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As the pandemic evolves and prevention fatigue rises, the vaccination sentiments and hesitancy of PWH require attention amid continued recommendations for boosters. Situated within South Carolina, this study aims to illustrate PWH\u2019s vaccination sentiments, as well as barriers and facilitators to vaccination. Semi-structured interviews were conducted online between March and August of 2023, among 24 PWH who were snowball and purposively sampled at a local AIDS Service Organization. An abductive approach was employed. All interviews were recorded, transcribed, and coded using an inductive, thematic analysis approach to identify and analyze emergent themes, which were then deductively categorized into the socioecological model. At the individual level, the need to protect oneself and others, prioritization of vaccination due to HIV status, and a positive personal history of vaccination facilitated uptake while a negative personal history acted as a barrier. Within the interpersonal and institutional level, family and friends as well as healthcare providers were found to serve as both positive and negative vaccine messengers. At the structural level, vaccine requirements and mandates (e.g., employer, travel) facilitated uptake while misinformation, misunderstanding, and skepticism (e.g., pace and process of vaccine development) acted as barriers to uptake. Tailored vaccination education and enhanced trust between providers and PWH may improve vaccination sentiments and mitigate hesitancy, as additional doses continue to be recommended.<\/jats:p>","DOI":"10.1007\/s10461-025-04642-w","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T13:45:53Z","timestamp":1741009553000},"page":"1650-1662","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u201cI\u2019m Afraid to Put Any More of It Into My Body\u201d: COVID-19 Vaccination and Booster Barriers and Facilitators Among People with HIV in South Carolina"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2569-0418","authenticated-orcid":false,"given":"Camryn","family":"Garrett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5332-498X","authenticated-orcid":false,"given":"Arielle","family":"N\u2019Diaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1834-1834","authenticated-orcid":false,"given":"Shan","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5555-9034","authenticated-orcid":false,"given":"Xiaoming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"unstructured":"Decades in the Making. mRNA COVID-19 Vaccines| NIH COVID-19 Research. 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Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors have no conflicts of interest to report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}