{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:00:35Z","timestamp":1782136835754,"version":"3.54.5"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"CRUK CITY OF LONDON CENTRE AWARD","award":["CTRQQR-2021\\100004"],"award-info":[{"award-number":["CTRQQR-2021\\100004"]}]},{"DOI":"10.13039\/501100007287","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","award":["Worldwide Cancer Research (19-0108)"],"award-info":[{"award-number":["Worldwide Cancer Research (19-0108)"]}],"id":[{"id":"10.13039\/501100007287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["Medical Research Council (MR\/V009621\/1)"],"award-info":[{"award-number":["Medical Research Council (MR\/V009621\/1)"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015652","name":"Barts Charity","doi-asserted-by":"publisher","award":["Barts Charity (MGU0601)"],"award-info":[{"award-number":["Barts Charity (MGU0601)"]}],"id":[{"id":"10.13039\/100015652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["CRUK DRCNPG- May21\/100004"],"award-info":[{"award-number":["CRUK DRCNPG- May21\/100004"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Angiogenesis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite its established role in breast cancer treatment, Doxorubicin treatment remains subject to adaptive resistance mechanisms that extend beyond cancer cell intrinsic alterations ultimately reducing therapy efficacy. Our study in a MMTV-PyMT-driven mouse breast cancer model reveals that prolonged Doxorubicin (Dox) exposure triggers significant reprogramming of the tumour vasculature, substantially altering the angiocrine landscape and shaping treatment outcomes. Notably, tumours that initially respond, but later revert, display an endothelial cell subclustering with activation of proliferative and NF-\u03baB-dependent cytokine pathways. We further identify a novel endothelial subpopulation characterised by higher expression of drug clearance and oxidative metabolism markers, suggesting an active role in mitigating Dox efficacy and angiogenesis promotion. These findings substantiate endothelial plasticity as a critical mediator of therapeutic failure. By uncovering these vascular adaptations, our work provides a new perspective on the underlying mechanisms of Dox resistance and the prolonged efficacy of chemotherapy in breast cancer.<\/jats:p>","DOI":"10.1007\/s10456-026-10063-7","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:16:26Z","timestamp":1782134186000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer"],"prefix":"10.1007","volume":"29","author":[{"given":"Jesus","family":"Gomez-Escudero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Maniati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Holdsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Beattie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maruan","family":"Hijazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Guelbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Elorbany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Cutillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kairbaan","family":"Hodivala-Dilke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"issue":"1","key":"10063_CR1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s13346-024-01648-0","volume":"15","author":"A Bisht","year":"2025","unstructured":"Bisht A, Avinash D, Sahu KK, Patel P, Das Gupta G, Das Kurmi B (2025) A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer. Drug Deliv Transl Res 15(1):102\u2013133. https:\/\/doi.org\/10.1007\/s13346-024-01648-0","journal-title":"Drug Deliv Transl Res"},{"issue":"1","key":"10063_CR2","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1186\/s12885-019-5939-z","volume":"19","author":"C van Christowitz","year":"2019","unstructured":"Christowitz C, Davis T, Isaacs A, van Niekerk G, Hattingh S, Engelbrecht A-M (2019) Mechanisms of doxorubicin-induced drug resistance and drug resistant tumour growth in a murine breast tumour model. BMC Cancer 19(1):757. https:\/\/doi.org\/10.1186\/s12885-019-5939-z","journal-title":"BMC Cancer"},{"key":"10063_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.708066","author":"X Wang","year":"2021","unstructured":"Wang X, Yan J, Shen B, Wei G (2021) Integrated chromatin accessibility and transcriptome landscapes of doxorubicin-resistant breast cancer cells. Front Cell Dev Biol 9. https:\/\/doi.org\/10.3389\/fcell.2021.708066","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"10063_CR4","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00280-022-04400-y","volume":"89","author":"RE Nicoletto","year":"2022","unstructured":"Nicoletto RE, Ofner CM (2022) Cytotoxic mechanisms of doxorubicin at clinically relevant concentrations in breast cancer cells. Cancer Chemother Pharmacol 89(3):285\u2013311. https:\/\/doi.org\/10.1007\/s00280-022-04400-y","journal-title":"Cancer Chemother Pharmacol"},{"issue":"4","key":"10063_CR5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ygeno.2012.11.009","volume":"101","author":"S