{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:15:11Z","timestamp":1792782911521,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Guangdong Outstanding Young Scientist Funding","award":["2021B1515020006"],"award-info":[{"award-number":["2021B1515020006"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270053"],"award-info":[{"award-number":["82270053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Science and Technology Program of Guangzhou","award":["SL2024A04J01572"],"award-info":[{"award-number":["SL2024A04J01572"]}]},{"name":"Program of Guangzhou National Laboratory","award":["GZNL2023A02013"],"award-info":[{"award-number":["GZNL2023A02013"]}],"id":[{"id":"https:\/\/ror.org\/03ybmxt82","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Angiogenesis"],"DOI":"10.1007\/s10456-026-10090-4","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:10:20Z","timestamp":1791112220000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["VEGF165b attenuates LPS-induced acute lung injury via antagonizing the VEGF165a\/VEGFR2 signaling pathway"],"prefix":"10.1007","volume":"29","author":[{"given":"Jia","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongquan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"issue":"10358","key":"10090_CR1","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/s0140-6736(22)01485-4","volume":"400","author":"LDJ Bos","year":"2022","unstructured":"Bos LDJ, Ware LB (2022) Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes. Lancet 400(10358):1145\u20131156. https:\/\/doi.org\/10.1016\/s0140-6736(22)01485-4","journal-title":"Lancet"},{"issue":"4587","key":"10090_CR2","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1126\/science.6823562","volume":"219","author":"DR Senger","year":"1983","unstructured":"Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF (1983) Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219(4587):983\u2013985. https:\/\/doi.org\/10.1126\/science.6823562","journal-title":"Science"},{"issue":"11","key":"10090_CR3","first-page":"5629","volume":"46","author":"DR Senger","year":"1986","unstructured":"Senger DR, Perruzzi CA, Feder J, Dvorak HF (1986) A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res 46(11):5629\u20135632","journal-title":"Cancer Res"},{"issue":"6","key":"10090_CR4","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","volume":"176","author":"RS Apte","year":"2019","unstructured":"Apte RS, Chen DS, Ferrara N (2019) VEGF in signaling and disease: beyond discovery and development. Cell 176(6):1248\u20131264. https:\/\/doi.org\/10.1016\/j.cell.2019.01.021","journal-title":"Cell"},{"issue":"11","key":"10090_CR5","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/s41580-023-00631-w","volume":"24","author":"L P\u00e9rez-Guti\u00e9rrez","year":"2023","unstructured":"P\u00e9rez-Guti\u00e9rrez L, Ferrara N (2023) Biology and therapeutic targeting of vascular endothelial growth factor A. Nat Rev Mol Cell Biol 24(11):816\u2013834. https:\/\/doi.org\/10.1038\/s41580-023-00631-w","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"10090_CR6","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nrm1911","volume":"7","author":"AK Olsson","year":"2006","unstructured":"Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L (2006) VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol 7(5):359\u2013371. https:\/\/doi.org\/10.1038\/nrm1911","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"10090_CR7","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1164\/ajrccm.164.9.2011071","volume":"164","author":"DR Thickett","year":"2001","unstructured":"Thickett DR, Armstrong L, Christie SJ, Millar AB (2001) Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome. Am J Respir Crit Care Med 