal model. Angiogenesis 14(3):393","journal-title":"Angiogenesis"},{"key":"9679_CR49","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.exer.2014.06.006","volume":"125","author":"P Mirabelli","year":"2014","unstructured":"Mirabelli P et al (2014) Early effects of dexamethasone and anti-VEGF therapy in an inflammatory corneal neovascularization model. Exp Eye Res 125:118\u2013127","journal-title":"Exp Eye Res"},{"issue":"2","key":"9679_CR50","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s10456-018-9604-y","volume":"21","author":"A Mukwaya","year":"2018","unstructured":"Mukwaya A et al (2018) Time-dependent LXR\/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization. Angiogenesis 21(2):395\u2013413","journal-title":"Angiogenesis"},{"issue":"8","key":"9679_CR51","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1167\/iovs.19-27591","volume":"60","author":"A Mukwaya","year":"2019","unstructured":"Mukwaya A et al (2019) Repeat corneal neovascularization is characterized by more aggressive inflammation and vessel invasion than in the initial phase. Invest Ophthalmol Vis Sci 60(8):2990\u20133001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"9679_CR52","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nm0901-987","volume":"7","author":"RK Jain","year":"2001","unstructured":"Jain RK (2001) Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 7(9):987","journal-title":"Nat Med"},{"issue":"6","key":"9679_CR53","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nrd3455","volume":"10","author":"P Carmeliet","year":"2011","unstructured":"Carmeliet P, Jain RK (2011) Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 10(6):417","journal-title":"Nat Rev Drug Discov"},{"issue":"3","key":"9679_CR54","doi-asserted-by":"publisher","first-page":"a006486","DOI":"10.1101\/cshperspect.a006486","volume":"2","author":"S Goel","year":"2012","unstructured":"Goel S, Wong AH-K, Jain RK (2012) Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease. Cold Spring Harb Perspect Med 2(3):a006486","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"2","key":"9679_CR55","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1046\/j.1469-7580.2000.19720157.x","volume":"197","author":"H Bartel","year":"2000","unstructured":"Bartel H, Lametschwandtner A (2000) Regression of blood vessels in the ventral velum of Xenopus laevis Daudin during metamorphosis: light microscopic and transmission electron microscopic study. J Anat 197(2):157\u2013166","journal-title":"J Anat"},{"issue":"18","key":"9679_CR56","doi-asserted-by":"publisher","first-page":"10820","DOI":"10.1073\/pnas.95.18.10820","volume":"95","author":"RK Jain","year":"1998","unstructured":"Jain RK et al (1998) Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. Proc Natl Acad Sci USA 95(18):10820\u201310825","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"9679_CR57","doi-asserted-by":"publisher","first-page":"725","DOI":"10.3233\/JAD-2010-100219","volume":"21","author":"WR Brown","year":"2010","unstructured":"Brown WR (2010) A review of string vessels or collapsed, empty basement membrane tubes. J Alzheimer\u2019s Dis 21(3):725\u2013739","journal-title":"J Alzheimer\u2019s Dis"},{"key":"9679_CR58","first-page":"284","volume":"38","author":"D Ausprunk","year":"1978","unstructured":"Ausprunk D (1978) The sequence of events in the regression of corneal capillaries. Lab Invest 38:284\u2013294","journal-title":"Lab Invest"},{"issue":"8","key":"9679_CR59","doi-asserted-by":"publisher","first-page":"a005090","DOI":"10.1101\/cshperspect.a005090","volume":"3","author":"DR Senger","year":"2011","unstructured":"Senger DR, Davis GE (2011) Angiogenesis. Cold Spring Harbor Perspec Biol 3(8):a005090","journal-title":"Cold Spring Harbor Perspec Biol"},{"issue":"1","key":"9679_CR60","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev.physiol.59.1.89","volume":"59","author":"K Stenmark","year":"1997","unstructured":"Stenmark K, Mecham R (1997) Cellular and molecular mechanisms of pulmonary vascular remodeling. Annu Rev Physiol 59(1):89\u2013144","journal-title":"Annu Rev Physiol"},{"issue":"24","key":"9679_CR61","doi-asserted-by":"publisher","first-page":"5091","DOI":"10.1182\/blood-2009-05-222364","volume":"114","author":"AN Stratman","year":"2009","unstructured":"Stratman AN et al (2009) Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. Blood 114(24):5091\u20135101","journal-title":"Blood"},{"issue":"1","key":"9679_CR62","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1017\/S1431927611012402","volume":"18","author":"AN Stratman","year":"2012","unstructured":"Stratman AN, Davis GE (2012) Endothelial cell-pericyte interactions stimulate basement membrane matrix assembly: influence on vascular tube remodeling, maturation, and stabilization. Microsc Microanal 18(1):68\u201380","journal-title":"Microsc Microanal"},{"issue":"2\u20133","key":"9679_CR63","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.mvr.2007.05.005","volume":"74","author":"TM Mundel","year":"2007","unstructured":"Mundel TM, Kalluri R (2007) Type IV collagen-derived angiogenesis inhibitors. Microvasc Res 74(2\u20133):85\u201389","journal-title":"Microvasc Res"},{"issue":"9","key":"9679_CR64","first-page":"2520","volume":"60","author":"PC Colorado","year":"2000","unstructured":"Colorado PC et al (2000) Anti-angiogenic cues from vascular basement membrane collagen. Can Res 60(9):2520\u20132526","journal-title":"Can Res"},{"issue":"6","key":"9679_CR65","doi-asserted-by":"publisher","first-page":"3060","DOI":"10.1167\/iovs.10-6101","volume":"52","author":"BB Peebo","year":"2011","unstructured":"Peebo BB et al (2011) Time-lapse in vivo imaging of corneal angiogenesis: the role of inflammatory cells in capillary sprouting. Invest Ophthalmol Vis Sci 52(6):3060\u20133068","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"9679_CR66","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1172\/JCI5028","volume":"103","author":"LE Benjamin","year":"1999","unstructured":"Benjamin LE et al (1999) Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 103(2):159\u2013165","journal-title":"J Clin Invest"},{"issue":"3","key":"9679_CR67","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s10456-018-9613-x","volume":"21","author":"P Nowak-Sliwinska","year":"2018","unstructured":"Nowak-Sliwinska P et al (2018) Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis 21(3):425\u2013532","journal-title":"Angiogenesis"}],"container-title":["Angiogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-019-09679-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10456-019-09679-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-019-09679-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T11:50:50Z","timestamp":1664279450000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10456-019-09679-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,4]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["9679"],"URL":"https:\/\/doi.org\/10.1007\/s10456-019-09679-9","relation":{},"ISSN":["0969-6970","1573-7209"],"issn-type":[{"value":"0969-6970","type":"print"},{"value":"1573-7209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,4]]},"assertion":[{"value":"10 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest regarding this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}