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Upon investigating the overlap of seemingly divergent reports currently defining putative endothelial progenitor cells (EPCs) using single-cell RNA-sequencing and flow cytometry, Protein C Receptor (PROCR) and Platelet-Derived Growth Factor Receptor Alpha (PDGFRA) largely overlapped with previously characterized murine aorta\u2019s CD34\n                    <jats:sup>+<\/jats:sup>\n                    CD31\n                    <jats:sup>low<\/jats:sup>\n                    endovascular progenitors (EVPs). Functional assays and lineage tracing in homeostatic aorta and excisional wounds demonstrated increased clonogenic capacity, engraftment potential, and ability to form differentiated endothelial (D) cells of PROCR\n                    <jats:sup>+<\/jats:sup>\n                    PDGFRA\n                    <jats:sup>+<\/jats:sup>\n                    EPCs, termed as refined endothelial progenitor cell (rEPC), as compared to PROCR\n                    <jats:sup>neg<\/jats:sup>\n                    PDGFRA\n                    <jats:sup>neg<\/jats:sup>\n                    EVPs. Similar\n                    <jats:italic>PROCR<\/jats:italic>\n                    and\n                    <jats:italic>PDGFRA<\/jats:italic>\n                    expression in normal human aorta, and increased clonogenic capacity of CD34\n                    <jats:sup>+<\/jats:sup>\n                    CD31\n                    <jats:sup>low<\/jats:sup>\n                    PROCR\n                    <jats:sup>+<\/jats:sup>\n                    endothelial cells from freshly isolated human term placenta were observed as compared to controls. Functional validation of human rEPCs is supported by PROCR enrichment, while PDGFRA co\u2011expression in human endothelial progenitor\u2013like cells is supported at the transcriptomic level only. Thus, overlapping PROCR and PDGFRA expression in EVPs narrows the population with true functional progenitor capacity.\n                  <\/jats:p>","DOI":"10.1007\/s10456-026-10078-0","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T13:25:30Z","timestamp":1785590730000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional definition of endothelial progenitors by PROCR and PDGFRA co-expression"],"prefix":"10.1007","volume":"29","author":[{"given":"Cassandra","family":"Styke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simranpreet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seen-Ling","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Yi","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwige","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervyn C.","family":"Yoder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Shafiee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiarash","family":"Khosrotehrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"issue":"5302","key":"10078_CR1","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1126\/science.275.5302.964","volume":"275","author":"T Asahara","year":"1997","unstructured":"Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM (1997) Isolation of putative progenitor endothelial cells for angiogenesis. 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