164(9):1601\u20131605. https:\/\/doi.org\/10.1164\/ajrccm.164.9.2011071","journal-title":"Am J Respir Crit Care Med"},{"issue":"Pt 20","key":"10090_CR8","doi-asserted-by":"publisher","first-page":"3487","DOI":"10.1242\/jcs.016410","volume":"121","author":"DG Nowak","year":"2008","unstructured":"Nowak DG, Woolard J, Amin EM, Konopatskaya O, Saleem MA, Churchill AJ, Ladomery MR, Harper SJ, Bates DO (2008) Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors. J Cell Sci 121(Pt 20):3487\u20133495. https:\/\/doi.org\/10.1242\/jcs.016410","journal-title":"J Cell Sci"},{"issue":"21","key":"10090_CR9","doi-asserted-by":"publisher","first-page":"7822","DOI":"10.1158\/0008-5472.Can-04-0934","volume":"64","author":"J Woolard","year":"2004","unstructured":"Woolard J, Wang WY, Bevan HS, Qiu Y, Morbidelli L, Pritchard-Jones RO, Cui TG, Sugiono M, Waine E, Perrin R, Foster R, Digby-Bell J, Shields JD, Whittles CE, Mushens RE, Gillatt DA, Ziche M, Harper SJ, Bates DO (2004) VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res 64(21):7822\u20137835. https:\/\/doi.org\/10.1158\/0008-5472.Can-04-0934","journal-title":"Cancer Res"},{"key":"10090_CR10","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/1476-4598-9-320","volume":"9","author":"R Catena","year":"2010","unstructured":"Catena R, Larzabal L, Larrayoz M, Molina E, Hermida J, Agorreta J, Montes R, Pio R, Montuenga LM, Calvo A (2010) VEGF\u2081\u2082\u2081b and VEGF\u2081\u2086\u2085b are weakly angiogenic isoforms of VEGF-A. Mol Cancer 9:320. https:\/\/doi.org\/10.1186\/1476-4598-9-320","journal-title":"Mol Cancer"},{"key":"10090_CR11","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/b978-0-12-386503-8.00006-5","volume":"114","author":"A Rapisarda","year":"2012","unstructured":"Rapisarda A, Melillo G (2012) Role of the VEGF\/VEGFR axis in cancer biology and therapy. Adv Cancer Res 114:237\u2013267. https:\/\/doi.org\/10.1016\/b978-0-12-386503-8.00006-5","journal-title":"Adv Cancer Res"},{"issue":"2","key":"10090_CR12","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1161\/circresaha.116.309516","volume":"120","author":"VC Ganta","year":"2017","unstructured":"Ganta VC, Choi M, Kutateladze A, Annex BH (2017) VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling pathway and angiogenesis in human and experimental peripheral arterial disease. Circ Res 120(2):282\u2013295. https:\/\/doi.org\/10.1161\/circresaha.116.309516","journal-title":"Circ Res"},{"issue":"1","key":"10090_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1164\/rccm.202303-0558WS","volume":"209","author":"MA Matthay","year":"2024","unstructured":"Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, Calfee CS, Combes A, Daniel BM, Ferguson ND, Gong MN, Gotts JE, Herridge MS, Laffey JG, Liu KD, Machado FR, Martin TR, McAuley DF, Mercat A, Moss M, Mularski RA, Pesenti A, Qiu H, Ramakrishnan N, Ranieri VM, Riviello ED, Rubin E, Slutsky AS, Thompson BT, Twagirumugabe T, Ware LB, Wick KD (2024) A new global definition of acute respiratory distress syndrome. Am J Respir Crit Care Med 209(1):37\u201347. https:\/\/doi.org\/10.1164\/rccm.202303-0558WS","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10090_CR14","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1465-9921-8-60","volume":"8","author":"H Koh","year":"2007","unstructured":"Koh H, Tasaka S, Hasegawa N, Yamada W, Shimizu M, Nakamura M, Yonemaru M, Ikeda E, Adachi Y, Fujishima S, Yamaguchi K, Ishizaka A (2007) Protective role of vascular endothelial growth factor in endotoxin-induced acute lung injury in mice. Respir Res 8(1):60. https:\/\/doi.org\/10.1186\/1465-9921-8-60","journal-title":"Respir Res"},{"issue":"13","key":"10090_CR15","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.ejca.2008.05.027","volume":"44","author":"ES