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Overall, higher internal strengths were related to better learning and memory, whereas higher socioemotional support was related to better processing speed and psychomotor speed. PWH had a stronger positive relationship between PPFs and verbal fluency than PWoH. Overall, higher internal strengths were associated with fewer daily functioning impairments; however, only PWoH showed fewer functional declines with higher socioemotional support. PWH may require greater socioemotional support to accommodate an increased burden of comorbidities leading to functional difficulties. 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