AbuHammad","year":"2013","unstructured":"AbuHammad S, Zihlif M (2013) Gene expression alterations in doxorubicin resistant MCF7 breast cancer cell line. Genomics 101(4):213\u2013220. https:\/\/doi.org\/10.1016\/j.ygeno.2012.11.009","journal-title":"Genomics"},{"key":"10063_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3953-6","author":"CJ Lovitt","year":"2018","unstructured":"Lovitt CJ, Shelper TB, Avery VM, Dec (2018) Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins. BMC Cancer. https:\/\/doi.org\/10.1186\/s12885-017-3953-6","journal-title":"BMC Cancer"},{"issue":"7520","key":"10063_CR7","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nature13541","volume":"514","author":"B Tavora","year":"2014","unstructured":"Tavora B et al (2014) Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy. Nature 514(7520):112\u2013116. https:\/\/doi.org\/10.1038\/nature13541","journal-title":"Nature"},{"issue":"12","key":"10063_CR8","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1002\/mc.23809","volume":"63","author":"S Sahoo","year":"2024","unstructured":"Sahoo S, Kumari S, Pulipaka S, Chandra Y, Kotamraju S (2024) SIRT1 promotes doxorubicin-induced breast cancer drug resistance and tumor angiogenesis via regulating GSH\u2010mediated redox homeostasis. Mol Carcinog 63(12):2291\u20132304. https:\/\/doi.org\/10.1002\/mc.23809","journal-title":"Mol Carcinog"},{"issue":"4","key":"10063_CR9","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1039\/D0LC01103G","volume":"21","author":"M Shang","year":"2021","unstructured":"Shang M et al (2021) Microfluidic studies of hydrostatic pressure-enhanced doxorubicin resistance in human breast cancer cells. Lab Chip 21(4):746\u2013754. https:\/\/doi.org\/10.1039\/D0LC01103G","journal-title":"Lab Chip"},{"key":"10063_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00337","author":"MH Joyce","year":"2018","unstructured":"Joyce MH, Sep (2018) Phenotypic basis for matrix stiffness-dependent chemoresistance of breast cancer cells to doxorubicin. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2018.00337","journal-title":"Front Oncol"},{"issue":"21","key":"10063_CR11","doi-asserted-by":"publisher","first-page":"3502","DOI":"10.1158\/0008-5472.CAN-24-3219","volume":"84","author":"K Skandha Gopalan","year":"2024","unstructured":"Skandha Gopalan K, Bergers G (2024) The Pan-Tumor Vasculature under the Transcriptomic Magnifying Glass. Cancer Res 84(21):3502\u20133504. https:\/\/doi.org\/10.1158\/0008-5472.CAN-24-3219","journal-title":"Cancer Res"},{"issue":"10","key":"10063_CR12","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1111\/cas.13336","volume":"108","author":"N Maishi","year":"2017","unstructured":"Maishi N, Hida K (2017) Tumor endothelial cells accelerate tumor metastasis. Cancer Sci 108(10):1921\u20131926. https:\/\/doi.org\/10.1111\/cas.13336","journal-title":"Cancer Sci"},{"issue":"3","key":"10063_CR13","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.ccr.2014.02.005","volume":"25","author":"Z Cao","year":"2014","unstructured":"Cao Z et al (2014) Angiocrine factors deployed by tumor vascular niche induce b cell lymphoma invasiveness and chemoresistance. Cancer Cell 25(3):350\u2013365. https:\/\/doi.org\/10.1016\/j.ccr.2014.02.005","journal-title":"Cancer Cell"},{"issue":"1","key":"10063_CR14","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12967-020-02244-9","volume":"18","author":"J Pasquier","year":"2020","unstructured":"Pasquier J, Ghiabi P, Chouchane L, Razzouk K, Rafii S, Rafii A (2020) Angiocrine endothelium: from physiology to cancer. J Transl Med 18(1):52. https:\/\/doi.org\/10.1186\/s12967-020-02244-9","journal-title":"J Transl Med"},{"issue":"3","key":"10063_CR15","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ccell.2017.01.007","volume":"31","author":"E Wieland","year":"2017","unstructured":"Wieland E et al (2017) Endothelial Notch1 activity facilitates metastasis. Cancer Cell 31(3):355\u2013367. https:\/\/doi.org\/10.1016\/j.ccell.2017.01.007","journal-title":"Cancer Cell"},{"issue":"11","key":"10063_CR16","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.3390\/cancers13112610","volume":"13","author":"E Alsina-Sanchis","year":"2021","unstructured":"Alsina-Sanchis E, M\u00fclfarth R, Fischer A (2021) Control of Tumor progression by angiocrine factors. Cancers (Basel) 13(11):2610. https:\/\/doi.org\/10.3390\/cancers13112610","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10063_CR17","doi-asserted-by":"publisher","first-page":"5511","DOI":"10.1038\/s41467-022-33052-y","volume":"13","author":"V Geldhof","year":"2022","unstructured":"Geldhof V et al (2022) Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast. Nat Commun 13(1):5511. https:\/\/doi.org\/10.1038\/s41467-022-33052-y","journal-title":"Nat Commun"},{"key":"10063_CR18","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwae231","author":"J Li","year":"2024","unstructured":"Li