Rennel","year":"2008","unstructured":"Rennel ES, Hamdollah-Zadeh MA, Wheatley ER, Magnussen A, Sch\u00fcler Y, Kelly SP, Finucane C, Ellison D, Cebe-Suarez S, Ballmer-Hofer K, Mather S, Stewart L, Bates DO, Harper SJ (2008) Recombinant human VEGF165b protein is an effective anti-cancer agent in mice. Eur J Cancer 44(13):1883\u20131894. https:\/\/doi.org\/10.1016\/j.ejca.2008.05.027","journal-title":"Eur J Cancer"},{"issue":"8","key":"10090_CR16","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/sj.bjc.6604308","volume":"98","author":"AH Varey","year":"2008","unstructured":"Varey AH, Rennel ES, Qiu Y, Bevan HS, Perrin RM, Raffy S, Dixon AR, Paraskeva C, Zaccheo O, Hassan AB, Harper SJ, Bates DO (2008) VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy. Br J Cancer 98(8):1366\u20131379. https:\/\/doi.org\/10.1038\/sj.bjc.6604308","journal-title":"Br J Cancer"},{"issue":"3","key":"10090_CR17","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1093\/cvr\/cvv147","volume":"107","author":"T Gerhardt","year":"2015","unstructured":"Gerhardt T, Ley K (2015) Monocyte trafficking across the vessel wall. Cardiovasc Res 107(3):321\u2013330. https:\/\/doi.org\/10.1093\/cvr\/cvv147","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10090_CR18","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12931-017-0602-1","volume":"18","author":"K Ourradi","year":"2017","unstructured":"Ourradi K, Blythe T, Jarrett C, Barratt SL, Welsh GI, Millar AB (2017) VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells. Respir Res 18(1):116. https:\/\/doi.org\/10.1186\/s12931-017-0602-1","journal-title":"Respir Res"},{"issue":"1","key":"10090_CR19","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41392-025-02249-0","volume":"10","author":"C Lee","year":"2025","unstructured":"Lee C, Kim MJ, Kumar A, Lee HW, Yang Y, Kim Y (2025) Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives. Signal Transduct Target Ther 10(1):170. https:\/\/doi.org\/10.1038\/s41392-025-02249-0","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"10090_CR20","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1073\/pnas.0404984102","volume":"102","author":"Y Sakurai","year":"2005","unstructured":"Sakurai Y, Ohgimoto K, Kataoka Y, Yoshida N, Shibuya M (2005) Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci U S A 102(4):1076\u20131081. https:\/\/doi.org\/10.1073\/pnas.0404984102","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10090_CR21","doi-asserted-by":"publisher","DOI":"10.1172\/jci161366","author":"E Sj\u00f6berg","year":"2023","unstructured":"Sj\u00f6berg E, Melssen M, Richards M, Ding Y, Chanoca C, Chen D, Nwadozi E, Pal S, Love DT, Ninchoji T, Shibuya M, Simons M, Dimberg A, Claesson-Welsh L (2023) Endothelial VEGFR2-PLC\u03b3 signaling regulates vascular permeability and antitumor immunity through eNOS\/Src. J Clin Invest 133(20). https:\/\/doi.org\/10.1172\/jci161366","journal-title":"J Clin Invest"},{"issue":"7","key":"10090_CR22","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1007\/s00424-016-1839-0","volume":"468","author":"M Siragusa","year":"2016","unstructured":"Siragusa M, Fleming I (2016) The eNOS signalosome and its link to endothelial dysfunction. Pflugers Arch 468(7):1125\u20131137. https:\/\/doi.org\/10.1007\/s00424-016-1839-0","journal-title":"Pflugers Arch"},{"issue":"1","key":"10090_CR23","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41467-017-02391-6","volume":"9","author":"M Schubert","year":"2018","unstructured":"Schubert M, Klinger B, Kl\u00fcnemann M, Sieber A, Uhlitz F, Sauer S, Garnett MJ, Bl\u00fcthgen N, Saez-Rodriguez J (2018) Perturbation-response genes reveal signaling footprints in cancer gene expression. Nat Commun 