{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:36:52Z","timestamp":1790217412828,"version":"4.1.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL126901"],"award-info":[{"award-number":["R01HL126901"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY017017"],"award-info":[{"award-number":["R01EY017017"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015993","name":"Kowa Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015993","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children\u2019s Hospital","doi-asserted-by":"publisher","award":["OFD\/BTREC\/CTREC Faculty Career Development Grant 97906"],"award-info":[{"award-number":["OFD\/BTREC\/CTREC Faculty Career Development Grant 97906"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children\u2019s Hospital","doi-asserted-by":"publisher","award":["IDDRC (1U54HD090255)"],"award-info":[{"award-number":["IDDRC (1U54HD090255)"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["DNR# #2020-01092"],"award-info":[{"award-number":["DNR# #2020-01092"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Government grants under the ALF agreement","award":["ALFGBG-717971"],"award-info":[{"award-number":["ALFGBG-717971"]}]},{"name":"The Wallenberg Clinical Scholars"},{"DOI":"10.13039\/100007745","name":"Massachusetts Lions Eye Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Angiogenesis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pathological neovascularization in retinopathy of prematurity (ROP) can cause visual impairment in preterm infants. Current ROP treatments which are not preventative and only address late neovascular ROP, are costly and can lead to severe complications. We showed that topical 0.1% dexamethasone eye drops administered prior to peak neovessel formation prevented neovascularization in five extremely preterm infants at high risk for ROP and suppressed neovascularization by 30% in mouse oxygen-induced retinopathy (OIR) modeling ROP. In contrast, in OIR, topical dexamethasone treatment before any neovessel formation had limited efficacy in preventing later neovascularization, while treatment after peak neovessel formation had a non-statistically significant trend to exacerbating disease. Optimally timed topical dexamethasone suppression of neovascularization in OIR was associated with increased retinal mitochondrial gene expression and decreased inflammatory marker expression, predominantly found in immune cells. Blocking mitochondrial ATP synthetase reversed the inhibitory effect of dexamethasone on neovascularization in OIR. This study provides new insights into topical steroid effects in retinal neovascularization and into mitochondrial function in phase II ROP, and suggests a simple clinical approach to prevent severe ROP.<\/jats:p>","DOI":"10.1007\/s10456-024-09948-2","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T13:16:11Z","timestamp":1726665371000},"page":"903-917","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity"],"prefix":"10.1007","volume":"27","author":[{"given":"Hitomi","family":"Yagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Boeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya","family":"Petrishka-Lozenska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Lundgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gael","family":"Cagnone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Neilsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaomei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha A.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-S\u00e9bastien","family":"Joyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Aikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuno","family":"Negishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjie","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois E.H.