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Latent class analysis identified subgroups with distinct combinations of adversities, including bullying, intimate partner violence, substance use, HIV stigma, low social support, histories of sex work, and below-income status. Significant interactive synergism were found as hypothesized, supporting a syndemic effect with qualitatively increasing levels of adversities on suicidality (score range: 3\u201317) over the 12 months. The interaction between moderate adversity clustering and depression (\u03b2<jats:sub>ow<\/jats:sub>\u2009=\u20092.50, 95% CI: 1.12\u20133.88) and high adversity clustering and depression (\u03b2<jats:sub>ow<\/jats:sub>\u2009=\u20093.61, 95% CI: 1.12\u20136.09) indicated that the impact of depression on suicidality was modified by pre-existing adversities. The findings suggest that, while a multi-component intervention addressing psychosocial problems is ideal, effective depression treatment alone could significantly reduce suicidality among YMSM living with HIV.<\/jats:p>","DOI":"10.1007\/s10461-024-04516-7","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T01:03:05Z","timestamp":1736384585000},"page":"420-434","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Syndemic Clustering of Adversities on Suicide Risk among YMSM Living with HIV in Bangkok: A Causal Latent Class Analysis"],"prefix":"10.1007","volume":"29","author":[{"given":"Doug H.","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Worawalan","family":"Waratworawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamol","family":"Kongjareon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai J.","family":"Jonas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin How","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis N.","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Guadamuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"4516_CR1","doi-asserted-by":"publisher","unstructured":"King M, Semlyen J, Tai SS, Killaspy H, Osborn D, Popelyuk D et al. 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