9(1):20. https:\/\/doi.org\/10.1038\/s41467-017-02391-6","journal-title":"Nat Commun"},{"key":"10090_CR24","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64944","author":"T Ninchoji","year":"2021","unstructured":"Ninchoji T, Love DT, Smith RO, Hedlund M, Vestweber D, Sessa WC, Claesson-Welsh L (2021) eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin. Elife 10. https:\/\/doi.org\/10.7554\/eLife.64944","journal-title":"Elife"},{"key":"10090_CR25","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/ncomms2199","volume":"3","author":"F Orsenigo","year":"2012","unstructured":"Orsenigo F, Giampietro C, Ferrari A, Corada M, Galaup A, Sigismund S, Ristagno G, Maddaluno L, Koh GY, Franco D, Kurtcuoglu V, Poulikakos D, Baluk P, McDonald D, Grazia Lampugnani M, Dejana E (2012) Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo. Nat Commun 3:1208. https:\/\/doi.org\/10.1038\/ncomms2199","journal-title":"Nat Commun"},{"issue":"Suppl 4","key":"10090_CR26","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1752-0509-8-s4-s11","volume":"4","author":"CH Chin","year":"2014","unstructured":"Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY (2014) cytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol 8 Suppl 4(Suppl 4):S11. https:\/\/doi.org\/10.1186\/1752-0509-8-s4-s11","journal-title":"BMC Syst Biol 8 Suppl"},{"key":"10090_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107598","author":"S Singh","year":"2021","unstructured":"Singh S, Anshita D, Ravichandiran V (2021) MCP-1: Function, regulation, and involvement in disease. Int Immunopharmaco l101(Pt B):107598. https:\/\/doi.org\/10.1016\/j.intimp.2021.107598","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"10090_CR28","doi-asserted-by":"publisher","first-page":"114193","DOI":"10.1016\/j.celrep.2024.114193","volume":"43","author":"Q Ye","year":"2024","unstructured":"Ye Q, Jo J, Wang CY, Oh H, Zhan J, Choy TJ, Kim KI, D\u2019Alessandro A, Reshetnyak YK, Jung SY, Chen Z, Marrelli SP, Lee HK (2024) Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation. Cell Rep 43(5):114193. https:\/\/doi.org\/10.1016\/j.celrep.2024.114193","journal-title":"Cell Rep"},{"key":"10090_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/genes9020098","author":"M Stevens","year":"2018","unstructured":"Stevens M, Oltean S (2018) Modulation of VEGF-A Alternative splicing as a novel treatment in chronic kidney disease. Genes (Basel) 9(2). https:\/\/doi.org\/10.3390\/genes9020098","journal-title":"Genes (Basel)"},{"key":"10090_CR30","doi-asserted-by":"publisher","first-page":"104299","DOI":"10.1016\/j.cellimm.2021.104299","volume":"362","author":"C Fu","year":"2021","unstructured":"Fu C, Hu Y, Liu J, Yang Y (2021) The splicing factor SRSF1 stabilizes the mRNA of TSLP to enhance acute lung injury. Cell Immunol 362:104299. https:\/\/doi.org\/10.1016\/j.cellimm.2021.104299","journal-title":"Cell Immunol"},{"key":"10090_CR31","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.82244","author":"AR Wagner","year":"2022","unstructured":"Wagner AR, Weindel CG, West KO, Scott HM, Watson RO, Patrick KL (2022) SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX. Elife 11. https:\/\/doi.org\/10.7554\/eLife.82244","journal-title":"Elife"},{"issue":"7","key":"10090_CR32","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1084\/jem.20111343","volume":"209","author":"Z Sun","year":"2012","unstructured":"Sun Z, Li X, Massena S, Kutschera S, Padhan N, Gualandi L, Sundvold-Gjerstad V, Gustafsson K, Choy WW, Zang G, Quach M, Jansson L, Phillipson M, Abid MR, Spurkland A, Claesson-Welsh L (2012) VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd. J Exp Med 209(7):1363\u20131377. https:\/\/doi.org\/10.1084\/jem.20111343","journal-title":"J Exp