J, Wang D, Tang F, Ling X, Zhang W, Zhang Z (2024) Pan-cancer integrative analyses dissect the remodeling of endothelial cells in human cancers. Natl Sci Rev. https:\/\/doi.org\/10.1093\/nsr\/nwae231","journal-title":"Natl Sci Rev"},{"issue":"8","key":"10063_CR19","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/s41568-023-00591-5","volume":"23","author":"Q Zeng","year":"2023","unstructured":"Zeng Q et al (2023) Understanding tumour endothelial cell heterogeneity and function from single-cell omics. Nat Rev Cancer 23(8):544\u2013564. https:\/\/doi.org\/10.1038\/s41568-023-00591-5","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"10063_CR20","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1038\/s41467-018-04695-7","volume":"9","author":"MKS Tang","year":"2018","unstructured":"Tang MKS (2018) Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface. Nat Commun 9(1):2270. https:\/\/doi.org\/10.1038\/s41467-018-04695-7","journal-title":"Nat Commun"},{"issue":"24","key":"10063_CR21","doi-asserted-by":"publisher","first-page":"6791","DOI":"10.1093\/emboj\/cdf688","volume":"21","author":"E Tzima","year":"2002","unstructured":"Tzima E (2002) Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J 21(24):6791\u20136800. https:\/\/doi.org\/10.1093\/emboj\/cdf688","journal-title":"EMBO J"},{"issue":"2","key":"10063_CR22","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s12672-017-0285-6","volume":"8","author":"JL Christenson","year":"2017","unstructured":"Christenson JL et al (2017) MMTV-PyMT and derived Met-1 mouse mammary tumor cells as models for studying the role of the androgen receptor in triple-negative breast cancer progression. Horm Cancer 8(2):69\u201377. https:\/\/doi.org\/10.1007\/s12672-017-0285-6","journal-title":"Horm Cancer"},{"issue":"3","key":"10063_CR23","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/s41388-020-01560-0","volume":"40","author":"S Attalla","year":"2021","unstructured":"Attalla S, Taifour T, Bui T, Muller W (2021) Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo. Oncogene 40(3):475\u2013491. https:\/\/doi.org\/10.1038\/s41388-020-01560-0","journal-title":"Oncogene"},{"issue":"9","key":"10063_CR24","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.3390\/v2092000","volume":"2","author":"SR Ross","year":"2010","unstructured":"Ross SR (2010) Mouse Mammary tumor virus molecular biology and oncogenesis. Viruses 2(9):2000\u20132012. https:\/\/doi.org\/10.3390\/v2092000","journal-title":"Viruses"},{"issue":"1","key":"10063_CR25","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/s41467-020-15104-3","volume":"11","author":"F Demircioglu","year":"2020","unstructured":"Demircioglu F et al (2020) Cancer associated fibroblast FAK regulates malignant cell metabolism. Nat Commun 11(1):1290. https:\/\/doi.org\/10.1038\/s41467-020-15104-3","journal-title":"Nat Commun"},{"key":"10063_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.90","author":"Z Xie","year":"2021","unstructured":"Xie Z, Mar (2021) Gene set knowledge discovery with enrichr. Curr Protoc. https:\/\/doi.org\/10.1002\/cpz1.90","journal-title":"Curr Protoc"},{"key":"10063_CR27","doi-asserted-by":"publisher","first-page":"W90","DOI":"10.1093\/nar\/gkw377","volume":"44","author":"MV Kuleshov","year":"2016","unstructured":"Kuleshov MV, Jul (2016) Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res 44:W90\u2013W97","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10063_CR28","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/1471-2105-14-128","volume":"14","author":"EY Chen","year":"2013","unstructured":"Chen EY, (2013) Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics 14(1):128. https:\/\/doi.org\/10.1186\/1471-2105-14-128","journal-title":"BMC Bioinformatics"},{"issue":"8024","key":"10063_CR29","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41586-024-07698-1","volume":"632","author":"X Pan","year":"2024","unstructured":"Pan X et al (2024) Tumour vasculature at single-cell resolution. Nature 632(8024):429\u2013436. https:\/\/doi.org\/10.1038\/s41586-024-07698-1","journal-title":"Nature"},{"issue":"4","key":"10063_CR30","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1161\/CIRCULATIONAHA.120.052318","volume":"144","author":"JC Schupp","year":"2021","unstructured":"Schupp JC et al (2021) Integrated single-cell atlas of endothelial cells of the human lung. Circulation 144(4):286\u2013302. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.120.052318","journal-title":"Circulation"},{"issue":"4","key":"10063_CR31","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.cell.2020.01.015","volume":"180","author":"J Kalucka","year":"2020","unstructured":"Kalucka J et al (2020) Single-cell transcriptome atlas of murine endothelial cells. Cell 180(4):764\u2013779 https:\/\/doi.org\/10.1016\/j.cell.2020.01.015","journal-title":"Cell"},{"issue":"1","key":"10063_CR32","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ccell.2019.12.001","volume":"37","author":"J Goveia","year":"2020","unstructured":"Goveia J et al (2020) An integrated gene expression landscape profiling approach to identify lung tumor endothelial cell heterogeneity and angiogenic candidates. Cancer Cell 37(1):21\u201336. https:\/\/doi.org\/10.1016\/j.ccell.2019.12.001","journal-title":"Cancer Cell"},{"issue":"1","key":"10063_CR33","doi-asserted-by":"publisher","first-page":"15022","DOI":"10.1038\/s41598-019-50866-x","volume":"9","author":"J G\u00f3mez-Escudero","year":"2019","unstructured":"G\u00f3mez-Escudero J et al (2019) PKM2 regulates endothelial cell junction dynamics and angiogenesis via ATP production. Sci Rep 9(1):15022. https:\/\/doi.org\/10.1038\/s41598-019-50866-x","journal-title":"Sci Rep"},{"issue":"7546","key":"10063_CR34","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/nature14362","volume":"520","author":"S Schoors","year":"2015","unstructured":"Schoors S et al (2015) Fatty acid carbon is essential for dNTP synthesis in endothelial cells. Nature 520(7546):192\u2013197. https:\/\/doi.org\/10.1038\/nature14362","journal-title":"Nature"},{"issue":"6","key":"10063_CR35","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.cmet.2018.07.016","volume":"28","author":"J Kalucka","year":"2018","unstructured":"Kalucka J et al (2018) Quiescent endothelial cells upregulate fatty acid \u03b2-Oxidation for vasculoprotection via redox homeostasis. Cell Metab 28(6):881\u2013894. https:\/\/doi.org\/10.1016\/j.cmet.2018.07.016","journal-title":"Cell Metab"},{"issue":"2","key":"10063_CR36","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s10456-021-09797-3","volume":"24","author":"A Pasut","year":"2021","unstructured":"Pasut A, Becker LM, Cuypers A, Carmeliet P (2021) Endothelial cell plasticity at the single-cell level. Angiogenesis 24(2):311\u2013326. https:\/\/doi.org\/10.1007\/s10456-021-09797-3","journal-title":"Angiogenesis"},{"issue":"4","key":"10063_CR37","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1593\/neo.04430","volume":"7","author":"IF Robey","year":"2005","unstructured":"Robey IF, Lien AD, Welsh SJ, Baggett BK, Gillies RJ (2005) Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia 7(4):324\u2013330. https:\/\/doi.org\/10.1593\/neo.04430","journal-title":"Neoplasia"},{"issue":"6","key":"10063_CR38","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/s43018-024-00780-7","volume":"5","author":"M De Palma","year":"2024","unstructured":"De Palma M, Hanahan D (2024) Milestones in tumor vascularization and its therapeutic targeting. Nat Cancer 5(6):827\u2013843. https:\/\/doi.org\/10.1038\/s43018-024-00780-7","journal-title":"Nat Cancer"},{"issue":"4","key":"10063_CR39","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nrclinonc.2011.21","volume":"8","author":"JML Ebos","year":"2011","unstructured":"Ebos JML, Kerbel RS (2011) Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol 8(4):210\u2013221. https:\/\/doi.org\/10.1038\/nrclinonc.2011.21","journal-title":"Nat Rev Clin Oncol"},{"issue":"4","key":"10063_CR40","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s10585-023-10243-5","volume":"41","author":"A Deo","year":"2024","unstructured":"Deo A, Sleeman JP, Shaked Y (2024) The role of host response to chemotherapy: resistance, metastasis and clinical implications. Clin Exp Metastasis 41(4):495\u2013507. https:\/\/doi.org\/10.1007\/s10585-023-10243-5","journal-title":"Clin Exp Metastasis"},{"issue":"10","key":"10063_CR41","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/nrclinonc.2016.57","volume":"13","author":"Y Shaked","year":"2016","unstructured":"Shaked Y (2016) Balancing efficacy of and host immune responses to cancer therapy: the yin and yang effects. Nat Rev Clin Oncol 13(10):611\u2013626. https:\/\/doi.org\/10.1038\/nrclinonc.2016.57","journal-title":"Nat Rev Clin Oncol"},{"issue":"5794","key":"10063_CR42","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1126\/science.1127592","volume":"313","author":"Y Shaked","year":"2006","unstructured":"Shaked Y et al (2006) Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313(5794):1785\u20131787. https:\/\/doi.org\/10.1126\/science.1127592","journal-title":"Science"},{"issue":"1","key":"10063_CR43","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s42826-023-00175-2","volume":"39","author":"W Yun","year":"2023","unstructured":"Yun W et al (2023) Chemosensitivity to doxorubicin in primary cells derived from tumor of FVB\/N-Trp53tm1Hw1 with TALEN-mediated Trp53 mutant gene. Lab Anim Res 39(1):23. https:\/\/doi.org\/10.1186\/s42826-023-00175-2","journal-title":"Lab Anim Res"},{"key":"10063_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.583572","author":"X Wan","year":"2021","unstructured":"Wan X et al (2021) Estrogen receptor \u03b1 mediates doxorubicin sensitivity in breast cancer cells by regulating E-Cadherin. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2021.583572","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"10063_CR45","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.3390\/nano10112236","volume":"10","author":"I Van Zundert","year":"2020","unstructured":"Van Zundert I, Fortuni B, Rocha S (2020) From 2D to 3D cancer cell models\u2014the enigmas of drug delivery research. Nanomaterials 10(11):2236. https:\/\/doi.org\/10.3390\/nano10112236","journal-title":"Nanomaterials"},{"key":"10063_CR46","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.63743","author":"M Kapa\u0142czy\u0144ska","year":"2016","unstructured":"Kapa\u0142czy\u0144ska M et al (2016) 2D and 3D cell cultures \u2013 a comparison of different types of cancer cell cultures. Archives Med Sci. https:\/\/doi.org\/10.5114\/aoms.2016.63743","journal-title":"Archives Med Sci"},{"issue":"1","key":"10063_CR47","doi-asserted-by":"publisher","first-page":"19506","DOI":"10.1038\/s41598-025-03504-8","volume":"15","author":"P Guerrero-L\u00f3pez","year":"2025","unstructured":"Guerrero-L\u00f3pez P et al (2025) 2D versus 3D tumor-on-chip models to study the impact of tumor organization on metabolic patterns in vitro. Sci Rep 15(1):19506. https:\/\/doi.org\/10.1038\/s41598-025-03504-8","journal-title":"Sci Rep"},{"key":"10063_CR48","doi-asserted-by":"publisher","first-page":"D956","DOI":"10.1093\/nar\/gkx1090","volume":"46","author":"SV Vasaikar","year":"2018","unstructured":"Vasaikar SV, Straub P, Wang J, Zhang B (2018) LinkedOmics: analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res 46:D956\u2013D963. https:\/\/doi.org\/10.1093\/nar\/gkx1090","journal-title":"Nucleic Acids Res"},{"key":"10063_CR49","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1016\/j.csbj.2025.08.038","volume":"27","author":"ES Rahmani","year":"2025","unstructured":"Rahmani ES et al (2025) OncoProExp: An interactive shiny web application for comprehensive cancer proteomics and phosphoproteomics analysis. Comput Struct Biotechnol J 27:3993\u20134006. https:\/\/doi.org\/10.1016\/j.csbj.2025.08.038","journal-title":"Comput Struct Biotechnol J"},{"key":"10063_CR50","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125679","author":"A Singh","year":"2019","unstructured":"Singh A et al (2019) Angiocrine signals regulate quiescence and therapy resistance in bone metastasis. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.125679","journal-title":"JCI Insight"},{"key":"10063_CR51","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.3390\/cells12202510","volume":"12","author":"VO Oria","year":"2023","unstructured":"Oria VO, Erler JT (2023) Tumor angiocrine signaling: novel targeting opportunity in cancer. Cells 12:2510. https:\/\/doi.org\/10.3390\/cells12202510","journal-title":"Cells"},{"issue":"29","key":"10063_CR52","doi-asserted-by":"publisher","first-page":"12117","DOI":"10.1073\/pnas.0702955104","volume":"104","author":"S Rottenberg","year":"2007","unstructured":"Rottenberg S et al (2007) Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci 104(29):12117\u201312122. https:\/\/doi.org\/10.1073\/pnas.0702955104","journal-title":"Proc Natl Acad Sci"},{"key":"10063_CR53","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd1616","author":"A Martinez-Usatorre","year":"2021","unstructured":"Martinez-Usatorre A et al (2021) Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.abd1616","journal-title":"Sci Transl Med"},{"issue":"7","key":"10063_CR54","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1158\/2159-8290.CD-16-1174","volume":"7","author":"M Zou","year":"2017","unstructured":"Zou M et al (2017) Transdifferentiation as a mechanism of treatment resistance in a mouse model of castration-resistant prostate cancer. Cancer Discov 7(7):736\u2013749. https:\/\/doi.org\/10.1158\/2159-8290.CD-16-1174","journal-title":"Cancer Discov"},{"issue":"6","key":"10063_CR55","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1002\/ijc.34629","volume":"153","author":"C Cheng","year":"2023","unstructured":"Cheng C et al (2023) Single-cell transcriptome analysis reveals cellular and molecular alterations in small cell lung cancer tumors following chemotherapy. Int J Cancer 153(6):1273\u20131286. https:\/\/doi.org\/10.1002\/ijc.34629","journal-title":"Int J Cancer"},{"issue":"7","key":"10063_CR56","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1007\/s00432-024-05787-2","volume":"150","author":"X Zheng","year":"2024","unstructured":"Zheng X, Wu W, Zhao Z, Zhang X, Yu S (2024) Single-cell transcriptomic insights into chemotherapy-induced remodeling of the osteosarcoma tumor microenvironment. J Cancer Res Clin Oncol 150(7):356. https:\/\/doi.org\/10.1007\/s00432-024-05787-2","journal-title":"J Cancer Res Clin Oncol"},{"key":"10063_CR57","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13832","author":"C Ahire","year":"2023","unstructured":"Ahire C et al (2023) Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)-induced chemobrain. Aging Cell. https:\/\/doi.org\/10.1111\/acel.13832","journal-title":"Aging Cell"},{"issue":"3","key":"10063_CR58","doi-asserted-by":"publisher","first-page":"3677","DOI":"10.1007\/s11357-025-01561-5","volume":"47","author":"R