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"issue":"9902","key":"9948_CR1","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","volume":"382","author":"A Hellstrom","year":"2013","unstructured":"Hellstrom A, Smith LE, Dammann O (2013) Retinopathy of prematurity. Lancet 382(9902):1445\u20131457. https:\/\/doi.org\/10.1016\/S0140-6736(13)60178-6","journal-title":"Lancet"},{"key":"9948_CR2","doi-asserted-by":"publisher","unstructured":"Fu Z, Nilsson AK, Hellstrom A, Smith LEH (2022) Retinopathy of prematurity: metabolic risk factors. Elife 11. https:\/\/doi.org\/10.7554\/eLife.80550","DOI":"10.7554\/eLife.80550"},{"issue":"2","key":"9948_CR3","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.ajo.2011.07.005","volume":"153","author":"T Sato","year":"2012","unstructured":"Sato T, Wada K, Arahori H, Kuno N, Imoto K, Iwahashi-Shima C, Kusaka S (2012) Serum concentrations of bevacizumab (avastin) and vascular endothelial growth factor in infants with retinopathy of prematurity. Am J Ophthalmol 153(2):327\u2013333e321. https:\/\/doi.org\/10.1016\/j.ajo.2011.07.005","journal-title":"Am J Ophthalmol"},{"issue":"10","key":"9948_CR4","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s11892-022-01491-y","volume":"22","author":"JA Zehden","year":"2022","unstructured":"Zehden JA, Mortensen XM, Reddy A, Zhang AY (2022) Systemic and ocular adverse events with Intravitreal Anti-VEGF therapy used in the treatment of Diabetic Retinopathy: a review. Curr Diab Rep 22(10):525\u2013536. https:\/\/doi.org\/10.1007\/s11892-022-01491-y","journal-title":"Curr Diab Rep"},{"issue":"10","key":"9948_CR5","first-page":"3095","volume":"41","author":"P Yossuck","year":"2000","unstructured":"Yossuck P, Yan Y, Tadesse M, Higgins RD (2000) Dexamethasone and critical effect of timing on retinopathy. Invest Ophthalmol Vis Sci 41(10):3095\u20133099","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"9948_CR6","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.2353\/ajpath.2007.070172","volume":"171","author":"S Nakao","year":"2007","unstructured":"Nakao S, Hata Y, Miura M, Noda K, Kimura YN, Kawahara S, Kita T, Hisatomi T, Nakazawa T, Jin Y, Dana MR, Kuwano M, Ono M, Ishibashi T, Hafezi-Moghadam A (2007) Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappab-activated stromal cells in inflammatory angiogenesis. Am J Pathol 171(3):1058\u20131065. https:\/\/doi.org\/10.2353\/ajpath.2007.070172","journal-title":"Am J Pathol"},{"key":"9948_CR7","doi-asserted-by":"publisher","first-page":"555","DOI":"10.2147\/DMSO.S73540","volume":"8","author":"Z Cebeci","year":"2015","unstructured":"Cebeci Z, Kir N (2015) Role of implants in the treatment of diabetic macular edema: focus on the dexamethasone intravitreal implant. Diabetes Metab Syndr Obes 8:555\u2013566. https:\/\/doi.org\/10.2147\/DMSO.S73540","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"1","key":"9948_CR8","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1203\/00006450-199907000-00016","volume":"46","author":"T Rotschild","year":"1999","unstructured":"Rotschild T, Nandgaonkar BN, Yu K, Higgins RD (1999) Dexamethasone reduces oxygen induced retinopathy in a mouse model. Pediatr Res 46(1):94\u2013100. https:\/\/doi.org\/10.1203\/00006450-199907000-00016","journal-title":"Pediatr Res"},{"issue":"3","key":"9948_CR9","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1203\/00006450-199903000-00004","volume":"45","author":"PA Lawas-Alejo","year":"1999","unstructured":"Lawas-Alejo PA, Slivka S, Hernandez H, Bry K, Hallman M (1999) Hyperoxia and glucocorticoid modify retinal vessel growth and interleukin-1 receptor antagonist in newborn rabbits. Pediatr Res 45(3):313\u2013317. https:\/\/doi.org\/10.1203\/00006450-199903000-00004","journal-title":"Pediatr Res"},{"issue":"7","key":"9948_CR10","first-page":"1653","volume":"42","author":"A Wenzel","year":"2001","unstructured":"Wenzel A, Grimm C, Seeliger MW, Jaissle