Med"},{"issue":"6","key":"10090_CR33","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1161\/01.RES.0000259593.07661.1e","volume":"100","author":"L Lamalice","year":"2007","unstructured":"Lamalice L, Le Boeuf F, Huot J (2007) Endothelial cell migration during angiogenesis. Circ Res 100(6):782\u2013794. https:\/\/doi.org\/10.1161\/01.RES.0000259593.07661.1e","journal-title":"Circ Res"},{"issue":"5","key":"10090_CR34","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.devcel.2010.02.016","volume":"18","author":"AA Lanahan","year":"2010","unstructured":"Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P, Simons M (2010) VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Dev Cell 18(5):713\u2013724. https:\/\/doi.org\/10.1016\/j.devcel.2010.02.016","journal-title":"Dev Cell"},{"issue":"6","key":"10090_CR35","doi-asserted-by":"publisher","first-page":"e1004158","DOI":"10.1371\/journal.pcbi.1004158","volume":"11","author":"LW Clegg","year":"2015","unstructured":"Clegg LW, Mac Gabhann F (2015) Site-specific phosphorylation of VEGFR2 is mediated by receptor trafficking: insights from a computational model. PLoS Comput Biol 11(6):e1004158. https:\/\/doi.org\/10.1371\/journal.pcbi.1004158","journal-title":"PLoS Comput Biol"},{"issue":"5","key":"10090_CR36","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1242\/bio.017434","volume":"5","author":"GW Fearnley","year":"2016","unstructured":"Fearnley GW, Smith GA, Abdul-Zani I, Yuldasheva N, Mughal NA, Homer-Vanniasinkam S, Kearney MT, Zachary IC, Tomlinson DC, Harrison MA, Wheatcroft SB, Ponnambalam S (2016) VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis. Biol Open 5(5):571\u2013583. https:\/\/doi.org\/10.1242\/bio.017434","journal-title":"Biol Open"},{"issue":"12","key":"10090_CR37","doi-asserted-by":"publisher","first-page":"e70126","DOI":"10.1111\/apha.70126","volume":"241","author":"SJ de Haan","year":"2025","unstructured":"de Haan SJ, van Buul JD (2025) Mechanisms that prevent vascular leakage during leukocyte extravasation. Acta Physiol (Oxf) 241(12):e70126. https:\/\/doi.org\/10.1111\/apha.70126","journal-title":"Acta Physiol (Oxf)"},{"issue":"12","key":"10090_CR38","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1002\/ijc.24748","volume":"125","author":"D Bai","year":"2009","unstructured":"Bai D, Ueno L, Vogt PK (2009) Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt. Int J Cancer 125(12):2863\u20132870. https:\/\/doi.org\/10.1002\/ijc.24748","journal-title":"Int J Cancer"},{"issue":"21","key":"10090_CR39","doi-asserted-by":"publisher","first-page":"10887","DOI":"10.1128\/jvi.00806-08","volume":"82","author":"P Luthra","year":"2008","unstructured":"Luthra P, Sun D, Wolfgang M, He B (2008) AKT1-dependent activation of NF-kappaB by the L protein of parainfluenza virus 5. J Virol 82(21):10887\u201310895. https:\/\/doi.org\/10.1128\/jvi.00806-08","journal-title":"J Virol"},{"issue":"1","key":"10090_CR40","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/s0002-9440(10)64179-x","volume":"161","author":"RF Guo","year":"2002","unstructured":"Guo RF, Lentsch AB, Sarma JV, Sun L, Riedemann NC, McClintock SD, McGuire SR, Van Rooijen N, Ward PA (2002) Activator protein-1 activation in acute lung injury. Am J Pathol 161(1):275\u2013282. https:\/\/doi.org\/10.1016\/s0002-9440(10)64179-x","journal-title":"Am J Pathol"},{"issue":"4","key":"10090_CR41","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00018-023-04752-5","volume":"80","author":"HD Cho","year":"2023","unstructured":"Cho HD, Nh\u00e0n NTT, Zhou C, Tu K, Nguyen T, Sarich NA, Yamada KH (2023) KIF13B mediates VEGFR2 recycling to modulate vascular permeability. Cell Mol Life Sci 