Patai","year":"2025","unstructured":"Patai R et al (2025) Transcriptomic profiling of senescence effects on blood\u2013brain barrier-related gene expression in brain capillary endothelial cells in a mouse model of paclitaxel-induced chemobrain. Geroscience 47(3):3677\u20133691. https:\/\/doi.org\/10.1007\/s11357-025-01561-5","journal-title":"Geroscience"},{"key":"10063_CR59","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1158\/0008-5472.CAN-19-3791","volume":"80","author":"H Kikuchi","year":"2020","unstructured":"Kikuchi H et al (2020) Chemotherapy-induced IL8 upregulates MDR1\/ABCB1 in tumor blood vessels and results in unfavorable outcome. Cancer Res 80:2996\u20133008. https:\/\/doi.org\/10.1158\/0008-5472.CAN-19-3791","journal-title":"Cancer Res"},{"issue":"6","key":"10063_CR60","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1111\/cas.70050","volume":"116","author":"T Hongu","year":"2025","unstructured":"Hongu T et al (2025) Permeable lung vasculature creates chemoresistant endothelial niche by producing SERPINE1 at breast cancer metastatic sites. Cancer Sci 116(6):1604\u20131615. https:\/\/doi.org\/10.1111\/cas.70050","journal-title":"Cancer Sci"},{"issue":"17","key":"10063_CR61","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.1002\/1878-0261.13282","volume":"16","author":"MA Skowron","year":"2022","unstructured":"Skowron MA et al (2022) Profiling the <\u2009scp>3D interaction between germ cell tumors and microenvironmental cells at the transcriptome and secretome level. Mol Oncol 16(17):3107\u20133127. https:\/\/doi.org\/10.1002\/1878-0261.13282","journal-title":"Mol Oncol"},{"issue":"5","key":"10063_CR62","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.3390\/ijms19051272","volume":"19","author":"K Hida","year":"2018","unstructured":"Hida K, Maishi N, Annan D, Hida Y (2018) Contribution of tumor endothelial cells in cancer progression. Int J Mol Sci 19(5):1272. https:\/\/doi.org\/10.3390\/ijms19051272","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10063_CR63","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1172\/JCI84876","volume":"126","author":"M Huang","year":"2016","unstructured":"Huang M et al (2016) c-Met\u2013mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J Clin Invest 126(5):1801\u20131814. https:\/\/doi.org\/10.1172\/JCI84876","journal-title":"J Clin Invest"},{"issue":"3","key":"10063_CR64","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jpha.2023.02.001","volume":"13","author":"G-Y Li","year":"2023","unstructured":"Li G-Y et al (2023) Overcoming chemoresistance in non-angiogenic colorectal cancer by metformin via inhibiting endothelial apoptosis and vascular immaturity. J Pharm Anal 13(3):262\u2013275. https:\/\/doi.org\/10.1016\/j.jpha.2023.02.001","journal-title":"J Pharm Anal"},{"issue":"5","key":"10063_CR65","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1101\/gad.7.5.812","volume":"7","author":"V Baldin","year":"1993","unstructured":"Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G (1993) Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 7(5):812\u2013821. https:\/\/doi.org\/10.1101\/gad.7.5.812","journal-title":"Genes Dev"},{"issue":"12","key":"10063_CR66","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.3390\/cells9122598","volume":"9","author":"DC Belisario","year":"2020","unstructured":"Belisario DC et al (2020) Hypoxia dictates metabolic rewiring of tumors: implications for chemoresistance. Cells 9(12):2598. https:\/\/doi.org\/10.3390\/cells9122598","journal-title":"Cells"},{"issue":"185","key":"10063_CR67","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.24976\/Discov.Med.202436185.102","volume":"36","author":"C RUMIO","year":"2024","unstructured":"RUMIO C (2024) The Role of Oxidative Metabolism in Tumorigenesis and Drug Resistance. Discov Med 36(185):1109. https:\/\/doi.org\/10.24976\/Discov.Med.202436185.102","journal-title":"Discov Med"},{"key":"10063_CR68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087076","author":"N Niu","year":"2023","unstructured":"Niu N, Ye J, Hu Z, Zhang J, Wang Y (2023) Regulative roles of metabolic plasticity caused by mitochondrial oxidative phosphorylation and glycolysis on the initiation and progression of tumorigenesis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24087076","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10063_CR69","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1016\/j.ccell.2022.11.002","volume":"40","author":"Y Hua","year":"2022","unstructured":"Hua Y et al (2022) Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1\u2009+\u2009T lymphocyte niches through a feed-forward loop. Cancer Cell 40(12):1600\u20131618. https:\/\/doi.org\/10.1016\/j.ccell.2022.11.002","journal-title":"Cancer Cell"},{"issue":"7","key":"10063_CR70","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1182\/blood-2007-08-105346","volume":"111","author":"GM