G, Hafezi F, Kretschmer R, Zrenner E, Reme CE (2001) Prevention of photoreceptor apoptosis by activation of the glucocorticoid receptor. Invest Ophthalmol Vis Sci 42(7):1653\u20131659","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"9948_CR11","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/0014-4835(92)90137-h","volume":"54","author":"J Fu","year":"1992","unstructured":"Fu J, Lam TT, Tso MO (1992) Dexamethasone ameliorates retinal photic injury in albino rats. Exp Eye Res 54(4):583\u2013594. https:\/\/doi.org\/10.1016\/0014-4835(92)90137-h","journal-title":"Exp Eye Res"},{"issue":"11","key":"9948_CR12","doi-asserted-by":"publisher","first-page":"5008","DOI":"10.1167\/iovs.07-1154","volume":"49","author":"H She","year":"2008","unstructured":"She H, Nakazawa T, Matsubara A, Connolly E, Hisatomi T, Noda K, Kim I, Gragoudas ES, Miller JW (2008) Photoreceptor protection after photodynamic therapy using dexamethasone in a rat model of choroidal neovascularization. Invest Ophthalmol Vis Sci 49(11):5008\u20135014. https:\/\/doi.org\/10.1167\/iovs.07-1154","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9948_CR13","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.expneurol.2015.08.007","volume":"273","author":"D Gallina","year":"2015","unstructured":"Gallina D, Zelinka CP, Cebulla CM, Fischer AJ (2015) Activation of glucocorticoid receptors in Muller glia is protective to retinal neurons and suppresses microglial reactivity. Exp Neurol 273:114\u2013125. https:\/\/doi.org\/10.1016\/j.expneurol.2015.08.007","journal-title":"Exp Neurol"},{"issue":"2","key":"9948_CR14","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/ng984","volume":"32","author":"W Hao","year":"2002","unstructured":"Hao W, Wenzel A, Obin MS, Chen CK, Brill E, Krasnoperova NV, Eversole-Cire P, Kleyner Y, Taylor A, Simon MI, Grimm C, Reme CE, Lem J (2002) Evidence for two apoptotic pathways in light-induced retinal degeneration. Nat Genet 32(2):254\u2013260. https:\/\/doi.org\/10.1038\/ng984","journal-title":"Nat Genet"},{"issue":"7","key":"9948_CR15","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/s41423-022-00859-0","volume":"19","author":"Y Hou","year":"2022","unstructured":"Hou Y, Xie J, Wang S, Li D, Wang L, Wang H, Ni X, Leng S, Li G, Hou M, Peng J (2022) Glucocorticoid receptor modulates myeloid-derived suppressor cell function via mitochondrial metabolism in immune thrombocytopenia. Cell Mol Immunol 19(7):764\u2013776. https:\/\/doi.org\/10.1038\/s41423-022-00859-0","journal-title":"Cell Mol Immunol"},{"issue":"10","key":"9948_CR16","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1016\/j.ophtha.2021.05.031","volume":"128","author":"MF Chiang","year":"2021","unstructured":"Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Paul Chan RV, Berrocal A, Binenbaum G, Blair M, Peter Campbell J, Capone A Jr., Chen Y, Dai S, Ells A, Fleck BW, Good WV, Elizabeth Hartnett M, Holmstrom G, Kusaka S, Kychenthal A, Lepore D, Lorenz B, Martinez-Castellanos MA, Ozdek S, Ademola-Popoola D, Reynolds JD, Shah PK, Shapiro M, Stahl A, Toth C, Vinekar A, Visser L, Wallace DK, Wu WC, Zhao P, Zin A (2021) International classification of retinopathy of Prematurity, Third Edition. Ophthalmology 128(10):e51\u2013e68. https:\/\/doi.org\/10.1016\/j.ophtha.2021.05.031","journal-title":"Ophthalmology"},{"issue":"2","key":"9948_CR17","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.oret.2021.09.002","volume":"6","author":"HM Ohnell","year":"2022","unstructured":"Ohnell HM, Andreasson S, Granse L (2022) Dexamethasone Eye drops for the treatment of retinopathy of Prematurity. Ophthalmol Retina 6(2):181\u2013182. https:\/\/doi.org\/10.1016\/j.oret.2021.09.002","journal-title":"Ophthalmol Retina"},{"issue":"1","key":"9948_CR18","first-page":"101","volume":"35","author":"LE Smith","year":"1994","unstructured":"Smith LE, Wesolowski E, McLellan A, Kostyk