{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:19:35Z","timestamp":1760300375130,"version":"3.37.3"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Angiogenesis"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s10456-020-09712-2","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T19:02:41Z","timestamp":1582916561000},"page":"271-274","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Intranasal Efudix reduces epistaxis in hereditary hemorrhagic telangiectasia"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8159-0089","authenticated-orcid":false,"given":"D. V. C.","family":"de Jel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J. M.","family":"Disch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kroon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Mager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J.","family":"Verdam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"9712_CR1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.blre.2010.07.001","volume":"24","author":"CL Shovlin","year":"2010","unstructured":"Shovlin CL (2010) Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment. Blood Rev 24:203\u2013219. https:\/\/doi.org\/10.1016\/j.blre.2010.07.001","journal-title":"Blood Rev"},{"key":"9712_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1177\/194589240602000116","volume":"20","author":"EJ Mahoney","year":"2006","unstructured":"Mahoney EJ, Shapshay SM (2006) New classification of nasal vasculature patterns in hereditary hemorrhagic telangiectasia. Am J Rhinol 20:87\u201390. https:\/\/doi.org\/10.1177\/194589240602000116","journal-title":"Am J Rhinol"},{"key":"9712_CR3","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1002\/ajmg.a.35309","volume":"158A","author":"A\u00d8 Geirdal","year":"2012","unstructured":"Geirdal A\u00d8, Dheyauldeen S, Bachmann-Harildstad G, Heimdal K (2012) Quality of life in patients with hereditary hemorrhagic telangiectasia in Norway: a population based study. Am J Med Genet Part A 158A:1269\u20131278. https:\/\/doi.org\/10.1002\/ajmg.a.35309","journal-title":"Am J Med Genet Part A"},{"key":"9712_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40463-016-0116-8","volume":"45","author":"CJ Chin","year":"2016","unstructured":"Chin CJ, Rotenberg BW, Witterick IJ (2016) Epistaxis in hereditary hemorrhagic telangiectasia: an evidence based review of surgical management. J Otolaryngol Head Neck Surg 45:3. https:\/\/doi.org\/10.1186\/s40463-016-0116-8","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"9712_CR5","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1097\/01.prs.0000169701.16509.d6","volume":"116","author":"NW Bulstrode","year":"2005","unstructured":"Bulstrode NW, Mudera V, McGrouther DA et al (2005) 5-fluorouracil selectively inhibits collagen synthesis. Plast Reconstr Surg 116:209\u2013221. https:\/\/doi.org\/10.1097\/01.prs.0000169701.16509.d6. discussion 222-3","journal-title":"Plast Reconstr Surg"},{"key":"9712_CR6","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1111\/ijd.14106","volume":"57","author":"GT Prince","year":"2018","unstructured":"Prince GT, Cameron MC, Fathi R, Alkousakis T (2018) Topical 5-fluorouracil in dermatologic disease. Int J Dermatol 57:1259\u20131264. https:\/\/doi.org\/10.1111\/ijd.14106","journal-title":"Int J Dermatol"},{"key":"9712_CR7","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1001\/archotol.127.2.141","volume":"127","author":"PP Knegt","year":"2001","unstructured":"Knegt PP, Ah-See KW, Vd Velden L-A, Kerrebijn J (2001) Adenocarcinoma of the ethmoidal sinus complex. Arch Otolaryngol Neck Surg 127:141. https:\/\/doi.org\/10.1001\/archotol.127.2.141","journal-title":"Arch Otolaryngol Neck Surg"},{"key":"9712_CR8","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1111\/j.1749-4486.2008.01790.x","volume":"33","author":"R Almeyda","year":"2008","unstructured":"Almeyda R, Capper J (2008) Is surgical debridement and topical 5 fluorouracil the optimum treatment for woodworkers\u2019 adenocarcinoma of the ethmoid sinuses? A case-controlled study of a 20-year experience. Clin Otolaryngol 33:435\u2013441. https:\/\/doi.org\/10.1111\/j.1749-4486.2008.01790.x","journal-title":"Clin Otolaryngol"},{"key":"9712_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20818","author":"JB Hoag","year":"2010","unstructured":"Hoag JB, Terry P, Mitchell S et al (2010) An epistaxis severity score for hereditary hemorrhagic telangiectasia. Laryngoscope. https:\/\/doi.org\/10.1002\/lary.20818","journal-title":"Laryngoscope"}],"container-title":["Angiogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-020-09712-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10456-020-09712-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-020-09712-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:17:36Z","timestamp":1614385056000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10456-020-09712-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,28]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["9712"],"URL":"https:\/\/doi.org\/10.1007\/s10456-020-09712-2","relation":{},"ISSN":["0969-6970","1573-7209"],"issn-type":[{"type":"print","value":"0969-6970"},{"type":"electronic","value":"1573-7209"}],"subject":[],"published":{"date-parts":[[2020,2,28]]},"assertion":[{"value":"14 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}