Birdsey","year":"2008","unstructured":"Birdsey GM et al (2008) Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin. Blood 111(7):3498\u20133506. https:\/\/doi.org\/10.1182\/blood-2007-08-105346","journal-title":"Blood"},{"key":"10063_CR71","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.683651","author":"S Harel","year":"2021","unstructured":"Harel S et al (2021) ETS1, ELK1, and ETV4 transcription factors regulate angiopoietin-1 signaling and the angiogenic response in endothelial cells. Front Physiol https:\/\/doi.org\/10.3389\/fphys.2021.683651","journal-title":"Front Physiol"},{"issue":"11","key":"10063_CR72","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.3390\/cells9112467","volume":"9","author":"A Trindade","year":"2020","unstructured":"Trindade A, Duarte A (2020) Notch signaling function in the angiocrine regulation of tumor development. Cells 9(11):2467. https:\/\/doi.org\/10.3390\/cells9112467","journal-title":"Cells"},{"issue":"1","key":"10063_CR73","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/s41467-018-03050-0","volume":"9","author":"Q Wang","year":"2018","unstructured":"Wang Q et al (2018) Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2\u03b1. Nat Commun 9(1):559. https:\/\/doi.org\/10.1038\/s41467-018-03050-0","journal-title":"Nat Commun"},{"issue":"3","key":"10063_CR74","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3390\/genes11030331","volume":"11","author":"JL Grit","year":"2020","unstructured":"Grit JL et al (2020) Kinome Profiling of NF1-related MPNSTs in Response to kinase inhibition and doxorubicin reveals therapeutic vulnerabilities. Genes (Basel) 11(3):331. https:\/\/doi.org\/10.3390\/genes11030331","journal-title":"Genes (Basel)"},{"issue":"1","key":"10063_CR75","doi-asserted-by":"publisher","first-page":"7487","DOI":"10.1038\/s41598-025-89884-3","volume":"15","author":"AM Abou-Shanab","year":"2025","unstructured":"Abou-Shanab AM et al (2025) PHD-2\/HIF-1\u03b1 axis mediates doxorubicin-induced angiogenesis in SH-SY5Y neuroblastoma microenvironment: a potential survival mechanism. Sci Rep 15(1):7487. https:\/\/doi.org\/10.1038\/s41598-025-89884-3","journal-title":"Sci Rep"},{"issue":"1","key":"10063_CR76","doi-asserted-by":"publisher","first-page":"6401","DOI":"10.1038\/s41467-022-33746-3","volume":"13","author":"J Bauer","year":"2022","unstructured":"Bauer J et al (2022) The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma. Nat Commun 13(1):6401. https:\/\/doi.org\/10.1038\/s41467-022-33746-3","journal-title":"Nat Commun"},{"issue":"1","key":"10063_CR77","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12038-017-9667-8","volume":"42","author":"R Kumari","year":"2017","unstructured":"Kumari R, Chouhan S, Singh S, Chhipa RR, Ajay AK, Bhat MK (2017) Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway. J Biosci 42(1):31\u201341. https:\/\/doi.org\/10.1007\/s12038-017-9667-8","journal-title":"J Biosci"},{"issue":"4","key":"10063_CR78","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.3892\/or.2018.6258","volume":"39","author":"S Keeratichamroen","year":"2018","unstructured":"Keeratichamroen S, Lirdprapamongkol K, Svasti J (2018) Mechanism of ECM-induced dormancy and chemoresistance in A549 human lung carcinoma cells. Oncol Rep 39(4):1765\u20131774. https:\/\/doi.org\/10.3892\/or.2018.6258","journal-title":"Oncol Rep"},{"issue":"1","key":"10063_CR79","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13046-018-0690-x","volume":"37","author":"X Guo","year":"2018","unstructured":"Guo X et al (2018) Dacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of ABCG2 in vitro and in vivo. J Exp Clin Cancer Res 37(1):31. https:\/\/doi.org\/10.1186\/s13046-018-0690-x","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"10063_CR80","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.bbamcr.2012.10.016","volume":"1833","author":"F Wei","year":"2013","unstructured":"Wei F et al (2013) Inhibition of ERK activation enhances the repair of double-stranded breaks via non-homologous end joining by increasing DNA-PKcs activation. Biochim Biophys Acta 1833(1):90\u2013100. https:\/\/doi.org\/10.1016\/j.bbamcr.2012.10.016","journal-title":"Biochim Biophys Acta"},{"key":"10063_CR81","doi-asserted-by":"publisher","first-page":"111818","DOI":"10.1016\/j.cellsig.2025.111818","volume":"132","author":"JC Sears","year":"2025","unstructured":"Sears JC, Broadie K (2025) PKA restricts ERK signaling in learning and memory Kenyon cell neurons. Cell Signal 132:111818. https:\/\/doi.org\/10.1016\/j.cellsig.2025.111818","journal-title":"Cell Signal"},{"key":"10063_CR82","doi-asserted-by":"publisher","first-page":"7112","DOI":"10.1038\/ncomms8112","volume":"6","author":"H Gu","year":"2015","unstructured":"Gu H et al (2015) Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling. Nat Commun 6:7112. https:\/\/doi.org\/10.1038\/ncomms8112","journal-title":"Nat Commun"},{"issue":"4","key":"10063_CR83","doi-asserted-by":"publisher","first-page":"e35638","DOI":"10.1371\/journal.pone.0035638","volume":"7","author":"MC