SK, D\u2019Amato R, Sullivan R, D\u2019Amore PA (1994) Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 35(1):101\u2013111","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"9948_CR19","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1038\/nprot.2009.187","volume":"4","author":"KM Connor","year":"2009","unstructured":"Connor KM, Krah NM, Dennison RJ, Aderman CM, Chen J, Guerin KI, Sapieha P, Stahl A, Willett KL, Smith LE (2009) Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc 4(11):1565\u20131573. https:\/\/doi.org\/10.1038\/nprot.2009.187","journal-title":"Nat Protoc"},{"issue":"7","key":"9948_CR20","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1001\/archopht.123.7.991","volume":"123","author":"International Committee for the Classification of Retinopathy of P","year":"2005","unstructured":"International Committee for the Classification of Retinopathy of P (2005) The International classification of retinopathy of Prematurity revisited. Arch Ophthalmol 123(7):991\u2013999. https:\/\/doi.org\/10.1001\/archopht.123.7.991","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"9948_CR21","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.2353\/ajpath.2010.100526","volume":"177","author":"A Stahl","year":"2010","unstructured":"Stahl A, Chen J, Sapieha P, Seaward MR, Krah NM, Dennison RJ, Favazza T, Bucher F, Lofqvist C, Ong H, Hellstrom A, Chemtob S, Akula JD, Smith LE (2010) Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy. Am J Pathol 177(6):2715\u20132723. https:\/\/doi.org\/10.2353\/ajpath.2010.100526","journal-title":"Am J Pathol"},{"issue":"4","key":"9948_CR22","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","volume":"30","author":"A Kramer","year":"2014","unstructured":"Kramer A, Green J, Pollard J Jr., Tugendreich S (2014) Causal analysis approaches in Ingenuity Pathway Analysis. Bioinformatics 30(4):523\u2013530. https:\/\/doi.org\/10.1093\/bioinformatics\/btt703","journal-title":"Bioinformatics"},{"key":"9948_CR23","doi-asserted-by":"publisher","unstructured":"Binet F, Cagnone G, Crespo-Garcia S, Hata M, Neault M, Dejda A, Wilson AM, Buscarlet M, Mawambo GT, Howard JP, Diaz-Marin R, Parinot C, Guber V, Pilon F, Juneau R, Laflamme R, Sawchyn C, Boulay K, Leclerc S, Abu-Thuraia A, Cote JF, Andelfinger G, Rezende FA, Sennlaub F, Joyal JS, Mallette FA, Sapieha P (2020) Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy. Science 369(6506). https:\/\/doi.org\/10.1126\/science.aay5356","DOI":"10.1126\/science.aay5356"},{"issue":"4","key":"9948_CR24","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.mito.2013.04.005","volume":"13","author":"A Pagliarani","year":"2013","unstructured":"Pagliarani A, Nesci S, Ventrella V (2013) Modifiers of the oligomycin sensitivity of the mitochondrial F1F0-ATPase. Mitochondrion 13(4):312\u2013319. https:\/\/doi.org\/10.1016\/j.mito.2013.04.005","journal-title":"Mitochondrion"},{"issue":"1","key":"9948_CR25","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12974-017-0943-1","volume":"14","author":"JC Rivera","year":"2017","unstructured":"Rivera JC, Holm M, Austeng D, Morken TS, Zhou TE, Beaudry-Richard A, Sierra EM, Dammann O, Chemtob S (2017) Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies. J Neuroinflammation 14(1):165. https:\/\/doi.org\/10.1186\/s12974-017-0943-1","journal-title":"J Neuroinflammation"},{"key":"9948_CR26","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.preteyeres.2014.11.004","volume":"45","author":"M Karlstetter","year":"2015","unstructured":"Karlstetter M, Scholz R, Rutar M, Wong WT, Provis JM, Langmann T (2015) Retinal microglia: just bystander or target for therapy? Prog Retin Eye Res 45:30\u201357. https:\/\/doi.org\/10.1016\/j.preteyeres.2014.11.004","journal-title":"Prog Retin Eye Res"},{"issue":"8","key":"9948_CR27","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1001\/archpedi.1994.02170080078015","volume":"148","author":"K