80(4):91. https:\/\/doi.org\/10.1007\/s00018-023-04752-5","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"10090_CR42","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/ncb2679","volume":"15","author":"M Nakayama","year":"2013","unstructured":"Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler HC, Itoh N, Hirose T, Breier G, Vestweber D, Cooper JA, Ohno S, Kaibuchi K, Adams RH (2013) Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol 15(3):249\u2013260. https:\/\/doi.org\/10.1038\/ncb2679","journal-title":"Nat Cell Biol"},{"issue":"7","key":"10090_CR43","doi-asserted-by":"publisher","first-page":"a006502","DOI":"10.1101\/cshperspect.a006502","volume":"2","author":"S Koch","year":"2012","unstructured":"Koch S, Claesson-Welsh L (2012) Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med 2(7):a006502. https:\/\/doi.org\/10.1101\/cshperspect.a006502","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"12","key":"10090_CR44","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.2337\/diabetes.52.12.2959","volume":"52","author":"J Cai","year":"2003","unstructured":"Cai J, Ahmad S, Jiang WG, Huang J, Kontos CD, Boulton M, Ahmed A (2003) Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells. Diabetes 52(12):2959\u20132968. https:\/\/doi.org\/10.2337\/diabetes.52.12.2959","journal-title":"Diabetes"},{"issue":"3","key":"10090_CR45","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1161\/circresaha.108.174128","volume":"103","author":"J Nishi","year":"2008","unstructured":"Nishi J, Minamino T, Miyauchi H, Nojima A, Tateno K, Okada S, Orimo M, Moriya J, Fong GH, Sunagawa K, Shibuya M, Komuro I (2008) Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt. Circ Res 103(3):261\u2013268. https:\/\/doi.org\/10.1161\/circresaha.108.174128","journal-title":"Circ Res"},{"issue":"2","key":"10090_CR46","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.bbagen.2014.10.023","volume":"1850","author":"S Li","year":"2015","unstructured":"Li S, Zhou XL, Dang YY, Kwan YW, Chan SW, Leung GP, Lee SM, Hoi MP (2015) Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis. Biochim Biophys Acta 1850(2):373\u2013384. https:\/\/doi.org\/10.1016\/j.bbagen.2014.10.023","journal-title":"Biochim Biophys Acta"},{"key":"10090_CR47","doi-asserted-by":"publisher","first-page":"15699","DOI":"10.1038\/ncomms15699","volume":"8","author":"JM Boucher","year":"2017","unstructured":"Boucher JM, Clark RP, Chong DC, Citrin KM, Wylie LA, Bautch VL (2017) Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis. Nat Commun 8:15699. https:\/\/doi.org\/10.1038\/ncomms15699","journal-title":"Nat Commun"},{"key":"10090_CR48","doi-asserted-by":"publisher","first-page":"117083","DOI":"10.1016\/j.taap.2024.117083","volume":"492","author":"M Osada","year":"2024","unstructured":"Osada M, Yamashita A, Akinaga S, Hosono K, Ito Y, Shibuya M, Asari Y, Amano H (2024) VEGFR1 TK signaling protects the lungs against LPS-induced injury by suppressing the activity of alveolar macrophages and enhancing the anti-inflammatory function of monocyte-derived macrophages. Toxicol Appl Pharmacol 492:117083. https:\/\/doi.org\/10.1016\/j.taap.2024.117083","journal-title":"Toxicol Appl Pharmacol"},{"issue":"9","key":"10090_CR49","doi-asserted-by":"publisher","first-page":"e18317","DOI":"10.7759\/cureus.18317","volume":"13","author":"G Patel","year":"2021","unstructured":"Patel G, Pielykh D, Patel SM, Patel MJ, Bhavsar K, Koritala T (2021) COVID-19 Coronavirus-induced atypical pneumonia: efficacy of the monoclonal antibody bevacizumab in moderate to severe cases. Cureus 13(9):e18317. https:\/\/doi.org\/10.7759\/cureus.18317","journal-title":"Cureus"},{"issue":"6","key":"10090_CR50","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1089\/hum.2008.169","volume":"20","author":"M Watanabe","year":"2009","unstructured":"Watanabe