Marazita","year":"2012","unstructured":"Marazita MC et al (2012) CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response. PLoS ONE 7(4):e35638. https:\/\/doi.org\/10.1371\/journal.pone.0035638","journal-title":"PLoS ONE"},{"issue":"14","key":"10063_CR84","doi-asserted-by":"publisher","first-page":"8145","DOI":"10.1093\/nar\/gkab585","volume":"49","author":"M Jessulat","year":"2021","unstructured":"Jessulat M et al (2021) The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF. Nucleic Acids Res 49(14):8145\u20138160. https:\/\/doi.org\/10.1093\/nar\/gkab585","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"10063_CR85","doi-asserted-by":"publisher","first-page":"e1002176","DOI":"10.1371\/journal.pgen.1002176","volume":"7","author":"JS Searle","year":"2011","unstructured":"Searle JS, Wood MD, Kaur M, Tobin DV, Sanchez Y (2011) Proteins in the nutrient-sensing and DNA damage checkpoint pathways cooperate to restrain mitotic progression following DNA damage. PLoS Genet 7(7):e1002176. https:\/\/doi.org\/10.1371\/journal.pgen.1002176","journal-title":"PLoS Genet"},{"issue":"3","key":"10063_CR86","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.cell.2010.09.043","volume":"143","author":"LA Gilbert","year":"2010","unstructured":"Gilbert LA, Hemann MT (2010) DNA damage-mediated induction of a chemoresistant niche. Cell 143(3):355\u2013366. https:\/\/doi.org\/10.1016\/j.cell.2010.09.043","journal-title":"Cell"},{"issue":"6","key":"10063_CR87","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1053\/j.gastro.2012.08.048","volume":"143","author":"M Hedl","year":"2012","unstructured":"Hedl M, Abraham C (2012) Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines. Gastroenterology 143(6):1530\u20131543. https:\/\/doi.org\/10.1053\/j.gastro.2012.08.048","journal-title":"Gastroenterology"},{"issue":"3\u20134","key":"10063_CR88","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/BF03033981","volume":"8","author":"K Von Saud","year":"2005","unstructured":"Saud K, Herrera-Molina R, Von Bernhardi R (2005) Pro- and anti-inflammatory cytokines regulate the ERK pathway: implication of the timing for the activation of microglial cells. Neurotox Res 8(3\u20134):277\u2013287. https:\/\/doi.org\/10.1007\/BF03033981","journal-title":"Neurotox Res"},{"issue":"2","key":"10063_CR89","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1124\/mol.107.040519","volume":"73","author":"AM Misior","year":"2008","unstructured":"Misior AM, Yan H, Pascual RM, Deshpande DA, Panettieri RA, Penn RB (2008) Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors. Mol Pharmacol 73(2):566\u2013574. https:\/\/doi.org\/10.1124\/mol.107.040519","journal-title":"Mol Pharmacol"},{"key":"10063_CR90","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1186\/s13059-015-0844-5","volume":"16","author":"G Finak","year":"2015","unstructured":"Finak G et al (2015) MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data. Genome Biol 16:278. https:\/\/doi.org\/10.1186\/s13059-015-0844-5","journal-title":"Genome Biol"},{"issue":"19","key":"10063_CR91","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1093\/bioinformatics\/btab209","volume":"37","author":"JF Ouyang","year":"2021","unstructured":"Ouyang JF, Kamaraj US, Cao EY, Rackham OJL (2021) ShinyCell: simple and sharable visualization of single-cell gene expression data. Bioinformatics 37(19):3374\u20133376. https:\/\/doi.org\/10.1093\/bioinformatics\/btab209","journal-title":"Bioinformatics"},{"issue":"1","key":"10063_CR92","doi-asserted-by":"publisher","first-page":"10953","DOI":"10.1038\/s41467-025-67209-2","volume":"16","author":"A Minello","year":"2025","unstructured":"Minello A et al (2025) A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-\u03baB-driven transcription. Nat Commun 16(1):10953. https:\/\/doi.org\/10.1038\/s41467-025-67209-2","journal-title":"Nat Commun"},{"key":"10063_CR93","doi-asserted-by":"publisher","DOI":"10.3791\/2720","author":"R Foty","year":"2011","unstructured":"Foty R (May 2011) A simple hanging drop cell culture protocol for generation of 3D spheroids. J Visualized Exper https:\/\/doi.org\/10.3791\/2720","journal-title":"J Visualized Experiments"}],"container-title":["Angiogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-026-10063-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10456-026-10063-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-026-10063-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:16:28Z","timestamp":1782134188000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10456-026-10063-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":93,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["10063"],"URL":"https:\/\/doi.org\/10.1007\/s10456-026-10063-7","relation":{},"ISSN":["1573-7209"],"issn-type":[{"value":"1573-7209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"26 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"48"}}