{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:34:43Z","timestamp":1787240083055,"version":"build-2736575974"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Angiogenesis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective (s)<\/jats:title>\n                    <jats:p>Circulating angiogenic factors are used for prediction of placenta-related complications, but their associations with first-trimester placental development is unknown. This study investigates associations between maternal angiogenic factors and utero-placental vascular volume (uPVV) and utero-placental vascular skeleton (uPVS) as novel imaging markers of volumetric and morphologic (branching) development of the first-trimester utero-placental vasculature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In 185 ongoing pregnancies from the VIRTUAL Placenta study, a subcohort of the ongoing prospective Rotterdam Periconception cohort, three-dimensional power Doppler ultrasounds of the placenta were obtained at 7\u20139\u201311\u00a0weeks gestational age (GA). The uPVV was measured as a parameter of volumetric development and reported the vascular quantity in cm\n                      <jats:sup>3<\/jats:sup>\n                      . The uPVS was generated as a parameter of morphologic (branching) development and reported the number of end-, bifurcation- crossing-\u00a0or vessel points and total vascular length. At 11\u00a0weeks GA, maternal serum biomarkers suggested to reflect placental (vascular) development were assessed: placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng). sFlt-1\/PlGF and sEng\/PlGF ratios were calculated. Multivariable linear regression with adjustments was used to estimate associations between serum biomarkers and uPVV and uPVS trajectories.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum PlGF was positively associated with uPVV and uPVS development (uPVV: \u03b2\u2009=\u20090.39, 95% CI\u2009=\u20090.15;0.64; bifurcation points: \u03b2\u2009=\u20094.64, 95% CI\u2009=\u20090.04;9.25; crossing points: \u03b2\u2009=\u20094.01, 95% CI\u2009=\u20090.65;7.37; total vascular length: \u03b2\u2009=\u200913.33, 95% CI\u2009=\u20093.09;23.58, all p-values\u2009&lt;\u20090.05). sEng\/PlGF ratio was negatively associated with uPVV and uPVS development. We observed no associations between sFlt-1, sEng or sFlt-1\/PlGF ratio and uPVV and uPVS development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion(s)<\/jats:title>\n                    <jats:p>Higher first-trimester maternal serum PlGF concentration is associated with increased first-trimester utero-placental vascular development as reflected by uPVV and uPVS.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Clinical trial registration number<\/jats:italic>\n                      Dutch Trial Register NTR6854.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10456-024-09939-3","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T14:02:16Z","timestamp":1723644136000},"page":"797-808","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal serum PlGF associates with 3D power doppler ultrasound markers of utero-placental vascular development in the first trimester: the rotterdam periconception cohort"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6933-3204","authenticated-orcid":false,"given":"Eline S.","family":"de Vos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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