{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T04:31:21Z","timestamp":1752985881624,"version":"3.37.3"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Angiogenesis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal-dominant disease characterized by pathologic angiogenesis that provokes vascular overgrowth. The evidence about the influence of Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in patients with rare diseases is scarce. We aimed to know the prevalence of coronavirus disease 2019 (COVID-19) in HHT patients. The HHT pathogenic angiogenesis and endothelial injury in COVID-19 are discussed using data from RiHHTa (Computerized Registry of Hereditary Hemorrhagic Telangiectasia) registry. RiHHTa is an open, multicenter, prospective, observational registry including adult patients with HHT. A 27-item survey that captured clinical data of admitted HHT patients for COVID-19 was distributed to all RiHHTa investigators from June 8th to June 24th 2020. Only one out of 1177 HHT patients was admitted for COVID-19 pneumonia. She is a 74\u00a0years-old woman with a pathogenic variant in <jats:italic>ACVRL1<\/jats:italic> gene. Her clinical course did not involve mechanical ventilation or worsening epistaxis, and she was successfully discharged after two weeks. The endothelial damage and the consequent angiogenic process in COVID-19 patients deserve further investigation.<\/jats:p>","DOI":"10.1007\/s10456-020-09755-5","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T15:03:09Z","timestamp":1602687789000},"page":"13-15","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Angiogenesis, hereditary hemorrhagic telangiectasia and COVID-19"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9411-804X","authenticated-orcid":false,"given":"Antoni","family":"Riera-Mestre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Iriarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"del Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"L\u00f3pez-Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"9755_CR1","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s13023-020-01422-8","volume":"15","author":"R S\u00e1nchez-Mart\u00ednez","year":"2020","unstructured":"S\u00e1nchez-Mart\u00ednez R, Iriarte A, Mora-Luj\u00e1n JM, Patier JL, L\u00f3pez-Wolf D, Ojeda A et al (2020) Current HHT genetic overview in Spain and its phenotypic correlation: data from RiHHTa registry. Orphanet J Rare Dis 15:138","journal-title":"Orphanet J Rare Dis"},{"key":"9755_CR2","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1056\/NEJMoa2015432","volume":"383","author":"M Ackermann","year":"2020","unstructured":"Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F et al (2020) Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med 383:120\u2013128","journal-title":"N Engl J Med"},{"key":"9755_CR3","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","volume":"395","author":"C Huang","year":"2020","unstructured":"Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y et al (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China Lancet 395:497\u2013506","journal-title":"China Lancet"},{"key":"9755_CR4","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1161\/ATVBAHA.120.314558","volume":"40","author":"D Gustafson","year":"2019","unstructured":"Gustafson D, Raju S, Wu R, Ching C, Veitch S, Rathnakumaret K, al, (2019) Overcoming barriers: the endothelium as a linchpin of coronavirus disease 2019 pathogenesis? Arterioscler Thromb Vasc Biol 40:1818\u20131829","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"9755_CR5","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa528","author":"C Guervilly","year":"2020","unstructured":"Guervilly C, Burtey S, Sabatier F, Cauchois R, Lano G, Abdili E et al (2020) Circulating endothelial cells as a marker of endothelial injury in severe COVID-19. J Infect Dis. https:\/\/doi.org\/10.1093\/infdis\/jiaa528","journal-title":"J Infect Dis"}],"container-title":["Angiogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-020-09755-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10456-020-09755-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-020-09755-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T01:25:12Z","timestamp":1634174712000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10456-020-09755-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,14]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["9755"],"URL":"https:\/\/doi.org\/10.1007\/s10456-020-09755-5","relation":{},"ISSN":["0969-6970","1573-7209"],"issn-type":[{"type":"print","value":"0969-6970"},{"type":"electronic","value":"1573-7209"}],"subject":[],"published":{"date-parts":[[2020,10,14]]},"assertion":[{"value":"28 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The methodology used in RiHHTa registry was approved by the Clinical Research Ethics Committee of the Hospital Universitari de Bellvitge (Barcelona, Spain; ethic approval number PR241\/16). Personal and clinical data that were collected for the study are in line with the Spanish (Organic Law 3\/2018) and European (UE 2016\/679) Data Protection Regulations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients (or their relatives) provided written consent for participation in the RiHHTa registry. To safeguard the identity of the included patients, the RiHHTa registry generate an encrypted identifier for each patient.<b>Consent for publication <\/b>Not applicable. This study does not contain any individual person\u2019s data in any form. Each patient was identified by a unique alphanumeric identification code and all data were made anonymous and analysed as aggregates.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}