Wright","year":"1994","unstructured":"Wright K, Wright SP (1994) Lack of association of glucocorticoid therapy and retinopathy of prematurity. Arch Pediatr Adolesc Med 148(8):848\u2013852. https:\/\/doi.org\/10.1001\/archpedi.1994.02170080078015","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"4","key":"9948_CR28","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1542\/peds.90.4.529","volume":"90","author":"DB Sobel","year":"1992","unstructured":"Sobel DB, Philip AG (1992) Prolonged dexamethasone therapy reduces the incidence of cryotherapy for retinopathy of prematurity in infants of less than 1 kilogram birth weight with bronchopulmonary dysplasia. Pediatrics 90(4):529\u2013533","journal-title":"Pediatrics"},{"key":"9948_CR29","doi-asserted-by":"publisher","first-page":"759742","DOI":"10.3389\/fphar.2022.759742","volume":"13","author":"Y Zeng","year":"2022","unstructured":"Zeng Y, Ge G, Lei C, Zhang M (2022) Beyond fetal immunity: a systematic review and Meta-analysis of the Association between Antenatal Corticosteroids and Retinopathy of Prematurity. Front Pharmacol 13:759742. https:\/\/doi.org\/10.3389\/fphar.2022.759742","journal-title":"Front Pharmacol"},{"issue":"4","key":"9948_CR30","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.jaapos.2016.05.008","volume":"20","author":"TZ Movsas","year":"2016","unstructured":"Movsas TZ, Spitzer AR, Gewolb IH (2016) Postnatal corticosteroids and risk of retinopathy of prematurity. J AAPOS 20(4):348\u2013352. https:\/\/doi.org\/10.1016\/j.jaapos.2016.05.008","journal-title":"J AAPOS"},{"issue":"4","key":"9948_CR31","doi-asserted-by":"publisher","first-page":"350","DOI":"10.4161\/cib.2.4.8554","volume":"2","author":"J Du","year":"2009","unstructured":"Du J, McEwen B, Manji HK (2009) Glucocorticoid receptors modulate mitochondrial function: a novel mechanism for neuroprotection. Commun Integr Biol 2(4):350\u2013352. https:\/\/doi.org\/10.4161\/cib.2.4.8554","journal-title":"Commun Integr Biol"},{"key":"9948_CR32","doi-asserted-by":"publisher","unstructured":"Kokkinopoulou I, Moutsatsou P (2021) Mitochondrial glucocorticoid receptors and their actions. Int J Mol Sci 22(11). https:\/\/doi.org\/10.3390\/ijms22116054","DOI":"10.3390\/ijms22116054"},{"issue":"32","key":"9948_CR33","doi-asserted-by":"publisher","first-page":"9099","DOI":"10.1073\/pnas.1602185113","volume":"113","author":"RG Hunter","year":"2016","unstructured":"Hunter RG, Seligsohn M, Rubin TG, Griffiths BB, Ozdemir Y, Pfaff DW, Datson NA, McEwen BS (2016) Stress and corticosteroids regulate rat hippocampal mitochondrial DNA gene expression via the glucocorticoid receptor. Proc Natl Acad Sci U S A 113(32):9099\u20139104. https:\/\/doi.org\/10.1073\/pnas.1602185113","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"9948_CR34","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1016\/j.bbamcr.2011.05.014","volume":"1813","author":"AM Psarra","year":"2011","unstructured":"Psarra AM, Sekeris CE (2011) Glucocorticoids induce mitochondrial gene transcription in HepG2 cells: role of the mitochondrial glucocorticoid receptor. Biochim Biophys Acta 1813(10):1814\u20131821. https:\/\/doi.org\/10.1016\/j.bbamcr.2011.05.014","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"9948_CR35","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1172\/JCI112722","volume":"78","author":"Z Chap","year":"1986","unstructured":"Chap Z, Jones RH, Chou J, Hartley CJ, Entman ML, Field JB (1986) Effect of dexamethasone on hepatic glucose and insulin metabolism after oral glucose in conscious dogs. J Clin Invest 78(5):1355\u20131361. https:\/\/doi.org\/10.1172\/JCI112722","journal-title":"J Clin Invest"},{"key":"9948_CR36","doi-asserted-by":"publisher","first-page":"960279","DOI":"10.3389\/fendo.2022.960279","volume":"13","author":"LL Koorneef","year":"2022","unstructured":"Koorneef