M, Boyer JL, Crystal RG (2009) Genetic delivery of bevacizumab to suppress vascular endothelial growth factor-induced high-permeability pulmonary edema. Hum Gene Ther 20(6):598\u2013610. https:\/\/doi.org\/10.1089\/hum.2008.169","journal-title":"Hum Gene Ther"},{"issue":"1","key":"10090_CR51","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/s41467-021-21085-8","volume":"12","author":"J Pang","year":"2021","unstructured":"Pang J, Xu F, Aondio G, Li Y, Fumagalli A, Lu M, Valmadre G, Wei J, Bian Y, Canesi M, Damiani G, Zhang Y, Yu D, Chen J, Ji X, Sui W, Wang B, Wu S, Kovacs A, Revera M, Wang H, Jing X, Zhang Y, Chen Y, Cao Y (2021) Efficacy and tolerability of bevacizumab in patients with severe Covid-19. Nat Commun 12(1):814. https:\/\/doi.org\/10.1038\/s41467-021-21085-8","journal-title":"Nat Commun"},{"key":"10090_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/cells8040288","author":"M Stevens","year":"2019","unstructured":"Stevens M, Oltean S (2019) Modulation of receptor tyrosine kinase activity through alternative splicing of ligands and receptors in the VEGF-A\/VEGFR axis. Cells 8(4). https:\/\/doi.org\/10.3390\/cells8040288","journal-title":"Cells"},{"issue":"2","key":"10090_CR53","doi-asserted-by":"publisher","first-page":"132","DOI":"10.2174\/157488408784293705","volume":"3","author":"JM Roodhart","year":"2008","unstructured":"Roodhart JM, Langenberg MH, Witteveen E, Voest EE (2008) The molecular basis of class side effects due to treatment with inhibitors of the VEGF\/VEGFR pathway. Curr Clin Pharmacol 3(2):132\u2013143. https:\/\/doi.org\/10.2174\/157488408784293705","journal-title":"Curr Clin Pharmacol"},{"issue":"2","key":"10090_CR54","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.ejca.2009.11.001","volume":"46","author":"H Izzedine","year":"2010","unstructured":"Izzedine H, Massard C, Spano JP, Goldwasser F, Khayat D, Soria JC (2010) VEGF signalling inhibition-induced proteinuria: Mechanisms, significance and management. Eur J Cancer 46(2):439\u2013448. https:\/\/doi.org\/10.1016\/j.ejca.2009.11.001","journal-title":"Eur J Cancer"},{"issue":"19","key":"10090_CR55","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1001\/jama.2008.656","volume":"300","author":"SR Nalluri","year":"2008","unstructured":"Nalluri SR, Chu D, Keresztes R, Zhu X, Wu S (2008) Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis. JAMA 300(19):2277\u20132285. https:\/\/doi.org\/10.1001\/jama.2008.656","journal-title":"JAMA"}],"container-title":["Angiogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-026-10090-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10456-026-10090-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10456-026-10090-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:10:22Z","timestamp":1791112222000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10456-026-10090-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,4]]},"references-count":55,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,11]]}},"alternative-id":["10090"],"URL":"https:\/\/doi.org\/10.1007\/s10456-026-10090-4","relation":{},"ISSN":["1573-7209"],"issn-type":[{"value":"1573-7209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,4]]},"assertion":[{"value":"18 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study received approval from the Ethics Committee of the First Affiliated Hospital of Guangzhou Medical University (Approval Number: 2020-36) and Zhujiang Hospital of Southern Medical University (Approval Number: 2023-KY-160-02) and was conducted in accordance with the principles of the Declaration of Helsinki. Written informed consent was obtained from all participants prior to their inclusion.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"75"}}