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Participants were people with HIV who had participated in the large RCT on the short-term effectiveness of the guided online intervention. The primary outcome measure was depressive symptoms [Patient Health Questionnaire-9 (PHQ-9)] and the secondary outcome measure was anxiety symptoms [Generalized Anxiety Disorder-2 (GAD-2) scale]. Forty-seven participants completed the long-term follow-up. PHQ-9 scores, previously found to have been significantly reduced on the short term, remained low on the long term. GAD-2 scores did not decrease significantly on the short term, however, on the long term, a significant decrease was found. The intervention may not only be effective in lowering depressive symptoms on the short term but also retain the results on the long term.<\/jats:p><jats:p><jats:italic>Trial registration<\/jats:italic> International Clinical Trials Registry Platform, NL8448, March 3, 2020.<\/jats:p>","DOI":"10.1007\/s10461-022-03901-4","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T19:08:03Z","timestamp":1666984083000},"page":"1694-1702","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Effectiveness of an Online Self-help Intervention for People with HIV and Depressive Symptoms"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7871-5888","authenticated-orcid":false,"given":"Sanne","family":"van Luenen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Garnefski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Spinhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Kraaij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"issue":"3","key":"3901_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.biopsych.2005.05.001","volume":"58","author":"DL Evans","year":"2005","unstructured":"Evans DL, Charney DS, Lewis L, Golden RN, Gorman JM, Krishnan KR, et al. 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