LL, van der Meulen M, Kooijman S, Sanchez-Lopez E, Scheerstra JF, Voorhoeve MC, Ramesh ANN, Rensen PCN, Giera M, Kroon J, Meijer OC (2022) Dexamethasone-associated metabolic effects in male mice are partially caused by depletion of endogenous corticosterone. Front Endocrinol (Lausanne) 13:960279. https:\/\/doi.org\/10.3389\/fendo.2022.960279","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"9948_CR37","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1001\/archpedi.153.8.795","volume":"153","author":"SB Amin","year":"1999","unstructured":"Amin SB, Sinkin RA, McDermott MP, Kendig JW (1999) Lipid intolerance in neonates receiving dexamethasone for bronchopulmonary dysplasia. Arch Pediatr Adolesc Med 153(8):795\u2013800. https:\/\/doi.org\/10.1001\/archpedi.153.8.795","journal-title":"Arch Pediatr Adolesc Med"},{"key":"9948_CR38","doi-asserted-by":"publisher","unstructured":"de Fatima Silva F, Komino ACM, Andreotti S, Boltes Reis G, Caminhotto RO, Landgraf RG, de Souza GO, Sertie RAL, Collins S, Donato J Jr., Bessa Lima F (2022) Dexamethasone-Induced adipose tissue redistribution and metabolic changes: is gene expression the main factor? An animal model of chronic hypercortisolism. Biomedicines 10(9). https:\/\/doi.org\/10.3390\/biomedicines10092328","DOI":"10.3390\/biomedicines10092328"},{"issue":"2","key":"9948_CR39","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1203\/pdr.0b013e31802d89ff","volume":"61","author":"Y Liu","year":"2007","unstructured":"Liu Y, Havinga R, Bloks VW, Baller JF, van der Leij FR, Reijngoud DJ, Sauer PJ, Kuipers F (2007) Postnatal treatment with dexamethasone perturbs hepatic and cardiac energy metabolism and is associated with a sustained atherogenic plasma lipid profile in suckling rats. Pediatr Res 61(2):165\u2013170. https:\/\/doi.org\/10.1203\/pdr.0b013e31802d89ff","journal-title":"Pediatr Res"},{"issue":"2","key":"9948_CR40","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1210\/en.2007-1214","volume":"149","author":"JS Gounarides","year":"2008","unstructured":"Gounarides JS, Korach-Andre M, Killary K, Argentieri G, Turner O, Laurent D (2008) Effect of dexamethasone on glucose tolerance and fat metabolism in a diet-induced obesity mouse model. Endocrinology 149(2):758\u2013766. https:\/\/doi.org\/10.1210\/en.2007-1214","journal-title":"Endocrinology"},{"key":"9948_CR41","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-024-09940-w","author":"H Yagi","year":"2024","unstructured":"Yagi H, Boeck M, Nian S, Neilsen K, Wang C, Lee J, Zeng Y, Grumbine M, Sweet IR, Kasai T, Negishi K, Singh SA, Aikawa M, Hellstrom A, Smith LEH, Fu Z (2024) Mitochondrial control of hypoxia-induced pathological retinal angiogenesis. Angiogenesis. https:\/\/doi.org\/10.1007\/s10456-024-09940-w","journal-title":"Angiogenesis"},{"issue":"2","key":"9948_CR42","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.preteyeres.2008.11.005","volume":"28","author":"EB Rodrigues","year":"2009","unstructured":"Rodrigues EB, Farah ME, Maia M, Penha FM, Regatieri C, Melo GB, Pinheiro MM, Zanetti CR (2009) Therapeutic monoclonal antibodies in ophthalmology. Prog Retin Eye Res 28(2):117\u2013144. https:\/\/doi.org\/10.1016\/j.preteyeres.2008.11.005","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"9948_CR43","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1161\/CIRCRESAHA.110.221317","volume":"107","author":"A Stahl","year":"2010","unstructured":"Stahl A, Sapieha P, Connor KM, Sangiovanni JP, Chen J, Aderman CM, Willett KL, Krah NM, Dennison RJ, Seaward MR, Guerin KI, Hua J, Smith LE (2010) Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy. Circ Res 107(4):495\u2013500. https:\/\/doi.org\/10.1161\/CIRCRESAHA.110.221317","journal-title":"Circ Res"},{"issue":"7","key":"9948_CR44","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/j.celrep.2017.01.014","volume":"18","author":"Z