{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:45:06Z","timestamp":1740123906065,"version":"3.37.3"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004869","name":"Universit\u00e4t M\u00fcnster","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004869","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Angiogenesis"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>In contrast to the extensive evidence from animal studies, only few human data are available on the relation of vascular growth factors and collateral function as well as on the conditions which may modify their release or function. In 31 patients with total coronary occlusion (TCOs) blood was collected from distal to the occlusion site (collateral circulation) and from the aortic root (systemic circulation). Serum was used to assess its mitogenic potential in [<jats:sup>3<\/jats:sup>H]-thymidine incorporation assay on human umbilical vein endothelial cells. Serum from patients with the duration of occlusion between 1 and 3 months was significantly more mitogenic as compared to either shorter or longer duration of occlusion. None of the demographic or clinical factors correlated with the mitogenic activity of serum. Serum from patients with TCOs shows a particular time-dependent mitogenic profile with a maximal activity between 1 and 3 months following the occlusion. This profile corresponds to the experimentally described time-line of strongest collateral development and indicates the time-window for possible modification.<\/jats:p>","DOI":"10.1007\/s10456-024-09958-0","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T06:48:19Z","timestamp":1733122099000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion"],"prefix":"10.1007","volume":"28","author":[{"given":"V.","family":"Tchaikovski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. S.","family":"Werner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fritzenwanger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Jandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Waltenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"issue":"1","key":"9958_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00395-008-0760-x","volume":"104","author":"W Schaper","year":"2009","unstructured":"Schaper W (2009) Collateral circulation: past and present. Basic Res Cardiol 104(1):5\u201321. https:\/\/doi.org\/10.1007\/s00395-008-0760-x","journal-title":"Basic Res Cardiol"},{"issue":"1","key":"9958_CR2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/1573403x113099990028","volume":"10","author":"C Seiler","year":"2014","unstructured":"Seiler C, Meier P (2014) Historical aspects and relevance of the human coronary collateral circulation. Curr Cardiol Rev 10(1):2\u201316. https:\/\/doi.org\/10.2174\/1573403x113099990028","journal-title":"Curr Cardiol Rev"},{"issue":"14","key":"9958_CR3","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1161\/01.CIR.0000143624.72027.11","volume":"110","author":"GS Werner","year":"2004","unstructured":"Werner GS, Jandt E, Krack A, Schwarz G, Mutschke O, Kuethe F, Ferrari M, Figulla HR (2004) Growth factors in the collateral circulation of chronic total coronary occlusions: relation to duration of occlusion and collateral function. Circulation 110(14):1940\u20131945. https:\/\/doi.org\/10.1161\/01.CIR.0000143624.72027.11","journal-title":"Circulation"},{"issue":"8","key":"9958_CR4","first-page":"985","volume":"79","author":"A Kranz","year":"1999","unstructured":"Kranz A, Mayr U, Frank H, Waltenberger J (1999) The coronary endothelium: a target for vascular endothelial growth factor. Human coronary artery endothelial cells express functional receptors for vascular endothelial growth factor in vitro and in vivo. Lab Invest 79(8):985\u2013991","journal-title":"Lab Invest"},{"issue":"2","key":"9958_CR5","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1161\/01.cir.102.2.185","volume":"102","author":"J Waltenberger","year":"2000","unstructured":"Waltenberger J, Lange J, Kranz A (2000) Vascular endothelial growth factor-A-induced chemotaxis of monocytes is attenuated in patients with diabetes mellitus: a potential predictor for the individual capacity to develop collaterals. Circulation 102(2):185\u2013190. https:\/\/doi.org\/10.1161\/01.cir.102.2.185","journal-title":"Circulation"},{"issue":"2","key":"9958_CR6","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1161\/CIRCULATIONAHA.108.817528","volume":"120","author":"V Tchaikovski","year":"2009","unstructured":"Tchaikovski V, Olieslagers S, Bohmer FD, Waltenberger J (2009) Diabetes mellitus activates signal transduction pathways resulting in vascular endothelial growth factor resistance of human monocytes. Circulation 120(2):150\u2013159. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.108.817528","journal-title":"Circulation"},{"issue":"17","key":"9958_CR7","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1161\/01.cir.99.17.2239","volume":"99","author":"A Abaci","year":"1999","unstructured":"Abaci A, Oguzhan A, Kahraman S, Eryol NK, Unal S, Arinc H, Ergin A (1999) Effect of diabetes mellitus on formation of coronary collateral vessels. Circulation 99(17):2239\u20132242. https:\/\/doi.org\/10.1161\/01.cir.99.17.2239","journal-title":"Circulation"},{"issue":"12","key":"9958_CR8","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/s0195-668x(03)00187-8","volume":"24","author":"GS Werner","year":"2003","unstructured":"Werner GS, Richartz BM, Heinke S, Ferrari M, Figulla HR (2003) Impaired acute collateral recruitment as a possible mechanism for increased cardiac adverse events in patients with diabetes mellitus. Eur Heart J 24(12):1134\u20131142. https:\/\/doi.org\/10.1016\/s0195-668x(03)00187-8","journal-title":"Eur Heart J"},{"issue":"Pt 6","key":"9958_CR9","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1042\/BST0371167","volume":"37","author":"J Waltenberger","year":"2009","unstructured":"Waltenberger J (2009) VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus. Biochem Soc Trans 37(Pt 6):1167\u20131170. https:\/\/doi.org\/10.1042\/BST0371167","journal-title":"Biochem Soc Trans"}],"container-title":["Angiogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-024-09958-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10456-024-09958-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-024-09958-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T15:06:13Z","timestamp":1739372773000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10456-024-09958-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,2]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["9958"],"URL":"https:\/\/doi.org\/10.1007\/s10456-024-09958-0","relation":{},"ISSN":["0969-6970","1573-7209"],"issn-type":[{"type":"print","value":"0969-6970"},{"type":"electronic","value":"1573-7209"}],"subject":[],"published":{"date-parts":[[2024,12,2]]},"assertion":[{"value":"16 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2"}}