Fu","year":"2017","unstructured":"Fu Z, Gong Y, Liegl R, Wang Z, Liu CH, Meng SS, Burnim SB, Saba NJ, Fredrick TW, Morss PC, Hellstrom A, Talukdar S, Smith LE (2017) FGF21 Administration suppresses retinal and choroidal neovascularization in mice. Cell Rep 18(7):1606\u20131613. https:\/\/doi.org\/10.1016\/j.celrep.2017.01.014","journal-title":"Cell Rep"},{"issue":"4","key":"9948_CR45","doi-asserted-by":"publisher","first-page":"879","DOI":"10.3945\/ajcn.114.099291","volume":"101","author":"Z Fu","year":"2015","unstructured":"Fu Z, Lofqvist CA, Shao Z, Sun Y, Joyal JS, Hurst CG, Cui RZ, Evans LP, Tian K, SanGiovanni JP, Chen J, Ley D, Hansen Pupp I, Hellstrom A, Smith LE (2015) Dietary omega-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr 101(4):879\u2013888. https:\/\/doi.org\/10.3945\/ajcn.114.099291","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"9948_CR46","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1172\/JCI33813","volume":"118","author":"J Chen","year":"2008","unstructured":"Chen J, Connor KM, Aderman CM, Smith LE (2008) Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest 118(2):526\u2013533. https:\/\/doi.org\/10.1172\/JCI33813","journal-title":"J Clin Invest"},{"issue":"8","key":"9948_CR47","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1056\/NEJMoa041773","volume":"353","author":"D Watanabe","year":"2005","unstructured":"Watanabe D, Suzuma K, Matsui S, Kurimoto M, Kiryu J, Kita M, Suzuma I, Ohashi H, Ojima T, Murakami T, Kobayashi T, Masuda S, Nagao M, Yoshimura N, Takagi H (2005) Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy. N Engl J Med 353(8):782\u2013792. https:\/\/doi.org\/10.1056\/NEJMoa041773","journal-title":"N Engl J Med"},{"issue":"2","key":"9948_CR48","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1172\/JCI34643","volume":"118","author":"MB Grant","year":"2008","unstructured":"Grant MB, Boulton ME, Ljubimov AV (2008) Erythropoietin: when liability becomes asset in neurovascular repair. J Clin Invest 118(2):467\u2013470. https:\/\/doi.org\/10.1172\/JCI34643","journal-title":"J Clin Invest"},{"issue":"7432","key":"9948_CR49","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nature11862","volume":"493","author":"LA O\u2019Neill","year":"2013","unstructured":"O\u2019Neill LA, Hardie DG (2013) Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 493(7432):346\u2013355. https:\/\/doi.org\/10.1038\/nature11862","journal-title":"Nature"},{"issue":"3","key":"9948_CR50","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.cmet.2019.06.005","volume":"30","author":"SH Baik","year":"2019","unstructured":"Baik SH, Kang S, Lee W, Choi H, Chung S, Kim JI, Mook-Jung I (2019) A breakdown in metabolic reprogramming causes Microglia Dysfunction in Alzheimer\u2019s Disease. Cell Metab 30(3):493\u2013507e496. https:\/\/doi.org\/10.1016\/j.cmet.2019.06.005","journal-title":"Cell Metab"},{"issue":"4","key":"9948_CR51","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.cmet.2022.02.013","volume":"34","author":"RY Pan","year":"2022","unstructured":"Pan RY, He L, Zhang J, Liu X, Liao Y, Gao J, Liao Y, Yan Y, Li Q, Zhou X, Cheng J, Xing Q, Guan F, Zhang J, Sun L, Yuan Z (2022) Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer\u2019s disease. Cell Metab 34(4):634\u2013648e636. https:\/\/doi.org\/10.1016\/j.cmet.2022.02.013","journal-title":"Cell Metab"},{"issue":"2","key":"9948_CR52","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/jnc.14267","volume":"144","author":"Y Li","year":"2018","unstructured":"Li Y, Lu B, Sheng L, Zhu Z, Sun H, Zhou Y, Yang Y, Xue D, Chen W, Tian X, Du Y, Yan M, Zhu W, Xing F, Li K, Lin S, Qiu P, Su X, Huang Y, Yan G, Yin W (2018) Hexokinase 2-dependent hyperglycolysis driving microglial activation contributes to ischemic brain injury. J Neurochem 144(2):186\u2013200. https:\/\/doi.org\/10.1111\/jnc.14267","journal-title":"J Neurochem"},{"key":"9948_CR53","doi-asserted-by":"publisher","unstructured":"Liu Z, Shi H, Xu J, Yang Q, Ma Q, Mao X, Xu Z, Zhou Y, Da Q, Cai Y, Fulton DJ, Dong Z, Sodhi A, Caldwell RB, Huo Y (2022) Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy. JCI Insight 7(23). https:\/\/doi.org\/10.1172\/jci.insight.160940","DOI":"10.1172\/jci.insight.160940"},{"issue":"3","key":"9948_CR54","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.cmet.2014.07.011","volume":"20","author":"Z Jin","year":"2014","unstructured":"Jin Z, Wei W, Yang M, Du Y, Wan Y (2014) Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization. Cell Metab 20(3):483\u2013498. https:\/\/doi.org\/10.1016\/j.cmet.2014.07.011","journal-title":"Cell Metab"},{"issue":"1","key":"9948_CR55","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cmet.2006.05.011","volume":"4","author":"D Vats","year":"2006","unstructured":"Vats D, Mukundan L, Odegaard JI, Zhang L, Smith KL, Morel CR, Wagner RA, Greaves DR, Murray PJ, Chawla A (2006) Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab 4(1):13\u201324. https:\/\/doi.org\/10.1016\/j.cmet.2006.05.011","journal-title":"Cell Metab"},{"issue":"1","key":"9948_CR56","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12974-021-02187-y","volume":"18","author":"J Cheng","year":"2021","unstructured":"Cheng J, Zhang R, Xu Z, Ke Y, Sun R, Yang H, Zhang X, Zhen X, Zheng LT (2021) Early glycolytic reprogramming controls microglial inflammatory activation. J Neuroinflammation 18(1):129. https:\/\/doi.org\/10.1186\/s12974-021-02187-y","journal-title":"J Neuroinflammation"},{"issue":"10","key":"9948_CR57","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1038\/s42255-022-00643-4","volume":"4","author":"L Leng","year":"2022","unstructured":"Leng L, Yuan Z, Pan R, Su X, Wang H, Xue J, Zhuang K, Gao J, Chen Z, Lin H, Xie W, Li H, Chen Z, Ren K, Zhang X, Wang W, Jin ZB, Wu S, Wang X, Yuan Z, Xu H, Chow HM, Zhang J (2022) Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to beta-amyloid clearance. Nat Metab 4(10):1287\u20131305. https:\/\/doi.org\/10.1038\/s42255-022-00643-4","journal-title":"Nat Metab"},{"key":"9948_CR58","doi-asserted-by":"publisher","unstructured":"Liu Z, Xu J, Ma Q, Zhang X, Yang Q, Wang L, Cao Y, Xu Z, Tawfik A, Sun Y, Weintraub NL, Fulton DJ, Hong M, Dong Z, Smith LEH, Caldwell RB, Sodhi A, Huo Y (2020) Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche. Sci Transl Med 12(555). https:\/\/doi.org\/10.1126\/scitranslmed.aay1371","DOI":"10.1126\/scitranslmed.aay1371"},{"issue":"D1","key":"9948_CR59","doi-asserted-by":"publisher","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","volume":"50","author":"Y Perez-Riverol","year":"2022","unstructured":"Perez-Riverol Y, Bai J, Bandla C, Garcia-Seisdedos D, Hewapathirana S, Kamatchinathan S, Kundu DJ, Prakash A, Frericks-Zipper A, Eisenacher M, Walzer M, Wang S, Brazma A, Vizcaino JA (2022) The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences. Nucleic Acids Res 50(D1):D543\u2013D552. https:\/\/doi.org\/10.1093\/nar\/gkab1038","journal-title":"Nucleic Acids Res"}],"container-title":["Angiogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-024-09948-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10456-024-09948-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-024-09948-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T13:25:29Z","timestamp":1731590729000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10456-024-09948-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,17]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["9948"],"URL":"https:\/\/doi.org\/10.1007\/s10456-024-09948-2","relation":{},"ISSN":["0969-6970","1573-7209"],"issn-type":[{"value":"0969-6970","type":"print"},{"value":"1573-7209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,17]]},"assertion":[{"value":"13 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}